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Protein
Submitted name:

Alpha globin 1

Gene

Hba-a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Oxygen transportUniRule annotationSAAS annotation, Transport

Keywords - Ligandi

HemeUniRule annotationSAAS annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_303694. Scavenging of heme from plasma.
REACT_309678. Erythrocytes take up oxygen and release carbon dioxide.
REACT_318918. Erythrocytes take up carbon dioxide and release oxygen.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha globin 1Imported
Submitted name:
Alpha globin 2Imported
Submitted name:
Alpha-globinImported
Submitted name:
Hemoglobin alpha, adult chain 1Imported
Submitted name:
Hemoglobin subunit alphaImported
Submitted name:
Protein Hba-a2Imported
Gene namesi
Name:Hba-a1Imported
Synonyms:haemaglobin alpha 1Imported, haemaglobin alpha 2Imported, Hba-a2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96015. Hba-a1.
MGI:96016. Hba-a2.

Subcellular locationi

GO - Cellular componenti

  1. hemoglobin complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiQ91VB8.
PRIDEiQ91VB8.

Expressioni

Gene expression databases

BgeeiQ91VB8.
ExpressionAtlasiQ91VB8. baseline and differential.
GenevestigatoriQ91VB8.

Interactioni

Protein-protein interaction databases

IntActiQ91VB8. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ91VB8.
SMRiQ91VB8. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119197.
HOVERGENiHBG009709.
KOiK13822.
OMAiDKFLCAV.
OrthoDBiEOG7KH9MP.
TreeFamiTF332328.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91VB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSGEDKSN IKAAWGKIGG HGAEYGAEAL ERMFASFPTT KTYFPHFDVS
60 70 80 90 100
HGSAQVKGHG KKVADALANA AGHLDDLPGA LSALSDLHAH KLRVDPVNFK
110 120 130 140
LLSHCLLVTL ASHHPADFTP AVHASLDKFL ASVSTVLTSK YR
Length:142
Mass (Da):15,112
Last modified:December 1, 2001 - v1
Checksum:i2F6A3712E555CB4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662780 Genomic DNA. No translation available.
BC043020 mRNA. Translation: AAH43020.1.
AY016021 Genomic DNA. Translation: AAL32371.1.
AY016021 Genomic DNA. Translation: AAL32372.1.
EF605472 Genomic DNA. Translation: ABU54054.1.
AK003077 mRNA. Translation: BAB22552.1.
AK005434 mRNA. Translation: BAB24028.1.
AK010923 mRNA. Translation: BAB27269.1.
AK010927 mRNA. Translation: BAB27272.1.
AK010933 mRNA. Translation: BAB27277.1.
AK010937 mRNA. Translation: BAB27279.1.
AK010987 mRNA. Translation: BAB27307.1.
AK011018 mRNA. Translation: BAB27336.1.
AK011023 mRNA. Translation: BAB27340.1.
AK011025 mRNA. Translation: BAB27342.1.
AK011028 mRNA. Translation: BAB27344.1.
AK011030 mRNA. Translation: BAB27346.1.
AK011055 mRNA. Translation: BAB27364.1.
AK011073 mRNA. Translation: BAB27378.1.
AK011121 mRNA. Translation: BAB27414.1.
AK012329 mRNA. Translation: BAB28166.1.
AK012348 mRNA. Translation: BAB28179.1.
AK012755 mRNA. Translation: BAB28446.1.
AK019138 mRNA. Translation: BAB31564.1.
AK028173 mRNA. Translation: BAC25790.1.
AK171893 mRNA. Translation: BAE42724.1.
RefSeqiNP_001077424.1. NM_001083955.1.
NP_032244.2. NM_008218.2.
UniGeneiMm.196110.
Mm.459653.

