Reviewed,
UniProtKB/Swiss-Prot Q91VR7 (MLP3A_MOUSE)
Last modified
September 2, 2008.
Version 44.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Microtubule-associated proteins 1A/1B light chain 3A Alternative name(s): Microtubule-associated protein 1 light chain 3 alpha MAP1A/1B light chain 3 A MAP1A/MAP1B LC3 A MAP1 light chain 3-like protein 1 Autophagy-related protein LC3 A Autophagy-related ubiquitin-like modifier LC3 A | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 121 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Probably involved in formation of autophagosomal vacuoles (autophagosomes) By similarity. |
| Subunit structure | 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins By similarity. |
| Subcellular location | Cytoplasm. Intracytoplasmic membrane; Lipid-anchor. Cytoplasmic vesicle › autophagosome membrane; Lipid-anchorBy similarity. Note= LC3-II binds to the autophagic membranes By similarity. |
| Post-translational modification | The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II By similarity. |
| Sequence similarities | Belongs to the MAP1 LC3 family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Autophagy Ubl conjugation pathway |
| Cellular component | Cytoplasm Cytoplasmic vesicle Membrane Microtubule |
| PTM | Lipoprotein |
Gene Ontology (GO) | |
| Biological process | autophagosome formation Inferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | autophagic vacuole Inferred from sequence or structural similarity. Source: UniProtKB organelle membraneInferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | protein binding Inferred from physical interaction. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 120 | 120 | Microtubule-associated proteins 1A/1B light chain 3A | |||||
| Propeptide | 121 | 1 | Removed in mature form Probable | |||||
Amino acid modifications | ||||||||
| Lipidation | 120 | 1 | Phosphatidylethanolamine amidated glycine Probable | |||||
Experimental info | ||||||||
| Sequence conflict | 12 | 1 | S → T in BAB22582. Ref.1 | |||||
Sequences
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References
| [1] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Heart. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: NMRI. Tissue: Mammary tumor. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AK003122 mRNA. Translation: BAB22582.1. BC010596 mRNA. Translation: AAH10596.1. | |
| RefSeq | NP_080011.1. |
| UniGene | Mm.196239 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EO6 based on UniProtKB P60519. |
| SMR | Q91VR7. Positions 1-120. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUSG00000027602. Mus musculus. [Contig view] |
| GeneID | 66734. |
| KEGG | mmu:66734. |
Organism-specific databases | |
| MGI | MGI:1915661. Map1lc3a. |
Phylogenomic databases | |
| HOGENOM | Q91VR7. |
| HOVERGEN | Q91VR7. |
Gene expression databases | |
| ArrayExpress | Q91VR7. |
| GermOnline | ENSMUSG00000027602. Mus musculus. |
Family and domain databases | |
| InterPro | IPR004241. MAP1_LC3. [Graphical view] |
| PANTHER | PTHR10969. MAP1_LC3. 1 hit. |
| Pfam | PF02991. MAP1_LC3. 1 hit. [Graphical view] |
| ProDom | Q91VR7. [Graphical view] [Entries sharing at least one domain] |
| BLOCKS | Search... |
Other Resources | |
| SOURCE | Search... |
| ProtoNet | Search... |
Entry information
| Entry name | MLP3A_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q91VR7 Secondary accession number(s): Q9DC74 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


