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Protein

MICOS complex subunit Mic25

Gene

Chchd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit Mic25
Alternative name(s):
Coiled-coil-helix-coiled-coil-helix domain-containing protein 6
Gene namesi
Name:Chchd6
Synonyms:Mic25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1913348. Chchd6.

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Lipid-anchor By similarity
  • Mitochondrion By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00001291702 – 273MICOS complex subunit Mic25Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1
Modified residuei13PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Disulfide bondi235 ↔ 266PROSITE-ProRule annotation
Disulfide bondi245 ↔ 256PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ91VN4.
MaxQBiQ91VN4.
PaxDbiQ91VN4.
PRIDEiQ91VN4.

PTM databases

iPTMnetiQ91VN4.
PhosphoSitePlusiQ91VN4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030086.
ExpressionAtlasiQ91VN4. baseline and differential.
GenevisibleiQ91VN4. MM.

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with DISC1. Interacts with IMMT/MIC60.By similarity

Protein-protein interaction databases

IntActiQ91VN4. 2 interactors.
MINTiMINT-4120987.
STRINGi10090.ENSMUSP00000032172.

Structurei

3D structure databases

ProteinModelPortaliQ91VN4.
SMRiQ91VN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini232 – 273CHCHPROSITE-ProRule annotationAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili130 – 189Sequence analysisAdd BLAST60

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi235 – 245Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi256 – 266Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Sequence similaritiesi

Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4083. Eukaryota.
ENOG41126BR. LUCA.
GeneTreeiENSGT00390000000903.
HOGENOMiHOG000252969.
HOVERGENiHBG050936.
InParanoidiQ91VN4.
KOiK17564.
OMAiLRAPHKE.
OrthoDBiEOG091G173O.
TreeFamiTF326279.

Family and domain databases

InterProiIPR007964. DUF737.
[Graphical view]
PfamiPF05300. DUF737. 1 hit.
[Graphical view]
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSAESAEAR RVSFEMDEEE RVRVLQGIRL SESVVNRMKD CSQPSAGEQL
60 70 80 90 100
VPGFGPSSSA PVPTVPLPAI SVPTVPAPTT PVPTAPSSSV RGLPGGTCKG
110 120 130 140 150
PLTDVKVPSA ESGGGLQSSA VKEDLKKFQQ EQLAVQDEMV RVAKKEKEAA
160 170 180 190 200
EKHLKASLPK KKASLTHEQQ QSARLARELE DREAELSRRD TFYKEQQGRI
210 220 230 240 250
QEKNAELYKL SSQQFHEAAS KAESTIKPRR VEPVCSGLQA QILRCYRDHL
260 270
HEVLLCSDLV KAYQHCVSTA RKG
Length:273
Mass (Da):29,852
Last modified:April 18, 2012 - v2
Checksum:i4A6345E4B17B0DDE
GO

Sequence cautioni

The sequence BAB24193 differs from that shown. Reason: Frameshift at position 12.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11R → S in BAB24193 (PubMed:16141072).Curated1
Sequence conflicti12 – 14VSF → WSL in BAB29792 (PubMed:16141072).Curated3
Sequence conflicti189R → C in AAH11331 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005696 mRNA. Translation: BAB24193.1. Frameshift.
AK015314 mRNA. Translation: BAB29792.1.
AK144093 mRNA. Translation: BAE25696.1.
AC122387 Genomic DNA. No translation available.
AC141634 Genomic DNA. No translation available.
BC011331 mRNA. Translation: AAH11331.1.
BC052929 mRNA. Translation: AAH52929.1.
CCDSiCCDS39557.1.
RefSeqiNP_001161208.1. NM_001167736.1.
NP_079627.3. NM_025351.3.
UniGeneiMm.20313.

Genome annotation databases

EnsembliENSMUST00000032172; ENSMUSP00000032172; ENSMUSG00000030086.
GeneIDi66098.
KEGGimmu:66098.
UCSCiuc009cwh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005696 mRNA. Translation: BAB24193.1. Frameshift.
AK015314 mRNA. Translation: BAB29792.1.
AK144093 mRNA. Translation: BAE25696.1.
AC122387 Genomic DNA. No translation available.
AC141634 Genomic DNA. No translation available.
BC011331 mRNA. Translation: AAH11331.1.
BC052929 mRNA. Translation: AAH52929.1.
CCDSiCCDS39557.1.
RefSeqiNP_001161208.1. NM_001167736.1.
NP_079627.3. NM_025351.3.
UniGeneiMm.20313.

3D structure databases

ProteinModelPortaliQ91VN4.
SMRiQ91VN4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91VN4. 2 interactors.
MINTiMINT-4120987.
STRINGi10090.ENSMUSP00000032172.

PTM databases

iPTMnetiQ91VN4.
PhosphoSitePlusiQ91VN4.

Proteomic databases

EPDiQ91VN4.
MaxQBiQ91VN4.
PaxDbiQ91VN4.
PRIDEiQ91VN4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032172; ENSMUSP00000032172; ENSMUSG00000030086.
GeneIDi66098.
KEGGimmu:66098.
UCSCiuc009cwh.2. mouse.

Organism-specific databases

CTDi84303.
MGIiMGI:1913348. Chchd6.

Phylogenomic databases

eggNOGiKOG4083. Eukaryota.
ENOG41126BR. LUCA.
GeneTreeiENSGT00390000000903.
HOGENOMiHOG000252969.
HOVERGENiHBG050936.
InParanoidiQ91VN4.
KOiK17564.
OMAiLRAPHKE.
OrthoDBiEOG091G173O.
TreeFamiTF326279.

Miscellaneous databases

PROiQ91VN4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030086.
ExpressionAtlasiQ91VN4. baseline and differential.
GenevisibleiQ91VN4. MM.

Family and domain databases

InterProiIPR007964. DUF737.
[Graphical view]
PfamiPF05300. DUF737. 1 hit.
[Graphical view]
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIC25_MOUSE
AccessioniPrimary (citable) accession number: Q91VN4
Secondary accession number(s): Q3UNQ1, Q9D5I5, Q9DAM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 18, 2012
Last modified: November 2, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.