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Q91VJ4

- STK38_MOUSE

UniProt

Q91VJ4 - STK38_MOUSE

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Protein
Serine/threonine-protein kinase 38
Gene
Stk38, Ndr1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 By similarity.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Magnesium.

Enzyme regulationi

Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181ATP By similarityBy similarity
Active sitei212 – 2121Proton acceptor By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi95 – 1039ATP By similarityBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. magnesium ion binding Source: UniProtKB
  3. protein binding Source: IntAct
  4. protein serine/threonine kinase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. intracellular signal transduction Source: UniProtKB
  2. negative regulation of MAP kinase activity Source: UniProtKB
  3. protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 38 (EC:2.7.11.1)
Alternative name(s):
NDR1 protein kinase
Nuclear Dbf2-related kinase 1
Gene namesi
Name:Stk38
Synonyms:Ndr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:2442572. Stk38.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity By similarity

GO - Cellular componenti

  1. MLL5-L complex Source: Ensembl
  2. cytoplasm Source: UniProtKB
  3. nucleus Source: UniProtKB
  4. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 465464Serine/threonine-protein kinase 38
PRO_0000086719Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei74 – 741Phosphothreonine By similarityBy similarity
Modified residuei264 – 2641Phosphoserine By similarity
Modified residuei281 – 2811Phosphoserine; by autocatalysis By similarityBy similarity
Modified residuei444 – 4441Phosphothreonine; by STK24/MST3 By similarityBy similarity

Post-translational modificationi

ISGylated By similarity.
Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ91VJ4.
PaxDbiQ91VJ4.
PRIDEiQ91VJ4.

PTM databases

PhosphoSiteiQ91VJ4.

Expressioni

Tissue specificityi

Expressed at high levels in spleen, lung, thymus, brain and fat tissue.1 Publication

Gene expression databases

ArrayExpressiQ91VJ4.
BgeeiQ91VJ4.
CleanExiMM_STK38.
GenevestigatoriQ91VJ4.

Interactioni

Subunit structurei

Homodimeric S100B binds two molecules of STK38. Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with MOB1 and MOB2 By similarity. Interacts with MAP3K1 and MAP3K2 (via the kinase catalytic domain) By similarity. Forms a tripartite complex with MOBKL1B and STK3/MST2 By similarity. Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Mical1Q8VDP39EBI-2527046,EBI-4394891
STK4Q130432EBI-2527046,EBI-367376From a different organism.

Protein-protein interaction databases

BioGridi223068. 10 interactions.
IntActiQ91VJ4. 11 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ91VJ4.
SMRiQ91VJ4. Positions 23-418.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 382294Protein kinase
Add
BLAST
Domaini383 – 45573AGC-kinase C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 8726Interaction with S100B By similarity
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00750000117396.
HOGENOMiHOG000233033.
HOVERGENiHBG104247.
InParanoidiQ91VJ4.
KOiK08790.
OMAiNAAYPPQ.
OrthoDBiEOG7BZVS1.
PhylomeDBiQ91VJ4.
TreeFamiTF105337.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VJ4-1 [UniParc]FASTAAdd to Basket

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MAMTGSTPCS SMSNHTKERV TMTKVTLENF YSNLIAQHEE REMRQKKLEK    50
VMEEEGLKDE EKRLRRSAHA RKETEFLRLK RTRLGLEDFE SLKVIGRGAF 100
GEVRLVQKKD TGHVYAMKIL RKADMLEKEQ VGHIRAERDI LVEADSLWVV 150
KMFYSFQDKL NLYLIMEFLP GGDMMTLLMK KDTLTEEETQ FYIAETVLAI 200
DSIHQLGFIH RDIKPDNLLL DSKGHVKLSD FGLCTGLKKA HRTEFYRNLN 250
HSLPSDFTFQ NMNSKRKAET WKRNRRQLAF STVGTPDYIA PEVFMQTGYN 300
KLCDWWSLGV IMYEMLIGYP PFCSETPQET YKKVMNWKET LTFPPEVPVS 350
EKAKGLILRF CCEWEHRIGA PGVEEIKNNL FFEGVDWEHI RERPAAISIE 400
IKSIDDTSNF DEFPESDILK PTVTTSSHPE TDYKNKDWVF INYTYKRFEG 450
LTARGAIPSY MKAAK 465
Length:465
Mass (Da):54,174
Last modified:December 1, 2001 - v1
Checksum:i00E29F8963196750
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY292399 mRNA. Translation: AAP44997.1.
BC009658 mRNA. Translation: AAH09658.1.
CCDSiCCDS28589.1.
RefSeqiNP_598876.1. NM_134115.2.
XP_006536793.1. XM_006536730.1.
UniGeneiMm.439986.

Genome annotation databases

EnsembliENSMUST00000009138; ENSMUSP00000009138; ENSMUSG00000024006.
ENSMUST00000119274; ENSMUSP00000113657; ENSMUSG00000024006.
GeneIDi106504.
KEGGimmu:106504.
UCSCiuc008bsa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY292399 mRNA. Translation: AAP44997.1 .
BC009658 mRNA. Translation: AAH09658.1 .
CCDSi CCDS28589.1.
RefSeqi NP_598876.1. NM_134115.2.
XP_006536793.1. XM_006536730.1.
UniGenei Mm.439986.

3D structure databases

ProteinModelPortali Q91VJ4.
SMRi Q91VJ4. Positions 23-418.
ModBasei Search...

Protein-protein interaction databases

BioGridi 223068. 10 interactions.
IntActi Q91VJ4. 11 interactions.

PTM databases

PhosphoSitei Q91VJ4.

Proteomic databases

MaxQBi Q91VJ4.
PaxDbi Q91VJ4.
PRIDEi Q91VJ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000009138 ; ENSMUSP00000009138 ; ENSMUSG00000024006 .
ENSMUST00000119274 ; ENSMUSP00000113657 ; ENSMUSG00000024006 .
GeneIDi 106504.
KEGGi mmu:106504.
UCSCi uc008bsa.1. mouse.

Organism-specific databases

CTDi 11329.
MGIi MGI:2442572. Stk38.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00750000117396.
HOGENOMi HOG000233033.
HOVERGENi HBG104247.
InParanoidi Q91VJ4.
KOi K08790.
OMAi NAAYPPQ.
OrthoDBi EOG7BZVS1.
PhylomeDBi Q91VJ4.
TreeFami TF105337.

Miscellaneous databases

ChiTaRSi STK38. mouse.
NextBioi 358230.
PROi Q91VJ4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91VJ4.
Bgeei Q91VJ4.
CleanExi MM_STK38.
Genevestigatori Q91VJ4.

Family and domain databases

InterProi IPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view ]
SMARTi SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein."
    Stegert M.R., Tamaskovic R., Bichsel S.J., Hergovich A., Hemmings B.A.
    J. Biol. Chem. 279:23806-23812(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. Cited for: FUNCTION, INTERACTION WITH MICAL1.

Entry informationi

Entry nameiSTK38_MOUSE
AccessioniPrimary (citable) accession number: Q91VJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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