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Q91VN0

- LRP5_MOUSE

UniProt

Q91VN0 - LRP5_MOUSE

Protein

Low-density lipoprotein receptor-related protein 5

Gene

Lrp5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin By similarity. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.By similarity2 Publications

    GO - Molecular functioni

    1. coreceptor activity Source: RefGenome
    2. protein binding Source: MGI
    3. Wnt-activated receptor activity Source: MGI
    4. Wnt-protein binding Source: MGI

    GO - Biological processi

    1. adipose tissue development Source: RefGenome
    2. anatomical structure regression Source: MGI
    3. anterior/posterior pattern specification Source: MGI
    4. apoptotic process involved in patterning of blood vessels Source: MGI
    5. bone development Source: BHF-UCL
    6. bone marrow development Source: RefGenome
    7. bone morphogenesis Source: RefGenome
    8. bone remodeling Source: MGI
    9. branching involved in mammary gland duct morphogenesis Source: MGI
    10. canonical Wnt signaling pathway Source: BHF-UCL
    11. cell-cell signaling involved in mammary gland development Source: MGI
    12. cell migration involved in gastrulation Source: MGI
    13. cholesterol homeostasis Source: RefGenome
    14. cholesterol metabolic process Source: MGI
    15. embryonic camera-type eye morphogenesis Source: RefGenome
    16. embryonic digit morphogenesis Source: MGI
    17. embryonic retina morphogenesis in camera-type eye Source: RefGenome
    18. endocytosis Source: UniProtKB-KW
    19. extracellular matrix-cell signaling Source: BHF-UCL
    20. gastrulation with mouth forming second Source: MGI
    21. glucose catabolic process Source: Ensembl
    22. limb morphogenesis Source: MGI
    23. mammary gland duct morphogenesis Source: MGI
    24. negative regulation of osteoblast differentiation Source: Ensembl
    25. negative regulation of protein serine/threonine kinase activity Source: Ensembl
    26. osteoblast development Source: BHF-UCL
    27. positive regulation of fat cell differentiation Source: Ensembl
    28. positive regulation of mesenchymal cell proliferation Source: Ensembl
    29. positive regulation of mitosis Source: Ensembl
    30. positive regulation of osteoblast proliferation Source: MGI
    31. positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    32. positive regulation of transcription, DNA-templated Source: BHF-UCL
    33. positive regulation of transcription from RNA polymerase II promoter Source: RefGenome
    34. regulation of apoptotic process Source: MGI
    35. regulation of blood pressure Source: Ensembl
    36. regulation of bone remodeling Source: MGI
    37. regulation of canonical Wnt signaling pathway Source: Ensembl
    38. regulation of fat cell differentiation Source: RefGenome
    39. regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
    40. regulation of ossification Source: RefGenome
    41. response to peptide hormone Source: Ensembl
    42. retinal blood vessel morphogenesis Source: RefGenome
    43. retina vasculature morphogenesis in camera-type eye Source: MGI
    44. somatic stem cell maintenance Source: MGI
    45. vasculature development Source: MGI
    46. Wnt signaling pathway Source: MGI
    47. Wnt signaling pathway involved in dorsal/ventral axis specification Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Endocytosis, Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low-density lipoprotein receptor-related protein 5
    Short name:
    LRP-5
    Alternative name(s):
    Low-density lipoprotein receptor-related protein 7
    Short name:
    LRP-7
    Lr3
    Gene namesi
    Name:Lrp5
    Synonyms:Lrp7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1278315. Lrp5.

    Subcellular locationi

    Membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endoplasmic reticulum 1 Publication
    Note: Chaperoned to the plasma membrane by MESD.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. mitochondrion Source: MGI
    4. plasma membrane Source: RefGenome
    5. receptor complex Source: RefGenome

