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Q91VJ5 (PQBP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polyglutamine-binding protein 1

Short name=PQBP-1
Alternative name(s):
38 kDa nuclear protein containing a WW domain
Short name=Npw38
Polyglutamine tract-binding protein 1
Gene names
Name:Pqbp1
Synonyms:Npw38
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery By similarity.

Subunit structure

Interacts with POU3F2/Brn-2, TXNL4A, HTT and AR By similarity.

Subcellular location

Nucleus. Note: Colocalized with POU3F2 By similarity.

Tissue specificity

Expressed in brain with high level in cerebellar cortex, hippocampus and olfactory bulb. Ref.4

Domain

The WW domain may play a role as a transcriptional activator. The WW domain mediates interaction with C-terminal domain of RNA polymerase II large subunit By similarity.

Sequence similarities

Contains 1 WW domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 263262Polyglutamine-binding protein 1
PRO_0000076090

Regions

Domain46 – 8035WW
Repeat104 – 11071-1; approximate
Repeat111 – 11771-2
Repeat118 – 12471-3; approximate
Repeat125 – 13171-4; approximate
Repeat132 – 13871-5; approximate
Repeat139 – 14022-1
Repeat141 – 14222-2
Repeat143 – 14422-3
Repeat150 – 15123-1
Repeat152 – 15323-2
Repeat154 – 15523-3
Repeat156 – 15723-4
Repeat158 – 15923-5
Repeat160 – 16123-6
Region104 – 138355 X 7 AA approximate tandem repeats of D-R-[NS]-H-E-K-S
Region139 – 14463 X 2 AA tandem repeats of [DE]-R
Region150 – 161126 X 2 AA tandem repeats of [DE]-R
Coiled coil85 – 11228 Potential

Amino acid modifications

Modified residue2451Phosphoserine By similarity

Experimental info

Sequence conflict151G → S in AAH51673. Ref.3
Sequence conflict1771H → L in CAB59205. Ref.1
Sequence conflict1771H → L in CAC15062. Ref.1
Sequence conflict1831A → V in CAB59205. Ref.1
Sequence conflict1831A → V in CAC15062. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q91VJ5 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: F62304963D34D22B

FASTA26330,597
        10         20         30         40         50         60 
MPLPVALQTR LAKRGILKHL EPEPEEEIIA EDYDDDPVDY EATRIEGLPP SWYKVFDPSC 

        70         80         90        100        110        120 
GLPYYWNVET DLVSWLSPHD PNFVVTKSAK KVRNNNADAE DKSDRNLEKV DRNHEKSDRS 

       130        140        150        160        170        180 
HEKPDRSHEK ADRNHEKNDR ERERNYDKVD RERDRDRERE RAFDKADREE GKDRRHHRRE 

       190        200        210        220        230        240 
ELAPYPKNKK ATSRKDEELD PMDPSSYSDA PRGTWSTGLP KRNEAKTGAD TTAAGPLFQQ 

       250        260 
RPYPSPGAVL RANAEASRTK QQD 

« Hide

References

« Hide 'large scale' references
[1]Okazawa H.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-263.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and FVB/N.
Tissue: Mammary tumor.
[4]"PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival."
Waragai M., Lammers C.-H., Takeuchi S., Imafuku I., Udagawa Y., Kanazawa I., Kawabata M., Mouradian M.M., Okazawa H.
Hum. Mol. Genet. 8:977-987(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ250406 mRNA. Translation: CAB59205.1.
AJ296289 Genomic DNA. Translation: CAC15062.1.
AK077652 mRNA. Translation: BAC36928.1.
BC009657 mRNA. Translation: AAH09657.1.
BC051673 mRNA. Translation: AAH51673.1.
CCDSCCDS29977.1.
RefSeqNP_001239457.1. NM_001252528.1.
NP_001239458.1. NM_001252529.1.
NP_062351.2. NM_019478.4.
XP_006527717.1. XM_006527654.1.
UniGeneMm.14616.

3D structure databases

ProteinModelPortalQ91VJ5.
SMRQ91VJ5. Positions 45-79.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ91VJ5.

Proteomic databases

PaxDbQ91VJ5.
PRIDEQ91VJ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033497; ENSMUSP00000033497; ENSMUSG00000031157.
ENSMUST00000115654; ENSMUSP00000111318; ENSMUSG00000031157.
ENSMUST00000115655; ENSMUSP00000111319; ENSMUSG00000031157.
GeneID54633.
KEGGmmu:54633.
UCSCuc009snd.2. mouse.

Organism-specific databases

CTD10084.
MGIMGI:1859638. Pqbp1.

Phylogenomic databases

eggNOGNOG265480.
GeneTreeENSGT00390000001905.
HOGENOMHOG000231359.
HOVERGENHBG053064.
InParanoidQ91VJ5.
KOK12865.
OMASHEKSDR.
OrthoDBEOG7GJ6F7.
PhylomeDBQ91VJ5.
TreeFamTF320689.

Gene expression databases

ArrayExpressQ91VJ5.
BgeeQ91VJ5.
CleanExMM_PQBP1.
GenevestigatorQ91VJ5.

Family and domain databases

InterProIPR001202. WW_dom.
[Graphical view]
PfamPF00397. WW. 1 hit.
[Graphical view]
SMARTSM00456. WW. 1 hit.
[Graphical view]
SUPFAMSSF51045. SSF51045. 1 hit.
PROSITEPS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio311456.
PROQ91VJ5.
SOURCESearch...

Entry information

Entry namePQBP1_MOUSE
AccessionPrimary (citable) accession number: Q91VJ5
Secondary accession number(s): Q80WW2, Q9ER43, Q9QYY2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot