Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

MICOS complex subunit Mic25

Gene

Chchd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit Mic25
Alternative name(s):
Coiled-coil-helix-coiled-coil-helix domain-containing protein 6
Gene namesi
Name:Chchd6
Synonyms:Mic25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1913348 Chchd6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00001291702 – 273MICOS complex subunit Mic25Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1
Modified residuei13PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Disulfide bondi235 ↔ 266PROSITE-ProRule annotation
Disulfide bondi245 ↔ 256PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ91VN4
MaxQBiQ91VN4
PaxDbiQ91VN4
PRIDEiQ91VN4

PTM databases

iPTMnetiQ91VN4
PhosphoSitePlusiQ91VN4

Expressioni

Gene expression databases

BgeeiENSMUSG00000030086
ExpressionAtlasiQ91VN4 baseline and differential
GenevisibleiQ91VN4 MM

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with DISC1. Interacts with IMMT/MIC60.By similarity

Protein-protein interaction databases

BioGridi211212, 3 interactors
IntActiQ91VN4, 3 interactors
MINTiQ91VN4
STRINGi10090.ENSMUSP00000032172

Structurei

3D structure databases

SMRiQ91VN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini232 – 273CHCHPROSITE-ProRule annotationAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili130 – 189Sequence analysisAdd BLAST60

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi235 – 245Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi256 – 266Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4083 Eukaryota
ENOG41126BR LUCA
GeneTreeiENSGT00390000000903
HOGENOMiHOG000252969
HOVERGENiHBG050936
InParanoidiQ91VN4
KOiK17564
OMAiIKPRRVE
OrthoDBiEOG091G173O
TreeFamiTF326279

Family and domain databases

InterProiView protein in InterPro
IPR007964 MIC19/MIC25
PfamiView protein in Pfam
PF05300 DUF737, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSAESAEAR RVSFEMDEEE RVRVLQGIRL SESVVNRMKD CSQPSAGEQL
60 70 80 90 100
VPGFGPSSSA PVPTVPLPAI SVPTVPAPTT PVPTAPSSSV RGLPGGTCKG
110 120 130 140 150
PLTDVKVPSA ESGGGLQSSA VKEDLKKFQQ EQLAVQDEMV RVAKKEKEAA
160 170 180 190 200
EKHLKASLPK KKASLTHEQQ QSARLARELE DREAELSRRD TFYKEQQGRI
210 220 230 240 250
QEKNAELYKL SSQQFHEAAS KAESTIKPRR VEPVCSGLQA QILRCYRDHL
260 270
HEVLLCSDLV KAYQHCVSTA RKG
Length:273
Mass (Da):29,852
Last modified:April 18, 2012 - v2
Checksum:i4A6345E4B17B0DDE
GO

Sequence cautioni

The sequence BAB24193 differs from that shown. Reason: Frameshift at position 12.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11R → S in BAB24193 (PubMed:16141072).Curated1
Sequence conflicti12 – 14VSF → WSL in BAB29792 (PubMed:16141072).Curated3
Sequence conflicti189R → C in AAH11331 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005696 mRNA Translation: BAB24193.1 Frameshift.
AK015314 mRNA Translation: BAB29792.1
AK144093 mRNA Translation: BAE25696.1
AC122387 Genomic DNA No translation available.
AC141634 Genomic DNA No translation available.
BC011331 mRNA Translation: AAH11331.1
BC052929 mRNA Translation: AAH52929.1
CCDSiCCDS39557.1
RefSeqiNP_001161208.1, NM_001167736.1
NP_079627.3, NM_025351.3
UniGeneiMm.20313

Genome annotation databases

EnsembliENSMUST00000032172; ENSMUSP00000032172; ENSMUSG00000030086
GeneIDi66098
KEGGimmu:66098
UCSCiuc009cwh.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMIC25_MOUSE
AccessioniPrimary (citable) accession number: Q91VN4
Secondary accession number(s): Q3UNQ1, Q9D5I5, Q9DAM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 18, 2012
Last modified: March 28, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health