Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q91VN0

- LRP5_MOUSE

UniProt

Q91VN0 - LRP5_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Low-density lipoprotein receptor-related protein 5

Gene

Lrp5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin (By similarity). Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.By similarity2 Publications

GO - Molecular functioni

  1. coreceptor activity Source: RefGenome
  2. Wnt-activated receptor activity Source: MGI
  3. Wnt-protein binding Source: MGI

GO - Biological processi

  1. adipose tissue development Source: RefGenome
  2. anatomical structure regression Source: MGI
  3. anterior/posterior pattern specification Source: MGI
  4. apoptotic process involved in patterning of blood vessels Source: MGI
  5. bone development Source: BHF-UCL
  6. bone marrow development Source: RefGenome
  7. bone morphogenesis Source: RefGenome
  8. bone remodeling Source: MGI
  9. branching involved in mammary gland duct morphogenesis Source: MGI
  10. canonical Wnt signaling pathway Source: BHF-UCL
  11. cell-cell signaling involved in mammary gland development Source: MGI
  12. cell migration involved in gastrulation Source: MGI
  13. cholesterol homeostasis Source: RefGenome
  14. cholesterol metabolic process Source: MGI
  15. embryonic camera-type eye morphogenesis Source: RefGenome
  16. embryonic digit morphogenesis Source: MGI
  17. embryonic retina morphogenesis in camera-type eye Source: RefGenome
  18. endocytosis Source: UniProtKB-KW
  19. extracellular matrix-cell signaling Source: BHF-UCL
  20. gastrulation with mouth forming second Source: MGI
  21. glucose catabolic process Source: Ensembl
  22. limb morphogenesis Source: MGI
  23. mammary gland duct morphogenesis Source: MGI
  24. negative regulation of osteoblast differentiation Source: Ensembl
  25. negative regulation of protein serine/threonine kinase activity Source: Ensembl
  26. osteoblast development Source: BHF-UCL
  27. positive regulation of fat cell differentiation Source: Ensembl
  28. positive regulation of mesenchymal cell proliferation Source: Ensembl
  29. positive regulation of mitosis Source: Ensembl
  30. positive regulation of osteoblast proliferation Source: MGI
  31. positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  32. positive regulation of transcription, DNA-templated Source: BHF-UCL
  33. positive regulation of transcription from RNA polymerase II promoter Source: RefGenome
  34. regulation of apoptotic process Source: MGI
  35. regulation of blood pressure Source: Ensembl
  36. regulation of bone remodeling Source: MGI
  37. regulation of canonical Wnt signaling pathway Source: Ensembl
  38. regulation of fat cell differentiation Source: RefGenome
  39. regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
  40. regulation of ossification Source: RefGenome
  41. response to peptide hormone Source: Ensembl
  42. retinal blood vessel morphogenesis Source: RefGenome
  43. retina vasculature morphogenesis in camera-type eye Source: MGI
  44. somatic stem cell maintenance Source: MGI
  45. vasculature development Source: MGI
  46. Wnt signaling pathway Source: MGI
  47. Wnt signaling pathway involved in dorsal/ventral axis specification Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Endocytosis, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 5
Short name:
LRP-5
Alternative name(s):
Low-density lipoprotein receptor-related protein 7
Short name:
LRP-7
Lr3
Gene namesi
Name:Lrp5
Synonyms:Lrp7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1278315. Lrp5.

