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Protein

Inorganic pyrophosphatase 2, mitochondrial

Gene

Ppa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi159Magnesium 1By similarity1
Metal bindingi164Magnesium 1By similarity1
Metal bindingi164Magnesium 2By similarity1
Metal bindingi196Magnesium 1By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-379726. Mitochondrial tRNA aminoacylation.
R-MMU-71737. Pyrophosphate hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphatase 2, mitochondrial (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase 2
Short name:
PPase 2
Gene namesi
Name:Ppa2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1922026. Ppa2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionBy similarityAdd BLAST27
ChainiPRO_000002541228 – 330Inorganic pyrophosphatase 2, mitochondrialAdd BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei211N6-succinyllysineCombined sources1
Modified residuei219N6-acetyllysineCombined sources1
Modified residuei254N6-succinyllysineCombined sources1
Modified residuei256N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91VM9.
PaxDbiQ91VM9.
PeptideAtlasiQ91VM9.
PRIDEiQ91VM9.

2D gel databases

REPRODUCTION-2DPAGEQ91VM9.

PTM databases

iPTMnetiQ91VM9.
PhosphoSitePlusiQ91VM9.
SwissPalmiQ91VM9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028013.
CleanExiMM_PPA2.
ExpressionAtlasiQ91VM9. baseline and differential.
GenevisibleiQ91VM9. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi217012. 2 interactors.
IntActiQ91VM9. 3 interactors.
MINTiMINT-1843615.
STRINGi10090.ENSMUSP00000029644.

Structurei

3D structure databases

ProteinModelPortaliQ91VM9.
SMRiQ91VM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1626. Eukaryota.
COG0221. LUCA.
GeneTreeiENSGT00390000017004.
HOGENOMiHOG000195569.
HOVERGENiHBG000491.
InParanoidiQ91VM9.
KOiK01507.
OMAiEIAKDEY.
OrthoDBiEOG091G0KFV.
PhylomeDBiQ91VM9.
TreeFamiTF300887.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91VM9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRALLPLLSV GRGWRVGAAA RPPRRVMSLY RTEELGHPRS QDYRLFFKHV
60 70 80 90 100
AGHYISPFHD IPLKADCKEE HDIPRKKARN DEYENLFNMV VEIPRWTNAK
110 120 130 140 150
MEIATEEPLN PIKQDIKNGK LRYTPNIFPH KGYIWNYGAL PQTWEDPHLR
160 170 180 190 200
DKSTDCCGDN DPIDVCEIGS KVLSRGDVVH VKILGTLALI DQSETDWKII
210 220 230 240 250
AINVNDPEAE KFHDIDDVKK FKPGYLEATL NWFRLYKVPD GKPENKFAFN
260 270 280 290 300
GEFKNKAFAL DVINSAHERW KEMVMKKCDK GAISCVNVHI CDSPFHCTME
310 320 330
EARSLVESVP TPSMNKESNV EEEVWHFLRN
Length:330
Mass (Da):38,115
Last modified:December 1, 2001 - v1
Checksum:i8AFD61FA561D7268
GO
Isoform 2 (identifier: Q91VM9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.
     127-170: IFPHKGYIWN...DPIDVCEIGS → MLDADAPQNC...FQAIETLSQM

Note: No experimental confirmation available.
Show »
Length:204
Mass (Da):23,274
Checksum:i27E5DA9D3A368CC9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti225 – 227YLE → HLQ in BAC41194 (PubMed:16141072).Curated3
Sequence conflicti254K → T in BAC41194 (PubMed:16141072).Curated1
Sequence conflicti321Missing in BAC41194 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0116531 – 126Missing in isoform 2. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_011654127 – 170IFPHK…CEIGS → MLDADAPQNCQSWEGKDKQI PGPHRPNSQACLVKFQAIET LSQM in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003660 mRNA. Translation: BAB22922.1.
AK090384 mRNA. Translation: BAC41194.1.
AK143475 mRNA. Translation: BAE25392.1.
BC011417 mRNA. Translation: AAH11417.1.
CCDSiCCDS17850.1. [Q91VM9-1]
RefSeqiNP_001280570.1. NM_001293641.1.
NP_666253.1. NM_146141.2. [Q91VM9-1]
UniGeneiMm.210305.

Genome annotation databases

EnsembliENSMUST00000029644; ENSMUSP00000029644; ENSMUSG00000028013. [Q91VM9-1]
GeneIDi74776.
KEGGimmu:74776.
UCSCiuc008rkm.2. mouse. [Q91VM9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003660 mRNA. Translation: BAB22922.1.
AK090384 mRNA. Translation: BAC41194.1.
AK143475 mRNA. Translation: BAE25392.1.
BC011417 mRNA. Translation: AAH11417.1.
CCDSiCCDS17850.1. [Q91VM9-1]
RefSeqiNP_001280570.1. NM_001293641.1.
NP_666253.1. NM_146141.2. [Q91VM9-1]
UniGeneiMm.210305.

3D structure databases

ProteinModelPortaliQ91VM9.
SMRiQ91VM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217012. 2 interactors.
IntActiQ91VM9. 3 interactors.
MINTiMINT-1843615.
STRINGi10090.ENSMUSP00000029644.

PTM databases

iPTMnetiQ91VM9.
PhosphoSitePlusiQ91VM9.
SwissPalmiQ91VM9.

2D gel databases

REPRODUCTION-2DPAGEQ91VM9.

Proteomic databases

EPDiQ91VM9.
PaxDbiQ91VM9.
PeptideAtlasiQ91VM9.
PRIDEiQ91VM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029644; ENSMUSP00000029644; ENSMUSG00000028013. [Q91VM9-1]
GeneIDi74776.
KEGGimmu:74776.
UCSCiuc008rkm.2. mouse. [Q91VM9-1]

Organism-specific databases

CTDi27068.
MGIiMGI:1922026. Ppa2.

Phylogenomic databases

eggNOGiKOG1626. Eukaryota.
COG0221. LUCA.
GeneTreeiENSGT00390000017004.
HOGENOMiHOG000195569.
HOVERGENiHBG000491.
InParanoidiQ91VM9.
KOiK01507.
OMAiEIAKDEY.
OrthoDBiEOG091G0KFV.
PhylomeDBiQ91VM9.
TreeFamiTF300887.

Enzyme and pathway databases

ReactomeiR-MMU-379726. Mitochondrial tRNA aminoacylation.
R-MMU-71737. Pyrophosphate hydrolysis.

Miscellaneous databases

ChiTaRSiPpa2. mouse.
PROiQ91VM9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028013.
CleanExiMM_PPA2.
ExpressionAtlasiQ91VM9. baseline and differential.
GenevisibleiQ91VM9. MM.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPYR2_MOUSE
AccessioniPrimary (citable) accession number: Q91VM9
Secondary accession number(s): Q3UPK3, Q8BTG5, Q9D1E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.