ID   FAM3C_MOUSE             Reviewed;         227 AA.
AC   Q91VU0; Q53YY7; Q7TML1; Q9CTB4;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   21-SEP-2011, entry version 72.
DE   RecName: Full=Protein FAM3C;
DE   AltName: Full=Interleukin-like EMT inducer;
DE   Flags: Precursor;
GN   Name=Fam3c; Synonyms=D6Wsu176e, Ilei;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE
RP   SPECIFICITY.
RC   STRAIN=CD-1; TISSUE=Inner ear;
RX   PubMed=15194199; DOI=10.1016/j.gene.2004.03.026;
RA   Pilipenko V.V., Reece A., Choo D.I., Greinwald J.H. Jr.;
RT   "Genomic organization and expression analysis of the murine Fam3c
RT   gene.";
RL   Gene 335:159-168(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Embryo;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   PROTEIN SEQUENCE OF 73-84, AND MASS SPECTROMETRY.
RC   STRAIN=C57BL/6; TISSUE=Brain;
RA   Lubec G., Kang S.U.;
RL   Submitted (APR-2007) to UniProtKB.
RN   [6]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=16959614; DOI=10.1016/j.ccr.2006.07.020;
RA   Waerner T., Alacakaptan M., Tamir I., Oberauer R., Gal A.,
RA   Brabletz T., Schreiber M., Jechlinger M., Beug H.;
RT   "ILEI: a cytokine essential for EMT, tumor formation, and late events
RT   in metastasis in epithelial cells.";
RL   Cancer Cell 10:227-239(2006).
RN   [7]
RP   FUNCTION.
RX   PubMed=19015638; DOI=10.1038/onc.2008.418;
RA   Lahsnig C., Mikula M., Petz M., Zulehner G., Schneller D.,
RA   van Zijl F., Huber H., Csiszar A., Beug H., Mikulits W.;
RT   "ILEI requires oncogenic Ras for the epithelial to mesenchymal
RT   transition of hepatocytes and liver carcinoma progression.";
RL   Oncogene 28:638-650(2009).
RN   [8]
RP   FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND DEVELOPMENTAL
RP   STAGE.
RX   PubMed=20059962; DOI=10.1016/j.bbrc.2009.12.180;
RA   Katahira T., Nakagiri S., Terada K., Furukawa T.;
RT   "Secreted factor FAM3C (ILEI) is involved in retinal laminar
RT   formation.";
RL   Biochem. Biophys. Res. Commun. 392:301-306(2010).
RN   [9]
RP   INDUCTION BY TGFB.
RX   PubMed=20154680; DOI=10.1038/ncb2029;
RA   Chaudhury A., Hussey G.S., Ray P.S., Jin G., Fox P.L., Howe P.H.;
RT   "TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via
RT   transcript-selective translational induction of Dab2 and ILEI.";
RL   Nat. Cell Biol. 12:286-293(2010).
CC   -!- FUNCTION: May be involved in retinal laminar formation. Promotes
CC       epithelial to mesenchymal transition.
CC   -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic vesicle (By
CC       similarity).
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in
CC       the retina. Up-regulated in mammary epithelial cells and
CC       hepatocytes undergoing epithelial to mesenchymal transition (at
CC       protein level).
CC   -!- DEVELOPMENTAL STAGE: Expressed at E15.5 in the nonsensory
CC       epithelium of the inner ear and at lower levels in the vestibule
CC       of the inner ear, the brain and hair follicles. Expressed in the
CC       ganglion cell layer of the retina and in the ciliary body at
CC       E15.5. At later stages, retinal expression becomes restricted to
CC       the ganglion cell layer.
CC   -!- INDUCTION: By TGF-beta in epithelial cells.
CC   -!- SIMILARITY: Belongs to the FAM3 family.
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DR   EMBL; AY424275; AAR84605.1; -; mRNA.
DR   EMBL; AK004059; BAB23146.1; -; mRNA.
DR   EMBL; AK154498; BAE32629.1; -; mRNA.
DR   EMBL; AK170887; BAE42094.1; -; mRNA.
DR   EMBL; CH466533; EDL13845.1; -; Genomic_DNA.
DR   EMBL; BC009086; AAH09086.1; -; mRNA.
DR   EMBL; BC055853; AAH55853.1; -; mRNA.
DR   IPI; IPI00454042; -.
DR   RefSeq; NP_613053.3; NM_138587.4.
DR   UniGene; Mm.400193; -.
DR   STRING; Q91VU0; -.
DR   PRIDE; Q91VU0; -.
DR   Ensembl; ENSMUST00000165576; ENSMUSP00000127709; ENSMUSG00000029672.
DR   Ensembl; ENSMUST00000169936; ENSMUSP00000132681; ENSMUSG00000029672.
DR   GeneID; 27999; -.
DR   KEGG; mmu:27999; -.
DR   NMPDR; fig|10090.3.peg.12994; -.
DR   UCSC; uc009bay.1; mouse.
DR   CTD; 10447; -.
DR   MGI; MGI:107892; Fam3c.
DR   GeneTree; ENSGT00530000063020; -.
DR   HOVERGEN; HBG051544; -.
DR   InParanoid; Q91VU0; -.
DR   OMA; VGPKICV; -.
DR   OrthoDB; EOG43R3NW; -.
DR   NextBio; 306500; -.
DR   ArrayExpress; Q91VU0; -.
DR   Bgee; Q91VU0; -.
DR   Genevestigator; Q91VU0; -.
DR   GermOnline; ENSMUSG00000029672; Mus musculus.
DR   GO; GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytoplasmic vesicle; Developmental protein;
KW   Direct protein sequencing; Disulfide bond; Oncogene;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL        1     24       Potential.
FT   CHAIN        25    227       Protein FAM3C.
FT                                /FTId=PRO_0000008753.
FT   DISULFID     58    221       Potential.
FT   DISULFID     64     86       Potential.
FT   CONFLICT     43     43       A -> T (in Ref. 4; AAH55853).
SQ   SEQUENCE   227 AA;  24753 MW;  9195280B92838CF4 CRC64;
     MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGNLFA RSALDSAIRS TKPPRYKCGI
     SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV GRGINIALVN GKTGEVIDTK
     FFDMWGGDVA PFIEFLKTIQ DGTVVLMATY DDGATKLTDE ARRLIAELGS TSITSLGFRD
     NWVFCGGKGI KTKSPFEQHI KNNKETNKYE GWPEVVEMEG CIPQKQD
//