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Protein

Ribonuclease inhibitor

Gene

Rnh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease inhibitor
Alternative name(s):
Ribonuclease/angiogenin inhibitor 1
Gene namesi
Name:Rnh1
Synonyms:Rnh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1195456. Rnh1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000973441 – 456Ribonuclease inhibitorAdd BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei86PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ91VI7.
MaxQBiQ91VI7.
PaxDbiQ91VI7.
PeptideAtlasiQ91VI7.
PRIDEiQ91VI7.

2D gel databases

UCD-2DPAGEQ91VI7.

PTM databases

iPTMnetiQ91VI7.
PhosphoSitePlusiQ91VI7.
SwissPalmiQ91VI7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038650.
CleanExiMM_RNH1.
GenevisibleiQ91VI7. MM.

Interactioni

Subunit structurei

Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.By similarity

Protein-protein interaction databases

BioGridi223500. 5 interactors.
IntActiQ91VI7. 3 interactors.
MINTiMINT-1868853.
STRINGi10090.ENSMUSP00000101651.

Structurei

Secondary structure

1456
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 7Combined sources7
Helixi12 – 22Combined sources11
Beta strandi26 – 33Combined sources8
Helixi37 – 39Combined sources3
Helixi40 – 48Combined sources9
Beta strandi55 – 57Combined sources3
Helixi64 – 74Combined sources11
Beta strandi84 – 86Combined sources3
Helixi94 – 99Combined sources6
Helixi100 – 106Combined sources7
Beta strandi112 – 114Combined sources3
Helixi121 – 132Combined sources12
Beta strandi140 – 143Combined sources4
Helixi151 – 153Combined sources3
Helixi154 – 163Combined sources10
Beta strandi169 – 171Combined sources3
Helixi178 – 191Combined sources14
Beta strandi198 – 200Combined sources3
Helixi208 – 210Combined sources3
Helixi211 – 220Combined sources10
Beta strandi226 – 228Combined sources3
Beta strandi231 – 233Combined sources3
Helixi235 – 246Combined sources12
Beta strandi255 – 257Combined sources3
Helixi265 – 277Combined sources13
Beta strandi283 – 285Combined sources3
Helixi292 – 303Combined sources12
Beta strandi312 – 314Combined sources3
Helixi322 – 324Combined sources3
Helixi325 – 334Combined sources10
Beta strandi340 – 342Combined sources3
Helixi349 – 360Combined sources12
Beta strandi369 – 371Combined sources3
Helixi379 – 381Combined sources3
Helixi382 – 391Combined sources10
Beta strandi397 – 399Combined sources3
Helixi407 – 417Combined sources11
Beta strandi426 – 428Combined sources3
Helixi436 – 448Combined sources13
Beta strandi453 – 455Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TSRX-ray2.20E/F/G/H1-456[»]
ProteinModelPortaliQ91VI7.
SMRiQ91VI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 43LRR 1Add BLAST29
Repeati44 – 71LRR 2Add BLAST28
Repeati72 – 100LRR 3Add BLAST29
Repeati101 – 128LRR 4Add BLAST28
Repeati129 – 157LRR 5Add BLAST29
Repeati158 – 185LRR 6Add BLAST28
Repeati186 – 214LRR 7Add BLAST29
Repeati215 – 242LRR 8Add BLAST28
Repeati243 – 271LRR 9Add BLAST29
Repeati272 – 299LRR 10Add BLAST28
Repeati300 – 328LRR 11Add BLAST29
Repeati329 – 356LRR 12Add BLAST28
Repeati357 – 385LRR 13Add BLAST29
Repeati386 – 413LRR 14Add BLAST28
Repeati414 – 442LRR 15Add BLAST29

Domaini

The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large protein interaction surface on its interior side.By similarity

