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Q91VH1

- ADR1_MOUSE

UniProt

Q91VH1 - ADR1_MOUSE

Protein

Adiponectin receptor protein 1

Gene

Adipor1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.1 Publication

    GO - Molecular functioni

    1. adiponectin binding Source: MGI
    2. hormone binding Source: UniProtKB
    3. identical protein binding Source: MGI
    4. protein binding Source: IntAct
    5. protein heterodimerization activity Source: MGI
    6. receptor activity Source: MGI

    GO - Biological processi

    1. adiponectin-activated signaling pathway Source: MGI
    2. fatty acid oxidation Source: UniProtKB
    3. hormone-mediated signaling pathway Source: UniProtKB
    4. leptin-mediated signaling pathway Source: Ensembl
    5. negative regulation of cell growth Source: Ensembl
    6. positive regulation of insulin receptor signaling pathway Source: Ensembl
    7. positive regulation of JAK-STAT cascade Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adiponectin receptor protein 1
    Gene namesi
    Name:Adipor1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1919924. Adipor1.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity
    Note: Localized to the cell membrane and intracellular organelles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Adiponectin receptor protein 1PRO_0000218828Add
    BLAST

    Proteomic databases

    PRIDEiQ91VH1.

    PTM databases

    PhosphoSiteiQ91VH1.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed in heart, kidney, liver, lung, skeletal muscle and spleen. Weakly expressed in brain and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ91VH1.
    BgeeiQ91VH1.
    CleanExiMM_ADIPOR1.
    GenevestigatoriQ91VH1.

    Interactioni

    Subunit structurei

    May form homomultimer and heteromultimers.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    APPL1Q9UKG13EBI-992398,EBI-741243From a different organism.

    Protein-protein interaction databases

    IntActiQ91VH1. 2 interactions.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 136136CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini158 – 17013ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini192 – 20918CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini231 – 2355ExtracellularSequence Analysis
    Topological domaini257 – 26711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini289 – 2968ExtracellularSequence Analysis
    Topological domaini318 – 33114CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini353 – 37523ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei137 – 15721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei210 – 23021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei297 – 31721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei332 – 35221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ADIPOR family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1272.
    GeneTreeiENSGT00530000062926.
    HOGENOMiHOG000197115.
    HOVERGENiHBG013916.
    InParanoidiQ91VH1.
    KOiK07297.
    OMAiAAFIHFY.
    OrthoDBiEOG7BS49P.
    PhylomeDBiQ91VH1.
    TreeFamiTF313640.

    Family and domain databases

    InterProiIPR004254. HlyIII-related.
    [Graphical view]
    PANTHERiPTHR20855. PTHR20855. 1 hit.
    PfamiPF03006. HlyIII. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91VH1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSHKGSAGA QGNGAPSGNR EADTVELAEL GPLLEEKGKR AASSPAKAEE    50
    DQACPVPQEE EEEVRVLTLP LQAHHAMEKM EEFVYKVWEG RWRVIPYDVL 100
    PDWLKDNDYL LHGHRPPMPS FRACFKSIFR IHTETGNIWT HLLGFVLFLF 150
    LGILTMLRPN MYFMAPLQEK VVFGMFFLGA VLCLSFSWLF HTVYCHSEKV 200
    SRTFSKLDYS GIALLIMGSF VPWLYYSFYC SPQPRLIYLS IVCVLGISAI 250
    IVAQWDRFAT PKHRQTRAGV FLGLGLSGVV PTMHFTIAEG FVKATTVGQM 300
    GWFFLMAVMY ITGAGLYAAR IPERFFPGKF DIWFQSHQIF HVLVVAAAFV 350
    HFYGVSNLQE FRYGLEGGCT DDSLL 375
    Length:375
    Mass (Da):42,366
    Last modified:December 1, 2001 - v1
    Checksum:i0E72F81B5E9938CE
    GO

    Sequence cautioni

    The sequence BAB28509.1 differs from that shown. Reason: Frameshift at position 376. This frameshift abolishes the stop codon.
    The sequence BAB28509.1 differs from that shown. Reason: Erroneous termination at position 353. Translated as Tyr.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012847 mRNA. Translation: BAB28509.1. Sequence problems.
    BC014875 mRNA. Translation: AAH14875.1.
    CCDSiCCDS15309.1.
    RefSeqiNP_082596.2. NM_028320.3.
    XP_006529951.1. XM_006529888.1.
    UniGeneiMm.259976.

    Genome annotation databases

    EnsembliENSMUST00000027727; ENSMUSP00000027727; ENSMUSG00000026457.
    ENSMUST00000112237; ENSMUSP00000107856; ENSMUSG00000026457.
    GeneIDi72674.
    KEGGimmu:72674.
    UCSCiuc007crx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012847 mRNA. Translation: BAB28509.1 . Sequence problems.
    BC014875 mRNA. Translation: AAH14875.1 .
    CCDSi CCDS15309.1.
    RefSeqi NP_082596.2. NM_028320.3.
    XP_006529951.1. XM_006529888.1.
    UniGenei Mm.259976.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q91VH1. 2 interactions.

    Chemistry

    GuidetoPHARMACOLOGYi 649.

    PTM databases

    PhosphoSitei Q91VH1.

    Proteomic databases

    PRIDEi Q91VH1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027727 ; ENSMUSP00000027727 ; ENSMUSG00000026457 .
    ENSMUST00000112237 ; ENSMUSP00000107856 ; ENSMUSG00000026457 .
    GeneIDi 72674.
    KEGGi mmu:72674.
    UCSCi uc007crx.1. mouse.

    Organism-specific databases

    CTDi 51094.
    MGIi MGI:1919924. Adipor1.

    Phylogenomic databases

    eggNOGi COG1272.
    GeneTreei ENSGT00530000062926.
    HOGENOMi HOG000197115.
    HOVERGENi HBG013916.
    InParanoidi Q91VH1.
    KOi K07297.
    OMAi AAFIHFY.
    OrthoDBi EOG7BS49P.
    PhylomeDBi Q91VH1.
    TreeFami TF313640.

    Miscellaneous databases

    ChiTaRSi ADIPOR1. mouse.
    NextBioi 336721.
    PROi Q91VH1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91VH1.
    Bgeei Q91VH1.
    CleanExi MM_ADIPOR1.
    Genevestigatori Q91VH1.

    Family and domain databases

    InterProi IPR004254. HlyIII-related.
    [Graphical view ]
    PANTHERi PTHR20855. PTHR20855. 1 hit.
    Pfami PF03006. HlyIII. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    3. Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiADR1_MOUSE
    AccessioniPrimary (citable) accession number: Q91VH1
    Secondary accession number(s): Q9CZA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3