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Protein

Collagen alpha-1(XXVI) chain

Gene

Col26a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. positive regulation of cell-substrate adhesion Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199055. Collagen degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXVI) chain
Alternative name(s):
Alpha-1 type XXVI collagen
EMI domain-containing protein 2
Emilin and multimerin domain-containing protein 2
Short name:
Emu2
Gene namesi
Name:Col26a1
Synonyms:Col26a, Emid2, Emu2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2155345. Col26a1.

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. endoplasmic reticulum Source: MGI
  3. extracellular matrix Source: MGI
  4. Golgi apparatus Source: MGI
  5. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 440420Collagen alpha-1(XXVI) chainPRO_0000007826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 118PROSITE-ProRule annotation
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi83 ↔ 89PROSITE-ProRule annotation
Disulfide bondi117 ↔ 126PROSITE-ProRule annotation
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Hydroxylated on proline residues.
N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiQ91VF6.
PRIDEiQ91VF6.

PTM databases

PhosphoSiteiQ91VF6.

Expressioni

Tissue specificityi

Specifically expressed in the testis and ovary in adult tissues.1 Publication

Developmental stagei

At E9.5 it is expressed in the somites and in mesenchymal cells of the head and the branchial arches. At E14.5 it is expressed in the surrounding mesenchyme of the kidney and the inner ear. Expression is also observed in the spinal nerves and ganglia, the mesenchyme of the skull, the diaphragm, and the skeletal muscles.

Gene expression databases

BgeeiQ91VF6.
CleanExiMM_EMID2.
GenevestigatoriQ91VF6.

Interactioni

Subunit structurei

Homotrimer or heterotrimer.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052095.

Structurei

3D structure databases

ProteinModelPortaliQ91VF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 12877EMIPROSITE-ProRule annotationAdd
BLAST
Domaini199 – 26769Collagen-like 1Add
BLAST
Domaini302 – 33433Collagen-like 2Add
BLAST

Sequence similaritiesi

Contains 2 collagen-like domains.Curated
Contains 1 EMI domain.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG74199.
GeneTreeiENSGT00660000095314.
HOGENOMiHOG000038011.
HOVERGENiHBG096014.
InParanoidiQ91VF6.
OMAiPCANLVS.
OrthoDBiEOG74R1RX.
PhylomeDBiQ91VF6.
TreeFamiTF336589.

Family and domain databases

InterProiIPR008160. Collagen.
IPR011489. EMI_domain.
[Graphical view]
PfamiPF01391. Collagen. 3 hits.
PF07546. EMI. 1 hit.
[Graphical view]
PROSITEiPS51041. EMI. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91VF6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLVLLLPWA CCCLCGSALA TGFLYPFPAA ALQQHGYPEQ GAGSPGNGYS
60 70 80 90 100
SRRHWCHHTV TRTVSCQVQN GSETVVQRVY QSCRWPGPCA NLVSYRTLIR
110 120 130 140 150
PTYRVSYRTV TALEWRCCPG FTGSNCEEEC MNCTRLSDMS ERLTTLEAKV
160 170 180 190 200
LLLEAAEQPS GPDNDLPPPQ STPPTWNEDF LPDAIPIAHP GPRRRRPTGP
210 220 230 240 250
AGPPGQMGPP GPAGPPGSKG EQGQTGEKGP VGPPGLLGPP GPRGLPGEMG
260 270 280 290 300
RPGPPGPPGP AGSPGLLPNT PQGVLYSLQT PTDKENGDSQ LNPAVVDTVL
310 320 330 340 350
TGIPGPRGPP GPPGPPGPHG PPGPPGAPGS QGLVDERVVA RPSGEPSVKE
360 370 380 390 400
EEDKASAAEG EGVQQLREAL KILAERVLIL EHMIGVHDPL ASPEGGSGQD
410 420 430 440
AALRANLKMK RGGPRPDGIL AALLGPDPAQ KSADQAGDRK
Length:440
Mass (Da):45,810
Last modified:December 1, 2001 - v1
Checksum:i10843475F53A2BB0
GO
Isoform 2 (identifier: Q91VF6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-95: Missing.

