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Protein

Protein BRICK1

Gene

Brk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • cell motility Source: MGI
  • in utero embryonic development Source: MGI
  • positive regulation of Arp2/3 complex-mediated actin nucleation Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of lamellipodium assembly Source: MGI
  • protein homotrimerization Source: MGI
  • Rac protein signal transduction Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-4420097. VEGFA-VEGFR2 Pathway.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BRICK1
Short name:
BRK1
Gene namesi
Name:Brk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1915406. Brk1.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: UniProtKB-SubCell
  • extracellular exosome Source: MGI
  • lamellipodium Source: UniProtKB
  • SCAR complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 7574Protein BRICK1PRO_0000283647Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91VR8.
MaxQBiQ91VR8.
PaxDbiQ91VR8.
PRIDEiQ91VR8.

PTM databases

iPTMnetiQ91VR8.

Expressioni

Gene expression databases

BgeeiQ91VR8.
CleanExiMM_6720456B07RIK.
GenevisibleiQ91VR8. MM.

Interactioni

Subunit structurei

Homotrimer when in free form. Directly interacts with WASF2. Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221634. 1 interaction.
IntActiQ91VR8. 3 interactions.
MINTiMINT-1748743.
STRINGi10090.ENSMUSP00000041644.

Structurei

3D structure databases

ProteinModelPortaliQ91VR8.
SMRiQ91VR8. Positions 10-73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 7232Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the BRK1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J0X8. Eukaryota.
ENOG4111UHX. LUCA.
GeneTreeiENSGT00390000011082.
HOGENOMiHOG000290240.
HOVERGENiHBG107432.
InParanoidiQ91VR8.
KOiK05752.
OMAiEACVTQG.
OrthoDBiEOG7X3QTS.
PhylomeDBiQ91VR8.
TreeFamiTF324876.

Family and domain databases

InterProiIPR033378. BRICK1.
[Graphical view]
PANTHERiPTHR33668. PTHR33668. 1 hit.
ProDomiPD593487. PD593487. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQEDPVQR EIHQDWANRE YIEIITSSIK KISDFLNSFD MSCRSRLATL
60 70
NEKLTALERR IEYIEARVTK GETLT
Length:75
Mass (Da):8,761
Last modified:December 1, 2001 - v1
Checksum:i637B43D779A36587
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711G → D in BAE38874 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020128 mRNA. Translation: BAC25616.1.
AK150689 mRNA. Translation: BAE29768.1.
AK163236 mRNA. Translation: BAE37248.1.
AK166585 mRNA. Translation: BAE38874.1.
BC010582 mRNA. Translation: AAH10582.1.
CCDSiCCDS39595.1.
RefSeqiNP_598698.1. NM_133937.1.
UniGeneiMm.485793.

Genome annotation databases

EnsembliENSMUST00000035725; ENSMUSP00000041644; ENSMUSG00000033940.
GeneIDi101314.
KEGGimmu:101314.
UCSCiuc009dgz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020128 mRNA. Translation: BAC25616.1.
AK150689 mRNA. Translation: BAE29768.1.
AK163236 mRNA. Translation: BAE37248.1.
AK166585 mRNA. Translation: BAE38874.1.
BC010582 mRNA. Translation: AAH10582.1.
CCDSiCCDS39595.1.
RefSeqiNP_598698.1. NM_133937.1.
UniGeneiMm.485793.

3D structure databases

ProteinModelPortaliQ91VR8.
SMRiQ91VR8. Positions 10-73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221634. 1 interaction.
IntActiQ91VR8. 3 interactions.
MINTiMINT-1748743.
STRINGi10090.ENSMUSP00000041644.

PTM databases

iPTMnetiQ91VR8.

Proteomic databases

EPDiQ91VR8.
MaxQBiQ91VR8.
PaxDbiQ91VR8.
PRIDEiQ91VR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035725; ENSMUSP00000041644; ENSMUSG00000033940.
GeneIDi101314.
KEGGimmu:101314.
UCSCiuc009dgz.1. mouse.

Organism-specific databases

CTDi55845.
MGIiMGI:1915406. Brk1.

Phylogenomic databases

eggNOGiENOG410J0X8. Eukaryota.
ENOG4111UHX. LUCA.
GeneTreeiENSGT00390000011082.
HOGENOMiHOG000290240.
HOVERGENiHBG107432.
InParanoidiQ91VR8.
KOiK05752.
OMAiEACVTQG.
OrthoDBiEOG7X3QTS.
PhylomeDBiQ91VR8.
TreeFamiTF324876.

Enzyme and pathway databases

ReactomeiR-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-4420097. VEGFA-VEGFR2 Pathway.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.

Miscellaneous databases

PROiQ91VR8.
SOURCEiSearch...

Gene expression databases

BgeeiQ91VR8.
CleanExiMM_6720456B07RIK.
GenevisibleiQ91VR8. MM.

Family and domain databases

InterProiIPR033378. BRICK1.
[Graphical view]
PANTHERiPTHR33668. PTHR33668. 1 hit.
ProDomiPD593487. PD593487. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Egg and Wolffian duct.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiBRK1_MOUSE
AccessioniPrimary (citable) accession number: Q91VR8
Secondary accession number(s): Q3TLB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.