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Protein

Protein kinase C delta-binding protein

Gene

Prkcdbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to have an immune potentiation function (By similarity). Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (PubMed:23079727).By similarity1 Publication

GO - Molecular functioni

  • protein kinase C binding Source: BHF-UCL

GO - Biological processi

  • circadian regulation of gene expression Source: UniProtKB
  • cortical actin cytoskeleton organization Source: MGI
  • negative regulation of fermentation Source: MGI
  • negative regulation of protein kinase B signaling Source: MGI
  • positive regulation of ERK1 and ERK2 cascade Source: MGI
Complete GO annotation...

Keywords - Biological processi

Biological rhythms

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C delta-binding protein
Alternative name(s):
Cavin-3
Serum deprivation response factor-related gene product that binds to C-kinase
Gene namesi
Name:Prkcdbp
Synonyms:Srbc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1923422. Prkcdbp.

Subcellular locationi

GO - Cellular componenti

  • caveola Source: MGI
  • cytoplasm Source: UniProtKB
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Protein kinase C delta-binding proteinPRO_0000331413Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 621PhosphoserineBy similarity
Modified residuei70 – 701PhosphoserineBy similarity
Modified residuei165 – 1651PhosphoserineCombined sources
Modified residuei166 – 1661PhosphoserineCombined sources
Modified residuei173 – 1731PhosphoserineCombined sources

Post-translational modificationi

In vitro, phosphorylated by PRKCD.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91VJ2.
PaxDbiQ91VJ2.
PeptideAtlasiQ91VJ2.
PRIDEiQ91VJ2.

PTM databases

iPTMnetiQ91VJ2.
PhosphoSiteiQ91VJ2.

Expressioni

Tissue specificityi

Strongly expressed in uterus, ovary, mammary and epithelial cells. Also expressed in brain, lung, heart, spleen, intestine, kidney, skeletal muscle and testis. Not found in liver.1 Publication

Inductioni

Up-regulated in serum-starvated cells or during cell growth arrest.1 Publication

Gene expression databases

BgeeiENSMUSG00000037060.
GenevisibleiQ91VJ2. MM.

Interactioni

Subunit structurei

Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding. Interacts with PER2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Per2O549434EBI-8094261,EBI-1266779

GO - Molecular functioni

  • protein kinase C binding Source: BHF-UCL

Protein-protein interaction databases

IntActiQ91VJ2. 2 interactions.
MINTiMINT-4120928.
STRINGi10090.ENSMUSP00000044979.

Structurei

3D structure databases

ProteinModelPortaliQ91VJ2.
SMRiQ91VJ2. Positions 21-112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTRF/SDPR family.Curated

Phylogenomic databases

eggNOGiENOG410IVVG. Eukaryota.
ENOG4111EFW. LUCA.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000115686.
HOVERGENiHBG108288.
InParanoidiQ91VJ2.
OMAiQSELGPE.
OrthoDBiEOG091G09Y1.
PhylomeDBiQ91VJ2.
TreeFamiTF331031.

Family and domain databases

InterProiIPR026752. Cavin_fam.
IPR033300. SRBC.
[Graphical view]
PANTHERiPTHR15240. PTHR15240. 1 hit.
PTHR15240:SF2. PTHR15240:SF2. 1 hit.
PfamiPF15237. PTRF_SDPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91VJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGESALEPGP VPETPAGGPV HAVTVVTLLE KLATMLEALR ERQGGLAERQ
60 70 80 90 100
GGLAGSVRRI QSGLGALSRS HDTTSNTLTQ LLAKAERVGS HADAAQERAV
110 120 130 140 150
RRAAQVQRLE ANHGLLVARG KLHVLLFKEE TEIPARAFQK VPELLGPEDQ
160 170 180 190 200
LVLGPDQPED EVGESSEEEP VESRAQRLRR TGLQKVQSLK RALSSRKAAQ
210 220 230 240 250
PTPVKPPRVG PVRSSEGPSE GQPAAQPEME SELETALEPE PPQPTKEDPE
260
KPVLQIESAA
Length:260
Mass (Da):27,853
Last modified:December 1, 2001 - v1
Checksum:iC895CDCB329A9728
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti225 – 2251A → G in BAB29133 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC009660 mRNA. Translation: AAH09660.1.
AK014051 mRNA. Translation: BAB29133.1.
AK032154 mRNA. Translation: BAC27728.1.
CCDSiCCDS21652.1.
RefSeqiNP_082720.1. NM_028444.1.
UniGeneiMm.3124.

Genome annotation databases

EnsembliENSMUST00000047040; ENSMUSP00000044979; ENSMUSG00000037060.
GeneIDi109042.
KEGGimmu:109042.
UCSCiuc009iye.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC009660 mRNA. Translation: AAH09660.1.
AK014051 mRNA. Translation: BAB29133.1.
AK032154 mRNA. Translation: BAC27728.1.
CCDSiCCDS21652.1.
RefSeqiNP_082720.1. NM_028444.1.
UniGeneiMm.3124.

3D structure databases

ProteinModelPortaliQ91VJ2.
SMRiQ91VJ2. Positions 21-112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91VJ2. 2 interactions.
MINTiMINT-4120928.
STRINGi10090.ENSMUSP00000044979.

PTM databases

iPTMnetiQ91VJ2.
PhosphoSiteiQ91VJ2.

Proteomic databases

MaxQBiQ91VJ2.
PaxDbiQ91VJ2.
PeptideAtlasiQ91VJ2.
PRIDEiQ91VJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047040; ENSMUSP00000044979; ENSMUSG00000037060.
GeneIDi109042.
KEGGimmu:109042.
UCSCiuc009iye.1. mouse.

Organism-specific databases

CTDi112464.
MGIiMGI:1923422. Prkcdbp.

Phylogenomic databases

eggNOGiENOG410IVVG. Eukaryota.
ENOG4111EFW. LUCA.
GeneTreeiENSGT00530000063058.
HOGENOMiHOG000115686.
HOVERGENiHBG108288.
InParanoidiQ91VJ2.
OMAiQSELGPE.
OrthoDBiEOG091G09Y1.
PhylomeDBiQ91VJ2.
TreeFamiTF331031.

Miscellaneous databases

PROiQ91VJ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037060.
GenevisibleiQ91VJ2. MM.

Family and domain databases

InterProiIPR026752. Cavin_fam.
IPR033300. SRBC.
[Graphical view]
PANTHERiPTHR15240. PTHR15240. 1 hit.
PTHR15240:SF2. PTHR15240:SF2. 1 hit.
PfamiPF15237. PTRF_SDPR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRDBP_MOUSE
AccessioniPrimary (citable) accession number: Q91VJ2
Secondary accession number(s): Q8C064, Q9CRW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.