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice exhibit decreased osteoblast proliferation, developing low bone mass postnatally. Also display persistent embryonic eye vascularization due to a failure of macrophage-induced endothelial cell apoptosis. Mutant animals exhibit a loss of middle phalanx ossification at 18.5 dpc. LRP5 and LRP6 double null mutants are more severely affected. Embryos arrest prior to mid-gestation.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 16141584Low-density lipoprotein receptor-related protein 5PRO_0000017329Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi298 ↔ 309PROSITE-ProRule annotation
    Disulfide bondi305 ↔ 320PROSITE-ProRule annotation
    Disulfide bondi322 ↔ 335PROSITE-ProRule annotation
    Glycosylationi445 – 4451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi604 ↔ 615PROSITE-ProRule annotation
    Disulfide bondi611 ↔ 624PROSITE-ProRule annotation
    Disulfide bondi626 ↔ 639PROSITE-ProRule annotation
    Glycosylationi704 – 7041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi877 – 8771N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi905 ↔ 916PROSITE-ProRule annotation
    Disulfide bondi912 ↔ 925PROSITE-ProRule annotation
    Disulfide bondi927 ↔ 940PROSITE-ProRule annotation
    Disulfide bondi1216 ↔ 1227PROSITE-ProRule annotation
    Disulfide bondi1223 ↔ 1237PROSITE-ProRule annotation
    Disulfide bondi1239 ↔ 1252PROSITE-ProRule annotation
    Disulfide bondi1258 ↔ 1272PROSITE-ProRule annotation
    Disulfide bondi1265 ↔ 1285PROSITE-ProRule annotation
    Disulfide bondi1279 ↔ 1294PROSITE-ProRule annotation
    Disulfide bondi1297 ↔ 1309PROSITE-ProRule annotation
    Disulfide bondi1304 ↔ 1322PROSITE-ProRule annotation
    Disulfide bondi1316 ↔ 1331PROSITE-ProRule annotation
    Disulfide bondi1335 ↔ 1347PROSITE-ProRule annotation
    Disulfide bondi1342 ↔ 1360PROSITE-ProRule annotation
    Disulfide bondi1354 ↔ 1369PROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylation of cytoplasmic PPPSP motifs regulates the signal transduction of the Wnt signaling pathway through acting as a docking site for AXIN1.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ91VN0.
    PRIDEiQ91VN0.

    PTM databases

    PhosphoSiteiQ91VN0.

    Expressioni

    Tissue specificityi

    Widely expressed, with the highest expression levels in liver, heart, and lung and the lowest levels in brain and spleen. Expressed in early embryo with strongest expression in visceral endoderm overlying the extraembryonic ectoderm. Not present in the mesoderm nor in endoderm emerging from the primitive streak.1 Publication

    Developmental stagei

    Expressed before or on embryonic day 7.

    Gene expression databases

    ArrayExpressiQ91VN0.
    BgeeiQ91VN0.
    GenevestigatoriQ91VN0.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling. Component of a WNT-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts with FZD8; the interaction is formed on WNT-binding and signaling. Interacts (via the phosphorylated PPPSP motif domains) with AXIN1; the interaction prevents inhibition of beta-catenin phosphorylation and signaling and is enhanced in the presence of GSK3B and WNT1 or WNT3A. Interacts (via beta-propeller regions 3 and 4) with DKK1; the interaction, enhanced by MESD and/or KREMEN, inhibits beta-catenin signaling by preventing GSK3-mediated phosphorylation of the PPPSP motifs and subsequent, AXIN1 binding. Interacts with CSNK1E. Interacts with SOST; the interaction antagonizes canonical Wnt signaling. Interacts with APCDD1 By similarity. Interacts with MESD; the interaction prevents the formation of LRP5 aggregates, targets LRP5 to the plasma membrane and, when complexed with KREMEN2, increases DKK1 binding.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi201202. 7 interactions.
    IntActiQ91VN0. 2 interactions.
    MINTiMINT-8293473.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91VN0.
    SMRiQ91VN0. Positions 31-1255.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 13831353ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1407 – 1614208CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1384 – 140623HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati74 – 11845LDL-receptor class B 1Add
    BLAST
    Repeati119 – 16143LDL-receptor class B 2Add
    BLAST
    Repeati162 – 20544LDL-receptor class B 3Add
    BLAST
    Repeati206 – 24641LDL-receptor class B 4Add
    BLAST
    Repeati247 – 28943LDL-receptor class B 5Add
    BLAST
    Domaini294 – 33643EGF-like 1Add
    BLAST
    Repeati384 – 42643LDL-receptor class B 6Add
    BLAST
    Repeati427 – 46943LDL-receptor class B 7Add
    BLAST
    Repeati470 – 51344LDL-receptor class B 8Add
    BLAST
    Repeati514 – 55643LDL-receptor class B 9Add
    BLAST
    Repeati557 – 59943LDL-receptor class B 10Add
    BLAST
    Domaini600 – 64041EGF-like 2Add
    BLAST
    Repeati686 – 72843LDL-receptor class B 11Add
    BLAST
    Repeati729 – 77143LDL-receptor class B 12Add
    BLAST
    Repeati772 – 81443LDL-receptor class B 13Add
    BLAST
    Repeati815 – 85440LDL-receptor class B 14Add
    BLAST
    Repeati855 – 89743LDL-receptor class B 15Add
    BLAST
    Domaini901 – 94141EGF-like 3Add
    BLAST
    Repeati988 – 103447LDL-receptor class B 16Add
    BLAST
    Repeati1035 – 107743LDL-receptor class B 17Add
    BLAST
    Repeati1078 – 112245LDL-receptor class B 18Add
    BLAST
    Repeati1123 – 116442LDL-receptor class B 19Add
    BLAST
    Repeati1165 – 120642LDL-receptor class B 20Add
    BLAST
    Domaini1212 – 125342EGF-like 4Add
    BLAST
    Domaini1257 – 129539LDL-receptor class A 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1296 – 133237LDL-receptor class A 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1334 – 137037LDL-receptor class A 3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni31 – 287257Beta-propeller 1Add
    BLAST
    Regioni340 – 601262Beta-propeller 2Add
    BLAST
    Regioni643 – 902260Beta-propeller 3Add
    BLAST
    Regioni944 – 1211268Beta-propeller 4Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1499 – 15057PPPSP motif A
    Motifi1537 – 15448PPPSP motif B
    Motifi1573 – 15808PPPSP motif C
    Motifi1590 – 15956PPPSP motif D
    Motifi1604 – 16118PPPSP motif E