Subcellular locationi

Membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endoplasmic reticulum 1 Publication
Note: Chaperoned to the plasma membrane by MESD.By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrion Source: MGI
  4. plasma membrane Source: RefGenome
  5. receptor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice exhibit decreased osteoblast proliferation, developing low bone mass postnatally. Also display persistent embryonic eye vascularization due to a failure of macrophage-induced endothelial cell apoptosis. Mutant animals exhibit a loss of middle phalanx ossification at 18.5 dpc. LRP5 and LRP6 double null mutants are more severely affected. Embryos arrest prior to mid-gestation.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 16141584Low-density lipoprotein receptor-related protein 5PRO_0000017329Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi298 ↔ 309PROSITE-ProRule annotation
Disulfide bondi305 ↔ 320PROSITE-ProRule annotation
Disulfide bondi322 ↔ 335PROSITE-ProRule annotation
Glycosylationi445 – 4451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi604 ↔ 615PROSITE-ProRule annotation
Disulfide bondi611 ↔ 624PROSITE-ProRule annotation
Disulfide bondi626 ↔ 639PROSITE-ProRule annotation
Glycosylationi704 – 7041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi877 – 8771N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi905 ↔ 916PROSITE-ProRule annotation
Disulfide bondi912 ↔ 925PROSITE-ProRule annotation
Disulfide bondi927 ↔ 940PROSITE-ProRule annotation
Disulfide bondi1216 ↔ 1227PROSITE-ProRule annotation
Disulfide bondi1223 ↔ 1237PROSITE-ProRule annotation
Disulfide bondi1239 ↔ 1252PROSITE-ProRule annotation
Disulfide bondi1258 ↔ 1272PROSITE-ProRule annotation
Disulfide bondi1265 ↔ 1285PROSITE-ProRule annotation
Disulfide bondi1279 ↔ 1294PROSITE-ProRule annotation
Disulfide bondi1297 ↔ 1309PROSITE-ProRule annotation
Disulfide bondi1304 ↔ 1322PROSITE-ProRule annotation
Disulfide bondi1316 ↔ 1331PROSITE-ProRule annotation
Disulfide bondi1335 ↔ 1347PROSITE-ProRule annotation
Disulfide bondi1342 ↔ 1360PROSITE-ProRule annotation
Disulfide bondi1354 ↔ 1369PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylation of cytoplasmic PPPSP motifs regulates the signal transduction of the Wnt signaling pathway through acting as a docking site for AXIN1.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ91VN0.
PRIDEiQ91VN0.

PTM databases

PhosphoSiteiQ91VN0.

Expressioni

Tissue specificityi

Widely expressed, with the highest expression levels in liver, heart, and lung and the lowest levels in brain and spleen. Expressed in early embryo with strongest expression in visceral endoderm overlying the extraembryonic ectoderm. Not present in the mesoderm nor in endoderm emerging from the primitive streak.1 Publication

Developmental stagei

Expressed before or on embryonic day 7.

Gene expression databases

BgeeiQ91VN0.
ExpressionAtlasiQ91VN0. baseline and differential.
GenevestigatoriQ91VN0.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling. Component of a WNT-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts with FZD8; the interaction is formed on WNT-binding and signaling. Interacts (via the phosphorylated PPPSP motif domains) with AXIN1; the interaction prevents inhibition of beta-catenin phosphorylation and signaling and is enhanced in the presence of GSK3B and WNT1 or WNT3A. Interacts (via beta-propeller regions 3 and 4) with DKK1; the interaction, enhanced by MESD and/or KREMEN, inhibits beta-catenin signaling by preventing GSK3-mediated phosphorylation of the PPPSP motifs and subsequent, AXIN1 binding. Interacts with CSNK1E. Interacts with SOST; the interaction antagonizes canonical Wnt signaling. Interacts with APCDD1 (By similarity). Interacts with MESD; the interaction prevents the formation of LRP5 aggregates, targets LRP5 to the plasma membrane and, when complexed with KREMEN2, increases DKK1 binding.By similarity1 Publication

Protein-protein interaction databases

BioGridi201202. 7 interactions.
IntActiQ91VN0. 2 interactions.
MINTiMINT-8293473.

