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Q91VF6 (COQA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Collagen alpha-1(XXVI) chain
Alternative name(s):
Alpha-1 type XXVI collagen
EMI domain-containing protein 2
Emilin and multimerin domain-containing protein 2
Short name=Emu2
Gene names
Name:Col26a1
Synonyms:Col26a, Emid2, Emu2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Homotrimer or heterotrimer.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Tissue specificity

Specifically expressed in the testis and ovary in adult tissues. Ref.1

Developmental stage

At E9.5 it is expressed in the somites and in mesenchymal cells of the head and the branchial arches. At E14.5 it is expressed in the surrounding mesenchyme of the kidney and the inner ear. Expression is also observed in the spinal nerves and ganglia, the mesenchyme of the skull, the diaphragm, and the skeletal muscles.

Post-translational modification

Hydroxylated on proline residues.

N-glycosylated.

Sequence similarities

Contains 2 collagen-like domains.

Contains 1 EMI domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q91VF6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q91VF6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     94-95: Missing.
Note: May be due to a competing acceptor splice site.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 440420Collagen alpha-1(XXVI) chain
PRO_0000007826

Regions

Domain52 – 12877EMI
Domain199 – 26769Collagen-like 1
Domain302 – 33433Collagen-like 2

Amino acid modifications

Glycosylation701N-linked (GlcNAc...) Potential
Glycosylation1321N-linked (GlcNAc...) Potential
Disulfide bond56 ↔ 118 By similarity
Disulfide bond83 ↔ 89 By similarity
Disulfide bond117 ↔ 126 By similarity

Natural variations

Alternative sequence94 – 952Missing in isoform 2.
VSP_008448

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 10843475F53A2BB0

FASTA44045,810
        10         20         30         40         50         60 
MKLVLLLPWA CCCLCGSALA TGFLYPFPAA ALQQHGYPEQ GAGSPGNGYS SRRHWCHHTV 

        70         80         90        100        110        120 
TRTVSCQVQN GSETVVQRVY QSCRWPGPCA NLVSYRTLIR PTYRVSYRTV TALEWRCCPG 

       130        140        150        160        170        180 
FTGSNCEEEC MNCTRLSDMS ERLTTLEAKV LLLEAAEQPS GPDNDLPPPQ STPPTWNEDF 

       190        200        210        220        230        240 
LPDAIPIAHP GPRRRRPTGP AGPPGQMGPP GPAGPPGSKG EQGQTGEKGP VGPPGLLGPP 

       250        260        270        280        290        300 
GPRGLPGEMG RPGPPGPPGP AGSPGLLPNT PQGVLYSLQT PTDKENGDSQ LNPAVVDTVL 

       310        320        330        340        350        360 
TGIPGPRGPP GPPGPPGPHG PPGPPGAPGS QGLVDERVVA RPSGEPSVKE EEDKASAAEG 

       370        380        390        400        410        420 
EGVQQLREAL KILAERVLIL EHMIGVHDPL ASPEGGSGQD AALRANLKMK RGGPRPDGIL 

       430        440 
AALLGPDPAQ KSADQAGDRK 

« Hide

Isoform 2 [UniParc].

Checksum: 39B82CC8401F88BD
Show »

FASTA43845,560

References

« Hide 'large scale' references
[1]"Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary."
Sato K., Yomogida K., Wada T., Yorihuzi T., Nishimune Y., Hosokawa N., Nagata K.
J. Biol. Chem. 277:37678-37684(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHARACTERIZATION, TISSUE SPECIFICITY.
Tissue: Testis.
[2]"Developmental expression and biochemical characterization of Emu family members."
Leimeister C., Steidl C., Schumacher N., Erhard S., Gessler M.
Dev. Biol. 249:204-218(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Olfactory epithelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB085837 mRNA. Translation: BAB96760.1.
AJ416092 mRNA. Translation: CAC94779.1.
BC075713 mRNA. Translation: AAH75713.1.
CCDSCCDS19755.1. [Q91VF6-1]
RefSeqNP_077794.2. NM_024474.2. [Q91VF6-1]
XP_006504424.1. XM_006504361.1. [Q91VF6-2]
UniGeneMm.295020.

3D structure databases

ProteinModelPortalQ91VF6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000052095.

PTM databases

PhosphoSiteQ91VF6.

Proteomic databases

PRIDEQ91VF6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000057497; ENSMUSP00000052095; ENSMUSG00000004415. [Q91VF6-1]
ENSMUST00000111103; ENSMUSP00000106732; ENSMUSG00000004415. [Q91VF6-2]
GeneID140709.
KEGGmmu:140709.
UCSCuc009aay.1. mouse. [Q91VF6-1]
uc009aaz.1. mouse. [Q91VF6-2]

Organism-specific databases

CTD136227.
MGIMGI:2155345. Col26a1.

Phylogenomic databases

eggNOGNOG74199.
GeneTreeENSGT00660000095314.
HOGENOMHOG000038011.
HOVERGENHBG096014.
InParanoidQ91VF6.
OMARWPGPCA.
OrthoDBEOG74R1RX.
PhylomeDBQ91VF6.
TreeFamTF336589.

Gene expression databases

BgeeQ91VF6.
CleanExMM_EMID2.
GenevestigatorQ91VF6.

Family and domain databases

InterProIPR008160. Collagen.
IPR011489. EMI_domain.
[Graphical view]
PfamPF01391. Collagen. 3 hits.
PF07546. EMI. 1 hit.
[Graphical view]
PROSITEPS51041. EMI. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio369943.
PROQ91VF6.
SOURCESearch...

Entry information

Entry nameCOQA1_MOUSE
AccessionPrimary (citable) accession number: Q91VF6
Secondary accession number(s): Q8K4P3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot