Q91VU0 (FAM3C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM3C

Alternative name(s):
Interleukin-like EMT inducer

Gene names

Name:	Fam3c
Synonyms:	D6Wsu176e, Ilei

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. Ref.6 Ref.7 Ref.8
Subcellular location	Secreted. Cytoplasmic vesicle By similarity Ref.8.
Tissue specificity	Ubiquitously expressed, with highest levels in the retina. Up-regulated in mammary epithelial cells and hepatocytes undergoing epithelial to mesenchymal transition (at protein level). Ref.1 Ref.6 Ref.8
Developmental stage	Expressed at E15.5 in the nonsensory epithelium of the inner ear and at lower levels in the vestibule of the inner ear, the brain and hair follicles. Expressed in the ganglion cell layer of the retina and in the ciliary body at E15.5. At later stages, retinal expression becomes restricted to the ganglion cell layer. Ref.1 Ref.8
Induction	By TGF-beta in epithelial cells. Ref.9
Sequence similarities	Belongs to the FAM3 family.

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle Secreted
Disease	Oncogene
Domain	Signal
Molecular function	Developmental protein
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasmic membrane-bounded vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 227	203	Protein FAM3C		PRO_0000008753
Amino acid modifications
	Disulfide bond	58 ↔ 221		Potential
	Disulfide bond	64 ↔ 86		Potential
Experimental info
	Sequence conflict	43	1	A → T in AAH55853. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q91VU0 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 9195280B92838CF4	FASTA	227	24,753
	10 20 30 40 50 60 MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGNLFA RSALDSAIRS TKPPRYKCGI 70 80 90 100 110 120 SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV GRGINIALVN GKTGEVIDTK 130 140 150 160 170 180 FFDMWGGDVA PFIEFLKTIQ DGTVVLMATY DDGATKLTDE ARRLIAELGS TSITSLGFRD 190 200 210 220 NWVFCGGKGI KTKSPFEQHI KNNKETNKYE GWPEVVEMEG CIPQKQD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic organization and expression analysis of the murine Fam3c gene." Pilipenko V.V., Reece A., Choo D.I., Greinwald J.H. Jr. Gene 335:159-168(2004) [PubMed: 15194199] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY. Strain: CD-1. Tissue: Inner ear.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Embryo.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Czech II. Tissue: Mammary tumor.
[5]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 73-84, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
[6]	"ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells." Waerner T., Alacakaptan M., Tamir I., Oberauer R., Gal A., Brabletz T., Schreiber M., Jechlinger M., Beug H. Cancer Cell 10:227-239(2006) [PubMed: 16959614] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[7]	"ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression." Lahsnig C., Mikula M., Petz M., Zulehner G., Schneller D., van Zijl F., Huber H., Csiszar A., Beug H., Mikulits W. Oncogene 28:638-650(2009) [PubMed: 19015638] [Abstract] Cited for: FUNCTION.
[8]	"Secreted factor FAM3C (ILEI) is involved in retinal laminar formation." Katahira T., Nakagiri S., Terada K., Furukawa T. Biochem. Biophys. Res. Commun. 392:301-306(2010) [PubMed: 20059962] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
[9]	"TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI." Chaudhury A., Hussey G.S., Ray P.S., Jin G., Fox P.L., Howe P.H. Nat. Cell Biol. 12:286-293(2010) [PubMed: 20154680] [Abstract] Cited for: INDUCTION BY TGFB.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY424275 mRNA. Translation: AAR84605.1. AK004059 mRNA. Translation: BAB23146.1. AK154498 mRNA. Translation: BAE32629.1. AK170887 mRNA. Translation: BAE42094.1. CH466533 Genomic DNA. Translation: EDL13845.1. BC009086 mRNA. Translation: AAH09086.1. BC055853 mRNA. Translation: AAH55853.1.
IPI	IPI00454042.
RefSeq	NP_613053.3. NM_138587.4.
UniGene	Mm.400193.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q91VU0.
Proteomic databases
PRIDE	Q91VU0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000165576; ENSMUSP00000127709; ENSMUSG00000029672. ENSMUST00000169936; ENSMUSP00000132681; ENSMUSG00000029672.
GeneID	27999.
KEGG	mmu:27999.
NMPDR	fig|10090.3.peg.12994.
UCSC	uc009bay.1. mouse.
Organism-specific databases
CTD	10447.
MGI	MGI:107892. Fam3c.
Phylogenomic databases
GeneTree	ENSGT00530000063020.
HOVERGEN	HBG051544.
InParanoid	Q91VU0.
OMA	VGPKICV.
OrthoDB	EOG43R3NW.
Gene expression databases
ArrayExpress	Q91VU0.
Bgee	Q91VU0.
Genevestigator	Q91VU0.
GermOnline	ENSMUSG00000029672. Mus musculus.
Family and domain databases
ProtoNet	Search...
Other
NextBio	306500.
SOURCE	Search...

Entry information

Entry name

FAM3C_MOUSE

Accession

Primary (citable) accession number: Q91VU0
Secondary accession number(s): Q53YY7, Q7TML1, Q9CTB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	December 1, 2001
Last modified:	September 21, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program