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Q91VN1 (ZNF24_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 24
Alternative name(s):
Hypomyelinated CNS protein
Zinc finger protein 191
Short name=Zfp-191
Zinc finger protein ZF-12
Gene names
Name:Znf24
Synonyms:Hmcns, Zfp191
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro. Ref.9 Ref.10

Subcellular location

Nucleus Ref.10.

Tissue specificity

Widely expressed with highest levels in heart, brain, liver, skeletal muscle, kidney and testis and very low levels in spleen and lung. Ref.1 Ref.10

Developmental stage

In the embryo, barely detectable at day 17, peaks at day 11 and remains constant thereafter. Detected early during embryogenesis in ectodermal, endodermal, mesodermal and extraembryonic tissues. Expressed in the developing central nervous system. In the developing central nervous system (CNS), mainly expressed in progenitors. Ref.1 Ref.8

Post-translational modification

Sumoylated By similarity.

Disruption phenotype

According to Ref.10, most mice die by postnatal day 25 (P25) due to myelination defects. Brains and spinal cords isolated from P14 mice appear to be smaller than those from wild-type mice and to lack white matter. Mutant oligodendrocytes arrest at a late stage of differentiation. Expression of genes expressed specifically in mature myelinating oligodendrocytes is down-regulated. According to Ref.6, embryos are severely retarded in development and die at approximately 7.5 days post-fertilization (E7.5). One possible explanation for the different phenotypes described is that the two null alleles are not identical. In the mutants described by Ref.10, the PGK-neo cassette used for positive selection of embryonic stem (ES) cells has been removed, whereas it remains in the allele described by Ref.6. Ref.6 Ref.10

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 4 C2H2-type zinc fingers.

Contains 1 SCAN box domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368Zinc finger protein 24
PRO_0000047353

Regions

Domain52 – 13483SCAN box
Zinc finger251 – 27323C2H2-type 1
Zinc finger279 – 30123C2H2-type 2
Zinc finger307 – 32923C2H2-type 3
Zinc finger335 – 35723C2H2-type 4

Amino acid modifications

Modified residue1321Phosphoserine By similarity
Modified residue1421Phosphoserine By similarity
Modified residue2741Phosphoserine By similarity
Modified residue3351Phosphotyrosine By similarity

Experimental info

Sequence conflict911I → M in AAD37421. Ref.1
Sequence conflict3661Missing in AAD37421. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q91VN1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 344974009D2A5469

FASTA36841,919
        10         20         30         40         50         60 
MSAQSVEEDS ILIIPNPDEE EKILRVKLEE DPDGEEGSSI SWNHLPDPEV FRQRFRQFGY 

        70         80         90        100        110        120 
QDSPGPREAV SQLRELCRLW LRPETHTKEQ ILELVVLEQF VAILPKELQT WVREHHPENG 

       130        140        150        160        170        180 
EEAVAVLEDL ESELDDPGQP VSLRRQKREV LVEEITSQED AQGLPSSELD AVENQLKWAS 

       190        200        210        220        230        240 
WELHSLRHCD DDATTENGAL APKQEMASAG ESHEGPGTLN IGVPQLFKYG ETCFPKGRFE 

       250        260        270        280        290        300 
RKRNPSRKKQ HICDECGKHF SQGSALILHQ RIHSGEKPYG CVECGKAFSR SSILVQHQRV 

       310        320        330        340        350        360 
HTGEKPYKCL ECGKAFSQNS GLINHQRIHT GEKPYECVQC GKSYSQSSNL FRHQRRHNAE 