    Sequence similaritiesi

    Belongs to the LDLR family.Curated
    Contains 4 EGF-like domains.Curated
    Contains 3 LDL-receptor class A domains.PROSITE-ProRule annotation
    Contains 20 LDL-receptor class B repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG121718.
    GeneTreeiENSGT00750000117273.
    HOVERGENiHBG049167.
    InParanoidiQ91VN0.
    KOiK03068.
    OMAiLFWTCEA.
    OrthoDBiEOG75XGK3.
    TreeFamiTF315253.

    Family and domain databases

    Gene3Di2.120.10.30. 4 hits.
    4.10.400.10. 3 hits.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR000742. EG-like_dom.
    IPR023415. LDLR_class-A_CS.
    IPR000033. LDLR_classB_rpt.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR017049. Low_density_Lipo_rcpt-rel_p5/6.
    [Graphical view]
    PfamiPF00057. Ldl_recept_a. 3 hits.
    PF00058. Ldl_recept_b. 14 hits.
    [Graphical view]
    PIRSFiPIRSF036314. LDL_recpt-rel_p5/6. 1 hit.
    PRINTSiPR00261. LDLRECEPTOR.
    SMARTiSM00181. EGF. 4 hits.
    SM00192. LDLa. 3 hits.
    SM00135. LY. 20 hits.
    [Graphical view]
    SUPFAMiSSF57424. SSF57424. 3 hits.
    PROSITEiPS01209. LDLRA_1. 3 hits.
    PS50068. LDLRA_2. 3 hits.
    PS51120. LDLRB. 20 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced.