Structurei

3D structure databases

ProteinModelPortaliQ91VN0.
SMRiQ91VN0. Positions 31-1255.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 13831353ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1407 – 1614208CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1384 – 140623HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati74 – 11845LDL-receptor class B 1Add
BLAST
Repeati119 – 16143LDL-receptor class B 2Add
BLAST
Repeati162 – 20544LDL-receptor class B 3Add
BLAST
Repeati206 – 24641LDL-receptor class B 4Add
BLAST
Repeati247 – 28943LDL-receptor class B 5Add
BLAST
Domaini294 – 33643EGF-like 1Add
BLAST
Repeati384 – 42643LDL-receptor class B 6Add
BLAST
Repeati427 – 46943LDL-receptor class B 7Add
BLAST
Repeati470 – 51344LDL-receptor class B 8Add
BLAST
Repeati514 – 55643LDL-receptor class B 9Add
BLAST
Repeati557 – 59943LDL-receptor class B 10Add
BLAST
Domaini600 – 64041EGF-like 2Add
BLAST
Repeati686 – 72843LDL-receptor class B 11Add
BLAST
Repeati729 – 77143LDL-receptor class B 12Add
BLAST
Repeati772 – 81443LDL-receptor class B 13Add
BLAST
Repeati815 – 85440LDL-receptor class B 14Add
BLAST
Repeati855 – 89743LDL-receptor class B 15Add
BLAST
Domaini901 – 94141EGF-like 3Add
BLAST
Repeati988 – 103447LDL-receptor class B 16Add
BLAST
Repeati1035 – 107743LDL-receptor class B 17Add
BLAST
Repeati1078 – 112245LDL-receptor class B 18Add
BLAST
Repeati1123 – 116442LDL-receptor class B 19Add
BLAST
Repeati1165 – 120642LDL-receptor class B 20Add
BLAST
Domaini1212 – 125342EGF-like 4Add
BLAST
Domaini1257 – 129539LDL-receptor class A 1PROSITE-ProRule annotationAdd
BLAST
Domaini1296 – 133237LDL-receptor class A 2PROSITE-ProRule annotationAdd
BLAST
Domaini1334 – 137037LDL-receptor class A 3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni31 – 287257Beta-propeller 1Add
BLAST
Regioni340 – 601262Beta-propeller 2Add
BLAST
Regioni643 – 902260Beta-propeller 3Add
BLAST
Regioni944 – 1211268Beta-propeller 4Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1499 – 15057PPPSP motif A
Motifi1537 – 15448PPPSP motif B
Motifi1573 – 15808PPPSP motif C
Motifi1590 – 15956PPPSP motif D
Motifi1604 – 16118PPPSP motif E

Sequence similaritiesi

Belongs to the LDLR family.Curated
Contains 4 EGF-like domains.Curated
Contains 3 LDL-receptor class A domains.PROSITE-ProRule annotation
Contains 20 LDL-receptor class B repeats.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG121718.
GeneTreeiENSGT00760000118968.
HOVERGENiHBG049167.
InParanoidiQ91VN0.
KOiK03068.
OMAiLFWTCEA.
OrthoDBiEOG75XGK3.
TreeFamiTF315253.

Family and domain databases

Gene3Di2.120.10.30. 4 hits.
4.10.400.10. 3 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
IPR017049. Low_density_Lipo_rcpt-rel_p5/6.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 3 hits.
PF00058. Ldl_recept_b. 14 hits.
[Graphical view]
PIRSFiPIRSF036314. LDL_recpt-rel_p5/6. 1 hit.
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00181. EGF. 4 hits.
SM00192. LDLa. 3 hits.
SM00135. LY. 20 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 3 hits.
PROSITEiPS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 3 hits.
PS51120. LDLRB. 20 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced.

