Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Caveolae-associated protein 3

Gene

Cavin3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the traffic and/or budding of caveolae (By similarity). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells (PubMed: 28285351, PubMed:23652019). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface (PubMed:25588833). Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (PubMed:23079727).By similarity4 Publications

GO - Molecular functioni

  • protein kinase C binding Source: BHF-UCL

GO - Biological processi

  • circadian regulation of gene expression Source: UniProtKB
  • cortical actin cytoskeleton organization Source: MGI
  • negative regulation of fermentation Source: MGI
  • negative regulation of protein kinase B signaling Source: MGI
  • positive regulation of ERK1 and ERK2 cascade Source: MGI

Keywordsi

Biological processBiological rhythms

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolae-associated protein 3
Alternative name(s):
Cavin-3
Protein kinase C delta-binding protein
Serum deprivation response factor-related gene product that binds to C-kinase
Gene namesi
Name:Cavin3
Synonyms:Prkcdbp, Srbc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1923422. Prkcdbp.

Subcellular locationi

GO - Cellular componenti

  • caveola Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB-SubCell
  • protein complex Source: MGI

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice show reduced density of membrane caveolae in the arterial smooth muscle and the urinary bladder but show no loss of endothelial caveolae in lung and heart.2 Publications

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003314131 – 260Caveolae-associated protein 3Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineBy similarity1
Modified residuei70PhosphoserineBy similarity1
Cross-linki128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei165PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1

Post-translational modificationi

In vitro, phosphorylated by PRKCD.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ91VJ2.
PaxDbiQ91VJ2.
PeptideAtlasiQ91VJ2.
PRIDEiQ91VJ2.

PTM databases

iPTMnetiQ91VJ2.
PhosphoSitePlusiQ91VJ2.

Expressioni

Tissue specificityi

Lung, heart, skeletal muscle, liver, brain, vascular and urinary bladder smooth muscle (at protein level). Strongly expressed in uterus, ovary, mammary and epithelial cells. Also expressed in spleen, intestine, kidney and testis.4 Publications

Inductioni

Up-regulated in serum-starvated cells or during cell growth arrest.1 Publication

Gene expression databases

BgeeiENSMUSG00000037060.
GenevisibleiQ91VJ2. MM.

Interactioni

Subunit structurei

Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4 (PubMed:19546242). Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding (PubMed:9054438). Interacts with PER2 (PubMed:23079727). Interacts with CAVIN1 (PubMed:19546242, PubMed:25588833). Interacts (via leucine-zipper domain) with CAV1 in a cholesterol-sensitive manner (PubMed:25588833). Interacts with EPS15L1 (By similarity).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Per2O549434EBI-8094261,EBI-1266779

GO - Molecular functioni

  • protein kinase C binding Source: BHF-UCL

Protein-protein interaction databases

IntActiQ91VJ2. 2 interactors.
MINTiMINT-4120928.
STRINGi10090.ENSMUSP00000044979.

Structurei

3D structure databases

ProteinModelPortaliQ91VJ2.
SMRiQ91VJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 84Interaction with CAVIN11 PublicationAdd BLAST84
Regioni20 – 78Leucine-zipperBy similarityAdd BLAST59
Regioni135 – 200Interaction with CAV11 PublicationAdd BLAST66

Domaini

The leucine-zipper domain is essential for its localization in the caveolae and for its interaction with CAV1 and EPS15L1.By similarity

Sequence similaritiesi

Belongs to the CAVIN family.Curated

Phylogenomic databases

eggNOGiENOG410IVVG. Eukaryota.
ENOG4111EFW. LUCA.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000115686.
HOVERGENiHBG108288.
InParanoidiQ91VJ2.
OMAiQSELGPE.
OrthoDBiEOG091G09Y1.
PhylomeDBiQ91VJ2.
TreeFamiTF331031.

Family and domain databases

InterProiView protein in InterPro
IPR026752. Cavin_fam.
IPR033300. SRBC.
PANTHERiPTHR15240. PTHR15240. 1 hit.
PTHR15240:SF9. PTHR15240:SF9. 1 hit.
PfamiView protein in Pfam
PF15237. PTRF_SDPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91VJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGESALEPGP VPETPAGGPV HAVTVVTLLE KLATMLEALR ERQGGLAERQ
60 70 80 90 100
GGLAGSVRRI QSGLGALSRS HDTTSNTLTQ LLAKAERVGS HADAAQERAV
110 120 130 140 150
RRAAQVQRLE ANHGLLVARG KLHVLLFKEE TEIPARAFQK VPELLGPEDQ
160 170 180 190 200
LVLGPDQPED EVGESSEEEP VESRAQRLRR TGLQKVQSLK RALSSRKAAQ
210 220 230 240 250
PTPVKPPRVG PVRSSEGPSE GQPAAQPEME SELETALEPE PPQPTKEDPE
260
KPVLQIESAA
Length:260
Mass (Da):27,853
Last modified:December 1, 2001 - v1
Checksum:iC895CDCB329A9728
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti225A → G in BAB29133 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC009660 mRNA. Translation: AAH09660.1.
AK014051 mRNA. Translation: BAB29133.1.
AK032154 mRNA. Translation: BAC27728.1.
CCDSiCCDS21652.1.
RefSeqiNP_082720.1. NM_028444.1.
UniGeneiMm.3124.

Genome annotation databases

EnsembliENSMUST00000047040; ENSMUSP00000044979; ENSMUSG00000037060.
GeneIDi109042.
KEGGimmu:109042.
UCSCiuc009iye.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCAVN3_MOUSE
AccessioniPrimary (citable) accession number: Q91VJ2
Secondary accession number(s): Q8C064, Q9CRW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: August 30, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families