Note: May be due to a competing acceptor splice site.

Show »
Length:438
Mass (Da):45,560
Checksum:i39B82CC8401F88BD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei94 – 952Missing in isoform 2. 2 PublicationsVSP_008448

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085837 mRNA. Translation: BAB96760.1.
AJ416092 mRNA. Translation: CAC94779.1.
BC075713 mRNA. Translation: AAH75713.1.
CCDSiCCDS19755.1. [Q91VF6-1]
RefSeqiNP_077794.2. NM_024474.2. [Q91VF6-1]
XP_006504424.1. XM_006504361.1. [Q91VF6-2]
UniGeneiMm.295020.

Genome annotation databases

EnsembliENSMUST00000057497; ENSMUSP00000052095; ENSMUSG00000004415. [Q91VF6-1]
ENSMUST00000111103; ENSMUSP00000106732; ENSMUSG00000004415. [Q91VF6-2]
GeneIDi140709.
KEGGimmu:140709.
UCSCiuc009aay.1. mouse. [Q91VF6-1]
uc009aaz.1. mouse. [Q91VF6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085837 mRNA. Translation: BAB96760.1.
AJ416092 mRNA. Translation: CAC94779.1.
BC075713 mRNA. Translation: AAH75713.1.
CCDSiCCDS19755.1. [Q91VF6-1]
RefSeqiNP_077794.2. NM_024474.2. [Q91VF6-1]
XP_006504424.1. XM_006504361.1. [Q91VF6-2]
UniGeneiMm.295020.

3D structure databases

ProteinModelPortaliQ91VF6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052095.

PTM databases

PhosphoSiteiQ91VF6.

Proteomic databases

MaxQBiQ91VF6.
PRIDEiQ91VF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057497; ENSMUSP00000052095; ENSMUSG00000004415. [Q91VF6-1]
ENSMUST00000111103; ENSMUSP00000106732; ENSMUSG00000004415. [Q91VF6-2]
GeneIDi140709.
KEGGimmu:140709.
UCSCiuc009aay.1. mouse. [Q91VF6-1]
uc009aaz.1. mouse. [Q91VF6-2]

Organism-specific databases

CTDi136227.
MGIiMGI:2155345. Col26a1.

Phylogenomic databases

eggNOGiNOG74199.
GeneTreeiENSGT00660000095314.
HOGENOMiHOG000038011.
HOVERGENiHBG096014.
InParanoidiQ91VF6.
OMAiPCANLVS.
OrthoDBiEOG74R1RX.
PhylomeDBiQ91VF6.
TreeFamiTF336589.

Enzyme and pathway databases

ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199055. Collagen degradation.

Miscellaneous databases

NextBioi369943.
PROiQ91VF6.
SOURCEiSearch...

Gene expression databases

BgeeiQ91VF6.
CleanExiMM_EMID2.
GenevestigatoriQ91VF6.

Family and domain databases

InterProiIPR008160. Collagen.
IPR011489. EMI_domain.
[Graphical view]
PfamiPF01391. Collagen. 3 hits.
PF07546. EMI. 1 hit.
[Graphical view]
PROSITEiPS51041. EMI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary."
    Sato K., Yomogida K., Wada T., Yorihuzi T., Nishimune Y., Hosokawa N., Nagata K.
    J. Biol. Chem. 277:37678-37684(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHARACTERIZATION, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "Developmental expression and biochemical characterization of Emu family members."
    Leimeister C., Steidl C., Schumacher N., Erhard S., Gessler M.
    Dev. Biol. 249:204-218(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiCOQA1_MOUSE
AccessioniPrimary (citable) accession number: Q91VF6
Secondary accession number(s): Q8K4P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 1, 2001
Last modified: February 4, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.