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Protein
Submitted name:

Alpha globin 1

Gene

Hba-a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi88Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cellular oxidant detoxification Source: GOC
  • erythrocyte development Source: MGI
  • in utero embryonic development Source: MGI

Keywordsi

Biological processOxygen transportPROSITE-ProRule annotationSAAS annotation, Transport
LigandHemePROSITE-ProRule annotationSAAS annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-MMU-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-MMU-2168880 Scavenging of heme from plasma

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha globin 1Imported
Submitted name:
Alpha globin 2Imported
Submitted name:
Alpha-globinImported
Submitted name:
Globin c1Imported
Submitted name:
Hemoglobin alpha, adult chain 1Imported
Submitted name:
Hemoglobin alpha, adult chain 2Imported
Gene namesi
Name:Hba-a1Imported
Synonyms:Glnc1Imported, haemaglobin alpha 1Imported, haemaglobin alpha 2Imported, Hba-a2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96015 Hba-a1
MGI:96016 Hba-a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000069917

Interactioni

Protein-protein interaction databases

IntActiQ91VB8, 1 interactor

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 142GLOBINInterPro annotationAdd BLAST140

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00760000119197
HOVERGENiHBG009709
KOiK13822
OMAiDKFLCAV
OrthoDBiEOG091G0S0X
TreeFamiTF332328

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
IPR002339 Haemoglobin_pi
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
PR00815 PIHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q91VB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSGEDKSN IKAAWGKIGG HGAEYGAEAL ERMFASFPTT KTYFPHFDVS
60 70 80 90 100
HGSAQVKGHG KKVADALANA AGHLDDLPGA LSALSDLHAH KLRVDPVNFK
110 120 130 140
LLSHCLLVTL ASHHPADFTP AVHASLDKFL ASVSTVLTSK YR
Length:142
Mass (Da):15,112
Last modified:December 1, 2001 - v1
Checksum:i2F6A3712E555CB4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662780 Genomic DNA No translation available.
BC043020 mRNA Translation: AAH43020.1
AY016021 Genomic DNA Translation: AAL32371.1
AY016021 Genomic DNA Translation: AAL32372.1
EF605472 Genomic DNA Translation: ABU54054.1
AK003077 mRNA Translation: BAB22552.1
AK005434 mRNA Translation: BAB24028.1
AK010923 mRNA Translation: BAB27269.1
AK010927 mRNA Translation: BAB27272.1
AK010933 mRNA Translation: BAB27277.1
AK010937 mRNA Translation: BAB27279.1
AK010987 mRNA Translation: BAB27307.1
AK011018 mRNA Translation: BAB27336.1
AK011023 mRNA Translation: BAB27340.1
AK011025 mRNA Translation: BAB27342.1
AK011028 mRNA Translation: BAB27344.1
AK011030 mRNA Translation: BAB27346.1
AK011055 mRNA Translation: BAB27364.1
AK011073 mRNA Translation: BAB27378.1
AK011121 mRNA Translation: BAB27414.1
AK012329 mRNA Translation: BAB28166.1
AK012348 mRNA Translation: BAB28179.1
AK012755 mRNA Translation: BAB28446.1
AK019138 mRNA Translation: BAB31564.1
AK028173 mRNA Translation: BAC25790.1
AK171893 mRNA Translation: BAE42724.1
LT548154 Genomic DNA Translation: SAI82198.1
RefSeqiNP_001077424.1, NM_001083955.1
NP_032244.2, NM_008218.2
UniGeneiMm.196110
Mm.459653

Genome annotation databases

EnsembliENSMUST00000093207; ENSMUSP00000090895; ENSMUSG00000069917
ENSMUST00000093209; ENSMUSP00000090897; ENSMUSG00000069919
GeneIDi110257
15122
KEGGimmu:110257
mmu:15122
UCSCiuc007ijk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ91VB8_MOUSE
AccessioniPrimary (citable) accession number: Q91VB8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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