Isoform 1 (identifier: Q91VN0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METAPTRAPP PPPPPLLLLV LYCSLVPAAA SPLLLFANRR DVRLVDAGGV
60 70 80 90 100
KLESTIVASG LEDAAAVDFQ FSKGAVYWTD VSEEAIKQTY LNQTGAAAQN
110 120 130 140 150
IVISGLVSPD GLACDWVGKK LYWTDSETNR IEVANLNGTS RKVLFWQDLD
160 170 180 190 200
QPRAIALDPA HGYMYWTDWG EAPRIERAGM DGSTRKIIVD SDIYWPNGLT
210 220 230 240 250
IDLEEQKLYW ADAKLSFIHR ANLDGSFRQK VVEGSLTHPF ALTLSGDTLY
260 270 280 290 300
WTDWQTRSIH ACNKWTGEQR KEILSALYSP MDIQVLSQER QPPFHTPCEE
310 320 330 340 350
DNGGCSHLCL LSPREPFYSC ACPTGVQLQD NGKTCKTGAE EVLLLARRTD
360 370 380 390 400
LRRISLDTPD FTDIVLQVGD IRHAIAIDYD PLEGYVYWTD DEVRAIRRAY
410 420 430 440 450
LDGSGAQTLV NTEINDPDGI AVDWVARNLY WTDTGTDRIE VTRLNGTSRK
460 470 480 490 500
ILVSEDLDEP RAIVLHPVMG LMYWTDWGEN PKIECANLDG RDRHVLVNTS
510 520 530 540 550
LGWPNGLALD LQEGKLYWGD AKTDKIEVIN IDGTKRKTLL EDKLPHIFGF
560 570 580 590 600
TLLGDFIYWT DWQRRSIERV HKVKASRDVI IDQLPDLMGL KAVNVAKVVG
610 620 630 640 650
TNPCADGNGG CSHLCFFTPR ATKCGCPIGL ELLSDMKTCI IPEAFLVFTS
660 670 680 690 700
RATIHRISLE TNNNDVAIPL TGVKEASALD FDVSNNHIYW TDVSLKTISR
710 720 730 740 750
AFMNGSSVEH VIEFGLDYPE GMAVDWMGKN LYWADTGTNR IEVARLDGQF
760 770 780 790 800
RQVLVWRDLD NPRSLALDPT KGYIYWTEWG GKPRIVRAFM DGTNCMTLVD
810 820 830 840 850
KVGRANDLTI DYADQRLYWT DLDTNMIESS NMLGQERMVI ADDLPYPFGL
860 870 880 890 900
TQYSDYIYWT DWNLHSIERA DKTSGRNRTL IQGHLDFVMD ILVFHSSRQD
910 920 930 940 950
GLNDCVHSNG QCGQLCLAIP GGHRCGCASH YTLDPSSRNC SPPSTFLLFS
960 970 980 990 1000
QKFAISRMIP DDQLSPDLVL PLHGLRNVKA INYDPLDKFI YWVDGRQNIK
1010 1020 1030 1040 1050
RAKDDGTQPS MLTSPSQSLS PDRQPHDLSI DIYSRTLFWT CEATNTINVH
1060 1070 1080 1090 1100
RLDGDAMGVV LRGDRDKPRA IAVNAERGYM YFTNMQDHAA KIERASLDGT
1110 1120 1130 1140 1150
EREVLFTTGL IRPVALVVDN ALGKLFWVDA DLKRIESCDL SGANRLTLED
1160 1170 1180 1190 1200
ANIVQPVGLT VLGRHLYWID RQQQMIERVE KTTGDKRTRV QGRVTHLTGI
1210 1220 1230 1240 1250
HAVEEVSLEE FSAHPCARDN GGCSHICIAK GDGTPRCSCP VHLVLLQNLL
1260 1270 1280 1290 1300
TCGEPPTCSP DQFACTTGEI DCIPGAWRCD GFPECADQSD EEGCPVCSAS
1310 1320 1330 1340 1350
QFPCARGQCV DLRLRCDGEA DCQDRSDEAN CDAVCLPNQF RCTSGQCVLI
1360 1370 1380 1390 1400
KQQCDSFPDC ADGSDELMCE INKPPSDDIP AHSSAIGPVI GIILSLFVMG
1410 1420 1430 1440 1450
GVYFVCQRVM CQRYTGASGP FPHEYVGGAP HVPLNFIAPG GSQHGPFPGI
1460 1470 1480 1490 1500
PCSKSVMSSM SLVGGRGSVP LYDRNHVTGA SSSSSSSTKA TLYPPILNPP
1510 1520 1530 1540 1550
PSPATDPSLY NVDVFYSSGI PATARPYRPY VIRGMAPPTT PCSTDVCDSD
1560 1570 1580 1590 1600
YSTSRWKSSK YYLDLNSDSD PYPPPPTPHS QYLSAEDSCP PSPGTERSYC
1610
HLFPPPPSPC TDSS
Length:1,614
Mass (Da):178,885
Last modified:July 27, 2011 - v3
Checksum:i80FF4288470A4FC5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti220 – 2201R → H in AAC70183. (PubMed:10049586)Curated
Sequence conflicti1520 – 15201I → S in AAH11374. (PubMed:15489334)Curated
Sequence conflicti1553 – 15531T → I in AAC36468. (PubMed:9714764)Curated
Sequence conflicti1553 – 15531T → I in AAC70183. (PubMed:10049586)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064984 mRNA. Translation: AAC36468.1.
AF077847 mRNA. Translation: AAC70183.1.
AC112990 Genomic DNA. No translation available.
AC117797 Genomic DNA. No translation available.
BC011374 mRNA. Translation: AAH11374.1.
CCDSiCCDS37881.1. [Q91VN0-1]
RefSeqiNP_032539.2. NM_008513.3. [Q91VN0-1]
UniGeneiMm.274581.

