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Protein

Basic leucine zipper and W2 domain-containing protein 2

Gene

Bzw2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in neuronal differentiation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper and W2 domain-containing protein 2
Gene namesi
Name:Bzw2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1914162. Bzw2.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002546201 – 419Basic leucine zipper and W2 domain-containing protein 2Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117N6-acetyllysineBy similarity1
Modified residuei412PhosphoserineCombined sources1
Modified residuei414PhosphoserineBy similarity1
Modified residuei419PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ91VK1.
MaxQBiQ91VK1.
PaxDbiQ91VK1.
PeptideAtlasiQ91VK1.
PRIDEiQ91VK1.

PTM databases

iPTMnetiQ91VK1.
PhosphoSitePlusiQ91VK1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020547.
GenevisibleiQ91VK1. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211804. 1 interactor.
IntActiQ91VK1. 1 interactor.
STRINGi10090.ENSMUSP00000020856.

Structurei

3D structure databases

ProteinModelPortaliQ91VK1.
SMRiQ91VK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini248 – 415W2PROSITE-ProRule annotationAdd BLAST168

Sequence similaritiesi

Belongs to the BZW family.Curated

Phylogenomic databases

eggNOGiKOG2297. Eukaryota.
ENOG410XR08. LUCA.
GeneTreeiENSGT00390000012561.
HOGENOMiHOG000252932.
HOVERGENiHBG080940.
InParanoidiQ91VK1.
OMAiFMNKHQK.
OrthoDBiEOG091G090E.
PhylomeDBiQ91VK1.
TreeFamiTF324313.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiView protein in InterPro
IPR016024. ARM-type_fold.
IPR016021. MIF4-like.
IPR003307. W2_domain.
PfamiView protein in Pfam
PF02020. W2. 1 hit.
SMARTiView protein in SMART
SM00515. eIF5C. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiView protein in PROSITE
PS51363. W2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91VK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKHQKPVLT GQRFKTRKRD EKEKFEPTVF RDTLVQGLNE AGDDLEAVAK
60 70 80 90 100
FLDSTGSRLD YRRYADTLFD ILVAGSMLAP GGTRIDDGDK TKMTNHCVFS
110 120 130 140 150
ANEDHETIRN YAQVFNKLIR RYKYLEKAFE DEMKKLLLFL KAFSEAEQTK
160 170 180 190 200
LAMLSGILLG NGTLPATILT SLFTDSLVKE GIAASFAVKL FKAWMAEKDA
210 220 230 240 250
NSVTSSLRKA NLDKRLLELF PVNRQSVDHF AKYFTDAGLK ELSDFLRVQQ
260 270 280 290 300
SLGTRKELQK ELQERLSQEC PIKEVVLYVK EEMKRNDLPE TAVIGLLWTC
310 320 330 340 350
IMNAVEWNKK EELVAEQALK HLKQYAPLLA VFSSQGQSEL VLLQKVQEYC
360 370 380 390 400
YDNIHFMKAF QKIVVLFYKA DVLSEEAILK WYKEAHAAKG KSVFLDQMKK
410
FVEWLQNAEE ESESEGEES
Length:419
Mass (Da):48,063
Last modified:December 1, 2001 - v1
Checksum:i996FC462B50EAF6F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69F → L in BAB27495 (PubMed:16141072).Curated1
Sequence conflicti326A → R in BAB27495 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011253 mRNA. Translation: BAB27495.1.
AK160544 mRNA. Translation: BAE35861.1.
BC013060 mRNA. Translation: AAH13060.1.
CCDSiCCDS25884.1.
RefSeqiNP_080116.2. NM_025840.3.
UniGeneiMm.288669.

Genome annotation databases

EnsembliENSMUST00000020856; ENSMUSP00000020856; ENSMUSG00000020547.
GeneIDi66912.
KEGGimmu:66912.
UCSCiuc007njp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011253 mRNA. Translation: BAB27495.1.
AK160544 mRNA. Translation: BAE35861.1.
BC013060 mRNA. Translation: AAH13060.1.
CCDSiCCDS25884.1.
RefSeqiNP_080116.2. NM_025840.3.
UniGeneiMm.288669.

3D structure databases

ProteinModelPortaliQ91VK1.
SMRiQ91VK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211804. 1 interactor.
IntActiQ91VK1. 1 interactor.
STRINGi10090.ENSMUSP00000020856.

PTM databases

iPTMnetiQ91VK1.
PhosphoSitePlusiQ91VK1.

Proteomic databases

EPDiQ91VK1.
MaxQBiQ91VK1.
PaxDbiQ91VK1.
PeptideAtlasiQ91VK1.
PRIDEiQ91VK1.

Protocols and materials databases

DNASUi66912.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020856; ENSMUSP00000020856; ENSMUSG00000020547.
GeneIDi66912.
KEGGimmu:66912.
UCSCiuc007njp.2. mouse.

Organism-specific databases

CTDi28969.
MGIiMGI:1914162. Bzw2.

Phylogenomic databases

eggNOGiKOG2297. Eukaryota.
ENOG410XR08. LUCA.
GeneTreeiENSGT00390000012561.
HOGENOMiHOG000252932.
HOVERGENiHBG080940.
InParanoidiQ91VK1.
OMAiFMNKHQK.
OrthoDBiEOG091G090E.
PhylomeDBiQ91VK1.
TreeFamiTF324313.

Miscellaneous databases

ChiTaRSiBzw2. mouse.
PROiQ91VK1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020547.
GenevisibleiQ91VK1. MM.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiView protein in InterPro
IPR016024. ARM-type_fold.
IPR016021. MIF4-like.
IPR003307. W2_domain.
PfamiView protein in Pfam
PF02020. W2. 1 hit.
SMARTiView protein in SMART
SM00515. eIF5C. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiView protein in PROSITE
PS51363. W2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBZW2_MOUSE
AccessioniPrimary (citable) accession number: Q91VK1
Secondary accession number(s): Q9D0N4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: March 15, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.