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Protein

Probable ATP-dependent RNA helicase DDX41

Gene

Ddx41

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi225 – 232ATPPROSITE-ProRule annotation8
Zinc fingeri580 – 597CCHC-typeAdd BLAST18

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: GO_Central
  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

  • cell differentiation Source: UniProtKB
  • cell proliferation Source: UniProtKB
  • cellular response to interferon-beta Source: MGI
  • defense response to virus Source: MGI
  • mRNA splicing, via spliceosome Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • RNA secondary structure unwinding Source: GO_Central

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processmRNA processing, mRNA splicing
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1834941 STING mediated induction of host immune responses
R-MMU-3134975 Regulation of innate immune responses to cytosolic DNA

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX41 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 41
Gene namesi
Name:Ddx41
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1920185 Ddx41

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000549711 – 622Probable ATP-dependent RNA helicase DDX41Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei21PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei33PhosphotyrosineCombined sources1
Cross-linki416Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki442Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ91VN6
MaxQBiQ91VN6
PaxDbiQ91VN6
PeptideAtlasiQ91VN6
PRIDEiQ91VN6

PTM databases

iPTMnetiQ91VN6
PhosphoSitePlusiQ91VN6

Expressioni

Gene expression databases

BgeeiENSMUSG00000021494
CleanExiMM_DDX41
ExpressionAtlasiQ91VN6 baseline and differential
GenevisibleiQ91VN6 MM

Interactioni

Subunit structurei

Identified in the spliceosome C complex.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi215656, 6 interactors
IntActiQ91VN6, 6 interactors
MINTiQ91VN6
STRINGi10090.ENSMUSP00000021956

Structurei

3D structure databases

ProteinModelPortaliQ91VN6
SMRiQ91VN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini212 – 396Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST185
Domaini407 – 567Helicase C-terminalPROSITE-ProRule annotationAdd BLAST161

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi181 – 209Q motifAdd BLAST29
Motifi344 – 347DEAD box4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri580 – 597CCHC-typeAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0341 Eukaryota
ENOG410XQQC LUCA
GeneTreeiENSGT00900000140933
HOGENOMiHOG000268792
HOVERGENiHBG015893
InParanoidiQ91VN6
KOiK13116
OMAiHIMVATP
OrthoDBiEOG091G04AF
TreeFamiTF300340

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

Q91VN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSEPERKR ARADEATAGG SRSEDEDEDD EDYVPYVPLR QRRQLLLQKL
60 70 80 90 100
LQRRRKGATE EEQQDSGSEP RGDEDDIPLG PQSNVSLLDQ HQHLKEKAEA
110 120 130 140 150
RKESAKEKQL KEEEKILESV AEGRALMSVK EMAKGITYDD PIKTSWTPPR
160 170 180 190 200
YVLSMSEERH ERVRKKYHIL VEGDGIPPPI KSFKEMKFPA AILRGLKKKG
210 220 230 240 250
ILHPTPIQIQ GIPTILSGRD MIGIAFTGSG KTLVFTLPVI MFCLEQEKRL
260 270 280 290 300
PFSKREGPYG LIICPSRELA RQTHGILEYY CRLLQEDSSP LLRCALCIGG
310 320 330 340 350
MSVKEQMETI RHGVHMMVAT PGRLMDLLQK KMVSLDICRY LALDEADRMI
360 370 380 390 400
DMGFEGDIRT IFSYFKGQRQ TLLFSATMPK KIQNFAKSAL VKPVTINVGR
410 420 430 440 450
AGAASLDVIQ EVEYVKEEAK MVYLLECLQK TPPPVLIFAE KKADVDAIHE
460 470 480 490 500
YLLLKGVEAV AIHGGKDQEE RTKAIEAFRE GKKDVLVATD VASKGLDFPA
510 520 530 540 550
IQHVINYDMP EEIENYVHRI GRTGRSGNTG IATTFINKAC DESVLMDLKA
560 570 580 590 600
LLLEAKQKVP PVLQVLHCGD ESMLDIGGER GCAFCGGLGH RITDCPKLEA
610 620
MQTKQVSNIG RKDYLAHSSM DF
Length:622
Mass (Da):69,820
Last modified:July 27, 2011 - v2
Checksum:i85829CA9BDD0F4E1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti562V → G in AAH11308 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156957 mRNA Translation: BAE33914.1
BC011308 mRNA Translation: AAH11308.1
CCDSiCCDS26549.1
RefSeqiNP_598820.2, NM_134059.2
UniGeneiMm.205045

Genome annotation databases

EnsembliENSMUST00000021956; ENSMUSP00000021956; ENSMUSG00000021494
GeneIDi72935
KEGGimmu:72935
UCSCiuc007qro.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDDX41_MOUSE
AccessioniPrimary (citable) accession number: Q91VN6
Secondary accession number(s): Q3U0E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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