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Q91VN0

- LRP5_MOUSE

UniProt

Q91VN0 - LRP5_MOUSE

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Protein
Low-density lipoprotein receptor-related protein 5
Gene
Lrp5, Lrp7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin By similarity. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.2 Publications

GO - Molecular functioni

  1. Wnt-activated receptor activity Source: MGI
  2. Wnt-protein binding Source: MGI
  3. coreceptor activity Source: RefGenome
  4. protein binding Source: MGI

GO - Biological processi

  1. Wnt signaling pathway Source: MGI
  2. Wnt signaling pathway involved in dorsal/ventral axis specification Source: RefGenome
  3. adipose tissue development Source: RefGenome
  4. anatomical structure regression Source: MGI
  5. anterior/posterior pattern specification Source: MGI
  6. apoptotic process involved in patterning of blood vessels Source: MGI
  7. bone development Source: BHF-UCL
  8. bone marrow development Source: RefGenome
  9. bone morphogenesis Source: RefGenome
  10. bone remodeling Source: MGI
  11. branching involved in mammary gland duct morphogenesis Source: MGI
  12. canonical Wnt signaling pathway Source: BHF-UCL
  13. cell migration involved in gastrulation Source: MGI
  14. cell-cell signaling involved in mammary gland development Source: MGI
  15. cholesterol homeostasis Source: RefGenome
  16. cholesterol metabolic process Source: MGI
  17. embryonic camera-type eye morphogenesis Source: RefGenome
  18. embryonic digit morphogenesis Source: MGI
  19. embryonic retina morphogenesis in camera-type eye Source: RefGenome
  20. endocytosis Source: UniProtKB-KW
  21. extracellular matrix-cell signaling Source: BHF-UCL
  22. gastrulation with mouth forming second Source: MGI
  23. glucose catabolic process Source: Ensembl
  24. limb morphogenesis Source: MGI
  25. mammary gland duct morphogenesis Source: MGI
  26. negative regulation of osteoblast differentiation Source: Ensembl
  27. negative regulation of protein serine/threonine kinase activity Source: Ensembl
  28. osteoblast development Source: BHF-UCL
  29. positive regulation of fat cell differentiation Source: Ensembl
  30. positive regulation of mesenchymal cell proliferation Source: Ensembl
  31. positive regulation of mitosis Source: Ensembl
  32. positive regulation of osteoblast proliferation Source: MGI
  33. positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  34. positive regulation of transcription from RNA polymerase II promoter Source: RefGenome
  35. positive regulation of transcription, DNA-templated Source: BHF-UCL
  36. regulation of apoptotic process Source: MGI
  37. regulation of blood pressure Source: Ensembl
  38. regulation of bone remodeling Source: MGI
  39. regulation of canonical Wnt signaling pathway Source: Ensembl
  40. regulation of fat cell differentiation Source: RefGenome
  41. regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
  42. regulation of ossification Source: RefGenome
  43. response to peptide hormone Source: Ensembl
  44. retina vasculature morphogenesis in camera-type eye Source: MGI
  45. retinal blood vessel morphogenesis Source: RefGenome
  46. somatic stem cell maintenance Source: MGI
  47. vasculature development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Endocytosis, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 5
Short name:
LRP-5
Alternative name(s):
Low-density lipoprotein receptor-related protein 7
Short name:
LRP-7
Lr3
Gene namesi
Name:Lrp5
Synonyms:Lrp7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1278315. Lrp5.