    Isoform 1 (identifier: Q91VN0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    METAPTRAPP PPPPPLLLLV LYCSLVPAAA SPLLLFANRR DVRLVDAGGV     50
    KLESTIVASG LEDAAAVDFQ FSKGAVYWTD VSEEAIKQTY LNQTGAAAQN 100
    IVISGLVSPD GLACDWVGKK LYWTDSETNR IEVANLNGTS RKVLFWQDLD 150
    QPRAIALDPA HGYMYWTDWG EAPRIERAGM DGSTRKIIVD SDIYWPNGLT 200
    IDLEEQKLYW ADAKLSFIHR ANLDGSFRQK VVEGSLTHPF ALTLSGDTLY 250
    WTDWQTRSIH ACNKWTGEQR KEILSALYSP MDIQVLSQER QPPFHTPCEE 300
    DNGGCSHLCL LSPREPFYSC ACPTGVQLQD NGKTCKTGAE EVLLLARRTD 350
    LRRISLDTPD FTDIVLQVGD IRHAIAIDYD PLEGYVYWTD DEVRAIRRAY 400
    LDGSGAQTLV NTEINDPDGI AVDWVARNLY WTDTGTDRIE VTRLNGTSRK 450
    ILVSEDLDEP RAIVLHPVMG LMYWTDWGEN PKIECANLDG RDRHVLVNTS 500
    LGWPNGLALD LQEGKLYWGD AKTDKIEVIN IDGTKRKTLL EDKLPHIFGF 550
    TLLGDFIYWT DWQRRSIERV HKVKASRDVI IDQLPDLMGL KAVNVAKVVG 600
    TNPCADGNGG CSHLCFFTPR ATKCGCPIGL ELLSDMKTCI IPEAFLVFTS 650
    RATIHRISLE TNNNDVAIPL TGVKEASALD FDVSNNHIYW TDVSLKTISR 700
    AFMNGSSVEH VIEFGLDYPE GMAVDWMGKN LYWADTGTNR IEVARLDGQF 750
    RQVLVWRDLD NPRSLALDPT KGYIYWTEWG GKPRIVRAFM DGTNCMTLVD 800
    KVGRANDLTI DYADQRLYWT DLDTNMIESS NMLGQERMVI ADDLPYPFGL 850
    TQYSDYIYWT DWNLHSIERA DKTSGRNRTL IQGHLDFVMD ILVFHSSRQD 900
    GLNDCVHSNG QCGQLCLAIP GGHRCGCASH YTLDPSSRNC SPPSTFLLFS 950
    QKFAISRMIP DDQLSPDLVL PLHGLRNVKA INYDPLDKFI YWVDGRQNIK 1000
    RAKDDGTQPS MLTSPSQSLS PDRQPHDLSI DIYSRTLFWT CEATNTINVH 1050
    RLDGDAMGVV LRGDRDKPRA IAVNAERGYM YFTNMQDHAA KIERASLDGT 1100
    EREVLFTTGL IRPVALVVDN ALGKLFWVDA DLKRIESCDL SGANRLTLED 1150
    ANIVQPVGLT VLGRHLYWID RQQQMIERVE KTTGDKRTRV QGRVTHLTGI 1200
    HAVEEVSLEE FSAHPCARDN GGCSHICIAK GDGTPRCSCP VHLVLLQNLL 1250
    TCGEPPTCSP DQFACTTGEI DCIPGAWRCD GFPECADQSD EEGCPVCSAS 1300
    QFPCARGQCV DLRLRCDGEA DCQDRSDEAN CDAVCLPNQF RCTSGQCVLI 1350
    KQQCDSFPDC ADGSDELMCE INKPPSDDIP AHSSAIGPVI GIILSLFVMG 1400
    GVYFVCQRVM CQRYTGASGP FPHEYVGGAP HVPLNFIAPG GSQHGPFPGI 1450
    PCSKSVMSSM SLVGGRGSVP LYDRNHVTGA SSSSSSSTKA TLYPPILNPP 1500
    PSPATDPSLY NVDVFYSSGI PATARPYRPY VIRGMAPPTT PCSTDVCDSD 1550
    YSTSRWKSSK YYLDLNSDSD PYPPPPTPHS QYLSAEDSCP PSPGTERSYC 1600
    HLFPPPPSPC TDSS 1614
    Length:1,614
    Mass (Da):178,885
    Last modified:July 27, 2011 - v3
    Checksum:i80FF4288470A4FC5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti220 – 2201R → H in AAC70183. (PubMed:10049586)Curated
    Sequence conflicti1520 – 15201I → S in AAH11374. (PubMed:15489334)Curated
    Sequence conflicti1553 – 15531T → I in AAC36468. (PubMed:9714764)Curated
    Sequence conflicti1553 – 15531T → I in AAC70183. (PubMed:10049586)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064984 mRNA. Translation: AAC36468.1.
    AF077847 mRNA. Translation: AAC70183.1.
    AC112990 Genomic DNA. No translation available.
    AC117797 Genomic DNA. No translation available.
    BC011374 mRNA. Translation: AAH11374.1.
    CCDSiCCDS37881.1. [Q91VN0-1]
    RefSeqiNP_032539.2. NM_008513.3. [Q91VN0-1]
    UniGeneiMm.274581.

