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Protein

Adiponectin receptor protein 1

Gene

Adipor1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:17327425, PubMed:17268472, PubMed:24742672). Required for normal glucose and fat homeostasis and for maintaining a normal body weight (PubMed:17327425, PubMed:24742672). ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis (PubMed:12802337, PubMed:17327425, PubMed:17268472, PubMed:24742672). Has high affinity for globular adiponectin and low affinity for full-length adiponectin (PubMed:12802337).4 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi191 – 1911ZincBy similarity
Metal bindingi337 – 3371ZincBy similarity
Metal bindingi341 – 3411ZincBy similarity

GO - Molecular functioni

  • adipokinetic hormone receptor activity Source: UniProtKB
  • adiponectin binding Source: MGI
  • hormone binding Source: MGI
  • identical protein binding Source: MGI
  • protein heterodimerization activity Source: MGI
  • protein kinase binding Source: MGI
  • receptor activity Source: MGI

GO - Biological processi

  • adiponectin-activated signaling pathway Source: MGI
  • fatty acid oxidation Source: UniProtKB
  • hormone-mediated signaling pathway Source: UniProtKB
  • leptin-mediated signaling pathway Source: Ensembl
  • negative regulation of cell growth Source: Ensembl
  • positive regulation of insulin receptor signaling pathway Source: Ensembl
  • positive regulation of JAK-STAT cascade Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Adiponectin receptor protein 1
Gene namesi
Name:Adipor1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1919924. Adipor1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 136136CytoplasmicBy similarityAdd
BLAST
Transmembranei137 – 15721Helical; Name=1By similarityAdd
BLAST
Topological domaini158 – 17013ExtracellularBy similarityAdd
BLAST
Transmembranei171 – 19121Helical; Name=2By similarityAdd
BLAST
Topological domaini192 – 20312CytoplasmicBy similarityAdd
BLAST
Transmembranei204 – 22421Helical; Name=3By similarityAdd
BLAST
Topological domaini225 – 23410ExtracellularBy similarity
Transmembranei235 – 25521Helical; Name=4By similarityAdd
BLAST
Topological domaini256 – 2649CytoplasmicBy similarity
Transmembranei265 – 28521Helical; Name=5By similarityAdd
BLAST
Topological domaini286 – 29813ExtracellularBy similarityAdd
BLAST
Transmembranei299 – 31921Helical; Name=6By similarityAdd
BLAST
Topological domaini320 – 33718CytoplasmicBy similarityAdd
BLAST
Transmembranei338 – 35821Helical; Name=7By similarityAdd
BLAST
Topological domaini359 – 37517ExtracellularBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant mice are viable and fertile, but display defects in glucose and lipid homeostasis. The precise phenotype may depend on experimental details and genetic background. Mutant mice have normal body weight, but increased plasma glucose and insulin levels (PubMed:17268472). Mutant male mice, but not female mice, display increased body weight gain on standard chow, in spite of similar food intake as wild-type (PubMed:17327425). Mutant mice display increased body weight, both on standard chow and on high fat and high sucrose diet (PubMed:24742672). Male mice have increased total body fat mass after 15 weeks, and have increased weights of both white and brown adipose tissue (PubMed:17327425, PubMed:24742672). Mutant mice have impaired glucose tolerance (PubMed:24742672). Male mice have decreased glucose tolerance, but no significant change in the insulin response (PubMed:17327425). Female mice display increased fasting glucose levels, but unchanged fasting insulin levels (PubMed:17327425). Male and female mice display increased levels of liver triglycerides relative to wild-type (PubMed:17327425, PubMed:24742672). Male mice display decreased locomotor activity and decreased energy expenditure relative to wild-type (PubMed:17327425). Mutant mice display normal revascularization after chronic limb ischemia caused by severing of blood vessels (PubMed:24742672). Hepatocytes from mice lacking both Adipor1 and Adipor2 show loss of adiponectin binding and lack of adiponectin-mediated activation of AMPK and Ppara (PubMed:17268472). Mice lacking both Adipor1 and Adipor2 display elevated glucose and insulin levels in blood plasma, indicative of glucose intolerance and insulin resistance (PubMed:17268472).3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Adiponectin receptor protein 1PRO_0000218828Add
BLAST

Proteomic databases

MaxQBiQ91VH1.
PRIDEiQ91VH1.

PTM databases

PhosphoSiteiQ91VH1.

Expressioni

Tissue specificityi

Detected in brain and quadriceps muscle (at protein level) (PubMed:17327425). Widely expressed (PubMed:12802337). Expressed in heart, kidney, liver, lung, skeletal muscle, white adipose tissue, brown adipose tissue, aorta and spleen (PubMed:12802337, PubMed:24742672). Weakly expressed in brain and testis (PubMed:12802337).4 Publications

Gene expression databases

BgeeiQ91VH1.
CleanExiMM_ADIPOR1.
ExpressionAtlasiQ91VH1. baseline and differential.
GenevisibleiQ91VH1. MM.

