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Protein

Protein phosphatase 1 regulatory subunit 14A

Gene

Ppp1r14a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to drug Source: MGI
  • regulation of phosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-5625740. RHO GTPases activate PKNs.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 14A
Alternative name(s):
17 kDa PKC-potentiated inhibitory protein of PP1
Protein kinase C-potentiated inhibitor protein of 17 kDa
Short name:
CPI-17
Gene namesi
Name:Ppp1r14a
Synonyms:Cpi17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1931139. Ppp1r14a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147Protein phosphatase 1 regulatory subunit 14APRO_0000071487Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261PhosphoserineCombined sources
Modified residuei38 – 381Phosphothreonine; by PKCBy similarity
Modified residuei128 – 1281PhosphoserineBy similarity
Modified residuei136 – 1361PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91VC7.
PaxDbiQ91VC7.
PRIDEiQ91VC7.

PTM databases

iPTMnetiQ91VC7.
PhosphoSiteiQ91VC7.

Expressioni

Gene expression databases

BgeeiQ91VC7.
GenevisibleiQ91VC7. MM.

Interactioni

Protein-protein interaction databases

IntActiQ91VC7. 1 interaction.
MINTiMINT-4108269.
STRINGi10090.ENSMUSP00000035642.

Structurei

3D structure databases

ProteinModelPortaliQ91VC7.
SMRiQ91VC7. Positions 22-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni35 – 12086InhibitoryAdd
BLAST

Sequence similaritiesi

Belongs to the PP1 inhibitor family.Curated

Phylogenomic databases

eggNOGiENOG410IZE6. Eukaryota.
ENOG4111Q1J. LUCA.
GeneTreeiENSGT00390000003608.
HOGENOMiHOG000231993.
HOVERGENiHBG054419.
InParanoidiQ91VC7.
KOiK12328.
OMAiLHKQPGF.
OrthoDBiEOG7RNK21.
PhylomeDBiQ91VC7.
TreeFamiTF105546.

Family and domain databases

Gene3Di1.10.150.220. 1 hit.
InterProiIPR008025. PP1_inhibitor.
[Graphical view]
PANTHERiPTHR16188. PTHR16188. 1 hit.
PfamiPF05361. PP1_inhibitor. 1 hit.
[Graphical view]
SUPFAMiSSF81790. SSF81790. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91VC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQRLGKRV LSKLQSPSRA RGPGGSPSGL QKRHARVTVK YDRRELQRRL
60 70 80 90 100
DVEKWIDGCL EELYRGRESD MPDEVNIDEL LELDSEEERC RKIQGLLEAC
110 120 130 140
ANPTEDFVQE LLAKLRGLHK QPGFPQPSPS DDPSLSPRQD RAHTAPP
Length:147
Mass (Da):16,649
Last modified:December 1, 2001 - v1
Checksum:i1E29065ACEB39C4D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131A → G in AAK35214 (Ref. 2) Curated
Sequence conflicti135 – 1351L → P in AAK35214 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050672 mRNA. Translation: AAL25830.1.
AF352573 mRNA. Translation: AAK35214.1.
BC010832 mRNA. Translation: AAH10832.1.
CCDSiCCDS21070.1.
RefSeqiNP_081007.2. NM_026731.3.
UniGeneiMm.2343.

Genome annotation databases

EnsembliENSMUST00000048187; ENSMUSP00000035642; ENSMUSG00000037166.
GeneIDi68458.
KEGGimmu:68458.
UCSCiuc009gbn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050672 mRNA. Translation: AAL25830.1.
AF352573 mRNA. Translation: AAK35214.1.
BC010832 mRNA. Translation: AAH10832.1.
CCDSiCCDS21070.1.
RefSeqiNP_081007.2. NM_026731.3.
UniGeneiMm.2343.

3D structure databases

ProteinModelPortaliQ91VC7.
SMRiQ91VC7. Positions 22-120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91VC7. 1 interaction.
MINTiMINT-4108269.
STRINGi10090.ENSMUSP00000035642.

PTM databases

iPTMnetiQ91VC7.
PhosphoSiteiQ91VC7.

Proteomic databases

MaxQBiQ91VC7.
PaxDbiQ91VC7.
PRIDEiQ91VC7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048187; ENSMUSP00000035642; ENSMUSG00000037166.
GeneIDi68458.
KEGGimmu:68458.
UCSCiuc009gbn.1. mouse.

Organism-specific databases

CTDi94274.
MGIiMGI:1931139. Ppp1r14a.

Phylogenomic databases

eggNOGiENOG410IZE6. Eukaryota.
ENOG4111Q1J. LUCA.
GeneTreeiENSGT00390000003608.
HOGENOMiHOG000231993.
HOVERGENiHBG054419.
InParanoidiQ91VC7.
KOiK12328.
OMAiLHKQPGF.
OrthoDBiEOG7RNK21.
PhylomeDBiQ91VC7.
TreeFamiTF105546.

Enzyme and pathway databases

ReactomeiR-MMU-5625740. RHO GTPases activate PKNs.

Miscellaneous databases

PROiQ91VC7.
SOURCEiSearch...

Gene expression databases

BgeeiQ91VC7.
GenevisibleiQ91VC7. MM.

Family and domain databases

Gene3Di1.10.150.220. 1 hit.
InterProiIPR008025. PP1_inhibitor.
[Graphical view]
PANTHERiPTHR16188. PTHR16188. 1 hit.
PfamiPF05361. PP1_inhibitor. 1 hit.
[Graphical view]
SUPFAMiSSF81790. SSF81790. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA."
    Liu Q.-R., Zhang P.-W., Lin Z., Li Q.-F., Woods A.S., Troncoso J., Uhl G.R.
    Biochem. J. 377:171-181(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Smooth muscle.
  2. Yu L.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26 AND SER-136, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiPP14A_MOUSE
AccessioniPrimary (citable) accession number: Q91VC7
Secondary accession number(s): Q99MB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.