Genome annotation databases

EnsembliENSMUST00000025856; ENSMUSP00000025856; ENSMUSG00000024913. [Q91VN0-1]
GeneIDi16973.
KEGGimmu:16973.
UCSCiuc008fwq.2. mouse. [Q91VN0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064984 mRNA. Translation: AAC36468.1 .
AF077847 mRNA. Translation: AAC70183.1 .
AC112990 Genomic DNA. No translation available.
AC117797 Genomic DNA. No translation available.
BC011374 mRNA. Translation: AAH11374.1 .
CCDSi CCDS37881.1. [Q91VN0-1 ]
RefSeqi NP_032539.2. NM_008513.3. [Q91VN0-1 ]
UniGenei Mm.274581.

3D structure databases

ProteinModelPortali Q91VN0.
SMRi Q91VN0. Positions 31-1255.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201202. 7 interactions.
IntActi Q91VN0. 2 interactions.
MINTi MINT-8293473.

PTM databases

PhosphoSitei Q91VN0.

Proteomic databases

PaxDbi Q91VN0.
PRIDEi Q91VN0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025856 ; ENSMUSP00000025856 ; ENSMUSG00000024913 . [Q91VN0-1 ]
GeneIDi 16973.
KEGGi mmu:16973.
UCSCi uc008fwq.2. mouse. [Q91VN0-1 ]

Organism-specific databases

CTDi 4041.
MGIi MGI:1278315. Lrp5.

Phylogenomic databases

eggNOGi NOG121718.
GeneTreei ENSGT00760000118968.
HOVERGENi HBG049167.
InParanoidi Q91VN0.
KOi K03068.
OMAi LFWTCEA.
OrthoDBi EOG75XGK3.
TreeFami TF315253.

Enzyme and pathway databases

Reactomei REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.

Miscellaneous databases

NextBioi 291030.
PROi Q91VN0.
SOURCEi Search...

Gene expression databases

Bgeei Q91VN0.
ExpressionAtlasi Q91VN0. baseline and differential.
Genevestigatori Q91VN0.

Family and domain databases

Gene3Di 2.120.10.30. 4 hits.
4.10.400.10. 3 hits.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
IPR017049. Low_density_Lipo_rcpt-rel_p5/6.
[Graphical view ]
Pfami PF00057. Ldl_recept_a. 3 hits.
PF00058. Ldl_recept_b. 14 hits.
[Graphical view ]
PIRSFi PIRSF036314. LDL_recpt-rel_p5/6. 1 hit.
PRINTSi PR00261. LDLRECEPTOR.
SMARTi SM00181. EGF. 4 hits.
SM00192. LDLa. 3 hits.
SM00135. LY. 20 hits.
[Graphical view ]
SUPFAMi SSF57424. SSF57424. 3 hits.
PROSITEi PS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 3 hits.
PS51120. LDLRB. 20 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. "Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping of orthologous genes in mouse and human."
    Chen D., Lathrop W., Dong Y.
    Genomics 55:314-321(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING.
    Tissue: Liver.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary tumor.
  5. "Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor."
    Kato M., Patel M.S., Levasseur R., Lobov I., Chang B.H., Glass D.A. II, Hartmann C., Li L., Hwang T.H., Brayton C.F., Lang R.A., Karsenty G., Chan L.
    J. Cell Biol. 157:303-314(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.
  6. "Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity."
    Hsieh J.-C., Lee L., Zhang L., Wefer S., Brown K., DeRossi C., Wines M.E., Rosenquist T., Holdener B.C.
    Cell 112:355-367(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MESD, OLIGOMERIZATION, SUBCELLULAR LOCATION.
  7. "The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice."
    Kelly O.G., Pinson K.I., Skarnes W.C.
    Development 131:2803-2815(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLRP5_MOUSE
AccessioniPrimary (citable) accession number: Q91VN0
Secondary accession number(s): E9QQ75, O88883, Q9R208
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3