    Genome annotation databases

    EnsembliENSMUST00000025856; ENSMUSP00000025856; ENSMUSG00000024913. [Q91VN0-1]
    GeneIDi16973.
    KEGGimmu:16973.
    UCSCiuc008fwq.2. mouse. [Q91VN0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064984 mRNA. Translation: AAC36468.1 .
    AF077847 mRNA. Translation: AAC70183.1 .
    AC112990 Genomic DNA. No translation available.
    AC117797 Genomic DNA. No translation available.
    BC011374 mRNA. Translation: AAH11374.1 .
    CCDSi CCDS37881.1. [Q91VN0-1 ]
    RefSeqi NP_032539.2. NM_008513.3. [Q91VN0-1 ]
    UniGenei Mm.274581.

    3D structure databases

    ProteinModelPortali Q91VN0.
    SMRi Q91VN0. Positions 31-1255.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201202. 7 interactions.
    IntActi Q91VN0. 2 interactions.
    MINTi MINT-8293473.

    PTM databases

    PhosphoSitei Q91VN0.

    Proteomic databases

    PaxDbi Q91VN0.
    PRIDEi Q91VN0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025856 ; ENSMUSP00000025856 ; ENSMUSG00000024913 . [Q91VN0-1 ]
    GeneIDi 16973.
    KEGGi mmu:16973.
    UCSCi uc008fwq.2. mouse. [Q91VN0-1 ]

    Organism-specific databases

    CTDi 4041.
    MGIi MGI:1278315. Lrp5.

    Phylogenomic databases

    eggNOGi NOG121718.
    GeneTreei ENSGT00750000117273.
    HOVERGENi HBG049167.
    InParanoidi Q91VN0.
    KOi K03068.
    OMAi LFWTCEA.
    OrthoDBi EOG75XGK3.
    TreeFami TF315253.

    Enzyme and pathway databases

    Reactomei REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.

    Miscellaneous databases

    NextBioi 291030.
    PROi Q91VN0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91VN0.
    Bgeei Q91VN0.
    Genevestigatori Q91VN0.

    Family and domain databases

    Gene3Di 2.120.10.30. 4 hits.
    4.10.400.10. 3 hits.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR000742. EG-like_dom.
    IPR023415. LDLR_class-A_CS.
    IPR000033. LDLR_classB_rpt.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR017049. Low_density_Lipo_rcpt-rel_p5/6.
    [Graphical view ]
    Pfami PF00057. Ldl_recept_a. 3 hits.
    PF00058. Ldl_recept_b. 14 hits.
    [Graphical view ]
    PIRSFi PIRSF036314. LDL_recpt-rel_p5/6. 1 hit.
    PRINTSi PR00261. LDLRECEPTOR.
    SMARTi SM00181. EGF. 4 hits.
    SM00192. LDLa. 3 hits.
    SM00135. LY. 20 hits.
    [Graphical view ]
    SUPFAMi SSF57424. SSF57424. 3 hits.
    PROSITEi PS01209. LDLRA_1. 3 hits.
    PS50068. LDLRA_2. 3 hits.
    PS51120. LDLRB. 20 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    2. "Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping of orthologous genes in mouse and human."
      Chen D., Lathrop W., Dong Y.
      Genomics 55:314-321(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING.
      Tissue: Liver.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Mammary tumor.
    5. "Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor."
      Kato M., Patel M.S., Levasseur R., Lobov I., Chang B.H., Glass D.A. II, Hartmann C., Li L., Hwang T.H., Brayton C.F., Lang R.A., Karsenty G., Chan L.
      J. Cell Biol. 157:303-314(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION.
    6. "Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity."
      Hsieh J.-C., Lee L., Zhang L., Wefer S., Brown K., DeRossi C., Wines M.E., Rosenquist T., Holdener B.C.
      Cell 112:355-367(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MESD, OLIGOMERIZATION, SUBCELLULAR LOCATION.
    7. "The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice."
      Kelly O.G., Pinson K.I., Skarnes W.C.
      Development 131:2803-2815(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLRP5_MOUSE
    AccessioniPrimary (citable) accession number: Q91VN0
    Secondary accession number(s): E9QQ75, O88883, Q9R208
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 118 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3