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Protein

ATP synthase subunit gamma, mitochondrial

Gene

Atp5f1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha3beta3. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-163210 Formation of ATP by chemiosmotic coupling
R-MMU-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit gamma, mitochondrialCurated
Alternative name(s):
ATP synthase F1 subunit gammaBy similarity
F-ATPase gamma subunit
Gene namesi
Name:Atp5f1cBy similarity
Synonyms:Atp5c1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1261437 Atp5c1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionAdd BLAST25
ChainiPRO_000000268626 – 298ATP synthase subunit gamma, mitochondrialAdd BLAST273

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39N6-acetyllysineCombined sources1
Modified residuei49N6-succinyllysineCombined sources1
Modified residuei55N6-acetyllysineBy similarity1
Modified residuei115N6-acetyllysine; alternateCombined sources1
Modified residuei115N6-succinyllysine; alternateCombined sources1
Modified residuei138N6-acetyllysineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei154N6-acetyllysine; alternateCombined sources1
Modified residuei154N6-succinyllysine; alternateCombined sources1
Modified residuei197N6-acetyllysineBy similarity1
Modified residuei270N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ91VR2
MaxQBiQ91VR2
PaxDbiQ91VR2
PRIDEiQ91VR2

2D gel databases

UCD-2DPAGEiQ91VR2

PTM databases

iPTMnetiQ91VR2
PhosphoSitePlusiQ91VR2
SwissPalmiQ91VR2

Expressioni

Gene expression databases

BgeeiENSMUSG00000025781
ExpressionAtlasiQ91VR2 baseline and differential
GenevisibleiQ91VR2 MM

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi198255, 6 interactors
IntActiQ91VR2, 9 interactors
MINTiQ91VR2
STRINGi10090.ENSMUSP00000110547

Structurei

3D structure databases

ProteinModelPortaliQ91VR2
SMRiQ91VR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase gamma chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1531 Eukaryota
COG0224 LUCA
GeneTreeiENSGT00390000006837
HOGENOMiHOG000215911
HOVERGENiHBG000933
InParanoidiQ91VR2
KOiK02136
OMAiDRGMCGG
OrthoDBiEOG091G0XX7
PhylomeDBiQ91VR2
TreeFamiTF105765

Family and domain databases

CDDicd12151 F1-ATPase_gamma, 1 hit
InterProiView protein in InterPro
IPR035968 ATP_synth_F1_ATPase_gsu
IPR000131 ATP_synth_F1_gsu
IPR023632 ATP_synth_F1_gsu_CS
PfamiView protein in Pfam
PF00231 ATP-synt, 1 hit
PRINTSiPR00126 ATPASEGAMMA
SUPFAMiSSF52943 SSF52943, 1 hit
TIGRFAMsiTIGR01146 ATPsyn_F1gamma, 1 hit
PROSITEiView protein in PROSITE
PS00153 ATPASE_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSRASVVGL SACAVQPQWI QVRNMATLKD ITRRLKSIKN IQKITKSMKM
60 70 80 90 100
VAAAKYARAE RELKPARVYG TGSLALYEKA DIKAPEDKKK HLIIGVSSDR
110 120 130 140 150
GLCGAIHSSV AKQMKNEVAA LTAAGKEVMI VGVGEKIKGI LYRTHSDQFL
160 170 180 190 200
VSFKDVGRKP PTFGDASVIA LELLNSGYEF DEGSIIFNQF KSVISYKTEE
210 220 230 240 250
KPIFSLNTIA TAETMSIYDD IDADVLQNYQ EYNLANLIYY SLKESTTSEQ
260 270 280 290
SARMTAMDNA SKNASDMIDK LTLTFNRTRQ AVITKELIEI ISGAAALD
Length:298
Mass (Da):32,886
Last modified:December 1, 2001 - v1
Checksum:i9BD63134AEFF3ABA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC010700 mRNA Translation: AAH10700.1
CCDSiCCDS38045.1
RefSeqiNP_065640.2, NM_020615.4
UniGeneiMm.12677

Genome annotation databases

EnsembliENSMUST00000114897; ENSMUSP00000110547; ENSMUSG00000025781
GeneIDi11949
KEGGimmu:11949
UCSCiuc008ihm.3 mouse

Similar proteinsi

Entry informationi

Entry nameiATPG_MOUSE
AccessioniPrimary (citable) accession number: Q91VR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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