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Protein

Protein MEMO1

Gene

Memo1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6785631. ERBB2 Regulates Cell Motility.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MEMO1
Alternative name(s):
Mediator of ErbB2-driven cell motility 1
Short name:
Memo-1
Gene namesi
Name:Memo1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1924140. Memo1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Protein MEMO1PRO_0000134395Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei210 – 2101PhosphotyrosineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91VH6.
MaxQBiQ91VH6.
PaxDbiQ91VH6.
PeptideAtlasiQ91VH6.
PRIDEiQ91VH6.

PTM databases

iPTMnetiQ91VH6.
PhosphoSiteiQ91VH6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000058704.
CleanExiMM_MEMO1.
GenevisibleiQ91VH6. MM.

Interactioni

Subunit structurei

Interacts with ERBB2 phosphorylated on 'Tyr-1249'.By similarity

Protein-protein interaction databases

IntActiQ91VH6. 1 interaction.
MINTiMINT-4120920.
STRINGi10090.ENSMUSP00000077553.

Structurei

3D structure databases

ProteinModelPortaliQ91VH6.
SMRiQ91VH6. Positions 5-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MEMO1 family.Curated

Phylogenomic databases

eggNOGiKOG3086. Eukaryota.
COG1355. LUCA.
GeneTreeiENSGT00390000006408.
HOVERGENiHBG050811.
InParanoidiQ91VH6.
KOiK06990.
OMAiYTYCGAC.
OrthoDBiEOG091G0GVZ.
TreeFamiTF300014.

Family and domain databases

HAMAPiMF_00055. MEMO1. 1 hit.
InterProiIPR002737. MEMO1_fam.
[Graphical view]
PANTHERiPTHR11060. PTHR11060. 1 hit.
PfamiPF01875. Memo. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04336. AmmeMemoSam_B. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91VH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNRVVCREA SHAGSWYTAS GPQLNAQLEG WLSQVQSTKR PARAIIAPHA
60 70 80 90 100
GYTYCGSCAA HAYKQVDPSV TRRIFILGPS HHVPLSRCAL SSVDIYRTPL
110 120 130 140 150
YDLRIDQKIY GELWKTGMFE RMSLQTDEDE HSIEMHLPYT AKAMESHKDE
160 170 180 190 200
FTIIPVLVGA LSESKEQEFG KLFSKYLADP SNLFVVSSDF CHWGQRFRYS
210 220 230 240 250
YYDESQGEIY RSIEHLDKMG MSIIEQLDPV SFSNYLKKYH NTICGRHPIG
260 270 280 290
VLLNAITELQ KNGMNMSFSF LNYAQSSQCR SWQDSSVSYA AGALTVH
Length:297
Mass (Da):33,692
Last modified:December 1, 2001 - v1
Checksum:iC3599434A6CFD33A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363447 mRNA. Translation: AAL34463.1.
BC013819 mRNA. Translation: AAH13819.1.
CCDSiCCDS28969.1.
RefSeqiNP_598532.1. NM_133771.2.
XP_006525172.1. XM_006525109.2.
UniGeneiMm.311874.

Genome annotation databases

EnsembliENSMUST00000078459; ENSMUSP00000077553; ENSMUSG00000058704.
GeneIDi76890.
KEGGimmu:76890.
UCSCiuc012axb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363447 mRNA. Translation: AAL34463.1.
BC013819 mRNA. Translation: AAH13819.1.
CCDSiCCDS28969.1.
RefSeqiNP_598532.1. NM_133771.2.
XP_006525172.1. XM_006525109.2.
UniGeneiMm.311874.

3D structure databases

ProteinModelPortaliQ91VH6.
SMRiQ91VH6. Positions 5-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91VH6. 1 interaction.
MINTiMINT-4120920.
STRINGi10090.ENSMUSP00000077553.

PTM databases

iPTMnetiQ91VH6.
PhosphoSiteiQ91VH6.

Proteomic databases

EPDiQ91VH6.
MaxQBiQ91VH6.
PaxDbiQ91VH6.
PeptideAtlasiQ91VH6.
PRIDEiQ91VH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078459; ENSMUSP00000077553; ENSMUSG00000058704.
GeneIDi76890.
KEGGimmu:76890.
UCSCiuc012axb.1. mouse.

Organism-specific databases

CTDi7795.
MGIiMGI:1924140. Memo1.

Phylogenomic databases

eggNOGiKOG3086. Eukaryota.
COG1355. LUCA.
GeneTreeiENSGT00390000006408.
HOVERGENiHBG050811.
InParanoidiQ91VH6.
KOiK06990.
OMAiYTYCGAC.
OrthoDBiEOG091G0GVZ.
TreeFamiTF300014.

Enzyme and pathway databases

ReactomeiR-MMU-6785631. ERBB2 Regulates Cell Motility.

Miscellaneous databases

ChiTaRSiMemo1. mouse.
PROiQ91VH6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058704.
CleanExiMM_MEMO1.
GenevisibleiQ91VH6. MM.

Family and domain databases

HAMAPiMF_00055. MEMO1. 1 hit.
InterProiIPR002737. MEMO1_fam.
[Graphical view]
PANTHERiPTHR11060. PTHR11060. 1 hit.
PfamiPF01875. Memo. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04336. AmmeMemoSam_B. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMEMO1_MOUSE
AccessioniPrimary (citable) accession number: Q91VH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.