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Q91VN1

- ZNF24_MOUSE

UniProt

Q91VN1 - ZNF24_MOUSE

Protein

Zinc finger protein 24

Gene

Znf24

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri251 – 27323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri279 – 30123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri307 – 32923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri335 – 35723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. sequence-specific DNA binding Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. myelination Source: UniProtKB
    2. negative regulation of transcription, DNA-templated Source: Ensembl
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 24
    Alternative name(s):
    Hypomyelinated CNS protein
    Zinc finger protein 191
    Short name:
    Zfp-191
    Zinc finger protein ZF-12
    Gene namesi
    Name:Znf24
    Synonyms:Hmcns, Zfp191
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1929704. Zfp191.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    According to PubMed:20080941, most mice die by postnatal day 25 (P25) due to myelination defects. Brains and spinal cords isolated from P14 mice appear to be smaller than those from wild-type mice and to lack white matter. Mutant oligodendrocytes arrest at a late stage of differentiation. Expression of genes expressed specifically in mature myelinating oligodendrocytes is down-regulated. According to PubMed:17064688, embryos are severely retarded in development and die at approximately 7.5 days post-fertilization (E7.5). One possible explanation for the different phenotypes described is that the two null alleles are not identical. In the mutants described by PubMed:20080941, the PGK-neo cassette used for positive selection of embryonic stem (ES) cells has been removed, whereas it remains in the allele described by PubMed:17064688.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 368368Zinc finger protein 24PRO_0000047353Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei132 – 1321PhosphoserineBy similarity
    Modified residuei142 – 1421PhosphoserineBy similarity
    Modified residuei274 – 2741PhosphoserineBy similarity
    Modified residuei335 – 3351PhosphotyrosineBy similarity

    Post-translational modificationi

    Sumoylated.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ91VN1.
    PRIDEiQ91VN1.

    PTM databases

    PhosphoSiteiQ91VN1.

    Expressioni

    Tissue specificityi

    Widely expressed with highest levels in heart, brain, liver, skeletal muscle, kidney and testis and very low levels in spleen and lung.2 Publications

    Developmental stagei

    In the embryo, barely detectable at day 17, peaks at day 11 and remains constant thereafter. Detected early during embryogenesis in ectodermal, endodermal, mesodermal and extraembryonic tissues. Expressed in the developing central nervous system. In the developing central nervous system (CNS), mainly expressed in progenitors.2 Publications

    Gene expression databases

    ArrayExpressiQ91VN1.
    BgeeiQ91VN1.
    CleanExiMM_ZFP191.
    GenevestigatoriQ91VN1.

    Interactioni

    Protein-protein interaction databases

    BioGridi208519. 1 interaction.
    IntActiQ91VN1. 1 interaction.
    STRINGi10090.ENSMUSP00000064637.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91VN1.
    SMRiQ91VN1. Positions 46-136, 248-361.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 13483SCAN boxPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni251 – 30151Necessary and sufficient for nuclear localizationBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SCAN box domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri251 – 27323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri279 – 30123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri307 – 32923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri335 – 35723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117592.
    HOGENOMiHOG000234619.
    HOVERGENiHBG018163.
    InParanoidiQ5MDG8.
    KOiK09230.
    OMAiILIIPNP.
    OrthoDBiEOG7HF1JG.
    PhylomeDBiQ91VN1.
    TreeFamiTF338304.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    InterProiIPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF02023. SCAN. 1 hit.
    [Graphical view]
    SMARTiSM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 4 hits.
    [Graphical view]
    SUPFAMiSSF47353. SSF47353. 1 hit.
    PROSITEiPS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91VN1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAQSVEEDS ILIIPNPDEE EKILRVKLEE DPDGEEGSSI SWNHLPDPEV    50
    FRQRFRQFGY QDSPGPREAV SQLRELCRLW LRPETHTKEQ ILELVVLEQF 100
    VAILPKELQT WVREHHPENG EEAVAVLEDL ESELDDPGQP VSLRRQKREV 150
    LVEEITSQED AQGLPSSELD AVENQLKWAS WELHSLRHCD DDATTENGAL 200
    APKQEMASAG ESHEGPGTLN IGVPQLFKYG ETCFPKGRFE RKRNPSRKKQ 250
    HICDECGKHF SQGSALILHQ RIHSGEKPYG CVECGKAFSR SSILVQHQRV 300
    HTGEKPYKCL ECGKAFSQNS GLINHQRIHT GEKPYECVQC GKSYSQSSNL 350
    FRHQRRHNAE KLLNVVKV 368
    Length:368
    Mass (Da):41,919
    Last modified:December 1, 2001 - v1
    Checksum:i344974009D2A5469
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 911I → M in AAD37421. (PubMed:10542327)Curated
    Sequence conflicti366 – 3661Missing in AAD37421. (PubMed:10542327)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF149093 mRNA. Translation: AAD37421.1.
    AY052495 Genomic DNA. Translation: AAL13429.1.
    AY832930 mRNA. Translation: AAV91152.1.
    AK146726 mRNA. Translation: BAE27389.1.
    CH466557 Genomic DNA. Translation: EDK96990.1.
    CH466557 Genomic DNA. Translation: EDK96991.1.
    BC011345 mRNA. Translation: AAH11345.1.
    BC054832 mRNA. Translation: AAH54832.1.
    CCDSiCCDS29098.1.
    RefSeqiNP_067534.2. NM_021559.2.
    XP_006526199.1. XM_006526136.1.
    XP_006526200.1. XM_006526137.1.
    UniGeneiMm.417427.

