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Protein

Protein FAM3C

Gene

Fam3c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM3C
Alternative name(s):
Interleukin-like EMT inducer
Gene namesi
Name:Fam3c
Synonyms:D6Wsu176e, Ilei
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107892. Fam3c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 227203Protein FAM3CPRO_0000008753Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 86By similarity
Disulfide bondi64 ↔ 221By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ91VU0.
MaxQBiQ91VU0.
PaxDbiQ91VU0.
PRIDEiQ91VU0.
TopDownProteomicsiQ91VU0.

PTM databases

PhosphoSiteiQ91VU0.

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in the retina. Up-regulated in mammary epithelial cells and hepatocytes undergoing epithelial to mesenchymal transition (at protein level).3 Publications

Developmental stagei

Expressed at E15.5 in the nonsensory epithelium of the inner ear and at lower levels in the vestibule of the inner ear, the brain and hair follicles. Expressed in the ganglion cell layer of the retina and in the ciliary body at E15.5. At later stages, retinal expression becomes restricted to the ganglion cell layer.2 Publications

Inductioni

By TGF-beta in epithelial cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000029672.
ExpressionAtlasiQ91VU0. baseline and differential.
GenevisibleiQ91VU0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127709.

Structurei

3D structure databases

ProteinModelPortaliQ91VU0.
SMRiQ91VU0. Positions 53-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEGC. Eukaryota.
ENOG4111I9K. LUCA.
GeneTreeiENSGT00530000063020.
HOVERGENiHBG051544.
InParanoidiQ91VU0.
PhylomeDBiQ91VU0.
TreeFamiTF353414.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGNLFA RSALDSAIRS
60 70 80 90 100
TKPPRYKCGI SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV
110 120 130 140 150
GRGINIALVN GKTGEVIDTK FFDMWGGDVA PFIEFLKTIQ DGTVVLMATY
160 170 180 190 200
DDGATKLTDE ARRLIAELGS TSITSLGFRD NWVFCGGKGI KTKSPFEQHI
210 220
KNNKETNKYE GWPEVVEMEG CIPQKQD
Length:227
Mass (Da):24,753
Last modified:December 1, 2001 - v1
Checksum:i9195280B92838CF4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431A → T in AAH55853 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424275 mRNA. Translation: AAR84605.1.
AK004059 mRNA. Translation: BAB23146.1.
AK154498 mRNA. Translation: BAE32629.1.
AK170887 mRNA. Translation: BAE42094.1.
CH466533 Genomic DNA. Translation: EDL13845.1.
BC009086 mRNA. Translation: AAH09086.1.
BC055853 mRNA. Translation: AAH55853.1.
CCDSiCCDS39436.1.
RefSeqiNP_613053.3. NM_138587.4.
XP_006505165.1. XM_006505102.2.
XP_006505166.1. XM_006505103.2.
UniGeneiMm.490307.

Genome annotation databases

EnsembliENSMUST00000165576; ENSMUSP00000127709; ENSMUSG00000029672.
GeneIDi27999.
KEGGimmu:27999.
UCSCiuc009bay.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424275 mRNA. Translation: AAR84605.1.
AK004059 mRNA. Translation: BAB23146.1.
AK154498 mRNA. Translation: BAE32629.1.
AK170887 mRNA. Translation: BAE42094.1.
CH466533 Genomic DNA. Translation: EDL13845.1.
BC009086 mRNA. Translation: AAH09086.1.
BC055853 mRNA. Translation: AAH55853.1.
CCDSiCCDS39436.1.
RefSeqiNP_613053.3. NM_138587.4.
XP_006505165.1. XM_006505102.2.
XP_006505166.1. XM_006505103.2.
UniGeneiMm.490307.

3D structure databases

ProteinModelPortaliQ91VU0.
SMRiQ91VU0. Positions 53-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127709.

PTM databases

PhosphoSiteiQ91VU0.

Proteomic databases

EPDiQ91VU0.
MaxQBiQ91VU0.
PaxDbiQ91VU0.
PRIDEiQ91VU0.
TopDownProteomicsiQ91VU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165576; ENSMUSP00000127709; ENSMUSG00000029672.
GeneIDi27999.
KEGGimmu:27999.
UCSCiuc009bay.1. mouse.

Organism-specific databases

CTDi10447.
MGIiMGI:107892. Fam3c.

Phylogenomic databases

eggNOGiENOG410IEGC. Eukaryota.
ENOG4111I9K. LUCA.
GeneTreeiENSGT00530000063020.
HOVERGENiHBG051544.
InParanoidiQ91VU0.
PhylomeDBiQ91VU0.
TreeFamiTF353414.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiFam3c. mouse.
PROiQ91VU0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029672.
ExpressionAtlasiQ91VU0. baseline and differential.
GenevisibleiQ91VU0. MM.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiFAM3C_MOUSE
AccessioniPrimary (citable) accession number: Q91VU0
Secondary accession number(s): Q53YY7, Q7TML1, Q9CTB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.