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Protein

DDB1- and CUL4-associated factor 11

Gene

Dcaf11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 11
Alternative name(s):
WD repeat-containing protein 23
Gene namesi
Name:Dcaf11
Synonyms:D14Ucla1, Wdr23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:90168. Dcaf11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549DDB1- and CUL4-associated factor 11PRO_0000051372Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei73 – 731PhosphoserineCombined sources
Modified residuei75 – 751PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91VU6.
MaxQBiQ91VU6.
PaxDbiQ91VU6.
PRIDEiQ91VU6.

PTM databases

iPTMnetiQ91VU6.
PhosphoSiteiQ91VU6.

Expressioni

Gene expression databases

BgeeiQ91VU6.
CleanExiMM_WDR23.
ExpressionAtlasiQ91VU6. baseline and differential.
GenevisibleiQ91VU6. MM.

Interactioni

Subunit structurei

Interacts with DDB1 and CUL4A.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072344.

Structurei

3D structure databases

ProteinModelPortaliQ91VU6.
SMRiQ91VU6. Positions 180-519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati170 – 21041WD 1Add
BLAST
Repeati216 – 25843WD 2Add
BLAST
Repeati263 – 30240WD 3Add
BLAST
Repeati305 – 34541WD 4Add
BLAST
Repeati353 – 39240WD 5Add
BLAST
Repeati435 – 48046WD 6Add
BLAST
Repeati481 – 52040WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQ14. Eukaryota.
ENOG410XP4W. LUCA.
GeneTreeiENSGT00720000108873.
HOGENOMiHOG000241217.
HOVERGENiHBG055176.
InParanoidiQ91VU6.
KOiK11801.
OMAiQDDMPES.
OrthoDBiEOG7NSB2H.
PhylomeDBiQ91VU6.
TreeFamiTF314126.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR017399. DCAF11/LEC14B.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
PIRSFiPIRSF038135. WD_repeat_p23. 1 hit.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91VU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSRNSSSAG SGSLEPSEGL SRRGTGLRRS EEEEEEDEDV DLAQVLAYLL
60 70 80 90 100
RRGQVRLVQG RGAANLQLIQ ALSDSEEEHD SAWDGRLGDR YNPPVDATPD
110 120 130 140 150
TRELEYNEIK TQVGLATGRL GLRRTALQQS FPQMLHQRER GLCHRGSFSL
160 170 180 190 200
GEQSRVMSHF LPNDLSFTDT YSQKAFCGIY SKDGQIFMSA CQDQTIRLYD
210 220 230 240 250
CRYGRFHKFK SIKARDVGWS VLDVAFTPDG NHFLYSSWSD YIHICNIYGE
260 270 280 290 300
GDTHTALDLR PDERRFAVFS IAVSSDGREV LGGANDGCLY VFDREQNRRT
310 320 330 340 350
LQIESHEDDV NAVAFADISS QILFSGGDDA ICKVWDRRTM REDDPKPVGA
360 370 380 390 400
LAGHQDGITF IDSKGDARYL ISNSKDQTIK LWDIRRFSSR EGMEASRLAA
410 420 430 440 450
TQQNWDYRWQ QVPKIAWKKL KLPGDSSLMT YRGHGVLHTL IRCRFSPAHS
460 470 480 490 500
TGQQFIYSGC STGKVVVYDL LSGHIVKKLT NHKACVRDVS WHPFEEKIVS
510 520 530 540
SSWDGNLRLW QYRQAEYFQD DMPESDMNRV CSSGPTPVPC PSVAFSSPQ
Length:549
Mass (Da):61,992
Last modified:December 1, 2001 - v1
Checksum:i0ACECBEC90887352
GO
Isoform 2 (identifier: Q91VU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.
     45-51: VLAYLLR → MKMWIWP

Show »
Length:505
Mass (Da):57,456
Checksum:iE887F063ABB267DB
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4444Missing in isoform 2. 1 PublicationVSP_008425Add
BLAST
Alternative sequencei45 – 517VLAYLLR → MKMWIWP in isoform 2. 1 PublicationVSP_008426