    Genome annotation databases

    EnsembliENSMUST00000066497; ENSMUSP00000064637; ENSMUSG00000051469.
    ENSMUST00000153337; ENSMUSP00000122579; ENSMUSG00000051469.
    GeneIDi59057.
    KEGGimmu:59057.
    UCSCiuc008egm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF149093 mRNA. Translation: AAD37421.1 .
    AY052495 Genomic DNA. Translation: AAL13429.1 .
    AY832930 mRNA. Translation: AAV91152.1 .
    AK146726 mRNA. Translation: BAE27389.1 .
    CH466557 Genomic DNA. Translation: EDK96990.1 .
    CH466557 Genomic DNA. Translation: EDK96991.1 .
    BC011345 mRNA. Translation: AAH11345.1 .
    BC054832 mRNA. Translation: AAH54832.1 .
    CCDSi CCDS29098.1.
    RefSeqi NP_067534.2. NM_021559.2.
    XP_006526199.1. XM_006526136.1.
    XP_006526200.1. XM_006526137.1.
    UniGenei Mm.417427.

    3D structure databases

    ProteinModelPortali Q91VN1.
    SMRi Q91VN1. Positions 46-136, 248-361.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208519. 1 interaction.
    IntActi Q91VN1. 1 interaction.
    STRINGi 10090.ENSMUSP00000064637.

    PTM databases

    PhosphoSitei Q91VN1.

    Proteomic databases

    PaxDbi Q91VN1.
    PRIDEi Q91VN1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000066497 ; ENSMUSP00000064637 ; ENSMUSG00000051469 .
    ENSMUST00000153337 ; ENSMUSP00000122579 ; ENSMUSG00000051469 .
    GeneIDi 59057.
    KEGGi mmu:59057.
    UCSCi uc008egm.1. mouse.

    Organism-specific databases

    CTDi 59057.
    MGIi MGI:1929704. Zfp191.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117592.
    HOGENOMi HOG000234619.
    HOVERGENi HBG018163.
    InParanoidi Q5MDG8.
    KOi K09230.
    OMAi ILIIPNP.
    OrthoDBi EOG7HF1JG.
    PhylomeDBi Q91VN1.
    TreeFami TF338304.

    Miscellaneous databases

    NextBioi 314706.
    PROi Q91VN1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91VN1.
    Bgeei Q91VN1.
    CleanExi MM_ZFP191.
    Genevestigatori Q91VN1.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    InterProi IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF02023. SCAN. 1 hit.
    [Graphical view ]
    SMARTi SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 4 hits.
    [Graphical view ]
    SUPFAMi SSF47353. SSF47353. 1 hit.
    PROSITEi PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, cloning, and expression of a new murine zinc finger encoding gene."
      Prost J.-P., Negre D., Cornet-Javaux F., Cortay J.-C., Cozzone A.J., Herbage D., Mallein-Gerin F.
      Biochim. Biophys. Acta 1447:278-283(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: CD-1.
      Tissue: Cartilage chondrocyte.
    2. "Cloning, genomic organization and promoter activity of the mouse zinc finger protein gene ZF-12."
      Li J.-Z., Chen X., Wang S.L., Sun X., Zhang Y.Z., Yu L., Fu J.-L.
      Yi Chuan Xue Bao 30:311-316(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Heart.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland and Retina.
    6. "The zinc finger transcription factor 191 is required for early embryonic development and cell proliferation."
      Li J., Chen X., Yang H., Wang S., Guo B., Yu L., Wang Z., Fu J.
      Exp. Cell Res. 312:3990-3998(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    7. "Characterization of the target DNA sequence for the DNA-binding domain of zinc finger protein 191."
      Wang H., Sun R., Liu G., Yao M., Fei J., Shen H.
      Acta Biochim. Biophys. Sin. 40:704-710(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING.
    8. "Expression of the transcription factor Zfp191 during embryonic development in the mouse."
      Khalfallah O., Faucon-Biguet N., Nardelli J., Meloni R., Mallet J.
      Gene Expr. Patterns 8:148-154(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    9. "Zinc finger protein 191 (ZNF191/Zfp191) is necessary to maintain neural cells as cycling progenitors."
      Khalfallah O., Ravassard P., Lagache C.S., Fligny C., Serre A., Bayard E., Faucon-Biguet N., Mallet J., Meloni R., Nardelli J.
      Stem Cells 27:1643-1653(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiZNF24_MOUSE
    AccessioniPrimary (citable) accession number: Q91VN1
    Secondary accession number(s): Q5MDG8, Q9WUQ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3