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Q91VF6

- COQA1_MOUSE

UniProt

Q91VF6 - COQA1_MOUSE

Protein

Collagen alpha-1(XXVI) chain

Gene

Col26a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. positive regulation of cell-substrate adhesion Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.
    REACT_199055. Collagen degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Collagen alpha-1(XXVI) chain
    Alternative name(s):
    Alpha-1 type XXVI collagen
    EMI domain-containing protein 2
    Emilin and multimerin domain-containing protein 2
    Short name:
    Emu2
    Gene namesi
    Name:Col26a1
    Synonyms:Col26a, Emid2, Emu2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2155345. Col26a1.

    Subcellular locationi

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. endoplasmic reticulum Source: MGI
    3. Golgi apparatus Source: MGI
    4. proteinaceous extracellular matrix Source: MGI

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 440420Collagen alpha-1(XXVI) chainPRO_0000007826Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 118PROSITE-ProRule annotation
    Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi83 ↔ 89PROSITE-ProRule annotation
    Disulfide bondi117 ↔ 126PROSITE-ProRule annotation
    Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Hydroxylated on proline residues.
    N-glycosylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Hydroxylation

    Proteomic databases

    PRIDEiQ91VF6.

    PTM databases

    PhosphoSiteiQ91VF6.

    Expressioni

    Tissue specificityi

    Specifically expressed in the testis and ovary in adult tissues.1 Publication

    Developmental stagei

    At E9.5 it is expressed in the somites and in mesenchymal cells of the head and the branchial arches. At E14.5 it is expressed in the surrounding mesenchyme of the kidney and the inner ear. Expression is also observed in the spinal nerves and ganglia, the mesenchyme of the skull, the diaphragm, and the skeletal muscles.

    Gene expression databases

    BgeeiQ91VF6.
    CleanExiMM_EMID2.
    GenevestigatoriQ91VF6.

    Interactioni

    Subunit structurei

    Homotrimer or heterotrimer.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000052095.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91VF6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 12877EMIPROSITE-ProRule annotationAdd
    BLAST
    Domaini199 – 26769Collagen-like 1Add
    BLAST
    Domaini302 – 33433Collagen-like 2Add
    BLAST

    Sequence similaritiesi

    Contains 2 collagen-like domains.Curated
    Contains 1 EMI domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG74199.
    GeneTreeiENSGT00660000095314.
    HOGENOMiHOG000038011.
    HOVERGENiHBG096014.
    InParanoidiQ91VF6.
    OMAiRWPGPCA.
    OrthoDBiEOG74R1RX.
    PhylomeDBiQ91VF6.
    TreeFamiTF336589.

    Family and domain databases

    InterProiIPR008160. Collagen.
    IPR011489. EMI_domain.
    [Graphical view]
    PfamiPF01391. Collagen. 3 hits.
    PF07546. EMI. 1 hit.
    [Graphical view]
    PROSITEiPS51041. EMI. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q91VF6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKLVLLLPWA CCCLCGSALA TGFLYPFPAA ALQQHGYPEQ GAGSPGNGYS    50
    SRRHWCHHTV TRTVSCQVQN GSETVVQRVY QSCRWPGPCA NLVSYRTLIR 100
    PTYRVSYRTV TALEWRCCPG FTGSNCEEEC MNCTRLSDMS ERLTTLEAKV 150
    LLLEAAEQPS GPDNDLPPPQ STPPTWNEDF LPDAIPIAHP GPRRRRPTGP 200
    AGPPGQMGPP GPAGPPGSKG EQGQTGEKGP VGPPGLLGPP GPRGLPGEMG 250
    RPGPPGPPGP AGSPGLLPNT PQGVLYSLQT PTDKENGDSQ LNPAVVDTVL 300
    TGIPGPRGPP GPPGPPGPHG PPGPPGAPGS QGLVDERVVA RPSGEPSVKE 350
    EEDKASAAEG EGVQQLREAL KILAERVLIL EHMIGVHDPL ASPEGGSGQD 400
    AALRANLKMK RGGPRPDGIL AALLGPDPAQ KSADQAGDRK 440
    Length:440
    Mass (Da):45,810
    Last modified:December 1, 2001 - v1
    Checksum:i10843475F53A2BB0
    GO
    Isoform 2 (identifier: Q91VF6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         94-95: Missing.

