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Q91VF6

- COQA1_MOUSE

UniProt

Q91VF6 - COQA1_MOUSE

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Protein
Collagen alpha-1(XXVI) chain
Gene
Col26a1, Col26a, Emid2, Emu2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. positive regulation of cell-substrate adhesion Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199055. Collagen degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXVI) chain
Alternative name(s):
Alpha-1 type XXVI collagen
EMI domain-containing protein 2
Emilin and multimerin domain-containing protein 2
Short name:
Emu2
Gene namesi
Name:Col26a1
Synonyms:Col26a, Emid2, Emu2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2155345. Col26a1.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: MGI
  2. collagen trimer Source: UniProtKB-KW
  3. endoplasmic reticulum Source: MGI
  4. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 440420Collagen alpha-1(XXVI) chain
PRO_0000007826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 118 By similarity
Glycosylationi70 – 701N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi83 ↔ 89 By similarity
Disulfide bondi117 ↔ 126 By similarity
Glycosylationi132 – 1321N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Hydroxylated on proline residues.
N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PRIDEiQ91VF6.

PTM databases

PhosphoSiteiQ91VF6.

Expressioni

Tissue specificityi

Specifically expressed in the testis and ovary in adult tissues.1 Publication

Developmental stagei

At E9.5 it is expressed in the somites and in mesenchymal cells of the head and the branchial arches. At E14.5 it is expressed in the surrounding mesenchyme of the kidney and the inner ear. Expression is also observed in the spinal nerves and ganglia, the mesenchyme of the skull, the diaphragm, and the skeletal muscles.

Gene expression databases

BgeeiQ91VF6.
CleanExiMM_EMID2.
GenevestigatoriQ91VF6.

Interactioni

Subunit structurei

Homotrimer or heterotrimer.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052095.

Structurei

3D structure databases

ProteinModelPortaliQ91VF6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 12877EMI
Add
BLAST
Domaini199 – 26769Collagen-like 1
Add
BLAST
Domaini302 – 33433Collagen-like 2
Add
BLAST

Sequence similaritiesi

Contains 1 EMI domain.

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG74199.
GeneTreeiENSGT00660000095314.
HOGENOMiHOG000038011.
HOVERGENiHBG096014.
InParanoidiQ91VF6.
OMAiRWPGPCA.
OrthoDBiEOG74R1RX.
PhylomeDBiQ91VF6.
TreeFamiTF336589.

Family and domain databases

InterProiIPR008160. Collagen.
IPR011489. EMI_domain.
[Graphical view]
PfamiPF01391. Collagen. 3 hits.
PF07546. EMI. 1 hit.
[Graphical view]
PROSITEiPS51041. EMI. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91VF6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKLVLLLPWA CCCLCGSALA TGFLYPFPAA ALQQHGYPEQ GAGSPGNGYS    50
SRRHWCHHTV TRTVSCQVQN GSETVVQRVY QSCRWPGPCA NLVSYRTLIR 100
PTYRVSYRTV TALEWRCCPG FTGSNCEEEC MNCTRLSDMS ERLTTLEAKV 150
LLLEAAEQPS GPDNDLPPPQ STPPTWNEDF LPDAIPIAHP GPRRRRPTGP 200
AGPPGQMGPP GPAGPPGSKG EQGQTGEKGP VGPPGLLGPP GPRGLPGEMG 250
RPGPPGPPGP AGSPGLLPNT PQGVLYSLQT PTDKENGDSQ LNPAVVDTVL 300
TGIPGPRGPP GPPGPPGPHG PPGPPGAPGS QGLVDERVVA RPSGEPSVKE 350
EEDKASAAEG EGVQQLREAL KILAERVLIL EHMIGVHDPL ASPEGGSGQD 400
AALRANLKMK RGGPRPDGIL AALLGPDPAQ KSADQAGDRK 440
Length:440
Mass (Da):45,810
Last modified:December 1, 2001 - v1
Checksum:i10843475F53A2BB0
GO
Isoform 2 (identifier: Q91VF6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-95: Missing.