Subcellular locationi

Membrane; Single-pass type I membrane protein. Endoplasmic reticulum
Note: Chaperoned to the plasma membrane by MESD By similarity.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 13831353Extracellular Reviewed prediction
Add
BLAST
Transmembranei1384 – 140623Helical; Reviewed prediction
Add
BLAST
Topological domaini1407 – 1614208Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrion Source: MGI
  4. plasma membrane Source: RefGenome
  5. receptor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice exhibit decreased osteoblast proliferation, developing low bone mass postnatally. Also display persistent embryonic eye vascularization due to a failure of macrophage-induced endothelial cell apoptosis. Mutant animals exhibit a loss of middle phalanx ossification at 18.5 dpc. LRP5 and LRP6 double null mutants are more severely affected. Embryos arrest prior to mid-gestation.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed prediction
Add
BLAST
Chaini31 – 16141584Low-density lipoprotein receptor-related protein 5
PRO_0000017329Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi92 – 921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi137 – 1371N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi298 ↔ 309 By similarity
Disulfide bondi305 ↔ 320 By similarity
Disulfide bondi322 ↔ 335 By similarity
Glycosylationi445 – 4451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi498 – 4981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi604 ↔ 615 By similarity
Disulfide bondi611 ↔ 624 By similarity
Disulfide bondi626 ↔ 639 By similarity
Glycosylationi704 – 7041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi877 – 8771N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi905 ↔ 916 By similarity
Disulfide bondi912 ↔ 925 By similarity
Disulfide bondi927 ↔ 940 By similarity
Disulfide bondi1216 ↔ 1227 By similarity
Disulfide bondi1223 ↔ 1237 By similarity
Disulfide bondi1239 ↔ 1252 By similarity
Disulfide bondi1258 ↔ 1272 By similarity
Disulfide bondi1265 ↔ 1285 By similarity
Disulfide bondi1279 ↔ 1294 By similarity
Disulfide bondi1297 ↔ 1309 By similarity
Disulfide bondi1304 ↔ 1322 By similarity
Disulfide bondi1316 ↔ 1331 By similarity
Disulfide bondi1335 ↔ 1347 By similarity
Disulfide bondi1342 ↔ 1360 By similarity
Disulfide bondi1354 ↔ 1369 By similarity

Post-translational modificationi

Phosphorylation of cytoplasmic PPPSP motifs regulates the signal transduction of the Wnt signaling pathway through acting as a docking site for AXIN1 By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ91VN0.
PRIDEiQ91VN0.

PTM databases

PhosphoSiteiQ91VN0.

Expressioni

Tissue specificityi

Widely expressed, with the highest expression levels in liver, heart, and lung and the lowest levels in brain and spleen. Expressed in early embryo with strongest expression in visceral endoderm overlying the extraembryonic ectoderm. Not present in the mesoderm nor in endoderm emerging from the primitive streak.1 Publication

Developmental stagei

Expressed before or on embryonic day 7.

Gene expression databases

ArrayExpressiQ91VN0.
BgeeiQ91VN0.
GenevestigatoriQ91VN0.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling. Component of a WNT-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts with FZD8; the interaction is formed on WNT-binding and signaling. Interacts (via the phosphorylated PPPSP motif domains) with AXIN1; the interaction prevents inhibition of beta-catenin phosphorylation and signaling and is enhanced in the presence of GSK3B and WNT1 or WNT3A. Interacts (via beta-propeller regions 3 and 4) with DKK1; the interaction, enhanced by MESD and/or KREMEN, inhibits beta-catenin signaling by preventing GSK3-mediated phosphorylation of the PPPSP motifs and subsequent, AXIN1 binding. Interacts with CSNK1E. Interacts with SOST; the interaction antagonizes canonical Wnt signaling. Interacts with APCDD1 By similarity. Interacts with MESD; the interaction prevents the formation of LRP5 aggregates, targets LRP5 to the plasma membrane and, when complexed with KREMEN2, increases DKK1 binding.1 Publication

Protein-protein interaction databases

BioGridi201202. 7 interactions.
IntActiQ91VN0. 2 interactions.
MINTiMINT-8293473.

