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Protein

Beta-defensin 6

Gene

Defb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has potent antibacterial activity against E.coli (ATCC 25922).1 Publication

GO - Biological processi

  • defense response to Gram-negative bacterium Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 6
Short name:
BD-6
Short name:
mBD-6
Alternative name(s):
Defensin, beta 6
Gene namesi
Name:Defb6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2151044. Defb6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000693223 – 63Beta-defensin 6Add BLAST41

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi31 ↔ 59By similarity
Disulfide bondi38 ↔ 52By similarity
Disulfide bondi42 ↔ 60By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ91VD6.
PRIDEiQ91VD6.

Expressioni

Tissue specificityi

Predominantly expressed in skeletal muscle, also expressed in esophagus, tongue, and trachea. Also expressed in lung when induced by lipopolysaccharide.1 Publication

Inductioni

Expressed constitutively and induced by lipopolysaccharide (LPS).

Gene expression databases

BgeeiENSMUSG00000050756.
CleanExiMM_DEFB6.
ExpressionAtlasiQ91VD6. baseline and differential.
GenevisibleiQ91VD6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060836.

Structurei

3D structure databases

ProteinModelPortaliQ91VD6.
SMRiQ91VD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00830000129362.
HOGENOMiHOG000015465.
HOVERGENiHBG004834.
InParanoidiQ91VD6.
OrthoDBiEOG091G16FK.
PhylomeDBiQ91VD6.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIHYLLFAF ILVMLSPLAA FSQLINSPVT CMSYGGSCQR SCNGGFRLGG
60
HCGHPKIRCC RRK
Length:63
Mass (Da):6,977
Last modified:December 1, 2001 - v1
Checksum:i15FDAB06429D924E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063110 Genomic DNA. Translation: BAB61109.1.
AB063109 mRNA. Translation: BAB61108.1.
CCDSiCCDS40255.1.
RefSeqiNP_473415.1. NM_054074.1.
UniGeneiMm.358822.

Genome annotation databases

EnsembliENSMUST00000063112; ENSMUSP00000060836; ENSMUSG00000050756.
GeneIDi116746.
KEGGimmu:116746.
UCSCiuc009lal.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063110 Genomic DNA. Translation: BAB61109.1.
AB063109 mRNA. Translation: BAB61108.1.
CCDSiCCDS40255.1.
RefSeqiNP_473415.1. NM_054074.1.
UniGeneiMm.358822.

3D structure databases

ProteinModelPortaliQ91VD6.
SMRiQ91VD6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060836.

Proteomic databases

PaxDbiQ91VD6.
PRIDEiQ91VD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063112; ENSMUSP00000060836; ENSMUSG00000050756.
GeneIDi116746.
KEGGimmu:116746.
UCSCiuc009lal.1. mouse.

Organism-specific databases

CTDi116746.
MGIiMGI:2151044. Defb6.

Phylogenomic databases

GeneTreeiENSGT00830000129362.
HOGENOMiHOG000015465.
HOVERGENiHBG004834.
InParanoidiQ91VD6.
OrthoDBiEOG091G16FK.
PhylomeDBiQ91VD6.

Miscellaneous databases

PROiQ91VD6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050756.
CleanExiMM_DEFB6.
ExpressionAtlasiQ91VD6. baseline and differential.
GenevisibleiQ91VD6. MM.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEFB6_MOUSE
AccessioniPrimary (citable) accession number: Q91VD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.