Interactioni

Subunit structurei

May form homooligomers and heterooligomers with ADIPOR2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
APPL1Q9UKG13EBI-992398,EBI-741243From a different organism.

Protein-protein interaction databases

IntActiQ91VH1. 2 interactions.
STRINGi10090.ENSMUSP00000027727.

Family & Domainsi

Domaini

The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.By similarity

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00530000062926.
HOGENOMiHOG000197115.
HOVERGENiHBG013916.
InParanoidiQ91VH1.
KOiK07297.
OMAiEQACPVP.
OrthoDBiEOG7BS49P.
PhylomeDBiQ91VH1.
TreeFamiTF313640.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91VH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHKGSAGA QGNGAPSGNR EADTVELAEL GPLLEEKGKR AASSPAKAEE
60 70 80 90 100
DQACPVPQEE EEEVRVLTLP LQAHHAMEKM EEFVYKVWEG RWRVIPYDVL
110 120 130 140 150
PDWLKDNDYL LHGHRPPMPS FRACFKSIFR IHTETGNIWT HLLGFVLFLF
160 170 180 190 200
LGILTMLRPN MYFMAPLQEK VVFGMFFLGA VLCLSFSWLF HTVYCHSEKV
210 220 230 240 250
SRTFSKLDYS GIALLIMGSF VPWLYYSFYC SPQPRLIYLS IVCVLGISAI
260 270 280 290 300
IVAQWDRFAT PKHRQTRAGV FLGLGLSGVV PTMHFTIAEG FVKATTVGQM
310 320 330 340 350
GWFFLMAVMY ITGAGLYAAR IPERFFPGKF DIWFQSHQIF HVLVVAAAFV
360 370
HFYGVSNLQE FRYGLEGGCT DDSLL
Length:375
Mass (Da):42,366
Last modified:December 1, 2001 - v1
Checksum:i0E72F81B5E9938CE
GO

Sequence cautioni

The sequence BAB28509.1 differs from that shown. Reason: Frameshift at position 376. This frameshift abolishes the stop codon.Curated
The sequence BAB28509.1 differs from that shown. Reason: Erroneous termination at position 353. Translated as Tyr.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012847 mRNA. Translation: BAB28509.1. Sequence problems.
BC014875 mRNA. Translation: AAH14875.1.
CCDSiCCDS15309.1.
RefSeqiNP_082596.2. NM_028320.4.
XP_006529951.1. XM_006529888.1.
UniGeneiMm.259976.

Genome annotation databases

EnsembliENSMUST00000027727; ENSMUSP00000027727; ENSMUSG00000026457.
ENSMUST00000112237; ENSMUSP00000107856; ENSMUSG00000026457.
GeneIDi72674.
KEGGimmu:72674.
UCSCiuc007crx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012847 mRNA. Translation: BAB28509.1. Sequence problems.
BC014875 mRNA. Translation: AAH14875.1.
CCDSiCCDS15309.1.
RefSeqiNP_082596.2. NM_028320.4.
XP_006529951.1. XM_006529888.1.
UniGeneiMm.259976.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91VH1. 2 interactions.
STRINGi10090.ENSMUSP00000027727.

Chemistry

GuidetoPHARMACOLOGYi649.

PTM databases

PhosphoSiteiQ91VH1.

Proteomic databases

MaxQBiQ91VH1.
PRIDEiQ91VH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027727; ENSMUSP00000027727; ENSMUSG00000026457.
ENSMUST00000112237; ENSMUSP00000107856; ENSMUSG00000026457.
GeneIDi72674.
KEGGimmu:72674.
UCSCiuc007crx.1. mouse.

Organism-specific databases

CTDi51094.
MGIiMGI:1919924. Adipor1.

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00530000062926.
HOGENOMiHOG000197115.
HOVERGENiHBG013916.
InParanoidiQ91VH1.
KOiK07297.
OMAiEQACPVP.
OrthoDBiEOG7BS49P.
PhylomeDBiQ91VH1.
TreeFamiTF313640.

Miscellaneous databases

ChiTaRSiAdipor1. mouse.
NextBioi336721.
PROiQ91VH1.
SOURCEiSearch...

Gene expression databases

BgeeiQ91VH1.
CleanExiMM_ADIPOR1.
ExpressionAtlasiQ91VH1. baseline and differential.
GenevisibleiQ91VH1. MM.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. Cited for: FUNCTION, TISSUE SPECIFICITY.
  4. Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.
  5. Cited for: DISRUPTION PHENOTYPE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. "Divergent roles for adiponectin receptor 1 (AdipoR1) and AdipoR2 in mediating revascularization and metabolic dysfunction in vivo."
    Parker-Duffen J.L., Nakamura K., Silver M., Zuriaga M.A., MacLauchlan S., Aprahamian T.R., Walsh K.
    J. Biol. Chem. 289:16200-16213(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiADR1_MOUSE
AccessioniPrimary (citable) accession number: Q91VH1
Secondary accession number(s): Q9CZA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.