    Note: May be due to a competing acceptor splice site.

    Show »
    Length:438
    Mass (Da):45,560
    Checksum:i39B82CC8401F88BD
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei94 – 952Missing in isoform 2. 2 PublicationsVSP_008448

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB085837 mRNA. Translation: BAB96760.1.
    AJ416092 mRNA. Translation: CAC94779.1.
    BC075713 mRNA. Translation: AAH75713.1.
    CCDSiCCDS19755.1. [Q91VF6-1]
    RefSeqiNP_077794.2. NM_024474.2. [Q91VF6-1]
    XP_006504424.1. XM_006504361.1. [Q91VF6-2]
    UniGeneiMm.295020.

    Genome annotation databases

    EnsembliENSMUST00000057497; ENSMUSP00000052095; ENSMUSG00000004415. [Q91VF6-1]
    ENSMUST00000111103; ENSMUSP00000106732; ENSMUSG00000004415. [Q91VF6-2]
    GeneIDi140709.
    KEGGimmu:140709.
    UCSCiuc009aay.1. mouse. [Q91VF6-1]
    uc009aaz.1. mouse. [Q91VF6-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB085837 mRNA. Translation: BAB96760.1 .
    AJ416092 mRNA. Translation: CAC94779.1 .
    BC075713 mRNA. Translation: AAH75713.1 .
    CCDSi CCDS19755.1. [Q91VF6-1 ]
    RefSeqi NP_077794.2. NM_024474.2. [Q91VF6-1 ]
    XP_006504424.1. XM_006504361.1. [Q91VF6-2 ]
    UniGenei Mm.295020.

    3D structure databases

    ProteinModelPortali Q91VF6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000052095.

    PTM databases

    PhosphoSitei Q91VF6.

    Proteomic databases

    PRIDEi Q91VF6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057497 ; ENSMUSP00000052095 ; ENSMUSG00000004415 . [Q91VF6-1 ]
    ENSMUST00000111103 ; ENSMUSP00000106732 ; ENSMUSG00000004415 . [Q91VF6-2 ]
    GeneIDi 140709.
    KEGGi mmu:140709.
    UCSCi uc009aay.1. mouse. [Q91VF6-1 ]
    uc009aaz.1. mouse. [Q91VF6-2 ]

    Organism-specific databases

    CTDi 136227.
    MGIi MGI:2155345. Col26a1.

    Phylogenomic databases

    eggNOGi NOG74199.
    GeneTreei ENSGT00660000095314.
    HOGENOMi HOG000038011.
    HOVERGENi HBG096014.
    InParanoidi Q91VF6.
    OMAi RWPGPCA.
    OrthoDBi EOG74R1RX.
    PhylomeDBi Q91VF6.
    TreeFami TF336589.

    Enzyme and pathway databases

    Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.
    REACT_199055. Collagen degradation.

    Miscellaneous databases

    NextBioi 369943.
    PROi Q91VF6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91VF6.
    CleanExi MM_EMID2.
    Genevestigatori Q91VF6.

    Family and domain databases

    InterProi IPR008160. Collagen.
    IPR011489. EMI_domain.
    [Graphical view ]
    Pfami PF01391. Collagen. 3 hits.
    PF07546. EMI. 1 hit.
    [Graphical view ]
    PROSITEi PS51041. EMI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary."
      Sato K., Yomogida K., Wada T., Yorihuzi T., Nishimune Y., Hosokawa N., Nagata K.
      J. Biol. Chem. 277:37678-37684(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHARACTERIZATION, TISSUE SPECIFICITY.
      Tissue: Testis.
    2. "Developmental expression and biochemical characterization of Emu family members."
      Leimeister C., Steidl C., Schumacher N., Erhard S., Gessler M.
      Dev. Biol. 249:204-218(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiCOQA1_MOUSE
    AccessioniPrimary (citable) accession number: Q91VF6
    Secondary accession number(s): Q8K4P3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3