Genome annotation databases

EnsembliENSMUST00000093207; ENSMUSP00000090895; ENSMUSG00000069917.
ENSMUST00000093209; ENSMUSP00000090897; ENSMUSG00000069919.
GeneIDi110257.
15122.
KEGGimmu:110257.
mmu:15122.
UCSCiuc007ijk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662780 Genomic DNA. No translation available.
BC043020 mRNA. Translation: AAH43020.1.
AY016021 Genomic DNA. Translation: AAL32371.1.
AY016021 Genomic DNA. Translation: AAL32372.1.
EF605472 Genomic DNA. Translation: ABU54054.1.
AK003077 mRNA. Translation: BAB22552.1.
AK005434 mRNA. Translation: BAB24028.1.
AK010923 mRNA. Translation: BAB27269.1.
AK010927 mRNA. Translation: BAB27272.1.
AK010933 mRNA. Translation: BAB27277.1.
AK010937 mRNA. Translation: BAB27279.1.
AK010987 mRNA. Translation: BAB27307.1.
AK011018 mRNA. Translation: BAB27336.1.
AK011023 mRNA. Translation: BAB27340.1.
AK011025 mRNA. Translation: BAB27342.1.
AK011028 mRNA. Translation: BAB27344.1.
AK011030 mRNA. Translation: BAB27346.1.
AK011055 mRNA. Translation: BAB27364.1.
AK011073 mRNA. Translation: BAB27378.1.
AK011121 mRNA. Translation: BAB27414.1.
AK012329 mRNA. Translation: BAB28166.1.
AK012348 mRNA. Translation: BAB28179.1.
AK012755 mRNA. Translation: BAB28446.1.
AK019138 mRNA. Translation: BAB31564.1.
AK028173 mRNA. Translation: BAC25790.1.
AK171893 mRNA. Translation: BAE42724.1.
RefSeqiNP_001077424.1. NM_001083955.1.
NP_032244.2. NM_008218.2.
UniGeneiMm.196110.
Mm.459653.

3D structure databases

ProteinModelPortaliQ91VB8.
SMRiQ91VB8. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91VB8. 1 interaction.

Proteomic databases

MaxQBiQ91VB8.
PRIDEiQ91VB8.

Protocols and materials databases

DNASUi110257.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093207; ENSMUSP00000090895; ENSMUSG00000069917.
ENSMUST00000093209; ENSMUSP00000090897; ENSMUSG00000069919.
GeneIDi110257.
15122.
KEGGimmu:110257.
mmu:15122.
UCSCiuc007ijk.1. mouse.

Organism-specific databases

CTDi110257.
15122.
MGIiMGI:96015. Hba-a1.
MGI:96016. Hba-a2.

Phylogenomic databases

GeneTreeiENSGT00760000119197.
HOVERGENiHBG009709.
KOiK13822.
OMAiDKFLCAV.
OrthoDBiEOG7KH9MP.
TreeFamiTF332328.

Enzyme and pathway databases

ReactomeiREACT_303694. Scavenging of heme from plasma.
REACT_309678. Erythrocytes take up oxygen and release carbon dioxide.
REACT_318918. Erythrocytes take up carbon dioxide and release oxygen.

Miscellaneous databases

NextBioi287546.
PROiQ91VB8.
SOURCEiSearch...

Gene expression databases

BgeeiQ91VB8.
ExpressionAtlasiQ91VB8. baseline and differential.
GenevestigatoriQ91VB8.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, LiverImported, PlacentaImported, SpleenImported and Whole bodyImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, LiverImported, PlacentaImported, SpleenImported and Whole bodyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, LiverImported, PlacentaImported, SpleenImported and Whole bodyImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LiverImported, PlacentaImported, SpleenImported and Whole bodyImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LiverImported.
  6. "Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster."
    Flint J., Tufarelli C., Peden J., Clark K., Daniels R.J., Hardison R., Miller W., Philipsen S., Tan-Un K.C., McMorrow T., Frampton J., Alter B.P., Frischauf A.-M., Higgs D.R.
    Hum. Mol. Genet. 10:371-382(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  7. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2000)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, LiverImported, PlacentaImported, SpleenImported and Whole bodyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LiverImported.
  9. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, LiverImported, PlacentaImported, SpleenImported and Whole bodyImported.
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  12. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, LiverImported, PlacentaImported, SpleenImported and Whole bodyImported.
  13. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, LiverImported, PlacentaImported, SpleenImported and Whole bodyImported.
  14. "Complex signatures of selection and gene conversion in the duplicated globin genes of house mice."
    Storz J.F., Baze M., Waite J.L., Hoffmann F.G., Opazo J.C., Hayes J.P.
    Genetics 177:481-500(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Lima_127Imported.
  15. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  16. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  17. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQ91VB8_MOUSE
AccessioniPrimary (citable) accession number: Q91VB8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: April 1, 2015
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.