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Protein

Protein BRICK1

Gene

Brk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • actin filament organization Source: InterPro
  • cell motility Source: MGI
  • in utero embryonic development Source: MGI
  • positive regulation of Arp2/3 complex-mediated actin nucleation Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of lamellipodium assembly Source: MGI
  • protein homotrimerization Source: MGI
  • Rac protein signal transduction Source: MGI
  • regulation of actin polymerization or depolymerization Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-4420097. VEGFA-VEGFR2 Pathway.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BRICK1
Short name:
BRK1
Gene namesi
Name:Brk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1915406. Brk1.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: UniProtKB-SubCell
  • extracellular exosome Source: MGI
  • lamellipodium Source: UniProtKB
  • SCAR complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002836472 – 75Protein BRICK1Add BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91VR8.
MaxQBiQ91VR8.
PaxDbiQ91VR8.
PeptideAtlasiQ91VR8.
PRIDEiQ91VR8.

PTM databases

iPTMnetiQ91VR8.
PhosphoSitePlusiQ91VR8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033940.
CleanExiMM_6720456B07RIK.
GenevisibleiQ91VR8. MM.

Interactioni

Subunit structurei

Homotrimer when in free form. Directly interacts with WASF2. Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221634. 1 interactor.
IntActiQ91VR8. 3 interactors.
MINTiMINT-1748743.
STRINGi10090.ENSMUSP00000041644.

Structurei

3D structure databases

ProteinModelPortaliQ91VR8.
SMRiQ91VR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 72Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the BRK1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J0X8. Eukaryota.
ENOG4111UHX. LUCA.
GeneTreeiENSGT00390000011082.
HOGENOMiHOG000290240.
HOVERGENiHBG107432.
InParanoidiQ91VR8.
KOiK05752.
OMAiEACVTQG.
OrthoDBiEOG091G172W.
PhylomeDBiQ91VR8.
TreeFamiTF324876.

Family and domain databases

InterProiIPR033378. BRICK1.
[Graphical view]
PANTHERiPTHR33668. PTHR33668. 1 hit.
ProDomiPD593487. PD593487. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQEDPVQR EIHQDWANRE YIEIITSSIK KISDFLNSFD MSCRSRLATL
60 70
NEKLTALERR IEYIEARVTK GETLT
Length:75
Mass (Da):8,761
Last modified:December 1, 2001 - v1
Checksum:i637B43D779A36587
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71G → D in BAE38874 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020128 mRNA. Translation: BAC25616.1.
AK150689 mRNA. Translation: BAE29768.1.
AK163236 mRNA. Translation: BAE37248.1.
AK166585 mRNA. Translation: BAE38874.1.
BC010582 mRNA. Translation: AAH10582.1.
CCDSiCCDS39595.1.
RefSeqiNP_598698.1. NM_133937.1.
UniGeneiMm.485793.

Genome annotation databases

EnsembliENSMUST00000035725; ENSMUSP00000041644; ENSMUSG00000033940.
GeneIDi101314.
KEGGimmu:101314.
UCSCiuc009dgz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020128 mRNA. Translation: BAC25616.1.
AK150689 mRNA. Translation: BAE29768.1.
AK163236 mRNA. Translation: BAE37248.1.
AK166585 mRNA. Translation: BAE38874.1.
BC010582 mRNA. Translation: AAH10582.1.
CCDSiCCDS39595.1.
RefSeqiNP_598698.1. NM_133937.1.
UniGeneiMm.485793.

3D structure databases

ProteinModelPortaliQ91VR8.
SMRiQ91VR8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221634. 1 interactor.
IntActiQ91VR8. 3 interactors.
MINTiMINT-1748743.
STRINGi10090.ENSMUSP00000041644.

PTM databases

iPTMnetiQ91VR8.
PhosphoSitePlusiQ91VR8.

Proteomic databases

EPDiQ91VR8.
MaxQBiQ91VR8.
PaxDbiQ91VR8.
PeptideAtlasiQ91VR8.
PRIDEiQ91VR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035725; ENSMUSP00000041644; ENSMUSG00000033940.
GeneIDi101314.
KEGGimmu:101314.
UCSCiuc009dgz.1. mouse.

Organism-specific databases

CTDi55845.
MGIiMGI:1915406. Brk1.

Phylogenomic databases

eggNOGiENOG410J0X8. Eukaryota.
ENOG4111UHX. LUCA.
GeneTreeiENSGT00390000011082.
HOGENOMiHOG000290240.
HOVERGENiHBG107432.
InParanoidiQ91VR8.
KOiK05752.
OMAiEACVTQG.
OrthoDBiEOG091G172W.
PhylomeDBiQ91VR8.
TreeFamiTF324876.

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-4420097. VEGFA-VEGFR2 Pathway.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.

Miscellaneous databases

PROiQ91VR8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033940.
CleanExiMM_6720456B07RIK.
GenevisibleiQ91VR8. MM.

Family and domain databases

InterProiIPR033378. BRICK1.
[Graphical view]
PANTHERiPTHR33668. PTHR33668. 1 hit.
ProDomiPD593487. PD593487. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiBRK1_MOUSE
AccessioniPrimary (citable) accession number: Q91VR8
Secondary accession number(s): Q3TLB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.