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Protein

Polymerase delta-interacting protein 2

Gene

Poldip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • mitochondrion morphogenesis Source: MGI
  • negative regulation of macroautophagy Source: MGI
  • positive regulation of mitotic cell cycle Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Polymerase delta-interacting protein 2
Gene namesi
Name:Poldip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915061. Poldip2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial nucleoid Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Polymerase delta-interacting protein 2PRO_0000197976Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei292 – 2921PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91VA6.
MaxQBiQ91VA6.
PaxDbiQ91VA6.
PeptideAtlasiQ91VA6.
PRIDEiQ91VA6.

PTM databases

iPTMnetiQ91VA6.
PhosphoSiteiQ91VA6.

Expressioni

Gene expression databases

BgeeiQ91VA6.
ExpressionAtlasiQ91VA6. baseline and differential.
GenevisibleiQ91VA6. MM.

Interactioni

Subunit structurei

Interacts with PCNA and POLD2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91VA6. 1 interaction.
MINTiMINT-1850346.
STRINGi10090.ENSMUSP00000001127.

Structurei

3D structure databases

ProteinModelPortaliQ91VA6.
SMRiQ91VA6. Positions 240-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini235 – 360126ApaGPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 apaG domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4408. Eukaryota.
COG2967. LUCA.
GeneTreeiENSGT00390000010198.
HOGENOMiHOG000008122.
HOVERGENiHBG053549.
InParanoidiQ91VA6.
KOiK17809.
OMAiFYMGCRE.
OrthoDBiEOG747PJK.
PhylomeDBiQ91VA6.
TreeFamiTF314882.

Family and domain databases

Gene3Di2.60.40.1470. 1 hit.
InterProiIPR007474. ApaG_domain.
IPR011722. Hemimethylated_DNA-bd_dom.
[Graphical view]
PfamiPF04379. DUF525. 1 hit.
PF08755. YccV-like. 1 hit.
[Graphical view]
SMARTiSM00992. YccV-like. 1 hit.
[Graphical view]
SUPFAMiSSF110069. SSF110069. 1 hit.
SSF141255. SSF141255. 2 hits.
PROSITEiPS51087. APAG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91VA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGCVARRAL AVGSRWWSRS LATTRGSRPL CAVGGAGGLP PVATATTRRH
60 70 80 90 100
LSSRNRAEGK VLETVGVFEV PKQNGKYETG QLFLHSVFGY RGVVLFPWQA
110 120 130 140 150
RLYDRDVASA TPEKAENPAG HGSKEVKGKT HTYYQVLIDA RDCPHISQRS
160 170 180 190 200
QTEAVTFLAN HDDSRALYAI PGLDYVSHED ILPYTSTDQV PIQHELFERF
210 220 230 240 250
LLYDQTKAPP FVARETLRAW QEKNHPWLEL SDVHRETTEN IRVTVIPFYM
260 270 280 290 300
GMREAQNSHV YWWRYCIRLE NLDSDVVQLR ERHWRIFSLS GTLETVRGRG
310 320 330 340 350
VVGREPVLSK EQPAFQYSSH VSLQASSGHM WGTFRFERPD GSHFDVRIPP
360
FSLESNKDEK TPPSGLHW
Length:368
Mass (Da):41,870
Last modified:December 1, 2001 - v1
Checksum:i4A399A13C795FCBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006833 mRNA. Translation: AAH06833.1.
BC012879 mRNA. Translation: AAH12879.1.
CCDSiCCDS25109.1.
RefSeqiNP_080665.1. NM_026389.3.
UniGeneiMm.197493.

Genome annotation databases

EnsembliENSMUST00000001127; ENSMUSP00000001127; ENSMUSG00000001100.
GeneIDi67811.
KEGGimmu:67811.
UCSCiuc007kjo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006833 mRNA. Translation: AAH06833.1.
BC012879 mRNA. Translation: AAH12879.1.
CCDSiCCDS25109.1.
RefSeqiNP_080665.1. NM_026389.3.
UniGeneiMm.197493.

3D structure databases

ProteinModelPortaliQ91VA6.
SMRiQ91VA6. Positions 240-355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91VA6. 1 interaction.
MINTiMINT-1850346.
STRINGi10090.ENSMUSP00000001127.

PTM databases

iPTMnetiQ91VA6.
PhosphoSiteiQ91VA6.

Proteomic databases

EPDiQ91VA6.
MaxQBiQ91VA6.
PaxDbiQ91VA6.
PeptideAtlasiQ91VA6.
PRIDEiQ91VA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001127; ENSMUSP00000001127; ENSMUSG00000001100.
GeneIDi67811.
KEGGimmu:67811.
UCSCiuc007kjo.1. mouse.

Organism-specific databases

CTDi26073.
MGIiMGI:1915061. Poldip2.

Phylogenomic databases

eggNOGiKOG4408. Eukaryota.
COG2967. LUCA.
GeneTreeiENSGT00390000010198.
HOGENOMiHOG000008122.
HOVERGENiHBG053549.
InParanoidiQ91VA6.
KOiK17809.
OMAiFYMGCRE.
OrthoDBiEOG747PJK.
PhylomeDBiQ91VA6.
TreeFamiTF314882.

Miscellaneous databases

ChiTaRSiPoldip2. mouse.
PROiQ91VA6.
SOURCEiSearch...

Gene expression databases

BgeeiQ91VA6.
ExpressionAtlasiQ91VA6. baseline and differential.
GenevisibleiQ91VA6. MM.

Family and domain databases

Gene3Di2.60.40.1470. 1 hit.
InterProiIPR007474. ApaG_domain.
IPR011722. Hemimethylated_DNA-bd_dom.
[Graphical view]
PfamiPF04379. DUF525. 1 hit.
PF08755. YccV-like. 1 hit.
[Graphical view]
SMARTiSM00992. YccV-like. 1 hit.
[Graphical view]
SUPFAMiSSF110069. SSF110069. 1 hit.
SSF141255. SSF141255. 2 hits.
PROSITEiPS51087. APAG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor and Salivary gland.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiPDIP2_MOUSE
AccessioniPrimary (citable) accession number: Q91VA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.