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Q91VE3

- KLK7_MOUSE

UniProt

Q91VE3 - KLK7_MOUSE

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Protein

Kallikrein-7

Gene
Klk7, Prss6, Scce
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.

Catalytic activityi

Cleavage of proteins with aromatic side chains in the P1 position.

Enzyme regulationi

Inhibited by Zn2+ and Cu2+ at low micromolar concentrations. Inhibited by SERPINA12 By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661Charge relay system By similarity
Sitei105 – 1051Major binding site for inhibitory zinc or copper By similarity
Active sitei108 – 1081Charge relay system By similarity
Active sitei201 – 2011Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiREACT_199052. Degradation of the extracellular matrix.

Protein family/group databases

MEROPSiS01.300.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-7 (EC:3.4.21.117)
Alternative name(s):
Serine protease 6
Stratum corneum chymotryptic enzyme
Thymopsin
Gene namesi
Name:Klk7
Synonyms:Prss6, Scce
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1346336. Klk7.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. epidermal lamellar body Source: Ensembl
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Propeptidei22 – 254Activation peptide By similarityPRO_0000027944
Chaini26 – 249224Kallikrein-7 By similarityPRO_0000027945Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 161 By similarity
Disulfide bondi51 ↔ 67 By similarity
Disulfide bondi133 ↔ 235 By similarity
Disulfide bondi140 ↔ 207 By similarity
Disulfide bondi172 ↔ 186 By similarity
Disulfide bondi197 ↔ 222 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiQ91VE3.
PRIDEiQ91VE3.

PTM databases

PhosphoSiteiQ91VE3.

Expressioni

Tissue specificityi

Expressed in skin and, at lower levels, in lung, kidney, brain, heart and spleen. In skin, expressed in high suprabasal keratinocytes and in the luminal parts of hair follicles. Not detected in liver and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ91VE3.
GenevestigatoriQ91VE3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032955.

Structurei

3D structure databases

ProteinModelPortaliQ91VE3.
SMRiQ91VE3. Positions 26-249.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 246221Serine protease By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00750000117409.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ91VE3.
KOiK08668.
OMAiVLVNERW.
OrthoDBiEOG75B84T.
PhylomeDBiQ91VE3.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VE3-1 [UniParc]FASTAAdd to Basket

« Hide

MGVWLLSLIT VLLSLALETA GQGERIIDGY KCKEGSHPWQ VALLKGNQLH    50
CGGVLVDKYW VLTAAHCKMG QYQVQLGSDK IGDQSAQKIK ATKSFRHPGY 100
STKTHVNDIM LVRLDEPVKM SSKVEAVQLP EHCEPPGTSC TVSGWGTTTS 150
PDVTFPSDLM CSDVKLISSR ECKKVYKDLL GKTMLCAGIP DSKTNTCNGD 200
SGGPLVCNDT LQGLVSWGTY PCGQPNDPGV YTQVCKYKRW VMETMKTHR 249
Length:249
Mass (Da):27,257
Last modified:December 1, 2001 - v1
Checksum:i0D4E380F12D14F87
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti215 – 2173VSW → ASR in AAF01139. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB008371 mRNA. Translation: BAB55604.1.
AF339930 Genomic DNA. Translation: AAK69652.1.
AK029477 mRNA. Translation: BAC26467.1.
AK077406 mRNA. Translation: BAC36787.1.
BC027823 mRNA. Translation: AAH27823.1.
AF124299 mRNA. Translation: AAF01139.1.
CCDSiCCDS21183.1.
RefSeqiNP_036002.1. NM_011872.2.
UniGeneiMm.251227.

Genome annotation databases

EnsembliENSMUST00000032955; ENSMUSP00000032955; ENSMUSG00000030713.
GeneIDi23993.
KEGGimmu:23993.
UCSCiuc009gnt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB008371 mRNA. Translation: BAB55604.1 .
AF339930 Genomic DNA. Translation: AAK69652.1 .
AK029477 mRNA. Translation: BAC26467.1 .
AK077406 mRNA. Translation: BAC36787.1 .
BC027823 mRNA. Translation: AAH27823.1 .
AF124299 mRNA. Translation: AAF01139.1 .
CCDSi CCDS21183.1.
RefSeqi NP_036002.1. NM_011872.2.
UniGenei Mm.251227.

3D structure databases

ProteinModelPortali Q91VE3.
SMRi Q91VE3. Positions 26-249.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000032955.

Protein family/group databases

MEROPSi S01.300.

PTM databases

PhosphoSitei Q91VE3.

Proteomic databases

PaxDbi Q91VE3.
PRIDEi Q91VE3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032955 ; ENSMUSP00000032955 ; ENSMUSG00000030713 .
GeneIDi 23993.
KEGGi mmu:23993.
UCSCi uc009gnt.1. mouse.

Organism-specific databases

CTDi 5650.
MGIi MGI:1346336. Klk7.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00750000117409.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi Q91VE3.
KOi K08668.
OMAi VLVNERW.
OrthoDBi EOG75B84T.
PhylomeDBi Q91VE3.
TreeFami TF331065.

Enzyme and pathway databases

Reactomei REACT_199052. Degradation of the extracellular matrix.

Miscellaneous databases

NextBioi 303901.
PROi Q91VE3.
SOURCEi Search...

Gene expression databases

Bgeei Q91VE3.
Genevestigatori Q91VE3.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel cDNA cloning of mouse serine protease, thymopsin."
    Yamaguchi N.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thymus.
  2. "Epidermal overexpression of stratum corneum chymotryptic enzyme in mice; a model for chronic ithchy dermatitis."
    Hansson L., Baeckman A., Ny A., Edlund M., Edholm E., Tornell J., Wallbrandt P., Egelrud T.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. "Molecular cloning and tissue expression of the murine analog to human stratum corneum chymotryptic enzyme."
    Baeckman A., Stranden P., Brattsand M., Hansson L., Egelrud T.
    J. Invest. Dermatol. 113:152-155(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-234, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Tail.

Entry informationi

Entry nameiKLK7_MOUSE
AccessioniPrimary (citable) accession number: Q91VE3
Secondary accession number(s): Q9R048
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi