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Q91VA7

- Q91VA7_MOUSE

UniProt

Q91VA7 - Q91VA7_MOUSE

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Protein
Submitted name:

Isocitrate dehydrogenase 3 (NAD+) beta

Gene

Idh3b

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. isocitrate dehydrogenase (NAD+) activity Source: Ensembl
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. 2-oxoglutarate metabolic process Source: Ensembl
  2. isocitrate metabolic process Source: Ensembl
  3. NADH metabolic process Source: Ensembl
  4. tricarboxylic acid cycle Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase 3 (NAD+) betaImported
Submitted name:
Protein Idh3bImported
Submitted name:
Tumor-related proteinImported
Gene namesi
Name:Idh3bImported
ORF Names:mCG_9915Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2158650. Idh3b.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: MGI
  2. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ91VA7.

Interactioni

Protein-protein interaction databases

MINTiMINT-1861326.
STRINGi10090.ENSMUSP00000028892.

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0473.
GeneTreeiENSGT00590000083091.
HOGENOMiHOG000021113.
HOVERGENiHBG052080.
KOiK00030.
OMAiILATPDY.
OrthoDBiEOG75B85R.
TreeFamiTF315033.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91VA7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAALSNVRWL TRAVLAARNS GAWRGLGTST AHAASQSQAQ DVRVEGAFPV
60 70 80 90 100
TMLPGDGVGP ELMHAVKEVF KAAAVPVEFK EHHLSEVQNM ASEEKLEQVL
110 120 130 140 150
SSMKENKVAI IGKIYTPMEY KGELASYDMQ LRRKLDLFAN VVHVKSLPGY
160 170 180 190 200
KTRHNNLDLV IIREQTEGEY SSLEHESAKG VIECLKIVTR TKSQRIAKFA
210 220 230 240 250
FDYATKKGRS KVTAVHKANI MKLGDGLFLQ CCEEVAELYP KIKFETMIID
260 270 280 290 300
NCCMQLVQNP YQFDVLVMPN LYGNIIDNLA AGLVGGAGVV PGESYSAEYA
310 320 330 340 350
VFETGARHPF AQAVGRNIAN PTAMLLSATN MLRHLNLEYH SSMIADAVKK
360 370 380
VIKAGKVRTR DMGGYSTTTD FIKSVIGHLH PHGG
Length:384
Mass (Da):42,195
Last modified:December 1, 2001 - v1
Checksum:i49162354C2A4DFBE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL833804 Genomic DNA. No translation available.
BC009022 mRNA. Translation: AAH09022.1.
AY035212 mRNA. Translation: AAK64606.1.
CH466519 Genomic DNA. Translation: EDL28255.1.
RefSeqiNP_570954.1. NM_130884.4.
UniGeneiMm.29590.

Genome annotation databases

EnsembliENSMUST00000028892; ENSMUSP00000028892; ENSMUSG00000027406.
GeneIDi170718.
KEGGimmu:170718.
UCSCiuc008min.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL833804 Genomic DNA. No translation available.
BC009022 mRNA. Translation: AAH09022.1 .
AY035212 mRNA. Translation: AAK64606.1 .
CH466519 Genomic DNA. Translation: EDL28255.1 .
RefSeqi NP_570954.1. NM_130884.4.
UniGenei Mm.29590.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1861326.
STRINGi 10090.ENSMUSP00000028892.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028892 ; ENSMUSP00000028892 ; ENSMUSG00000027406 .
GeneIDi 170718.
KEGGi mmu:170718.
UCSCi uc008min.2. mouse.

Organism-specific databases

CTDi 3420.
MGIi MGI:2158650. Idh3b.

Phylogenomic databases

eggNOGi COG0473.
GeneTreei ENSGT00590000083091.
HOGENOMi HOG000021113.
HOVERGENi HBG052080.
KOi K00030.
OMAi ILATPDY.
OrthoDBi EOG75B85R.
TreeFami TF315033.

Miscellaneous databases

ChiTaRSi IDH3B. mouse.
NextBioi 370230.
PROi Q91VA7.
SOURCEi Search...

Gene expression databases

Genevestigatori Q91VA7.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Yang J.S., Chen S.S., Zheng X.M.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SwissImported.
  2. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NMRIImported.
    Tissue: Mammary tumor. WAP-Tag model. 5 months oldImported.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ91VA7_MOUSE
AccessioniPrimary (citable) accession number: Q91VA7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3