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Q91VB8

- Q91VB8_MOUSE

UniProt

Q91VB8 - Q91VB8_MOUSE

Protein
Submitted name:

Alpha globin 1

Gene

Hba-a2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB-KW

    Keywords - Biological processi

    Oxygen transportUniRule annotationSAAS annotation, Transport

    Keywords - Ligandi

    HemeUniRule annotationSAAS annotation, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196575. Scavenging of heme from plasma.
    REACT_199094. Erythrocytes take up carbon dioxide and release oxygen.
    REACT_199098. Erythrocytes take up oxygen and release carbon dioxide.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Alpha globin 1Imported
    Submitted name:
    Alpha globin 2Imported
    Submitted name:
    Alpha-globinImported
    Submitted name:
    Hemoglobin alpha, adult chain 1Imported
    Submitted name:
    Hemoglobin subunit alphaImported
    Submitted name:
    Protein Hba-a2Imported
    Gene namesi
    Name:Hba-a2Imported
    Synonyms:haemaglobin alpha 1Imported, haemaglobin alpha 2Imported, Hba-a1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96015. Hba-a1.
    MGI:96016. Hba-a2.

    Subcellular locationi

    GO - Cellular componenti

    1. hemoglobin complex Source: InterPro

    Expressioni

    Gene expression databases

    GenevestigatoriQ91VB8.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115388.
    HOVERGENiHBG009709.
    InParanoidiQ91VB8.
    KOiK13822.
    OMAiDKFLCAV.
    OrthoDBiEOG7KH9MP.
    TreeFamiTF332328.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002338. Haemoglobin_a.
    IPR002339. Haemoglobin_pi.
    [Graphical view]
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR00612. ALPHAHAEM.
    PR00815. PIHAEM.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91VB8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLSGEDKSN IKAAWGKIGG HGAEYGAEAL ERMFASFPTT KTYFPHFDVS    50
    HGSAQVKGHG KKVADALANA AGHLDDLPGA LSALSDLHAH KLRVDPVNFK 100
    LLSHCLLVTL ASHHPADFTP AVHASLDKFL ASVSTVLTSK YR 142
    Length:142
    Mass (Da):15,112
    Last modified:December 1, 2001 - v1
    Checksum:i2F6A3712E555CB4A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL662780 Genomic DNA. No translation available.
    BC043020 mRNA. Translation: AAH43020.1.
    AY016021 Genomic DNA. Translation: AAL32371.1.
    AY016021 Genomic DNA. Translation: AAL32372.1.
    EF605472 Genomic DNA. Translation: ABU54054.1.
    AK003077 mRNA. Translation: BAB22552.1.
    AK005434 mRNA. Translation: BAB24028.1.
    AK010923 mRNA. Translation: BAB27269.1.
    AK010927 mRNA. Translation: BAB27272.1.
    AK010933 mRNA. Translation: BAB27277.1.
    AK010937 mRNA. Translation: BAB27279.1.
    AK010987 mRNA. Translation: BAB27307.1.
    AK011018 mRNA. Translation: BAB27336.1.
    AK011023 mRNA. Translation: BAB27340.1.
    AK011025 mRNA. Translation: BAB27342.1.
    AK011028 mRNA. Translation: BAB27344.1.
    AK011030 mRNA. Translation: BAB27346.1.
    AK011055 mRNA. Translation: BAB27364.1.
    AK011073 mRNA. Translation: BAB27378.1.
    AK011121 mRNA. Translation: BAB27414.1.
    AK012329 mRNA. Translation: BAB28166.1.
    AK012348 mRNA. Translation: BAB28179.1.
    AK012755 mRNA. Translation: BAB28446.1.
    AK019138 mRNA. Translation: BAB31564.1.
    AK028173 mRNA. Translation: BAC25790.1.
    AK171893 mRNA. Translation: BAE42724.1.
    RefSeqiNP_001077424.1. NM_001083955.1.
    NP_032244.2. NM_008218.2.
    UniGeneiMm.196110.
    Mm.459653.

    Genome annotation databases

    EnsembliENSMUST00000093207; ENSMUSP00000090895; ENSMUSG00000069917.
    ENSMUST00000093209; ENSMUSP00000090897; ENSMUSG00000069919.
    GeneIDi110257.
    15122.
    KEGGimmu:110257.
    mmu:15122.
    UCSCiuc007ijk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL662780 Genomic DNA. No translation available.
    BC043020 mRNA. Translation: AAH43020.1 .
    AY016021 Genomic DNA. Translation: AAL32371.1 .
    AY016021 Genomic DNA. Translation: AAL32372.1 .
    EF605472 Genomic DNA. Translation: ABU54054.1 .
    AK003077 mRNA. Translation: BAB22552.1 .
    AK005434 mRNA. Translation: BAB24028.1 .
    AK010923 mRNA. Translation: BAB27269.1 .
    AK010927 mRNA. Translation: BAB27272.1 .
    AK010933 mRNA. Translation: BAB27277.1 .
    AK010937 mRNA. Translation: BAB27279.1 .
    AK010987 mRNA. Translation: BAB27307.1 .
    AK011018 mRNA. Translation: BAB27336.1 .
    AK011023 mRNA. Translation: BAB27340.1 .
    AK011025 mRNA. Translation: BAB27342.1 .
    AK011028 mRNA. Translation: BAB27344.1 .
    AK011030 mRNA. Translation: BAB27346.1 .
    AK011055 mRNA. Translation: BAB27364.1 .
    AK011073 mRNA. Translation: BAB27378.1 .
    AK011121 mRNA. Translation: BAB27414.1 .
    AK012329 mRNA. Translation: BAB28166.1 .
    AK012348 mRNA. Translation: BAB28179.1 .
    AK012755 mRNA. Translation: BAB28446.1 .
    AK019138 mRNA. Translation: BAB31564.1 .
    AK028173 mRNA. Translation: BAC25790.1 .
    AK171893 mRNA. Translation: BAE42724.1 .
    RefSeqi NP_001077424.1. NM_001083955.1.
    NP_032244.2. NM_008218.2.
    UniGenei Mm.196110.
    Mm.459653.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 110257.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000093207 ; ENSMUSP00000090895 ; ENSMUSG00000069917 .
    ENSMUST00000093209 ; ENSMUSP00000090897 ; ENSMUSG00000069919 .
    GeneIDi 110257.
    15122.
    KEGGi mmu:110257.
    mmu:15122.
    UCSCi uc007ijk.1. mouse.

    Organism-specific databases

    CTDi 110257.
    15122.
    MGIi MGI:96015. Hba-a1.
    MGI:96016. Hba-a2.

    Phylogenomic databases

    GeneTreei ENSGT00740000115388.
    HOVERGENi HBG009709.
    InParanoidi Q91VB8.
    KOi K13822.
    OMAi DKFLCAV.
    OrthoDBi EOG7KH9MP.
    TreeFami TF332328.

    Enzyme and pathway databases

    Reactomei REACT_196575. Scavenging of heme from plasma.
    REACT_199094. Erythrocytes take up carbon dioxide and release oxygen.
    REACT_199098. Erythrocytes take up oxygen and release carbon dioxide.

    Miscellaneous databases

    NextBioi 287546.
    PROi Q91VB8.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q91VB8.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002338. Haemoglobin_a.
    IPR002339. Haemoglobin_pi.
    [Graphical view ]
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR00612. ALPHAHAEM.
    PR00815. PIHAEM.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported, LiverImported, PlacentaImported, SpleenImported and Whole bodyImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported, LiverImported, PlacentaImported, SpleenImported and Whole bodyImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported, LiverImported, PlacentaImported, SpleenImported and Whole bodyImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LiverImported, PlacentaImported, SpleenImported and Whole bodyImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LiverImported.
    6. "Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster."
      Flint J., Tufarelli C., Peden J., Clark K., Daniels R.J., Hardison R., Miller W., Philipsen S., Tan-Un K.C., McMorrow T., Frampton J., Alter B.P., Frischauf A.-M., Higgs D.R.
      Hum. Mol. Genet. 10:371-382(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    7. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported, LiverImported, PlacentaImported, SpleenImported and Whole bodyImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LiverImported.
    9. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported, LiverImported, PlacentaImported, SpleenImported and Whole bodyImported.
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported.
      Tissue: BrainImported.
    11. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    12. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported, LiverImported, PlacentaImported, SpleenImported and Whole bodyImported.
    13. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported and NODImported.
      Tissue: Activated spleenImported, LiverImported, PlacentaImported, SpleenImported and Whole bodyImported.
    14. "Complex signatures of selection and gene conversion in the duplicated globin genes of house mice."
      Storz J.F., Baze M., Waite J.L., Hoffmann F.G., Opazo J.C., Hayes J.P.
      Genetics 177:481-500(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Lima_127Imported.
    15. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    16. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    17. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiQ91VB8_MOUSE
    AccessioniPrimary (citable) accession number: Q91VB8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3