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Protein

Protamine-2

Gene

Prm2

Organism
Rattus tunneyi (Tunney's rat) (Pale field rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. chromosome condensation Source: UniProtKB-KW
  3. multicellular organismal development Source: UniProtKB-KW
  4. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, DNA condensation, Spermatogenesis

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protamine-2
Alternative name(s):
Sperm histone P2
Sperm protamine P2
Gene namesi
Name:Prm2
OrganismiRattus tunneyi (Tunney's rat) (Pale field rat)
Taxonomic identifieri10121 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Subcellular locationi

GO - Cellular componenti

  1. nucleosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 105105Protamine-2PRO_0000254959Add
BLAST

Expressioni

Tissue specificityi

Testis.

Family & Domainsi

Sequence similaritiesi

Belongs to the protamine P2 family.Curated

Family and domain databases

InterProiIPR000492. PRM2.
[Graphical view]
PANTHERiPTHR21341. PTHR21341. 1 hit.
PfamiPF00841. Protamine_P2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91VB3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRYRMRSPS ESPHQGPGQD HESEEQGQGQ ELNPERVEDY GRTHRGHHRH
60 70 80 90 100
RRCSRKRLHR IHKRRRSCRR RRRHSCCHRR RHRRGCRRSR RRRRCRCRKC

RRQCH
Length:105
Mass (Da):13,328
Last modified:December 1, 2001 - v1
Checksum:i390B5B50A5F0911F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268199 Genomic DNA. Translation: AAK98518.1.
AF268200 mRNA. Translation: AAK98519.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268199 Genomic DNA. Translation: AAK98518.1.
AF268200 mRNA. Translation: AAK98519.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000492. PRM2.
[Graphical view]
PANTHERiPTHR21341. PTHR21341. 1 hit.
PfamiPF00841. Protamine_P2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Variable regulation of protamine 2 gene expression in muroid rodents."
    Dolan C.E., Fabes S.E., Mazrimas J.A., Corzett M.H., Breed W.G., Balhorn R.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Entry informationi

Entry nameiPRM2_RATTU
AccessioniPrimary (citable) accession number: Q91VB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.