Reviewed, UniProtKB/Swiss-Prot Q91VK1 (BZW2_MOUSE)

Names and origin

Protein names

Recommended name:
    Basic leucine zipper and W2 domain-containing protein 2

Gene names

Name:

Bzw2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in neuronal differentiation By similarity.
Sequence similarities	Belongs to the BZW family. Contains 1 W2 domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Molecular function	Developmental protein
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Ikbkb	O88351	2	EBI-646202,EBI-447960

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	Basic leucine zipper and W2 domain-containing protein 2		PRO_0000254620
Regions
	Domain	248 – 415	168	W2
Amino acid modifications
	Modified residue	117	1	N6-acetyllysine By similarity
	Modified residue	412	1	Phosphoserine Ref.3
	Modified residue	414	1	Phosphoserine Ref.3
Experimental info
	Sequence conflict	69	1	F → L in BAB27495. Ref.1
	Sequence conflict	326	1	A → R in BAB27495. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q91VK1-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 996FC462B50EAF6F	FASTA	419	48,063
	10 20 30 40 50 60 MNKHQKPVLT GQRFKTRKRD EKEKFEPTVF RDTLVQGLNE AGDDLEAVAK FLDSTGSRLD 70 80 90 100 110 120 YRRYADTLFD ILVAGSMLAP GGTRIDDGDK TKMTNHCVFS ANEDHETIRN YAQVFNKLIR 130 140 150 160 170 180 RYKYLEKAFE DEMKKLLLFL KAFSEAEQTK LAMLSGILLG NGTLPATILT SLFTDSLVKE 190 200 210 220 230 240 GIAASFAVKL FKAWMAEKDA NSVTSSLRKA NLDKRLLELF PVNRQSVDHF AKYFTDAGLK 250 260 270 280 290 300 ELSDFLRVQQ SLGTRKELQK ELQERLSQEC PIKEVVLYVK EEMKRNDLPE TAVIGLLWTC 310 320 330 340 350 360 IMNAVEWNKK EELVAEQALK HLKQYAPLLA VFSSQGQSEL VLLQKVQEYC YDNIHFMKAF 370 380 390 400 410 QKIVVLFYKA DVLSEEAILK WYKEAHAAKG KSVFLDQMKK FVEWLQNAEE ESESEGEES

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Embryo.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
[3]	"Phosphoproteomic analysis of the developing mouse brain." Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P. Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed: 15345747] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412 AND SER-414, MASS SPECTROMETRY. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK011253 mRNA. Translation: BAB27495.1. AK160544 mRNA. Translation: BAE35861.1. BC013060 mRNA. Translation: AAH13060.1.
IPI	IPI00387337.
RefSeq	NP_080116.2.
UniGene	Mm.288669
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q91VK1. 1 interaction.
STRING	Q91VK1.
PTM databases
PhosphoSite	Q91VK1.
Proteomic databases
PRIDE	Q91VK1.
Genome annotation databases
Ensembl	ENSMUST00000020856; ENSMUSP00000020856; ENSMUSG00000020547; Mus musculus. [Genome view]
GeneID	66912.
KEGG	mmu:66912.
UCSC	uc007njp.1. mouse.
Organism-specific databases
CTD	66912.
MGI	MGI:1914162. Bzw2.
Phylogenomic databases
HOVERGEN	Q91VK1.
OMA	ECPIKEM
OrthoDB	EOG973S9J
Gene expression databases
ArrayExpress	Q91VK1.
Bgee	Q91VK1.
Genevestigator	Q91VK1.
GermOnline	ENSMUSG00000020547. Mus musculus.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. IPR003307. eIF5C. [Graphical view]
Gene3D	G3DSA:1.25.40.230. eIF5C. 1 hit.
Pfam	PF02020. W2. 1 hit. [Graphical view]
SMART	SM00515. eIF5C. 1 hit. [Graphical view]
PROSITE	PS51363. W2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	322995.
SOURCE	Search...

Entry information

Entry name

BZW2_MOUSE

Accession

Primary (citable) accession number: Q91VK1
Secondary accession number(s): Q9D0N4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	December 1, 2001
Last modified:	November 24, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)