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Protein

Protein phosphatase 1 regulatory subunit 14A

Gene

Ppp1r14a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to drug Source: MGI
  • regulation of phosphorylation Source: InterPro

Keywordsi

Molecular functionProtein phosphatase inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-5625740. RHO GTPases activate PKNs.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 14A
Alternative name(s):
17 kDa PKC-potentiated inhibitory protein of PP1
Protein kinase C-potentiated inhibitor protein of 17 kDa
Short name:
CPI-17
Gene namesi
Name:Ppp1r14a
Synonyms:Cpi17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1931139. Ppp1r14a.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714871 – 147Protein phosphatase 1 regulatory subunit 14AAdd BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineCombined sources1
Modified residuei38Phosphothreonine; by PKCBy similarity1
Modified residuei128PhosphoserineBy similarity1
Modified residuei134PhosphoserineBy similarity1
Modified residuei136PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91VC7.
PaxDbiQ91VC7.
PeptideAtlasiQ91VC7.
PRIDEiQ91VC7.

PTM databases

iPTMnetiQ91VC7.
PhosphoSitePlusiQ91VC7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037166.
ExpressionAtlasiQ91VC7. baseline and differential.
GenevisibleiQ91VC7. MM.

Interactioni

Protein-protein interaction databases

IntActiQ91VC7. 1 interactor.
MINTiMINT-4108269.
STRINGi10090.ENSMUSP00000035642.

Structurei

3D structure databases

ProteinModelPortaliQ91VC7.
SMRiQ91VC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 120InhibitoryAdd BLAST86

Sequence similaritiesi

Belongs to the PP1 inhibitor family.Curated

Phylogenomic databases

eggNOGiENOG410IZE6. Eukaryota.
ENOG4111Q1J. LUCA.
GeneTreeiENSGT00390000003608.
HOGENOMiHOG000231993.
HOVERGENiHBG054419.
InParanoidiQ91VC7.
KOiK12328.
OMAiLHKQPGF.
OrthoDBiEOG091G122D.
PhylomeDBiQ91VC7.
TreeFamiTF105546.

Family and domain databases

Gene3Di1.10.150.220. 1 hit.
InterProiView protein in InterPro
IPR008025. PP1_inhibitor.
PANTHERiPTHR16188. PTHR16188. 1 hit.
PfamiView protein in Pfam
PF05361. PP1_inhibitor. 1 hit.
SUPFAMiSSF81790. SSF81790. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91VC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQRLGKRV LSKLQSPSRA RGPGGSPSGL QKRHARVTVK YDRRELQRRL
60 70 80 90 100
DVEKWIDGCL EELYRGRESD MPDEVNIDEL LELDSEEERC RKIQGLLEAC
110 120 130 140
ANPTEDFVQE LLAKLRGLHK QPGFPQPSPS DDPSLSPRQD RAHTAPP
Length:147
Mass (Da):16,649
Last modified:December 1, 2001 - v1
Checksum:i1E29065ACEB39C4D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113A → G in AAK35214 (Ref. 2) Curated1
Sequence conflicti135L → P in AAK35214 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050672 mRNA. Translation: AAL25830.1.
AF352573 mRNA. Translation: AAK35214.1.
BC010832 mRNA. Translation: AAH10832.1.
CCDSiCCDS21070.1.
RefSeqiNP_081007.2. NM_026731.3.
UniGeneiMm.2343.

Genome annotation databases

EnsembliENSMUST00000048187; ENSMUSP00000035642; ENSMUSG00000037166.
GeneIDi68458.
KEGGimmu:68458.
UCSCiuc009gbn.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPP14A_MOUSE
AccessioniPrimary (citable) accession number: Q91VC7
Secondary accession number(s): Q99MB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: December 1, 2001
Last modified: August 30, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families