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Protein

dCTP pyrophosphatase 1

Gene

Dctpp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity).By similarity

Catalytic activityi

dCTP + H2O = dCMP + diphosphate.

Cofactori

Mg2+By similarityNote: Probably binds two or three Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38SubstrateBy similarity1
Metal bindingi63MagnesiumBy similarity1
Metal bindingi66MagnesiumBy similarity1
Binding sitei73SubstrateBy similarity1
Metal bindingi95MagnesiumBy similarity1
Metal bindingi98MagnesiumBy similarity1
Binding sitei102SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP pyrophosphatase 1 (EC:3.6.1.12)
Alternative name(s):
Deoxycytidine-triphosphatase 1
Short name:
dCTPase 1
RS21-C6
XTP3-transactivated gene A protein homolog
Gene namesi
Name:Dctpp1
Synonyms:Rs21c6, Xtp3tpa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620933. Dctpp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002917712 – 170dCTP pyrophosphatase 1Add BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ91VC0.
PRIDEiQ91VC0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017850.
GenevisibleiQ91VC0. RN.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024074.

Structurei

3D structure databases

ProteinModelPortaliQ91VC0.
SMRiQ91VC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 75EARAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni47 – 51Substrate bindingBy similarity5

Sequence similaritiesi

Contains 1 EAR repeat.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IXWQ. Eukaryota.
ENOG4111PYX. LUCA.
GeneTreeiENSGT00390000017709.
HOGENOMiHOG000056700.
InParanoidiQ91VC0.
KOiK16904.
OMAiWKTDGEP.
OrthoDBiEOG091G0RYZ.
PhylomeDBiQ91VC0.
TreeFamiTF300237.

Family and domain databases

CDDicd11537. NTP-PPase_RS21-C6_like. 1 hit.
InterProiIPR025984. DCTPP.
IPR009039. EAR.
[Graphical view]
PfamiPF12643. MazG-like. 1 hit.
[Graphical view]
PROSITEiPS50912. EAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91VC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAGTGVCG NGGQEDSAAA GPFSFSPEPT LEDIRRLHAE FAAERDWEQF
60 70 80 90 100
HQPRNLLLAL VGEVGELAEL FQWKSDAEPG PQAWQPKERA ALQEELSDVL
110 120 130 140 150
IYLVALAARC HVDLPRAVIS KMDTNRQRYP VHLSRGSACK YTDLPRGTLS
160 170
ENEAVGSGDP ASELGNQAST
Length:170
Mass (Da):18,474
Last modified:December 1, 2001 - v1
Checksum:i2D344276C3A1228E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029335 mRNA. Translation: AAK37408.1.
AF331839 mRNA. Translation: AAK38638.1.
RefSeqiNP_620247.1. NM_138892.1.
UniGeneiRn.8733.

Genome annotation databases

EnsembliENSRNOT00000024074; ENSRNOP00000024074; ENSRNOG00000017850.
GeneIDi192252.
KEGGirno:192252.
UCSCiRGD:620933. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029335 mRNA. Translation: AAK37408.1.
AF331839 mRNA. Translation: AAK38638.1.
RefSeqiNP_620247.1. NM_138892.1.
UniGeneiRn.8733.

3D structure databases

ProteinModelPortaliQ91VC0.
SMRiQ91VC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024074.

Proteomic databases

PaxDbiQ91VC0.
PRIDEiQ91VC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024074; ENSRNOP00000024074; ENSRNOG00000017850.
GeneIDi192252.
KEGGirno:192252.
UCSCiRGD:620933. rat.

Organism-specific databases

CTDi79077.
RGDi620933. Dctpp1.

Phylogenomic databases

eggNOGiENOG410IXWQ. Eukaryota.
ENOG4111PYX. LUCA.
GeneTreeiENSGT00390000017709.
HOGENOMiHOG000056700.
InParanoidiQ91VC0.
KOiK16904.
OMAiWKTDGEP.
OrthoDBiEOG091G0RYZ.
PhylomeDBiQ91VC0.
TreeFamiTF300237.

Miscellaneous databases

PROiQ91VC0.

Gene expression databases

BgeeiENSRNOG00000017850.
GenevisibleiQ91VC0. RN.

Family and domain databases

CDDicd11537. NTP-PPase_RS21-C6_like. 1 hit.
InterProiIPR025984. DCTPP.
IPR009039. EAR.
[Graphical view]
PfamiPF12643. MazG-like. 1 hit.
[Graphical view]
PROSITEiPS50912. EAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCTP1_RAT
AccessioniPrimary (citable) accession number: Q91VC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.