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Q91VJ5

- PQBP1_MOUSE

UniProt

Q91VJ5 - PQBP1_MOUSE

Protein

Polyglutamine-binding protein 1

Gene

Pqbp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Probably functions as scaffold protein that is part of numerous complexes and thereby plays a role in pre-mRNA splicing, transcription regulation and neuron development. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit By similarity. Required for normal alternative splicing of target pre-mRNA species (PubMed:23512658).By similarity1 Publication

    GO - Biological processi

    1. alternative mRNA splicing, via spliceosome Source: UniProtKB
    2. neuron projection development Source: UniProtKB
    3. regulation of dendrite morphogenesis Source: MGI
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. stress granule assembly Source: MGI
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA processing, mRNA splicing, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyglutamine-binding protein 1
    Short name:
    PQBP-1
    Alternative name(s):
    38 kDa nuclear protein containing a WW domain
    Short name:
    Npw38
    Polyglutamine tract-binding protein 1
    Gene namesi
    Name:Pqbp1
    Synonyms:Npw38
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1859638. Pqbp1.

    Subcellular locationi

    Nucleus 1 Publication. Nucleus speckle 1 Publication
    Note: Colocalized with ATXN1 in nuclear inclusion bodies. Colocalized with POU3F2 By similarity. Colocalizes with SRSF2 in nuclear speckles.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytoplasmic stress granule Source: MGI
    3. neuronal ribonucleoprotein granule Source: MGI
    4. nuclear speck Source: UniProtKB
    5. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 263262Polyglutamine-binding protein 1PRO_0000076090Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei245 – 2451PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ91VJ5.
    PRIDEiQ91VJ5.

    PTM databases

    PhosphoSiteiQ91VJ5.

    Expressioni

    Tissue specificityi

    Detected in brain cortex and hippocampus neurons (at protein level). Expressed in brain with high level in cerebellar cortex, hippocampus and olfactory bulb.2 Publications

    Gene expression databases

    ArrayExpressiQ91VJ5.
    BgeeiQ91VJ5.
    CleanExiMM_PQBP1.
    GenevestigatoriQ91VJ5.

    Interactioni

    Subunit structurei

    Interacts with POU3F2/Brn-2, ATXN1, TXNL4A, HTT and AR. Interaction with ATXN1 correlates positively with the length of the polyglutamine tract. Interacts with RNA polymerase II large subunit in a phosphorylation-dependent manner. Forms a ternary complex with ATXN1 mutant and phosphorylated RNA polymerase II. Interacts (via C-terminus) with TXNL4A and CD2BP2. Interacts (via WW domain) with ATN1, WBP11 and SF3B1, and may interact with additional splice factors By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ91VJ5.
    SMRiQ91VJ5. Positions 45-79.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 8035WWPROSITE-ProRule annotationAdd
    BLAST
    Repeati104 – 11071-1; approximate
    Repeati111 – 11771-2
    Repeati118 – 12471-3; approximate
    Repeati125 – 13171-4; approximate
    Repeati132 – 13871-5; approximate
    Repeati139 – 14022-1
    Repeati141 – 14222-2
    Repeati143 – 14422-3
    Repeati150 – 15123-1
    Repeati152 – 15323-2
    Repeati154 – 15523-3
    Repeati156 – 15723-4
    Repeati158 – 15923-5
    Repeati160 – 16123-6

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 263170Intrinsically disorderedBy similarityAdd
    BLAST
    Regioni104 – 138355 X 7 AA approximate tandem repeats of D-R-[NS]-H-E-K-SAdd
    BLAST
    Regioni139 – 14463 X 2 AA tandem repeats of [DE]-R
    Regioni150 – 161126 X 2 AA tandem repeats of [DE]-RAdd
    BLAST
    Regioni243 – 25311Important for interaction with TXNL4ABy similarityAdd
    BLAST

    Domaini

    The WW domain may play a role as a transcriptional activator directly or via association with the transcription machinery. The WW domain mediates interaction with WBP11, ATN1, SF3B1 and the C-terminal domain of the RNA polymerase II large subunit By similarity.By similarity
    Except for the WW domain, the protein is intrinsically disordered.By similarity

    Sequence similaritiesi

    Contains 1 WW domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG265480.
    GeneTreeiENSGT00390000001905.
    HOGENOMiHOG000231359.
    HOVERGENiHBG053064.
    InParanoidiQ91VJ5.
    KOiK12865.
    OMAiSHEKSDR.
    OrthoDBiEOG7GJ6F7.
    PhylomeDBiQ91VJ5.
    TreeFamiTF320689.

