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Q91VU0

- FAM3C_MOUSE

UniProt

Q91VU0 - FAM3C_MOUSE

Protein

Protein FAM3C

Gene

Fam3c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.3 Publications

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM3C
    Alternative name(s):
    Interleukin-like EMT inducer
    Gene namesi
    Name:Fam3c
    Synonyms:D6Wsu176e, Ilei
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:107892. Fam3c.

    Subcellular locationi

    Secreted 1 Publication. Cytoplasmic vesicle By similarity

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-SubCell
    3. Golgi apparatus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 227203Protein FAM3CPRO_0000008753Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi58 ↔ 86By similarity
    Disulfide bondi64 ↔ 221By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ91VU0.
    PaxDbiQ91VU0.
    PRIDEiQ91VU0.

    PTM databases

    PhosphoSiteiQ91VU0.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed, with highest levels in the retina. Up-regulated in mammary epithelial cells and hepatocytes undergoing epithelial to mesenchymal transition (at protein level).3 Publications

    Developmental stagei

    Expressed at E15.5 in the nonsensory epithelium of the inner ear and at lower levels in the vestibule of the inner ear, the brain and hair follicles. Expressed in the ganglion cell layer of the retina and in the ciliary body at E15.5. At later stages, retinal expression becomes restricted to the ganglion cell layer.2 Publications

    Inductioni

    By TGF-beta in epithelial cells.1 Publication

    Gene expression databases

    ArrayExpressiQ91VU0.
    BgeeiQ91VU0.
    GenevestigatoriQ91VU0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91VU0.
    SMRiQ91VU0. Positions 53-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM3 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG79275.
    GeneTreeiENSGT00530000063020.
    HOVERGENiHBG051544.
    InParanoidiQ53YY7.
    OrthoDBiEOG79PJQG.
    PhylomeDBiQ91VU0.
    TreeFamiTF353414.

    Family and domain databases

    InterProiIPR026101. FAM3.
    [Graphical view]
    PANTHERiPTHR14592. PTHR14592. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91VU0-1 [UniParc]FASTAAdd to Basket

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    MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGNLFA RSALDSAIRS    50
    TKPPRYKCGI SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV 100
    GRGINIALVN GKTGEVIDTK FFDMWGGDVA PFIEFLKTIQ DGTVVLMATY 150
    DDGATKLTDE ARRLIAELGS TSITSLGFRD NWVFCGGKGI KTKSPFEQHI 200
    KNNKETNKYE GWPEVVEMEG CIPQKQD 227
    Length:227
    Mass (Da):24,753
    Last modified:December 1, 2001 - v1
    Checksum:i9195280B92838CF4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti43 – 431A → T in AAH55853. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY424275 mRNA. Translation: AAR84605.1.
    AK004059 mRNA. Translation: BAB23146.1.
    AK154498 mRNA. Translation: BAE32629.1.
    AK170887 mRNA. Translation: BAE42094.1.
    CH466533 Genomic DNA. Translation: EDL13845.1.
    BC009086 mRNA. Translation: AAH09086.1.
    BC055853 mRNA. Translation: AAH55853.1.
    CCDSiCCDS39436.1.
    RefSeqiNP_613053.3. NM_138587.4.
    XP_006505165.1. XM_006505102.1.
    XP_006505166.1. XM_006505103.1.
    UniGeneiMm.490307.

    Genome annotation databases

    EnsembliENSMUST00000165576; ENSMUSP00000127709; ENSMUSG00000029672.
    GeneIDi27999.
    KEGGimmu:27999.
    UCSCiuc009bay.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY424275 mRNA. Translation: AAR84605.1 .
    AK004059 mRNA. Translation: BAB23146.1 .
    AK154498 mRNA. Translation: BAE32629.1 .
    AK170887 mRNA. Translation: BAE42094.1 .
    CH466533 Genomic DNA. Translation: EDL13845.1 .
    BC009086 mRNA. Translation: AAH09086.1 .
    BC055853 mRNA. Translation: AAH55853.1 .
    CCDSi CCDS39436.1.
    RefSeqi NP_613053.3. NM_138587.4.
    XP_006505165.1. XM_006505102.1.
    XP_006505166.1. XM_006505103.1.
    UniGenei Mm.490307.

    3D structure databases

    ProteinModelPortali Q91VU0.
    SMRi Q91VU0. Positions 53-224.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91VU0.

    Proteomic databases

    MaxQBi Q91VU0.
    PaxDbi Q91VU0.
    PRIDEi Q91VU0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000165576 ; ENSMUSP00000127709 ; ENSMUSG00000029672 .
    GeneIDi 27999.
    KEGGi mmu:27999.
    UCSCi uc009bay.1. mouse.

    Organism-specific databases

    CTDi 10447.
    MGIi MGI:107892. Fam3c.

    Phylogenomic databases

    eggNOGi NOG79275.
    GeneTreei ENSGT00530000063020.
    HOVERGENi HBG051544.
    InParanoidi Q53YY7.
    OrthoDBi EOG79PJQG.
    PhylomeDBi Q91VU0.
    TreeFami TF353414.

    Miscellaneous databases

    NextBioi 306500.
    PROi Q91VU0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91VU0.
    Bgeei Q91VU0.
    Genevestigatori Q91VU0.

    Family and domain databases

    InterProi IPR026101. FAM3.
    [Graphical view ]
    PANTHERi PTHR14592. PTHR14592. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization and expression analysis of the murine Fam3c gene."
      Pilipenko V.V., Reece A., Choo D.I., Greinwald J.H. Jr.
      Gene 335:159-168(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
      Strain: CD-1.
      Tissue: Inner ear.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Embryo.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.
    5. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 73-84, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    6. "ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells."
      Waerner T., Alacakaptan M., Tamir I., Oberauer R., Gal A., Brabletz T., Schreiber M., Jechlinger M., Beug H.
      Cancer Cell 10:227-239(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    7. "ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression."
      Lahsnig C., Mikula M., Petz M., Zulehner G., Schneller D., van Zijl F., Huber H., Csiszar A., Beug H., Mikulits W.
      Oncogene 28:638-650(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Secreted factor FAM3C (ILEI) is involved in retinal laminar formation."
      Katahira T., Nakagiri S., Terada K., Furukawa T.
      Biochem. Biophys. Res. Commun. 392:301-306(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    9. "TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI."
      Chaudhury A., Hussey G.S., Ray P.S., Jin G., Fox P.L., Howe P.H.
      Nat. Cell Biol. 12:286-293(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY TGFB.

    Entry informationi

    Entry nameiFAM3C_MOUSE
    AccessioniPrimary (citable) accession number: Q91VU0
    Secondary accession number(s): Q53YY7, Q7TML1, Q9CTB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3