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033540 mRNA. Translation: BAC28348.1.
AK152395 mRNA. Translation: BAE31183.1.
BC008545 mRNA. Translation: AAH08545.1.
BC037001 mRNA. Translation: AAH37001.1.
CCDSiCCDS27115.1. [Q91VU6-1]
RefSeqiNP_001185938.1. NM_001199009.1. [Q91VU6-1]
NP_598495.1. NM_133734.3. [Q91VU6-1]
XP_006519144.1. XM_006519081.2. [Q91VU6-1]
XP_006519146.1. XM_006519083.2. [Q91VU6-1]
XP_006519147.1. XM_006519084.2. [Q91VU6-1]
XP_006519148.1. XM_006519085.2. [Q91VU6-1]
XP_006519149.1. XM_006519086.2. [Q91VU6-1]
XP_006519150.1. XM_006519087.2. [Q91VU6-2]
XP_006519151.1. XM_006519088.2. [Q91VU6-2]
XP_006519152.1. XM_006519089.2. [Q91VU6-2]
XP_006519153.1. XM_006519090.2. [Q91VU6-2]
XP_006519154.1. XM_006519091.2. [Q91VU6-2]
UniGeneiMm.11535.
Mm.488383.

Genome annotation databases

EnsembliENSMUST00000072530; ENSMUSP00000072344; ENSMUSG00000022214. [Q91VU6-1]
ENSMUST00000117236; ENSMUSP00000113014; ENSMUSG00000022214. [Q91VU6-1]
ENSMUST00000121622; ENSMUSP00000113202; ENSMUSG00000022214. [Q91VU6-1]
GeneIDi28199.
KEGGimmu:28199.
UCSCiuc007tyz.2. mouse. [Q91VU6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033540 mRNA. Translation: BAC28348.1.
AK152395 mRNA. Translation: BAE31183.1.
BC008545 mRNA. Translation: AAH08545.1.
BC037001 mRNA. Translation: AAH37001.1.
CCDSiCCDS27115.1. [Q91VU6-1]
RefSeqiNP_001185938.1. NM_001199009.1. [Q91VU6-1]
NP_598495.1. NM_133734.3. [Q91VU6-1]
XP_006519144.1. XM_006519081.2. [Q91VU6-1]
XP_006519146.1. XM_006519083.2. [Q91VU6-1]
XP_006519147.1. XM_006519084.2. [Q91VU6-1]
XP_006519148.1. XM_006519085.2. [Q91VU6-1]
XP_006519149.1. XM_006519086.2. [Q91VU6-1]
XP_006519150.1. XM_006519087.2. [Q91VU6-2]
XP_006519151.1. XM_006519088.2. [Q91VU6-2]
XP_006519152.1. XM_006519089.2. [Q91VU6-2]
XP_006519153.1. XM_006519090.2. [Q91VU6-2]
XP_006519154.1. XM_006519091.2. [Q91VU6-2]
UniGeneiMm.11535.
Mm.488383.

3D structure databases

ProteinModelPortaliQ91VU6.
SMRiQ91VU6. Positions 180-519.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072344.

PTM databases

iPTMnetiQ91VU6.
PhosphoSiteiQ91VU6.

Proteomic databases

EPDiQ91VU6.
MaxQBiQ91VU6.
PaxDbiQ91VU6.
PRIDEiQ91VU6.

Protocols and materials databases

DNASUi28199.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072530; ENSMUSP00000072344; ENSMUSG00000022214. [Q91VU6-1]
ENSMUST00000117236; ENSMUSP00000113014; ENSMUSG00000022214. [Q91VU6-1]
ENSMUST00000121622; ENSMUSP00000113202; ENSMUSG00000022214. [Q91VU6-1]
GeneIDi28199.
KEGGimmu:28199.
UCSCiuc007tyz.2. mouse. [Q91VU6-1]

Organism-specific databases

CTDi80344.
MGIiMGI:90168. Dcaf11.

Phylogenomic databases

eggNOGiENOG410IQ14. Eukaryota.
ENOG410XP4W. LUCA.
GeneTreeiENSGT00720000108873.
HOGENOMiHOG000241217.
HOVERGENiHBG055176.
InParanoidiQ91VU6.
KOiK11801.
OMAiQDDMPES.
OrthoDBiEOG7NSB2H.
PhylomeDBiQ91VU6.
TreeFamiTF314126.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiDcaf11. mouse.
PROiQ91VU6.
SOURCEiSearch...

Gene expression databases

BgeeiQ91VU6.
CleanExiMM_WDR23.
ExpressionAtlasiQ91VU6. baseline and differential.
GenevisibleiQ91VU6. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR017399. DCAF11/LEC14B.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
PIRSFiPIRSF038135. WD_repeat_p23. 1 hit.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Bone marrow and Colon.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Liver and Mammary tumor.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73 AND SER-75, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiDCA11_MOUSE
AccessioniPrimary (citable) accession number: Q91VU6
Secondary accession number(s): Q3U836, Q8JZV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.