Sequence similaritiesi

Contains 15 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00860000133669.
HOGENOMiHOG000140402.
HOVERGENiHBG001059.
InParanoidiQ91VI7.
KOiK16634.
OMAiCRDLCSI.
OrthoDBiEOG091G01CG.
PhylomeDBiQ91VI7.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91VI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLDIQCEQL SDARWTELLP LIQQYEVVRL DDCGLTEVRC KDISSAVQAN
60 70 80 90 100
PALTELSLRT NELGDGGVGL VLQGLQNPTC KIQKLSLQNC GLTEAGCGIL
110 120 130 140 150
PGMLRSLSTL RELHLNDNPM GDAGLKLLCE GLQDPQCRLE KLQLEYCNLT
160 170 180 190 200
ATSCEPLASV LRVKADFKEL VLSNNDLHEP GVRILCQGLK DSACQLESLK
210 220 230 240 250
LENCGITAAN CKDLCDVVAS KASLQELDLS SNKLGNAGIA ALCPGLLLPS
260 270 280 290 300
CKLRTLWLWE CDITAEGCKD LCRVLRAKQS LKELSLASNE LKDEGARLLC
310 320 330 340 350
ESLLEPGCQL ESLWIKTCSL TAASCPYFCS VLTKSRSLLE LQMSSNPLGD
360 370 380 390 400
EGVQELCKAL SQPDTVLREL WLGDCDVTNS GCSSLANVLL ANRSLRELDL
410 420 430 440 450
SNNCMGGPGV LQLLESLKQP SCTLQQLVLY DIYWTNEVEE QLRALEEERP

SLRIIS
Length:456
Mass (Da):49,816
Last modified:December 1, 2001 - v1
Checksum:i007B782F05A357E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11S → G in AAK68859 (Ref. 1) Curated1
Sequence conflicti68V → A in AAK68859 (Ref. 1) Curated1
Sequence conflicti254R → G in AAK68859 (Ref. 1) Curated1
Sequence conflicti278K → N in AAK68859 (Ref. 1) Curated1
Sequence conflicti448E → G in AAK68859 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071546 mRNA. Translation: AAK68859.1.
AK133822 mRNA. Translation: BAE21862.1.
AK141351 mRNA. Translation: BAE24659.1.
AK147059 mRNA. Translation: BAE27643.1.
BC010331 mRNA. Translation: AAH10331.1.
CCDSiCCDS22002.1.
RefSeqiNP_001165571.1. NM_001172100.1.
NP_001165572.1. NM_001172101.1.
NP_660117.2. NM_145135.3.
UniGeneiMm.197493.
Mm.279485.

Genome annotation databases

EnsembliENSMUST00000106033; ENSMUSP00000101651; ENSMUSG00000038650.
ENSMUST00000167493; ENSMUSP00000133061; ENSMUSG00000038650.
GeneIDi107702.
KEGGimmu:107702.
UCSCiuc009kjs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071546 mRNA. Translation: AAK68859.1.
AK133822 mRNA. Translation: BAE21862.1.
AK141351 mRNA. Translation: BAE24659.1.
AK147059 mRNA. Translation: BAE27643.1.
BC010331 mRNA. Translation: AAH10331.1.
CCDSiCCDS22002.1.
RefSeqiNP_001165571.1. NM_001172100.1.
NP_001165572.1. NM_001172101.1.
NP_660117.2. NM_145135.3.
UniGeneiMm.197493.
Mm.279485.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TSRX-ray2.20E/F/G/H1-456[»]
ProteinModelPortaliQ91VI7.
SMRiQ91VI7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223500. 5 interactors.
IntActiQ91VI7. 3 interactors.
MINTiMINT-1868853.
STRINGi10090.ENSMUSP00000101651.

PTM databases

iPTMnetiQ91VI7.
PhosphoSitePlusiQ91VI7.
SwissPalmiQ91VI7.

2D gel databases

UCD-2DPAGEQ91VI7.

Proteomic databases

EPDiQ91VI7.
MaxQBiQ91VI7.
PaxDbiQ91VI7.
PeptideAtlasiQ91VI7.
PRIDEiQ91VI7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106033; ENSMUSP00000101651; ENSMUSG00000038650.
ENSMUST00000167493; ENSMUSP00000133061; ENSMUSG00000038650.
GeneIDi107702.
KEGGimmu:107702.
UCSCiuc009kjs.2. mouse.

Organism-specific databases

CTDi6050.
MGIiMGI:1195456. Rnh1.

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00860000133669.
HOGENOMiHOG000140402.
HOVERGENiHBG001059.
InParanoidiQ91VI7.
KOiK16634.
OMAiCRDLCSI.
OrthoDBiEOG091G01CG.
PhylomeDBiQ91VI7.

Miscellaneous databases

ChiTaRSiRnh1. mouse.
PROiQ91VI7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038650.
CleanExiMM_RNH1.
GenevisibleiQ91VI7. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRINI_MOUSE
AccessioniPrimary (citable) accession number: Q91VI7
Secondary accession number(s): Q924P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.