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Q91VF2

- HNMT_MOUSE

UniProt

Q91VF2 - HNMT_MOUSE

Protein

Histamine N-methyltransferase

Gene

Hnmt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.PROSITE-ProRule annotation

    Kineticsi

    1. KM=5.8 µM for S-adenosyl-L-methionine1 Publication
    2. KM=5.3 µM for histamine1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei28 – 281SubstratePROSITE-ProRule annotation
    Binding sitei60 – 601S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
    Binding sitei89 – 891S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei94 – 941S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei120 – 1201S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
    Binding sitei143 – 1431S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
    Binding sitei284 – 2841SubstratePROSITE-ProRule annotation

    GO - Molecular functioni

    1. histamine N-methyltransferase activity Source: UniProtKB-EC
    2. N-methyltransferase activity Source: MGI

    GO - Biological processi

    1. brain development Source: Ensembl
    2. hyperosmotic response Source: Ensembl
    3. regulation of neurotransmitter levels Source: MGI
    4. response to amine Source: Ensembl
    5. response to cocaine Source: Ensembl
    6. response to glucocorticoid Source: Ensembl
    7. response to interleukin-1 Source: Ensembl
    8. response to tumor cell Source: Ensembl

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histamine N-methyltransferase (EC:2.1.1.8)
    Short name:
    HMT
    Gene namesi
    Name:Hnmt
    Synonyms:Hmt
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2153181. Hnmt.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. neuron projection Source: Ensembl
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295Histamine N-methyltransferasePRO_0000084022Add
    BLAST

    Proteomic databases

    MaxQBiQ91VF2.
    PaxDbiQ91VF2.
    PRIDEiQ91VF2.

    PTM databases

    PhosphoSiteiQ91VF2.

    Expressioni

    Gene expression databases

    BgeeiQ91VF2.
    CleanExiMM_HNMT.
    GenevestigatoriQ91VF2.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000110141.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91VF2.
    SMRiQ91VF2. Positions 5-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG39680.
    GeneTreeiENSGT00390000002862.
    HOGENOMiHOG000231790.
    HOVERGENiHBG051914.
    InParanoidiQ91VF2.
    KOiK00546.
    OMAiMDISDCF.
    OrthoDBiEOG7Z69CQ.
    PhylomeDBiQ91VF2.
    TreeFamiTF331080.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR016673. Histamine_N-methyltransferase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PIRSFiPIRSF016616. HHMT. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51597. SAM_HNMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91VF2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASCMRSLFS DQGRYVESFR RFLNNSTEHQ CMQEFMDKKL PGIIARIGEA    50
    KAEIKILSVG GGAGEVDLQI LSKVQAQYPG ICINNEVVEP SAEQIVKYKE 100
    LVAKTSNMEN IKFSWHKETS SEYQKRMLEE EEEPPKWDFI HMIQMLYYVK 150
    DIPATLKFFH GLLAASAKIL IILVSGTSGW EKLWKKYGSR LPRDDLCQYV 200
    TSSDLAQILD DLGIKYECYD LVSTMDITDC FIDGNENGDL LWDFLTETCN 250
    FSKTAPLDLK AEIMKDLQEP EFSVKKEGKV LFNNNLSFIV VEANV 295
    Length:295
    Mass (Da):33,665
    Last modified:December 1, 2001 - v1
    Checksum:i04FA324ED14A51CA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF297037 mRNA. Translation: AAL09305.1.
    AF298150
    , AF297039, AF297040, AF297041, AF297042, AF297043 Genomic DNA. Translation: AAL09306.1.
    AB070523 Genomic DNA. Translation: BAB84320.1.
    AB070524 mRNA. Translation: BAB84318.1.
    AK050129 mRNA. Translation: BAC34081.1.
    AK160131 mRNA. Translation: BAE35648.1.
    BC033928 mRNA. Translation: AAH33928.1.
    CCDSiCCDS15731.1.
    RefSeqiNP_536710.1. NM_080462.2.
    XP_006497734.1. XM_006497671.1.
    UniGeneiMm.33120.

    Genome annotation databases

    EnsembliENSMUST00000051416; ENSMUSP00000062747; ENSMUSG00000026986.
    ENSMUST00000114497; ENSMUSP00000110141; ENSMUSG00000026986.
    ENSMUST00000114498; ENSMUSP00000110142; ENSMUSG00000026986.
    GeneIDi140483.
    KEGGimmu:140483.
    UCSCiuc008iok.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF297037 mRNA. Translation: AAL09305.1 .
    AF298150
    , AF297039 , AF297040 , AF297041 , AF297042 , AF297043 Genomic DNA. Translation: AAL09306.1 .
    AB070523 Genomic DNA. Translation: BAB84320.1 .
    AB070524 mRNA. Translation: BAB84318.1 .
    AK050129 mRNA. Translation: BAC34081.1 .
    AK160131 mRNA. Translation: BAE35648.1 .
    BC033928 mRNA. Translation: AAH33928.1 .
    CCDSi CCDS15731.1.
    RefSeqi NP_536710.1. NM_080462.2.
    XP_006497734.1. XM_006497671.1.
    UniGenei Mm.33120.

    3D structure databases

    ProteinModelPortali Q91VF2.
    SMRi Q91VF2. Positions 5-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000110141.

    PTM databases

    PhosphoSitei Q91VF2.

    Proteomic databases

    MaxQBi Q91VF2.
    PaxDbi Q91VF2.
    PRIDEi Q91VF2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000051416 ; ENSMUSP00000062747 ; ENSMUSG00000026986 .
    ENSMUST00000114497 ; ENSMUSP00000110141 ; ENSMUSG00000026986 .
    ENSMUST00000114498 ; ENSMUSP00000110142 ; ENSMUSG00000026986 .
    GeneIDi 140483.
    KEGGi mmu:140483.
    UCSCi uc008iok.2. mouse.

    Organism-specific databases

    CTDi 3176.
    MGIi MGI:2153181. Hnmt.

    Phylogenomic databases

    eggNOGi NOG39680.
    GeneTreei ENSGT00390000002862.
    HOGENOMi HOG000231790.
    HOVERGENi HBG051914.
    InParanoidi Q91VF2.
    KOi K00546.
    OMAi MDISDCF.
    OrthoDBi EOG7Z69CQ.
    PhylomeDBi Q91VF2.
    TreeFami TF331080.

    Miscellaneous databases

    NextBioi 369786.
    PROi Q91VF2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91VF2.
    CleanExi MM_HNMT.
    Genevestigatori Q91VF2.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR016673. Histamine_N-methyltransferase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PIRSFi PIRSF016616. HHMT. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51597. SAM_HNMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse histamine N-methyltransferase: cDNA cloning, expression, gene cloning and chromosomal localization."
      Wang L., Yan L., McGuire C., Kozak C.A., Wang M., Kim U.J., Siciliano M., Weinshilboum R.M.
      Inflamm. Res. 50:300-308(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], BIOPHYSICOCHEMICAL PROPERTIES.
      Strain: BALB/c.
      Tissue: Liver.
    2. "Genomic structure of the rat and mouse histamine N-methyltransferase gene."
      Kitanaka N., Kitanaka J., Oue T., Tada Y., Tanaka T., Takemura M.
      Jpn. J. Pharmacol. 88:85-92(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: 129/Sv and ddY.
      Tissue: Liver.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum and Liver.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiHNMT_MOUSE
    AccessioniPrimary (citable) accession number: Q91VF2
    Secondary accession number(s): Q3TVH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3