Structurei

3D structure databases

ProteinModelPortaliQ91VN0.
SMRiQ91VN0. Positions 31-1255.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati74 – 11845LDL-receptor class B 1
Add
BLAST
Repeati119 – 16143LDL-receptor class B 2
Add
BLAST
Repeati162 – 20544LDL-receptor class B 3
Add
BLAST
Repeati206 – 24641LDL-receptor class B 4
Add
BLAST
Repeati247 – 28943LDL-receptor class B 5
Add
BLAST
Domaini294 – 33643EGF-like 1
Add
BLAST
Repeati384 – 42643LDL-receptor class B 6
Add
BLAST
Repeati427 – 46943LDL-receptor class B 7
Add
BLAST
Repeati470 – 51344LDL-receptor class B 8
Add
BLAST
Repeati514 – 55643LDL-receptor class B 9
Add
BLAST
Repeati557 – 59943LDL-receptor class B 10
Add
BLAST
Domaini600 – 64041EGF-like 2
Add
BLAST
Repeati686 – 72843LDL-receptor class B 11
Add
BLAST
Repeati729 – 77143LDL-receptor class B 12
Add
BLAST
Repeati772 – 81443LDL-receptor class B 13
Add
BLAST
Repeati815 – 85440LDL-receptor class B 14
Add
BLAST
Repeati855 – 89743LDL-receptor class B 15
Add
BLAST
Domaini901 – 94141EGF-like 3
Add
BLAST
Repeati988 – 103447LDL-receptor class B 16
Add
BLAST
Repeati1035 – 107743LDL-receptor class B 17
Add
BLAST
Repeati1078 – 112245LDL-receptor class B 18
Add
BLAST
Repeati1123 – 116442LDL-receptor class B 19
Add
BLAST
Repeati1165 – 120642LDL-receptor class B 20
Add
BLAST
Domaini1212 – 125342EGF-like 4
Add
BLAST
Domaini1257 – 129539LDL-receptor class A 1
Add
BLAST
Domaini1296 – 133237LDL-receptor class A 2
Add
BLAST
Domaini1334 – 137037LDL-receptor class A 3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni31 – 287257Beta-propeller 1
Add
BLAST
Regioni340 – 601262Beta-propeller 2
Add
BLAST
Regioni643 – 902260Beta-propeller 3
Add
BLAST
Regioni944 – 1211268Beta-propeller 4
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1499 – 15057PPPSP motif A
Motifi1537 – 15448PPPSP motif B
Motifi1573 – 15808PPPSP motif C
Motifi1590 – 15956PPPSP motif D
Motifi1604 – 16118PPPSP motif E

Sequence similaritiesi

Belongs to the LDLR family.
Contains 4 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG121718.
GeneTreeiENSGT00750000117273.
HOVERGENiHBG049167.
InParanoidiQ91VN0.
KOiK03068.
OMAiLFWTCEA.
OrthoDBiEOG75XGK3.
TreeFamiTF315253.

Family and domain databases

Gene3Di2.120.10.30. 4 hits.
4.10.400.10. 3 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
IPR017049. Low_density_Lipo_rcpt-rel_p5/6.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 3 hits.
PF00058. Ldl_recept_b. 14 hits.
[Graphical view]
PIRSFiPIRSF036314. LDL_recpt-rel_p5/6. 1 hit.
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00181. EGF. 4 hits.
SM00192. LDLa. 3 hits.
SM00135. LY. 20 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 3 hits.
PROSITEiPS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 3 hits.
PS51120. LDLRB. 20 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced.

Isoform 1 (identifier: Q91VN0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