KLLNVVKV 

« Hide

References

« Hide 'large scale' references
[1]"Isolation, cloning, and expression of a new murine zinc finger encoding gene."
Prost J.-P., Negre D., Cornet-Javaux F., Cortay J.-C., Cozzone A.J., Herbage D., Mallein-Gerin F.
Biochim. Biophys. Acta 1447:278-283(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Strain: CD-1.
Tissue: Cartilage chondrocyte.
[2]"Cloning, genomic organization and promoter activity of the mouse zinc finger protein gene ZF-12."
Li J.-Z., Chen X., Wang S.L., Sun X., Zhang Y.Z., Yu L., Fu J.-L.
Yi Chuan Xue Bao 30:311-316(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Heart.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland and Retina.
[6]"The zinc finger transcription factor 191 is required for early embryonic development and cell proliferation."
Li J., Chen X., Yang H., Wang S., Guo B., Yu L., Wang Z., Fu J.
Exp. Cell Res. 312:3990-3998(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
[7]"Characterization of the target DNA sequence for the DNA-binding domain of zinc finger protein 191."
Wang H., Sun R., Liu G., Yao M., Fei J., Shen H.
Acta Biochim. Biophys. Sin. 40:704-710(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: DNA-BINDING.
[8]"Expression of the transcription factor Zfp191 during embryonic development in the mouse."
Khalfallah O., Faucon-Biguet N., Nardelli J., Meloni R., Mallet J.
Gene Expr. Patterns 8:148-154(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
[9]"Zinc finger protein 191 (ZNF191/Zfp191) is necessary to maintain neural cells as cycling progenitors."
Khalfallah O., Ravassard P., Lagache C.S., Fligny C., Serre A., Bayard E., Faucon-Biguet N., Mallet J., Meloni R., Nardelli J.
Stem Cells 27:1643-1653(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[10]"ZFP191 is required by oligodendrocytes for CNS myelination."
Howng S.Y., Avila R.L., Emery B., Traka M., Lin W., Watkins T., Cook S., Bronson R., Davisson M., Barres B.A., Popko B.
Genes Dev. 24:301-311(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF149093 mRNA. Translation: AAD37421.1.
AY052495 Genomic DNA. Translation: AAL13429.1.
AY832930 mRNA. Translation: AAV91152.1.
AK146726 mRNA. Translation: BAE27389.1.
CH466557 Genomic DNA. Translation: EDK96990.1.
CH466557 Genomic DNA. Translation: EDK96991.1.
BC011345 mRNA. Translation: AAH11345.1.
BC054832 mRNA. Translation: AAH54832.1.
CCDSCCDS29098.1.
RefSeqNP_067534.2. NM_021559.2.
XP_006526199.1. XM_006526136.1.
XP_006526200.1. XM_006526137.1.
UniGeneMm.417427.

3D structure databases

ProteinModelPortalQ91VN1.
SMRQ91VN1. Positions 46-136, 248-361.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid208519. 1 interaction.
IntActQ91VN1. 1 interaction.
STRING10090.ENSMUSP00000064637.

PTM databases

PhosphoSiteQ91VN1.

Proteomic databases

PaxDbQ91VN1.
PRIDEQ91VN1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000066497; ENSMUSP00000064637; ENSMUSG00000051469.
ENSMUST00000153337; ENSMUSP00000122579; ENSMUSG00000051469.
GeneID59057.
KEGGmmu:59057.
UCSCuc008egm.1. mouse.

Organism-specific databases

CTD59057.
MGIMGI:1929704. Zfp191.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00750000117592.
HOGENOMHOG000234619.
HOVERGENHBG018163.
InParanoidQ5MDG8.
KOK09230.
OMAILIIPNP.
OrthoDBEOG7HF1JG.
PhylomeDBQ91VN1.
TreeFamTF338304.

Gene expression databases

ArrayExpressQ91VN1.
BgeeQ91VN1.
CleanExMM_ZFP191.
GenevestigatorQ91VN1.

Family and domain databases

Gene3D3.30.160.60. 4 hits.
InterProIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF02023. SCAN. 1 hit.
[Graphical view]
SMARTSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMSSF47353. SSF47353. 1 hit.
PROSITEPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio314706.
PROQ91VN1.
SOURCESearch...

Entry information

Entry nameZNF24_MOUSE
AccessionPrimary (citable) accession number: Q91VN1
Secondary accession number(s): Q5MDG8, Q9WUQ0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot