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Q91VU0

- FAM3C_MOUSE

UniProt

Q91VU0 - FAM3C_MOUSE

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Protein

Protein FAM3C

Gene

Fam3c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.3 Publications

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM3C
Alternative name(s):
Interleukin-like EMT inducer
Gene namesi
Name:Fam3c
Synonyms:D6Wsu176e, Ilei
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:107892. Fam3c.

Subcellular locationi

Secreted 1 Publication. Cytoplasmic vesicle By similarity

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
  3. Golgi apparatus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 227203Protein FAM3CPRO_0000008753Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 86By similarity
Disulfide bondi64 ↔ 221By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ91VU0.
PaxDbiQ91VU0.
PRIDEiQ91VU0.

PTM databases

PhosphoSiteiQ91VU0.

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in the retina. Up-regulated in mammary epithelial cells and hepatocytes undergoing epithelial to mesenchymal transition (at protein level).3 Publications

Developmental stagei

Expressed at E15.5 in the nonsensory epithelium of the inner ear and at lower levels in the vestibule of the inner ear, the brain and hair follicles. Expressed in the ganglion cell layer of the retina and in the ciliary body at E15.5. At later stages, retinal expression becomes restricted to the ganglion cell layer.2 Publications

Inductioni

By TGF-beta in epithelial cells.1 Publication

Gene expression databases

BgeeiQ91VU0.
ExpressionAtlasiQ91VU0. baseline and differential.
GenevestigatoriQ91VU0.

Structurei

3D structure databases

ProteinModelPortaliQ91VU0.
SMRiQ91VU0. Positions 53-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG79275.
GeneTreeiENSGT00530000063020.
HOVERGENiHBG051544.
InParanoidiQ91VU0.
OrthoDBiEOG79PJQG.
PhylomeDBiQ91VU0.
TreeFamiTF353414.

Family and domain databases

InterProiIPR026101. FAM3.
[Graphical view]
PANTHERiPTHR14592. PTHR14592. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VU0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGNLFA RSALDSAIRS
60 70 80 90 100
TKPPRYKCGI SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV
110 120 130 140 150
GRGINIALVN GKTGEVIDTK FFDMWGGDVA PFIEFLKTIQ DGTVVLMATY
160 170 180 190 200
DDGATKLTDE ARRLIAELGS TSITSLGFRD NWVFCGGKGI KTKSPFEQHI
210 220
KNNKETNKYE GWPEVVEMEG CIPQKQD
Length:227
Mass (Da):24,753
Last modified:December 1, 2001 - v1
Checksum:i9195280B92838CF4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431A → T in AAH55853. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY424275 mRNA. Translation: AAR84605.1.
AK004059 mRNA. Translation: BAB23146.1.
AK154498 mRNA. Translation: BAE32629.1.
AK170887 mRNA. Translation: BAE42094.1.
CH466533 Genomic DNA. Translation: EDL13845.1.
BC009086 mRNA. Translation: AAH09086.1.
BC055853 mRNA. Translation: AAH55853.1.
CCDSiCCDS39436.1.
RefSeqiNP_613053.3. NM_138587.4.
XP_006505165.1. XM_006505102.1.
XP_006505166.1. XM_006505103.1.
UniGeneiMm.490307.

Genome annotation databases

EnsembliENSMUST00000165576; ENSMUSP00000127709; ENSMUSG00000029672.
GeneIDi27999.
KEGGimmu:27999.
UCSCiuc009bay.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY424275 mRNA. Translation: AAR84605.1 .
AK004059 mRNA. Translation: BAB23146.1 .
AK154498 mRNA. Translation: BAE32629.1 .
AK170887 mRNA. Translation: BAE42094.1 .
CH466533 Genomic DNA. Translation: EDL13845.1 .
BC009086 mRNA. Translation: AAH09086.1 .
BC055853 mRNA. Translation: AAH55853.1 .
CCDSi CCDS39436.1.
RefSeqi NP_613053.3. NM_138587.4.
XP_006505165.1. XM_006505102.1.
XP_006505166.1. XM_006505103.1.
UniGenei Mm.490307.

3D structure databases

ProteinModelPortali Q91VU0.
SMRi Q91VU0. Positions 53-224.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91VU0.

Proteomic databases

MaxQBi Q91VU0.
PaxDbi Q91VU0.
PRIDEi Q91VU0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000165576 ; ENSMUSP00000127709 ; ENSMUSG00000029672 .
GeneIDi 27999.
KEGGi mmu:27999.
UCSCi uc009bay.1. mouse.

Organism-specific databases

CTDi 10447.
MGIi MGI:107892. Fam3c.

Phylogenomic databases

eggNOGi NOG79275.
GeneTreei ENSGT00530000063020.
HOVERGENi HBG051544.
InParanoidi Q91VU0.
OrthoDBi EOG79PJQG.
PhylomeDBi Q91VU0.
TreeFami TF353414.

Miscellaneous databases

NextBioi 306500.
PROi Q91VU0.
SOURCEi Search...

Gene expression databases

Bgeei Q91VU0.
ExpressionAtlasi Q91VU0. baseline and differential.
Genevestigatori Q91VU0.

Family and domain databases

InterProi IPR026101. FAM3.
[Graphical view ]
PANTHERi PTHR14592. PTHR14592. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization and expression analysis of the murine Fam3c gene."
    Pilipenko V.V., Reece A., Choo D.I., Greinwald J.H. Jr.
    Gene 335:159-168(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: CD-1.
    Tissue: Inner ear.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Embryo.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  5. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 73-84, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  6. "ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells."
    Waerner T., Alacakaptan M., Tamir I., Oberauer R., Gal A., Brabletz T., Schreiber M., Jechlinger M., Beug H.
    Cancer Cell 10:227-239(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  7. "ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression."
    Lahsnig C., Mikula M., Petz M., Zulehner G., Schneller D., van Zijl F., Huber H., Csiszar A., Beug H., Mikulits W.
    Oncogene 28:638-650(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Secreted factor FAM3C (ILEI) is involved in retinal laminar formation."
    Katahira T., Nakagiri S., Terada K., Furukawa T.
    Biochem. Biophys. Res. Commun. 392:301-306(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  9. "TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI."
    Chaudhury A., Hussey G.S., Ray P.S., Jin G., Fox P.L., Howe P.H.
    Nat. Cell Biol. 12:286-293(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY TGFB.

Entry informationi

Entry nameiFAM3C_MOUSE
AccessioniPrimary (citable) accession number: Q91VU0
Secondary accession number(s): Q53YY7, Q7TML1, Q9CTB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3