METAPTRAPP PPPPPLLLLV LYCSLVPAAA SPLLLFANRR DVRLVDAGGV     50
KLESTIVASG LEDAAAVDFQ FSKGAVYWTD VSEEAIKQTY LNQTGAAAQN 100
IVISGLVSPD GLACDWVGKK LYWTDSETNR IEVANLNGTS RKVLFWQDLD 150
QPRAIALDPA HGYMYWTDWG EAPRIERAGM DGSTRKIIVD SDIYWPNGLT 200
IDLEEQKLYW ADAKLSFIHR ANLDGSFRQK VVEGSLTHPF ALTLSGDTLY 250
WTDWQTRSIH ACNKWTGEQR KEILSALYSP MDIQVLSQER QPPFHTPCEE 300
DNGGCSHLCL LSPREPFYSC ACPTGVQLQD NGKTCKTGAE EVLLLARRTD 350
LRRISLDTPD FTDIVLQVGD IRHAIAIDYD PLEGYVYWTD DEVRAIRRAY 400
LDGSGAQTLV NTEINDPDGI AVDWVARNLY WTDTGTDRIE VTRLNGTSRK 450
ILVSEDLDEP RAIVLHPVMG LMYWTDWGEN PKIECANLDG RDRHVLVNTS 500
LGWPNGLALD LQEGKLYWGD AKTDKIEVIN IDGTKRKTLL EDKLPHIFGF 550
TLLGDFIYWT DWQRRSIERV HKVKASRDVI IDQLPDLMGL KAVNVAKVVG 600
TNPCADGNGG CSHLCFFTPR ATKCGCPIGL ELLSDMKTCI IPEAFLVFTS 650
RATIHRISLE TNNNDVAIPL TGVKEASALD FDVSNNHIYW TDVSLKTISR 700
AFMNGSSVEH VIEFGLDYPE GMAVDWMGKN LYWADTGTNR IEVARLDGQF 750
RQVLVWRDLD NPRSLALDPT KGYIYWTEWG GKPRIVRAFM DGTNCMTLVD 800
KVGRANDLTI DYADQRLYWT DLDTNMIESS NMLGQERMVI ADDLPYPFGL 850
TQYSDYIYWT DWNLHSIERA DKTSGRNRTL IQGHLDFVMD ILVFHSSRQD 900
GLNDCVHSNG QCGQLCLAIP GGHRCGCASH YTLDPSSRNC SPPSTFLLFS 950
QKFAISRMIP DDQLSPDLVL PLHGLRNVKA INYDPLDKFI YWVDGRQNIK 1000
RAKDDGTQPS MLTSPSQSLS PDRQPHDLSI DIYSRTLFWT CEATNTINVH 1050
RLDGDAMGVV LRGDRDKPRA IAVNAERGYM YFTNMQDHAA KIERASLDGT 1100
EREVLFTTGL IRPVALVVDN ALGKLFWVDA DLKRIESCDL SGANRLTLED 1150
ANIVQPVGLT VLGRHLYWID RQQQMIERVE KTTGDKRTRV QGRVTHLTGI 1200
HAVEEVSLEE FSAHPCARDN GGCSHICIAK GDGTPRCSCP VHLVLLQNLL 1250
TCGEPPTCSP DQFACTTGEI DCIPGAWRCD GFPECADQSD EEGCPVCSAS 1300
QFPCARGQCV DLRLRCDGEA DCQDRSDEAN CDAVCLPNQF RCTSGQCVLI 1350
KQQCDSFPDC ADGSDELMCE INKPPSDDIP AHSSAIGPVI GIILSLFVMG 1400
GVYFVCQRVM CQRYTGASGP FPHEYVGGAP HVPLNFIAPG GSQHGPFPGI 1450
PCSKSVMSSM SLVGGRGSVP LYDRNHVTGA SSSSSSSTKA TLYPPILNPP 1500
PSPATDPSLY NVDVFYSSGI PATARPYRPY VIRGMAPPTT PCSTDVCDSD 1550
YSTSRWKSSK YYLDLNSDSD PYPPPPTPHS QYLSAEDSCP PSPGTERSYC 1600
HLFPPPPSPC TDSS 1614
Length:1,614
Mass (Da):178,885
Last modified:July 27, 2011 - v3
Checksum:i80FF4288470A4FC5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti220 – 2201R → H in AAC70183. 1 Publication
Sequence conflicti1520 – 15201I → S in AAH11374. 1 Publication
Sequence conflicti1553 – 15531T → I in AAC36468. 1 Publication
Sequence conflicti1553 – 15531T → I in AAC70183. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064984 mRNA. Translation: AAC36468.1.
AF077847 mRNA. Translation: AAC70183.1.
AC112990 Genomic DNA. No translation available.
AC117797 Genomic DNA. No translation available.
BC011374 mRNA. Translation: AAH11374.1.
CCDSiCCDS37881.1. [Q91VN0-1]
RefSeqiNP_032539.2. NM_008513.3. [Q91VN0-1]
UniGeneiMm.274581.

