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Protein
Submitted name:

Alpha globin 1

Gene

Hba-a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi88Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cellular oxidant detoxification Source: GOC
  • erythrocyte development Source: MGI
  • in utero embryonic development Source: MGI

Keywordsi

Biological processOxygen transportPROSITE-ProRule annotationSAAS annotation, Transport
LigandHemePROSITE-ProRule annotationSAAS annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-1237044. Erythrocytes take up carbon dioxide and release oxygen.
R-MMU-1247673. Erythrocytes take up oxygen and release carbon dioxide.
R-MMU-2168880. Scavenging of heme from plasma.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha globin 1Imported
Submitted name:
Alpha globin 2Imported
Submitted name:
Alpha-globinImported
Submitted name:
Globin c1Imported
Submitted name:
Hemoglobin alpha, adult chain 1Imported
Submitted name:
Hemoglobin alpha, adult chain 2Imported
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Hba-a1Imported
Synonyms:Glnc1Imported, haemaglobin alpha 1Imported, haemaglobin alpha 2Imported, Hba-a2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96015. Hba-a1.
MGI:96016. Hba-a2.

Subcellular locationi

GO - Cellular componenti

Expressioni

Gene expression databases

BgeeiENSMUSG00000069917.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 142GLOBINInterPro annotationAdd BLAST140

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOVERGENiHBG009709.
KOiK13822.
OMAiDKFLCAV.
OrthoDBiEOG091G0S0X.
TreeFamiTF332328.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91VB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSGEDKSN IKAAWGKIGG HGAEYGAEAL ERMFASFPTT KTYFPHFDVS
60 70 80 90 100
HGSAQVKGHG KKVADALANA AGHLDDLPGA LSALSDLHAH KLRVDPVNFK
110 120 130 140
LLSHCLLVTL ASHHPADFTP AVHASLDKFL ASVSTVLTSK YR
Length:142
Mass (Da):15,112
Last modified:December 1, 2001 - v1
Checksum:i2F6A3712E555CB4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662780 Genomic DNA. No translation available.
BC043020 mRNA. Translation: AAH43020.1.
AY016021 Genomic DNA. Translation: AAL32371.1.
AY016021 Genomic DNA. Translation: AAL32372.1.
EF605472 Genomic DNA. Translation: ABU54054.1.
AK003077 mRNA. Translation: BAB22552.1.
AK005434 mRNA. Translation: BAB24028.1.
AK010923 mRNA. Translation: BAB27269.1.
AK010927 mRNA. Translation: BAB27272.1.
AK010933 mRNA. Translation: BAB27277.1.
AK010937 mRNA. Translation: BAB27279.1.
AK010987 mRNA. Translation: BAB27307.1.
AK011018 mRNA. Translation: BAB27336.1.
AK011023 mRNA. Translation: BAB27340.1.
AK011025 mRNA. Translation: BAB27342.1.
AK011028 mRNA. Translation: BAB27344.1.
AK011030 mRNA. Translation: BAB27346.1.
AK011055 mRNA. Translation: BAB27364.1.
AK011073 mRNA. Translation: BAB27378.1.
AK011121 mRNA. Translation: BAB27414.1.
AK012329 mRNA. Translation: BAB28166.1.
AK012348 mRNA. Translation: BAB28179.1.
AK012755 mRNA. Translation: BAB28446.1.
AK019138 mRNA. Translation: BAB31564.1.
AK028173 mRNA. Translation: BAC25790.1.
AK171893 mRNA. Translation: BAE42724.1.
LT548154 Genomic DNA. Translation: SAI82198.1.
RefSeqiNP_001077424.1. NM_001083955.1.
NP_032244.2. NM_008218.2.
UniGeneiMm.196110.
Mm.459653.

Genome annotation databases

EnsembliENSMUST00000093207; ENSMUSP00000090895; ENSMUSG00000069917.
ENSMUST00000093209; ENSMUSP00000090897; ENSMUSG00000069919.
GeneIDi110257.
15122.
KEGGimmu:110257.
mmu:15122.
UCSCiuc007ijk.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ91VB8_MOUSE
AccessioniPrimary (citable) accession number: Q91VB8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: July 5, 2017
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported