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Protein

dCTP pyrophosphatase 1

Gene

Dctpp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.By similarity

Catalytic activityi

dCTP + H2O = dCMP + diphosphate.By similarity

Cofactori

Mg2+By similarityNote: Probably binds two or three Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38SubstrateBy similarity1
Metal bindingi63MagnesiumBy similarity1
Metal bindingi66MagnesiumBy similarity1
Binding sitei73SubstrateBy similarity1
Metal bindingi95MagnesiumBy similarity1
Metal bindingi98MagnesiumBy similarity1
Binding sitei102SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP pyrophosphatase 1 (EC:3.6.1.12By similarity)
Alternative name(s):
Deoxycytidine-triphosphatase 1
Short name:
dCTPase 1
RS21-C6Imported
Gene namesi
Name:Dctpp1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620933 Dctpp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002917712 – 170dCTP pyrophosphatase 1Add BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ91VC0
PRIDEiQ91VC0

Expressioni

Gene expression databases

BgeeiENSRNOG00000017850
GenevisibleiQ91VC0 RN

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024074

Structurei

3D structure databases

ProteinModelPortaliQ91VC0
SMRiQ91VC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni47 – 51Substrate bindingBy similarity5

Phylogenomic databases

eggNOGiENOG410IXWQ Eukaryota
ENOG4111PYX LUCA
GeneTreeiENSGT00390000017709
HOGENOMiHOG000056700
InParanoidiQ91VC0
KOiK16904
OMAiELFQWKT
OrthoDBiEOG091G0RYZ
PhylomeDBiQ91VC0
TreeFamiTF300237

Family and domain databases

CDDicd11537 NTP-PPase_RS21-C6_like, 1 hit
InterProiView protein in InterPro
IPR025984 DCTPP
PfamiView protein in Pfam
PF12643 MazG-like, 1 hit
PIRSFiPIRSF029826 UCP029826_pph, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAGTGVCG NGGQEDSAAA GPFSFSPEPT LEDIRRLHAE FAAERDWEQF
60 70 80 90 100
HQPRNLLLAL VGEVGELAEL FQWKSDAEPG PQAWQPKERA ALQEELSDVL
110 120 130 140 150
IYLVALAARC HVDLPRAVIS KMDTNRQRYP VHLSRGSACK YTDLPRGTLS
160 170
ENEAVGSGDP ASELGNQAST
Length:170
Mass (Da):18,474
Last modified:December 1, 2001 - v1
Checksum:i2D344276C3A1228E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029335 mRNA Translation: AAK37408.1
AF331839 mRNA Translation: AAK38638.1
RefSeqiNP_620247.1, NM_138892.1
UniGeneiRn.8733

Genome annotation databases

EnsembliENSRNOT00000024074; ENSRNOP00000024074; ENSRNOG00000017850
GeneIDi192252
KEGGirno:192252
UCSCiRGD:620933 rat

Similar proteinsi

Entry informationi

Entry nameiDCTP1_RAT
AccessioniPrimary (citable) accession number: Q91VC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health