    Family and domain databases

    InterProiIPR001202. WW_dom.
    [Graphical view]
    PfamiPF00397. WW. 1 hit.
    [Graphical view]
    SMARTiSM00456. WW. 1 hit.
    [Graphical view]
    SUPFAMiSSF51045. SSF51045. 1 hit.
    PROSITEiPS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91VJ5-1 [UniParc]FASTAAdd to Basket

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    MPLPVALQTR LAKRGILKHL EPEPEEEIIA EDYDDDPVDY EATRIEGLPP    50
    SWYKVFDPSC GLPYYWNVET DLVSWLSPHD PNFVVTKSAK KVRNNNADAE 100
    DKSDRNLEKV DRNHEKSDRS HEKPDRSHEK ADRNHEKNDR ERERNYDKVD 150
    RERDRDRERE RAFDKADREE GKDRRHHRRE ELAPYPKNKK ATSRKDEELD 200
    PMDPSSYSDA PRGTWSTGLP KRNEAKTGAD TTAAGPLFQQ RPYPSPGAVL 250
    RANAEASRTK QQD 263
    Length:263
    Mass (Da):30,597
    Last modified:December 1, 2001 - v1
    Checksum:iF62304963D34D22B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151G → S in AAH51673. (PubMed:15489334)Curated
    Sequence conflicti177 – 1771H → L in CAB59205. 1 PublicationCurated
    Sequence conflicti177 – 1771H → L in CAC15062. 1 PublicationCurated
    Sequence conflicti183 – 1831A → V in CAB59205. 1 PublicationCurated
    Sequence conflicti183 – 1831A → V in CAC15062. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250406 mRNA. Translation: CAB59205.1.
    AJ296289 Genomic DNA. Translation: CAC15062.1.
    AK077652 mRNA. Translation: BAC36928.1.
    BC009657 mRNA. Translation: AAH09657.1.
    BC051673 mRNA. Translation: AAH51673.1.
    CCDSiCCDS29977.1.
    RefSeqiNP_001239457.1. NM_001252528.1.
    NP_001239458.1. NM_001252529.1.
    NP_062351.2. NM_019478.4.
    XP_006527717.1. XM_006527654.1.
    UniGeneiMm.14616.

    Genome annotation databases

    EnsembliENSMUST00000033497; ENSMUSP00000033497; ENSMUSG00000031157.
    ENSMUST00000115654; ENSMUSP00000111318; ENSMUSG00000031157.
    ENSMUST00000115655; ENSMUSP00000111319; ENSMUSG00000031157.
    GeneIDi54633.
    KEGGimmu:54633.
    UCSCiuc009snd.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250406 mRNA. Translation: CAB59205.1 .
    AJ296289 Genomic DNA. Translation: CAC15062.1 .
    AK077652 mRNA. Translation: BAC36928.1 .
    BC009657 mRNA. Translation: AAH09657.1 .
    BC051673 mRNA. Translation: AAH51673.1 .
    CCDSi CCDS29977.1.
    RefSeqi NP_001239457.1. NM_001252528.1.
    NP_001239458.1. NM_001252529.1.
    NP_062351.2. NM_019478.4.
    XP_006527717.1. XM_006527654.1.
    UniGenei Mm.14616.

    3D structure databases

    ProteinModelPortali Q91VJ5.
    SMRi Q91VJ5. Positions 45-79.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91VJ5.

    Proteomic databases

    PaxDbi Q91VJ5.
    PRIDEi Q91VJ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033497 ; ENSMUSP00000033497 ; ENSMUSG00000031157 .
    ENSMUST00000115654 ; ENSMUSP00000111318 ; ENSMUSG00000031157 .
    ENSMUST00000115655 ; ENSMUSP00000111319 ; ENSMUSG00000031157 .
    GeneIDi 54633.
    KEGGi mmu:54633.
    UCSCi uc009snd.2. mouse.

    Organism-specific databases

    CTDi 10084.
    MGIi MGI:1859638. Pqbp1.

    Phylogenomic databases

    eggNOGi NOG265480.
    GeneTreei ENSGT00390000001905.
    HOGENOMi HOG000231359.
    HOVERGENi HBG053064.
    InParanoidi Q91VJ5.
    KOi K12865.
    OMAi SHEKSDR.
    OrthoDBi EOG7GJ6F7.
    PhylomeDBi Q91VJ5.
    TreeFami TF320689.

    Miscellaneous databases

    NextBioi 311456.
    PROi Q91VJ5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91VJ5.
    Bgeei Q91VJ5.
    CleanExi MM_PQBP1.
    Genevestigatori Q91VJ5.

    Family and domain databases

    InterProi IPR001202. WW_dom.
    [Graphical view ]
    Pfami PF00397. WW. 1 hit.
    [Graphical view ]
    SMARTi SM00456. WW. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51045. SSF51045. 1 hit.
    PROSITEi PS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Okazawa H.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-263.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and FVB/N.
      Tissue: Mammary tumor.
    4. "PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival."
      Waragai M., Lammers C.-H., Takeuchi S., Imafuku I., Udagawa Y., Kanazawa I., Kawabata M., Mouradian M.M., Okazawa H.
      Hum. Mol. Genet. 8:977-987(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth."
      Wang Q., Moore M.J., Adelmant G., Marto J.A., Silver P.A.
      Genes Dev. 27:615-626(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPQBP1_MOUSE
    AccessioniPrimary (citable) accession number: Q91VJ5
    Secondary accession number(s): Q80WW2, Q9ER43, Q9QYY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3