Genome annotation databases

EnsembliENSMUST00000025856; ENSMUSP00000025856; ENSMUSG00000024913. [Q91VN0-1]
GeneIDi16973.
KEGGimmu:16973.
UCSCiuc008fwq.2. mouse. [Q91VN0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064984 mRNA. Translation: AAC36468.1 .
AF077847 mRNA. Translation: AAC70183.1 .
AC112990 Genomic DNA. No translation available.
AC117797 Genomic DNA. No translation available.
BC011374 mRNA. Translation: AAH11374.1 .
CCDSi CCDS37881.1. [Q91VN0-1 ]
RefSeqi NP_032539.2. NM_008513.3. [Q91VN0-1 ]
UniGenei Mm.274581.

3D structure databases

ProteinModelPortali Q91VN0.
SMRi Q91VN0. Positions 31-1255.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201202. 7 interactions.
IntActi Q91VN0. 2 interactions.
MINTi MINT-8293473.

PTM databases

PhosphoSitei Q91VN0.

Proteomic databases

PaxDbi Q91VN0.
PRIDEi Q91VN0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025856 ; ENSMUSP00000025856 ; ENSMUSG00000024913 . [Q91VN0-1 ]
GeneIDi 16973.
KEGGi mmu:16973.
UCSCi uc008fwq.2. mouse. [Q91VN0-1 ]

Organism-specific databases

CTDi 4041.
MGIi MGI:1278315. Lrp5.

Phylogenomic databases

eggNOGi NOG121718.
GeneTreei ENSGT00750000117273.
HOVERGENi HBG049167.
InParanoidi Q91VN0.
KOi K03068.
OMAi LFWTCEA.
OrthoDBi EOG75XGK3.
TreeFami TF315253.

Enzyme and pathway databases

Reactomei REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.

Miscellaneous databases

NextBioi 291030.
PROi Q91VN0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91VN0.
Bgeei Q91VN0.
Genevestigatori Q91VN0.

Family and domain databases

Gene3Di 2.120.10.30. 4 hits.
4.10.400.10. 3 hits.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
IPR017049. Low_density_Lipo_rcpt-rel_p5/6.
[Graphical view ]
Pfami PF00057. Ldl_recept_a. 3 hits.
PF00058. Ldl_recept_b. 14 hits.
[Graphical view ]
PIRSFi PIRSF036314. LDL_recpt-rel_p5/6. 1 hit.
PRINTSi PR00261. LDLRECEPTOR.
SMARTi SM00181. EGF. 4 hits.
SM00192. LDLa. 3 hits.
SM00135. LY. 20 hits.
[Graphical view ]
SUPFAMi SSF57424. SSF57424. 3 hits.
PROSITEi PS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 3 hits.
PS51120. LDLRB. 20 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. "Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping of orthologous genes in mouse and human."
    Chen D., Lathrop W., Dong Y.
    Genomics 55:314-321(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING.
    Tissue: Liver.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary tumor.
  5. "Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor."
    Kato M., Patel M.S., Levasseur R., Lobov I., Chang B.H., Glass D.A. II, Hartmann C., Li L., Hwang T.H., Brayton C.F., Lang R.A., Karsenty G., Chan L.
    J. Cell Biol. 157:303-314(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.
  6. "Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity."
    Hsieh J.-C., Lee L., Zhang L., Wefer S., Brown K., DeRossi C., Wines M.E., Rosenquist T., Holdener B.C.
    Cell 112:355-367(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MESD, OLIGOMERIZATION, SUBCELLULAR LOCATION.
  7. "The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice."
    Kelly O.G., Pinson K.I., Skarnes W.C.
    Development 131:2803-2815(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLRP5_MOUSE
AccessioniPrimary (citable) accession number: Q91VN0
Secondary accession number(s): E9QQ75, O88883, Q9R208
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi