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Q91VF2

- HNMT_MOUSE

UniProt

Q91VF2 - HNMT_MOUSE

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Protein

Histamine N-methyltransferase

Gene

Hnmt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.PROSITE-ProRule annotation

Kineticsi

  1. KM=5.8 µM for S-adenosyl-L-methionine1 Publication
  2. KM=5.3 µM for histamine1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281SubstratePROSITE-ProRule annotation
Binding sitei60 – 601S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei89 – 891S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei94 – 941S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei120 – 1201S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
Binding sitei143 – 1431S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei284 – 2841SubstratePROSITE-ProRule annotation

GO - Molecular functioni

  1. histamine N-methyltransferase activity Source: UniProtKB-EC
  2. N-methyltransferase activity Source: MGI

GO - Biological processi

  1. brain development Source: Ensembl
  2. hyperosmotic response Source: Ensembl
  3. regulation of neurotransmitter levels Source: MGI
  4. response to amine Source: Ensembl
  5. response to cocaine Source: Ensembl
  6. response to glucocorticoid Source: Ensembl
  7. response to interleukin-1 Source: Ensembl
  8. response to tumor cell Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine N-methyltransferase (EC:2.1.1.8)
Short name:
HMT
Gene namesi
Name:Hnmt
Synonyms:Hmt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2153181. Hnmt.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
  3. neuron projection Source: Ensembl
  4. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Histamine N-methyltransferasePRO_0000084022Add
BLAST

Proteomic databases

MaxQBiQ91VF2.
PaxDbiQ91VF2.
PRIDEiQ91VF2.

PTM databases

PhosphoSiteiQ91VF2.

Expressioni

Gene expression databases

BgeeiQ91VF2.
CleanExiMM_HNMT.
ExpressionAtlasiQ91VF2. baseline and differential.
GenevestigatoriQ91VF2.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110141.

Structurei

3D structure databases

ProteinModelPortaliQ91VF2.
SMRiQ91VF2. Positions 5-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG39680.
GeneTreeiENSGT00390000002862.
HOGENOMiHOG000231790.
HOVERGENiHBG051914.
InParanoidiQ91VF2.
KOiK00546.
OMAiMDISDCF.
OrthoDBiEOG7Z69CQ.
PhylomeDBiQ91VF2.
TreeFamiTF331080.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PIRSFiPIRSF016616. HHMT. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51597. SAM_HNMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91VF2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASCMRSLFS DQGRYVESFR RFLNNSTEHQ CMQEFMDKKL PGIIARIGEA
60 70 80 90 100
KAEIKILSVG GGAGEVDLQI LSKVQAQYPG ICINNEVVEP SAEQIVKYKE
110 120 130 140 150
LVAKTSNMEN IKFSWHKETS SEYQKRMLEE EEEPPKWDFI HMIQMLYYVK
160 170 180 190 200
DIPATLKFFH GLLAASAKIL IILVSGTSGW EKLWKKYGSR LPRDDLCQYV
210 220 230 240 250
TSSDLAQILD DLGIKYECYD LVSTMDITDC FIDGNENGDL LWDFLTETCN
260 270 280 290
FSKTAPLDLK AEIMKDLQEP EFSVKKEGKV LFNNNLSFIV VEANV
Length:295
Mass (Da):33,665
Last modified:December 1, 2001 - v1
Checksum:i04FA324ED14A51CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297037 mRNA. Translation: AAL09305.1.
AF298150
, AF297039, AF297040, AF297041, AF297042, AF297043 Genomic DNA. Translation: AAL09306.1.
AB070523 Genomic DNA. Translation: BAB84320.1.
AB070524 mRNA. Translation: BAB84318.1.
AK050129 mRNA. Translation: BAC34081.1.
AK160131 mRNA. Translation: BAE35648.1.
BC033928 mRNA. Translation: AAH33928.1.
CCDSiCCDS15731.1.
RefSeqiNP_536710.1. NM_080462.2.
XP_006497734.1. XM_006497671.1.
UniGeneiMm.33120.

Genome annotation databases

EnsembliENSMUST00000051416; ENSMUSP00000062747; ENSMUSG00000026986.
ENSMUST00000114497; ENSMUSP00000110141; ENSMUSG00000026986.
ENSMUST00000114498; ENSMUSP00000110142; ENSMUSG00000026986.
GeneIDi140483.
KEGGimmu:140483.
UCSCiuc008iok.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297037 mRNA. Translation: AAL09305.1 .
AF298150
, AF297039 , AF297040 , AF297041 , AF297042 , AF297043 Genomic DNA. Translation: AAL09306.1 .
AB070523 Genomic DNA. Translation: BAB84320.1 .
AB070524 mRNA. Translation: BAB84318.1 .
AK050129 mRNA. Translation: BAC34081.1 .
AK160131 mRNA. Translation: BAE35648.1 .
BC033928 mRNA. Translation: AAH33928.1 .
CCDSi CCDS15731.1.
RefSeqi NP_536710.1. NM_080462.2.
XP_006497734.1. XM_006497671.1.
UniGenei Mm.33120.

3D structure databases

ProteinModelPortali Q91VF2.
SMRi Q91VF2. Positions 5-293.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000110141.

PTM databases

PhosphoSitei Q91VF2.

Proteomic databases

MaxQBi Q91VF2.
PaxDbi Q91VF2.
PRIDEi Q91VF2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000051416 ; ENSMUSP00000062747 ; ENSMUSG00000026986 .
ENSMUST00000114497 ; ENSMUSP00000110141 ; ENSMUSG00000026986 .
ENSMUST00000114498 ; ENSMUSP00000110142 ; ENSMUSG00000026986 .
GeneIDi 140483.
KEGGi mmu:140483.
UCSCi uc008iok.2. mouse.

Organism-specific databases

CTDi 3176.
MGIi MGI:2153181. Hnmt.

Phylogenomic databases

eggNOGi NOG39680.
GeneTreei ENSGT00390000002862.
HOGENOMi HOG000231790.
HOVERGENi HBG051914.
InParanoidi Q91VF2.
KOi K00546.
OMAi MDISDCF.
OrthoDBi EOG7Z69CQ.
PhylomeDBi Q91VF2.
TreeFami TF331080.

Miscellaneous databases

NextBioi 369786.
PROi Q91VF2.
SOURCEi Search...

Gene expression databases

Bgeei Q91VF2.
CleanExi MM_HNMT.
ExpressionAtlasi Q91VF2. baseline and differential.
Genevestigatori Q91VF2.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PIRSFi PIRSF016616. HHMT. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51597. SAM_HNMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse histamine N-methyltransferase: cDNA cloning, expression, gene cloning and chromosomal localization."
    Wang L., Yan L., McGuire C., Kozak C.A., Wang M., Kim U.J., Siciliano M., Weinshilboum R.M.
    Inflamm. Res. 50:300-308(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], BIOPHYSICOCHEMICAL PROPERTIES.
    Strain: BALB/c.
    Tissue: Liver.
  2. "Genomic structure of the rat and mouse histamine N-methyltransferase gene."
    Kitanaka N., Kitanaka J., Oue T., Tada Y., Tanaka T., Takemura M.
    Jpn. J. Pharmacol. 88:85-92(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv and ddY.
    Tissue: Liver.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Liver.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiHNMT_MOUSE
AccessioniPrimary (citable) accession number: Q91VF2
Secondary accession number(s): Q3TVH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3