Note: May be due to a competing acceptor splice site.

Show »
Length:438
Mass (Da):45,560
Checksum:i39B82CC8401F88BD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei94 – 952Missing in isoform 2.
VSP_008448

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB085837 mRNA. Translation: BAB96760.1.
AJ416092 mRNA. Translation: CAC94779.1.
BC075713 mRNA. Translation: AAH75713.1.
CCDSiCCDS19755.1. [Q91VF6-1]
RefSeqiNP_077794.2. NM_024474.2. [Q91VF6-1]
XP_006504424.1. XM_006504361.1. [Q91VF6-2]
UniGeneiMm.295020.

Genome annotation databases

EnsembliENSMUST00000057497; ENSMUSP00000052095; ENSMUSG00000004415. [Q91VF6-1]
ENSMUST00000111103; ENSMUSP00000106732; ENSMUSG00000004415. [Q91VF6-2]
GeneIDi140709.
KEGGimmu:140709.
UCSCiuc009aay.1. mouse. [Q91VF6-1]
uc009aaz.1. mouse. [Q91VF6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB085837 mRNA. Translation: BAB96760.1 .
AJ416092 mRNA. Translation: CAC94779.1 .
BC075713 mRNA. Translation: AAH75713.1 .
CCDSi CCDS19755.1. [Q91VF6-1 ]
RefSeqi NP_077794.2. NM_024474.2. [Q91VF6-1 ]
XP_006504424.1. XM_006504361.1. [Q91VF6-2 ]
UniGenei Mm.295020.

3D structure databases

ProteinModelPortali Q91VF6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000052095.

PTM databases

PhosphoSitei Q91VF6.

Proteomic databases

PRIDEi Q91VF6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000057497 ; ENSMUSP00000052095 ; ENSMUSG00000004415 . [Q91VF6-1 ]
ENSMUST00000111103 ; ENSMUSP00000106732 ; ENSMUSG00000004415 . [Q91VF6-2 ]
GeneIDi 140709.
KEGGi mmu:140709.
UCSCi uc009aay.1. mouse. [Q91VF6-1 ]
uc009aaz.1. mouse. [Q91VF6-2 ]

Organism-specific databases

CTDi 136227.
MGIi MGI:2155345. Col26a1.

Phylogenomic databases

eggNOGi NOG74199.
GeneTreei ENSGT00660000095314.
HOGENOMi HOG000038011.
HOVERGENi HBG096014.
InParanoidi Q91VF6.
OMAi RWPGPCA.
OrthoDBi EOG74R1RX.
PhylomeDBi Q91VF6.
TreeFami TF336589.

Enzyme and pathway databases

Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199055. Collagen degradation.

Miscellaneous databases

NextBioi 369943.
PROi Q91VF6.
SOURCEi Search...

Gene expression databases

Bgeei Q91VF6.
CleanExi MM_EMID2.
Genevestigatori Q91VF6.

Family and domain databases

InterProi IPR008160. Collagen.
IPR011489. EMI_domain.
[Graphical view ]
Pfami PF01391. Collagen. 3 hits.
PF07546. EMI. 1 hit.
[Graphical view ]
PROSITEi PS51041. EMI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary."
    Sato K., Yomogida K., Wada T., Yorihuzi T., Nishimune Y., Hosokawa N., Nagata K.
    J. Biol. Chem. 277:37678-37684(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHARACTERIZATION, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "Developmental expression and biochemical characterization of Emu family members."
    Leimeister C., Steidl C., Schumacher N., Erhard S., Gessler M.
    Dev. Biol. 249:204-218(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiCOQA1_MOUSE
AccessioniPrimary (citable) accession number: Q91VF6
Secondary accession number(s): Q8K4P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi