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Q91VL8

- TE2IP_MOUSE

UniProt

Q91VL8 - TE2IP_MOUSE

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Protein

Telomeric repeat-binding factor 2-interacting protein 1

Gene

Terf2ip

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.3 Publications

GO - Molecular functioni

  1. DNA binding Source: InterPro

GO - Biological processi

  1. negative regulation of DNA recombination at telomere Source: UniProtKB
  2. negative regulation of telomere maintenance Source: Ensembl
  3. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  4. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  5. protein localization to chromosome, telomeric region Source: Ensembl
  6. regulation of double-strand break repair via homologous recombination Source: UniProtKB
  7. regulation of transcription, DNA-templated Source: UniProtKB
  8. telomere maintenance via telomere lengthening Source: UniProtKB
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_188819. DNA Damage/Telomere Stress Induced Senescence.
REACT_198626. Meiotic synapsis.
REACT_226125. Packaging Of Telomere Ends.
REACT_75800. Meiotic Synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
Telomeric repeat-binding factor 2-interacting protein 1
Short name:
TERF2-interacting telomeric protein 1
Short name:
TRF2-interacting telomeric protein 1
Alternative name(s):
Repressor/activator protein 1 homolog
Short name:
RAP1 homolog
Gene namesi
Name:Terf2ip
Synonyms:Rap1
ORF Names:MNCb-0448, MNCb-0628
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1929871. Terf2ip.

Subcellular locationi

Nucleus. Cytoplasm. Chromosome. Chromosometelomere
Note: Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex.

GO - Cellular componenti

  1. chromosome, telomeric region Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. Mre11 complex Source: Ensembl
  4. nuclear chromosome, telomeric region Source: MGI
  5. nuclear telomere cap complex Source: Ensembl
  6. nucleoplasm Source: Reactome
  7. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus, Telomere

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile. No major telomere dysfunction such as telomere fusions are observed. An increased telomere fragility and recombination due to defects in HDR are however present. Mice with conditional deletion in stratified epithelia display shorter telomeres and developed skin hyperpigmentation in adulthood.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 393392Telomeric repeat-binding factor 2-interacting protein 1PRO_0000197127Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei36 – 361PhosphoserineBy similarity
Modified residuei151 – 1511PhosphoserineBy similarity
Modified residuei153 – 1531PhosphoserineBy similarity
Modified residuei200 – 2001PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ91VL8.
PaxDbiQ91VL8.
PRIDEiQ91VL8.

PTM databases

PhosphoSiteiQ91VL8.

Expressioni

Gene expression databases

BgeeiQ91VL8.
GenevestigatoriQ91VL8.

Interactioni

Subunit structurei

Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Binds to TERF2 (but not TERF1) with its C-terminus. Interacts with SLX4/BTBD12 (By similarity). Interacts with TERF2; the interaction is direct. Does not interact with TERF1. Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG.By similarity2 Publications

Protein-protein interaction databases

IntActiQ91VL8. 2 interactions.
MINTiMINT-4137361.

Structurei

3D structure databases

ProteinModelPortaliQ91VL8.
SMRiQ91VL8. Positions 129-187, 300-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 10124BRCTAdd
BLAST
Domaini125 – 18561Myb-likeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi377 – 39317Nuclear localization signalSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi232 – 29766Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the RAP1 family.Curated
Contains 1 BRCT domain.Curated
Contains 1 Myb-like domain.Curated

Phylogenomic databases

eggNOGiNOG39788.
GeneTreeiENSGT00390000005351.
HOGENOMiHOG000120115.
HOVERGENiHBG054209.
InParanoidiQ91VL8.
KOiK11113.
OMAiSISFYVR.
OrthoDBiEOG7KDFBG.
PhylomeDBiQ91VL8.
TreeFamiTF332348.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR021661. Rap1_C.
IPR015010. Rap1_Myb_dom.
[Graphical view]
PfamiPF08914. Myb_DNA-bind_2. 1 hit.
PF11626. Rap1_C. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VL8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEAMDLGKD PNGPTHSSTL FVREDGSAMS FYVRPSSAKR RLSTLILHGG
60 70 80 90 100
GTVCRVQEPG AVLLAQPGEA LAEASGDFIS TQYILDCVDR NEKLDLEAYR
110 120 130 140 150
LGLTEQASDP KPGASTEGST EPEPQPLTGR IAYTDAEDVA ILTYVKENAR
160 170 180 190 200
SPSSVTGNAL WKAMEKSSLT QHSWQSLKDR YLKHLRGQEH KYLLGNAPVS
210 220 230 240 250
PSSQKLKRKA EQDPEAADSG EPQNKRAPDL PEEECVKGEI KENGEADNKL
260 270 280 290 300
FEEAAPEFGE AVVDESPDFE IHITMCDGDP PTPEEDSETQ PDEEEEEPKV
310 320 330 340 350
STQEVGTAIK VIRQLMEKFN LDLSTVTQAL LKNSGELEAT SSFLESGRRP
360 370 380 390
DGYPIWCRQD DLDLQKDDDD TKNALVKKFG AQNVARRIEF RKK
Length:393
Mass (Da):43,353
Last modified:December 1, 2001 - v1
Checksum:i7A15CFD83733BE2D
GO

Sequence cautioni

The sequence BAA95043.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti281 – 2866PTPEED → HTHTQS in BAA95042. 1 PublicationCurated
Sequence conflicti281 – 2866PTPEED → HTHTQS in BAA95043. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041613 mRNA. Translation: BAC31005.1.
AK051818 mRNA. Translation: BAC34781.1.
AK081557 mRNA. Translation: BAC38258.1.
AK087729 mRNA. Translation: BAC39985.1.
AK084563 mRNA. Translation: BAC39217.1.
AK148508 mRNA. Translation: BAE28592.1.
AK148537 mRNA. Translation: BAE28607.1.
AK161452 mRNA. Translation: BAE36404.1.
AK165074 mRNA. Translation: BAE38026.1.
AC114648 Genomic DNA. No translation available.
BC012270 mRNA. Translation: AAH12270.1.
BC017641 mRNA. Translation: AAH17641.1.
AB041557 mRNA. Translation: BAA95042.1.
AB041559 mRNA. Translation: BAA95043.1. Different initiation.
CCDSiCCDS52678.1.
RefSeqiNP_065609.2. NM_020584.2.
UniGeneiMm.213064.

Genome annotation databases

EnsembliENSMUST00000052138; ENSMUSP00000052170; ENSMUSG00000033430.
GeneIDi57321.
KEGGimmu:57321.
UCSCiuc012gla.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041613 mRNA. Translation: BAC31005.1 .
AK051818 mRNA. Translation: BAC34781.1 .
AK081557 mRNA. Translation: BAC38258.1 .
AK087729 mRNA. Translation: BAC39985.1 .
AK084563 mRNA. Translation: BAC39217.1 .
AK148508 mRNA. Translation: BAE28592.1 .
AK148537 mRNA. Translation: BAE28607.1 .
AK161452 mRNA. Translation: BAE36404.1 .
AK165074 mRNA. Translation: BAE38026.1 .
AC114648 Genomic DNA. No translation available.
BC012270 mRNA. Translation: AAH12270.1 .
BC017641 mRNA. Translation: AAH17641.1 .
AB041557 mRNA. Translation: BAA95042.1 .
AB041559 mRNA. Translation: BAA95043.1 . Different initiation.
CCDSi CCDS52678.1.
RefSeqi NP_065609.2. NM_020584.2.
UniGenei Mm.213064.

3D structure databases

ProteinModelPortali Q91VL8.
SMRi Q91VL8. Positions 129-187, 300-392.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q91VL8. 2 interactions.
MINTi MINT-4137361.

PTM databases

PhosphoSitei Q91VL8.

Proteomic databases

MaxQBi Q91VL8.
PaxDbi Q91VL8.
PRIDEi Q91VL8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052138 ; ENSMUSP00000052170 ; ENSMUSG00000033430 .
GeneIDi 57321.
KEGGi mmu:57321.
UCSCi uc012gla.1. mouse.

Organism-specific databases

CTDi 54386.
MGIi MGI:1929871. Terf2ip.

Phylogenomic databases

eggNOGi NOG39788.
GeneTreei ENSGT00390000005351.
HOGENOMi HOG000120115.
HOVERGENi HBG054209.
InParanoidi Q91VL8.
KOi K11113.
OMAi SISFYVR.
OrthoDBi EOG7KDFBG.
PhylomeDBi Q91VL8.
TreeFami TF332348.

Enzyme and pathway databases

Reactomei REACT_188819. DNA Damage/Telomere Stress Induced Senescence.
REACT_198626. Meiotic synapsis.
REACT_226125. Packaging Of Telomere Ends.
REACT_75800. Meiotic Synapsis.

Miscellaneous databases

ChiTaRSi Terf2ip. mouse.
NextBioi 313686.
PROi Q91VL8.
SOURCEi Search...

Gene expression databases

Bgeei Q91VL8.
Genevestigatori Q91VL8.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR009057. Homeodomain-like.
IPR021661. Rap1_C.
IPR015010. Rap1_Myb_dom.
[Graphical view ]
Pfami PF08914. Myb_DNA-bind_2. 1 hit.
PF11626. Rap1_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye, Head, Heart, Ovary, Oviduct, Pancreas, Testis and Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  4. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-286.
    Strain: C57BL/6.
    Tissue: Brain.
  5. "The telomeric protein Rap1 is conserved in vertebrates and is expressed from a bidirectional promoter positioned between the Rap1 and KARS genes."
    Tan M., Wei C., Price C.M.
    Gene 323:1-10(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: BIDIRECTIONAL PROMOTER WITH KARS.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. "Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites."
    Martinez P., Thanasoula M., Carlos A.R., Gomez-Lopez G., Tejera A.M., Schoeftner S., Dominguez O., Pisano D.G., Tarsounas M., Blasco M.A.
    Nat. Cell Biol. 12:768-780(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  9. Cited for: FUNCTION IN NF-KAPPA-B PATHWAY, SUBCELLULAR LOCATION, INTERACTION WITH TERF2; CHUK; IKBKB AND IKBKG.
  10. "Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal."
    Sfeir A., Kabir S., van Overbeek M., Celli G.B., de Lange T.
    Science 327:1657-1661(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, INTERACTION WITH TERF2.

Entry informationi

Entry nameiTE2IP_MOUSE
AccessioniPrimary (citable) accession number: Q91VL8
Secondary accession number(s): D3YWE8
, Q543F4, Q8C2Y1, Q9JJE8, Q9JJE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Shares a bidirectional promoter with KARS (PubMed:14659874). This shared promoter with an essential gene complicated the task when generating knockout mice; the problem was overcome by generating conditional knockout strategies (PubMed:20339076 and PubMed:20622869;).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3