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Protein

Zinc finger protein 24

Gene

Znf24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 273C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • myelination Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 24Imported
Alternative name(s):
Hypomyelinated CNS protein1 Publication
Zinc finger protein 191By similarity
Zinc finger protein ZF-121 Publication
Gene namesi
Name:Znf24By similarity
Synonyms:Hmcns1 Publication, Zfp191By similarity, Zfp24Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1929704. Zfp24.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

According to PubMed:20080941, most mice die by postnatal day 25 (P25) due to myelination defects. Brains and spinal cords isolated from P14 mice appear to be smaller than those from wild-type mice and to lack white matter. Mutant oligodendrocytes arrest at a late stage of differentiation. Expression of genes expressed specifically in mature myelinating oligodendrocytes is down-regulated. According to PubMed:17064688, embryos are severely retarded in development and die at approximately 7.5 days post-fertilization (E7.5). One possible explanation for the different phenotypes described is that the two null alleles are not identical. In the mutants described by PubMed:20080941, the PGK-neo cassette used for positive selection of embryonic stem (ES) cells has been removed, whereas it remains in the allele described by PubMed:17064688.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473531 – 368Zinc finger protein 24Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei132PhosphoserineBy similarity1
Modified residuei142PhosphoserineBy similarity1
Modified residuei274PhosphoserineBy similarity1
Cross-linki277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei292PhosphoserineBy similarity1
Modified residuei335PhosphotyrosineBy similarity1

Post-translational modificationi

Sumoylated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ91VN1.
MaxQBiQ91VN1.
PaxDbiQ91VN1.
PeptideAtlasiQ91VN1.
PRIDEiQ91VN1.

PTM databases

iPTMnetiQ91VN1.
PhosphoSitePlusiQ91VN1.

Expressioni

Tissue specificityi

Widely expressed with highest levels in heart, brain, liver, skeletal muscle, kidney and testis and very low levels in spleen and lung.2 Publications

Developmental stagei

In the embryo, barely detectable at day 17, peaks at day 11 and remains constant thereafter. Detected early during embryogenesis in ectodermal, endodermal, mesodermal and extraembryonic tissues. Expressed in the developing central nervous system. In the developing central nervous system (CNS), mainly expressed in progenitors.2 Publications

Gene expression databases

BgeeiENSMUSG00000051469.
CleanExiMM_ZFP191.
ExpressionAtlasiQ91VN1. baseline and differential.
GenevisibleiQ91VN1. MM.

Interactioni

Protein-protein interaction databases

BioGridi208519. 1 interactor.
IntActiQ91VN1. 1 interactor.
STRINGi10090.ENSMUSP00000064637.

Structurei

3D structure databases

ProteinModelPortaliQ91VN1.
SMRiQ91VN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 134SCAN boxPROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni251 – 301Necessary and sufficient for nuclear localizationBy similarityAdd BLAST51

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 273C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ91VN1.
KOiK09230.
OMAiILIIPNP.
OrthoDBiEOG091G09O3.
PhylomeDBiQ91VN1.
TreeFamiTF338304.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91VN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAQSVEEDS ILIIPNPDEE EKILRVKLEE DPDGEEGSSI SWNHLPDPEV
60 70 80 90 100
FRQRFRQFGY QDSPGPREAV SQLRELCRLW LRPETHTKEQ ILELVVLEQF
110 120 130 140 150
VAILPKELQT WVREHHPENG EEAVAVLEDL ESELDDPGQP VSLRRQKREV
160 170 180 190 200
LVEEITSQED AQGLPSSELD AVENQLKWAS WELHSLRHCD DDATTENGAL
210 220 230 240 250
APKQEMASAG ESHEGPGTLN IGVPQLFKYG ETCFPKGRFE RKRNPSRKKQ
260 270 280 290 300
HICDECGKHF SQGSALILHQ RIHSGEKPYG CVECGKAFSR SSILVQHQRV
310 320 330 340 350
HTGEKPYKCL ECGKAFSQNS GLINHQRIHT GEKPYECVQC GKSYSQSSNL
360
FRHQRRHNAE KLLNVVKV
Length:368
Mass (Da):41,919
Last modified:December 1, 2001 - v1
Checksum:i344974009D2A5469
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91I → M in AAD37421 (PubMed:10542327).Curated1
Sequence conflicti366Missing in AAD37421 (PubMed:10542327).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149093 mRNA. Translation: AAD37421.1.
AY052495 Genomic DNA. Translation: AAL13429.1.
AY832930 mRNA. Translation: AAV91152.1.
AK146726 mRNA. Translation: BAE27389.1.
CH466557 Genomic DNA. Translation: EDK96990.1.
CH466557 Genomic DNA. Translation: EDK96991.1.
BC011345 mRNA. Translation: AAH11345.1.
BC054832 mRNA. Translation: AAH54832.1.
CCDSiCCDS29098.1.
RefSeqiNP_067534.2. NM_021559.2.
XP_006526199.1. XM_006526136.3.
XP_006526200.1. XM_006526137.3.
UniGeneiMm.417427.

Genome annotation databases

EnsembliENSMUST00000066497; ENSMUSP00000064637; ENSMUSG00000051469.
ENSMUST00000153337; ENSMUSP00000122579; ENSMUSG00000051469.
GeneIDi59057.
KEGGimmu:59057.
UCSCiuc008egm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149093 mRNA. Translation: AAD37421.1.
AY052495 Genomic DNA. Translation: AAL13429.1.
AY832930 mRNA. Translation: AAV91152.1.
AK146726 mRNA. Translation: BAE27389.1.
CH466557 Genomic DNA. Translation: EDK96990.1.
CH466557 Genomic DNA. Translation: EDK96991.1.
BC011345 mRNA. Translation: AAH11345.1.
BC054832 mRNA. Translation: AAH54832.1.
CCDSiCCDS29098.1.
RefSeqiNP_067534.2. NM_021559.2.
XP_006526199.1. XM_006526136.3.
XP_006526200.1. XM_006526137.3.
UniGeneiMm.417427.

3D structure databases

ProteinModelPortaliQ91VN1.
SMRiQ91VN1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208519. 1 interactor.
IntActiQ91VN1. 1 interactor.
STRINGi10090.ENSMUSP00000064637.

PTM databases

iPTMnetiQ91VN1.
PhosphoSitePlusiQ91VN1.

Proteomic databases

EPDiQ91VN1.
MaxQBiQ91VN1.
PaxDbiQ91VN1.
PeptideAtlasiQ91VN1.
PRIDEiQ91VN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066497; ENSMUSP00000064637; ENSMUSG00000051469.
ENSMUST00000153337; ENSMUSP00000122579; ENSMUSG00000051469.
GeneIDi59057.
KEGGimmu:59057.
UCSCiuc008egm.1. mouse.

Organism-specific databases

CTDi59057.
MGIiMGI:1929704. Zfp24.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ91VN1.
KOiK09230.
OMAiILIIPNP.
OrthoDBiEOG091G09O3.
PhylomeDBiQ91VN1.
TreeFamiTF338304.

Miscellaneous databases

PROiQ91VN1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051469.
CleanExiMM_ZFP191.
ExpressionAtlasiQ91VN1. baseline and differential.
GenevisibleiQ91VN1. MM.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF24_MOUSE
AccessioniPrimary (citable) accession number: Q91VN1
Secondary accession number(s): Q5MDG8, Q9WUQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.