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Q91VM9 (IPYR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inorganic pyrophosphatase 2, mitochondrial
EC=3.6.1.1
Alternative name(s):
Pyrophosphate phospho-hydrolase 2
Short name=PPase 2
Gene names
Name:Ppa2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Diphosphate + H2O = 2 phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion Potential.

Sequence similarities

Belongs to the PPase family.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityAlternative splicing
   DomainTransit peptide
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processphosphate-containing compound metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentmitochondrion

Inferred from direct assay. Source: MGI

   Molecular functioninorganic diphosphatase activity

Inferred from electronic annotation. Source: EC

magnesium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q91VM9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q91VM9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.
     127-170: IFPHKGYIWN...DPIDVCEIGS → MLDADAPQNC...FQAIETLSQM
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2727Mitochondrion By similarity
Chain28 – 330303Inorganic pyrophosphatase 2, mitochondrial
PRO_0000025412

Sites

Metal binding1591Magnesium 1 By similarity
Metal binding1641Magnesium 1 By similarity
Metal binding1641Magnesium 2 By similarity
Metal binding1961Magnesium 1 By similarity

Amino acid modifications

Modified residue481N6-acetyllysine By similarity
Modified residue2111N6-acetyllysine By similarity
Modified residue2561N6-acetyllysine By similarity
Modified residue2711N6-acetyllysine By similarity

Natural variations

Alternative sequence1 – 126126Missing in isoform 2.
VSP_011653
Alternative sequence127 – 17044IFPHK…CEIGS → MLDADAPQNCQSWEGKDKQI PGPHRPNSQACLVKFQAIET LSQM in isoform 2.
VSP_011654

Experimental info

Sequence conflict225 – 2273YLE → HLQ in BAC41194. Ref.1
Sequence conflict2541K → T in BAC41194. Ref.1
Sequence conflict3211Missing in BAC41194. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 8AFD61FA561D7268

FASTA33038,115
        10         20         30         40         50         60 
MRALLPLLSV GRGWRVGAAA RPPRRVMSLY RTEELGHPRS QDYRLFFKHV AGHYISPFHD 

        70         80         90        100        110        120 
IPLKADCKEE HDIPRKKARN DEYENLFNMV VEIPRWTNAK MEIATEEPLN PIKQDIKNGK 

       130        140        150        160        170        180 
LRYTPNIFPH KGYIWNYGAL PQTWEDPHLR DKSTDCCGDN DPIDVCEIGS KVLSRGDVVH 

       190        200        210        220        230        240 
VKILGTLALI DQSETDWKII AINVNDPEAE KFHDIDDVKK FKPGYLEATL NWFRLYKVPD 

       250        260        270        280        290        300 
GKPENKFAFN GEFKNKAFAL DVINSAHERW KEMVMKKCDK GAISCVNVHI CDSPFHCTME 

       310        320        330 
EARSLVESVP TPSMNKESNV EEEVWHFLRN

« Hide

Isoform 2 [UniParc].

Checksum: 27E5DA9D3A368CC9
Show »

FASTA20423,274

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Embryo and Spinal cord.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: NMRI.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK003660 mRNA. Translation: BAB22922.1.
AK090384 mRNA. Translation: BAC41194.1.
AK143475 mRNA. Translation: BAE25392.1.
BC011417 mRNA. Translation: AAH11417.1.
IPIIPI00127050.
IPI00408727.
RefSeqNP_666253.1. NM_146141.1.
UniGeneMm.210305.

3D structure databases

ProteinModelPortalQ91VM9.
SMRQ91VM9. Positions 29-329.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ91VM9.

PTM databases

PhosphoSiteQ91VM9.

2D gel databases

REPRODUCTION-2DPAGEQ91VM9.

Proteomic databases

PRIDEQ91VM9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029644; ENSMUSP00000029644; ENSMUSG00000028013.
ENSMUST00000125858; ENSMUSP00000117201; ENSMUSG00000028013.
GeneID74776.
KEGGmmu:74776.
UCSCuc008rkm.1. mouse.

Organism-specific databases

CTD27068.
MGIMGI:1922026. Ppa2.

Phylogenomic databases

eggNOGroNOG04947.
GeneTreeENSGT00390000017004.
HOGENOMHBG434750.
HOVERGENHBG000491.
InParanoidQ91VM9.
OMAWFFISGS.
OrthoDBEOG4KPTBC.
PhylomeDBQ91VM9.

Gene expression databases

ArrayExpressQ91VM9.
BgeeQ91VM9.
CleanExMM_PPA2.
GenevestigatorQ91VM9.
GermOnlineENSMUSG00000028013. Mus musculus.

Family and domain databases

InterProIPR008162. Pyrophosphatase.
[Graphical view]
Gene3DG3DSA:3.90.80.10. Pyrophosphatase. 1 hit.
KOK01507.
PANTHERPTHR10286. Pyrophosphatase. 1 hit.
PfamPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMSSF50324. Pyrophosphatase. 1 hit.
PROSITEPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio341614.
SOURCESearch...

Entry information

Entry nameIPYR2_MOUSE
AccessionPrimary (citable) accession number: Q91VM9
Secondary accession number(s): Q3UPK3, Q8BTG5, Q9D1E3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 1, 2001
Last modified: November 16, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents