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Protein

Integral membrane protein 2C

Gene

Itm2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.1 Publication

GO - Molecular functioni

  • ATP binding Source: MGI
  • beta-amyloid binding Source: MGI

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein 2C
Alternative name(s):
Transmembrane protein BRI3
Cleaved into the following chain:
Gene namesi
Name:Itm2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1927594. Itm2c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei57 – 77Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001548271 – 269Integral membrane protein 2CAdd BLAST269
PeptideiPRO_0000232646244 – 269CT-BRI3Add BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39PhosphothreonineBy similarity1
Disulfide bondi165 ↔ 224By similarity
Glycosylationi171N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembanaire cleavage by SPPL2B (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei243 – 244Cleavage; by furinBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ91VK4.
MaxQBiQ91VK4.
PaxDbiQ91VK4.
PeptideAtlasiQ91VK4.
PRIDEiQ91VK4.

PTM databases

iPTMnetiQ91VK4.
PhosphoSitePlusiQ91VK4.
SwissPalmiQ91VK4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026223.
CleanExiMM_ITM2C.
ExpressionAtlasiQ91VK4. baseline and differential.
GenevisibleiQ91VK4. MM.

Interactioni

Subunit structurei

Interacts with BACE1. Interacts with APP. Interacts with STMN2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027425.

Structurei

3D structure databases

ProteinModelPortaliQ91VK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 232BRICHOSPROSITE-ProRule annotationAdd BLAST95

Sequence similaritiesi

Belongs to the ITM2 family.Curated
Contains 1 BRICHOS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4681. Eukaryota.
ENOG410XRNN. LUCA.
GeneTreeiENSGT00390000005162.
HOGENOMiHOG000231259.
HOVERGENiHBG059373.
InParanoidiQ91VK4.
KOiK18265.
OMAiNPRMLIE.
OrthoDBiEOG091G0E78.
PhylomeDBiQ91VK4.
TreeFamiTF317770.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKISFQPAV AGIKADKADK AAASGPASAS APAAEILLTP AREERPPRHR
60 70 80 90 100
SRKGGSVGGV CYLSMGMVVL LMGLVFASVY IYRYFFLAQL ARDNFFHCGV
110 120 130 140 150
LYEDSLSSQI RTRLELEEDV KIYLEENYER INVPVPQFGG GDPADIIHDF
160 170 180 190 200
QRGLTAYHDI SLDKCYVIEL NTTIVLPPRN FWELLMNVKR GTYLPQTYII
210 220 230 240 250
QEEMVVTEHV RDKEALGSFI YHLCNGKDTY RLRRRSTRRR INKRGGKNCN
260
AIRHFENTFV VETLICGVV
Length:269
Mass (Da):30,482
Last modified:April 26, 2005 - v2
Checksum:iB949E6E05EA65502
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12Missing in BAA92762 (PubMed:10679242).Curated1
Sequence conflicti246G → A in AAH12952 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030199 mRNA. Translation: BAA92762.1.
AF272044 mRNA. Translation: AAF89493.1.
AF282981 mRNA. Translation: AAK00277.1.
AK036377 mRNA. Translation: BAC29403.1.
BC012952 mRNA. Translation: AAH12952.1.
CCDSiCCDS35641.1.
RefSeqiNP_071862.2. NM_022417.3.
UniGeneiMm.29870.

Genome annotation databases

EnsembliENSMUST00000027425; ENSMUSP00000027425; ENSMUSG00000026223.
GeneIDi64294.
KEGGimmu:64294.
UCSCiuc011wof.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030199 mRNA. Translation: BAA92762.1.
AF272044 mRNA. Translation: AAF89493.1.
AF282981 mRNA. Translation: AAK00277.1.
AK036377 mRNA. Translation: BAC29403.1.
BC012952 mRNA. Translation: AAH12952.1.
CCDSiCCDS35641.1.
RefSeqiNP_071862.2. NM_022417.3.
UniGeneiMm.29870.

3D structure databases

ProteinModelPortaliQ91VK4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027425.

PTM databases

iPTMnetiQ91VK4.
PhosphoSitePlusiQ91VK4.
SwissPalmiQ91VK4.

Proteomic databases

EPDiQ91VK4.
MaxQBiQ91VK4.
PaxDbiQ91VK4.
PeptideAtlasiQ91VK4.
PRIDEiQ91VK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027425; ENSMUSP00000027425; ENSMUSG00000026223.
GeneIDi64294.
KEGGimmu:64294.
UCSCiuc011wof.1. mouse.

Organism-specific databases

CTDi81618.
MGIiMGI:1927594. Itm2c.

Phylogenomic databases

eggNOGiKOG4681. Eukaryota.
ENOG410XRNN. LUCA.
GeneTreeiENSGT00390000005162.
HOGENOMiHOG000231259.
HOVERGENiHBG059373.
InParanoidiQ91VK4.
KOiK18265.
OMAiNPRMLIE.
OrthoDBiEOG091G0E78.
PhylomeDBiQ91VK4.
TreeFamiTF317770.

Miscellaneous databases

ChiTaRSiItm2c. mouse.
PROiQ91VK4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026223.
CleanExiMM_ITM2C.
ExpressionAtlasiQ91VK4. baseline and differential.
GenevisibleiQ91VK4. MM.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITM2C_MOUSE
AccessioniPrimary (citable) accession number: Q91VK4
Secondary accession number(s): Q9JI06, Q9JME8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 2, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.