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Protein

Integral membrane protein 2C

Gene

Itm2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.1 Publication

GO - Molecular functioni

  • amyloid-beta binding Source: MGI
  • ATP binding Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein 2C
Alternative name(s):
Transmembrane protein BRI3
Cleaved into the following chain:
Gene namesi
Name:Itm2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1927594 Itm2c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei57 – 77Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001548271 – 269Integral membrane protein 2CAdd BLAST269
PeptideiPRO_0000232646244 – 269CT-BRI3Add BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39PhosphothreonineBy similarity1
Disulfide bondi165 ↔ 224By similarity
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembanaire cleavage by SPPL2B (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei243 – 244Cleavage; by furinBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ91VK4
MaxQBiQ91VK4
PaxDbiQ91VK4
PeptideAtlasiQ91VK4
PRIDEiQ91VK4

PTM databases

iPTMnetiQ91VK4
PhosphoSitePlusiQ91VK4
SwissPalmiQ91VK4

Expressioni

Gene expression databases

BgeeiENSMUSG00000026223
CleanExiMM_ITM2C
ExpressionAtlasiQ91VK4 baseline and differential
GenevisibleiQ91VK4 MM

Interactioni

Subunit structurei

Interacts with BACE1. Interacts with APP. Interacts with STMN2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi2110561 interactor.
STRINGi10090.ENSMUSP00000027425

Structurei

3D structure databases

ProteinModelPortaliQ91VK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 232BRICHOSPROSITE-ProRule annotationAdd BLAST95

Sequence similaritiesi

Belongs to the ITM2 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4681 Eukaryota
ENOG410XRNN LUCA
GeneTreeiENSGT00390000005162
HOGENOMiHOG000231259
HOVERGENiHBG059373
InParanoidiQ91VK4
KOiK18265
OMAiKKGTYLP
OrthoDBiEOG091G0E78
PhylomeDBiQ91VK4
TreeFamiTF317770

Family and domain databases

InterProiView protein in InterPro
IPR007084 BRICHOS_dom
PfamiView protein in Pfam
PF04089 BRICHOS, 1 hit
SMARTiView protein in SMART
SM01039 BRICHOS, 1 hit
PROSITEiView protein in PROSITE
PS50869 BRICHOS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKISFQPAV AGIKADKADK AAASGPASAS APAAEILLTP AREERPPRHR
60 70 80 90 100
SRKGGSVGGV CYLSMGMVVL LMGLVFASVY IYRYFFLAQL ARDNFFHCGV
110 120 130 140 150
LYEDSLSSQI RTRLELEEDV KIYLEENYER INVPVPQFGG GDPADIIHDF
160 170 180 190 200
QRGLTAYHDI SLDKCYVIEL NTTIVLPPRN FWELLMNVKR GTYLPQTYII
210 220 230 240 250
QEEMVVTEHV RDKEALGSFI YHLCNGKDTY RLRRRSTRRR INKRGGKNCN
260
AIRHFENTFV VETLICGVV
Length:269
Mass (Da):30,482
Last modified:April 26, 2005 - v2
Checksum:iB949E6E05EA65502
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12Missing in BAA92762 (PubMed:10679242).Curated1
Sequence conflicti246G → A in AAH12952 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030199 mRNA Translation: BAA92762.1
AF272044 mRNA Translation: AAF89493.1
AF282981 mRNA Translation: AAK00277.1
AK036377 mRNA Translation: BAC29403.1
BC012952 mRNA Translation: AAH12952.1
CCDSiCCDS35641.1
RefSeqiNP_071862.2, NM_022417.3
UniGeneiMm.29870

Genome annotation databases

EnsembliENSMUST00000027425; ENSMUSP00000027425; ENSMUSG00000026223
GeneIDi64294
KEGGimmu:64294
UCSCiuc011wof.1 mouse

Similar proteinsi

Entry informationi

Entry nameiITM2C_MOUSE
AccessioniPrimary (citable) accession number: Q91VK4
Secondary accession number(s): Q9JI06, Q9JME8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: February 28, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome