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Q91VA1 (CTL4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Choline transporter-like protein 4
Alternative name(s):
Solute carrier family 44 member 4
Gene names
Name:Slc44a4
Synonyms:Ctl4, Ng22
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length707 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the CTL (choline transporter-like) family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 707707Choline transporter-like protein 4
PRO_0000191724

Regions

Topological domain1 – 3232Cytoplasmic Potential
Transmembrane33 – 5321Helical; Potential
Topological domain54 – 227174Extracellular Potential
Transmembrane228 – 24821Helical; Potential
Topological domain249 – 2502Cytoplasmic Potential
Transmembrane251 – 27121Helical; Potential
Topological domain272 – 30736Extracellular Potential
Transmembrane308 – 32821Helical; Potential
Topological domain329 – 35628Cytoplasmic Potential
Transmembrane357 – 37721Helical; Potential
Topological domain378 – 45275Extracellular Potential
Transmembrane453 – 47321Helical; Potential
Topological domain474 – 49825Cytoplasmic Potential
Transmembrane499 – 51921Helical; Potential
Topological domain520 – 55738Extracellular Potential
Transmembrane558 – 57821Helical; Potential
Topological domain579 – 59416Cytoplasmic Potential
Transmembrane595 – 61521Helical; Potential
Topological domain616 – 63520Extracellular Potential
Transmembrane636 – 65621Helical; Potential
Topological domain657 – 70751Cytoplasmic Potential

Amino acid modifications

Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation1851N-linked (GlcNAc...) Potential
Glycosylation1951N-linked (GlcNAc...) Potential
Glycosylation1961N-linked (GlcNAc...) Ref.4
Glycosylation2011N-linked (GlcNAc...); atypical Ref.4
Glycosylation2961N-linked (GlcNAc...) Potential
Glycosylation3911N-linked (GlcNAc...) Potential
Glycosylation4031N-linked (GlcNAc...) Potential
Glycosylation4131N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict4611V → A in AAH10808. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q91VA1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 544118B5B030A376

FASTA70778,723
        10         20         30         40         50         60 
MGRKQNENEA HGNSAKYDPS FRGPIKNRGC TDIICCVLFL IFILGYIIVG LVAWVYGDPR 

        70         80         90        100        110        120 
QVLYPRNSTG AYCGVGDNKD KPYVLYFDIL SCAAAINIIS IAENGLQCPT PQVCVSSCPL 

       130        140        150        160        170        180 
APWAVEVFQF SKTVGEVYGE RRNFCLPAVS PDMIVEESLQ KGLCPRFLLP STPALGRCFP 

       190        200        210        220        230        240 
LPNINFTLPE DLRINNTTVS NGISGLLDSI NARDVSVKIF EDFAQSWYWI LVALGVALAL 

       250        260        270        280        290        300 
SLLFILLLRL VAAPLVLLLI VGVLAVLAYG IYHCWQQYQV FRDKGASITQ LGFTTNFSAY 

       310        320        330        340        350        360 
QSVKETWLAA LIVLAVLEGI LLLMLIFLRQ RIRIAIALLK EASRAVGQMM STMFYPLVTF 

       370        380        390        400        410        420 
VLLVICIGYW AVTALYLATS GQPQYIYWAS NTSTPGCENV PVNMTCDPMA PLNSSCPNLK 

       430        440        450        460        470        480 
CVFKGYSTTG LAQRSLFNLQ IYGVLGLFWT VNWVLALGQC VLAGAFASFY WAFHKPRDIP 

       490        500        510        520        530        540 
TFPLSSAFIR TLRYHTGSLA FGALILSLVQ IARVILEYID HKLRGSQNPV ARCIICCFKC 

       550        560        570        580        590        600 
CLWCLEKFIK FLNRNAYIMI AIYGKNFCVS AKNAFMLLMR NVLRVVVLDK VTDLLLFFGK 

       610        620        630        640        650        660 
LLVVGGVGVL SFFFFSGRIK GLGKDFENPN LNYYWLPIMT SIMGAYVIAS GFFSVFGMCV 

       670        680        690        700 
DTLFLCFLED LERNDGSQER PYYMPKALLK ILGKKNEAPT GGKTRKK 

« Hide

References

[1]"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 129.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Blastocyst and Kidney.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 340-707.
Strain: C57BL/6J.
Tissue: Stomach.
[4]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-196 AND ASN-201.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF109906 Genomic DNA. Translation: AAC84166.1.
BC010808 mRNA. Translation: AAH10808.1.
BC052652 mRNA. Translation: AAH52652.1.
AK008864 mRNA. Translation: BAB25938.1.
RefSeqNP_076046.1. NM_023557.3.
UniGeneMm.183126.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ91VA1.

Proteomic databases

PaxDbQ91VA1.
PRIDEQ91VA1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000007249; ENSMUSP00000007249; ENSMUSG00000007034.
GeneID70129.
KEGGmmu:70129.
UCSCuc008ceh.2. mouse.

Organism-specific databases

CTD80736.
MGIMGI:1917379. Slc44a4.

Phylogenomic databases

eggNOGNOG310633.
GeneTreeENSGT00550000074521.
HOGENOMHOG000007110.
HOVERGENHBG062155.
InParanoidQ91VA1.
KOK15377.
OMAPVNSSCP.
OrthoDBEOG7FR7G4.
PhylomeDBQ91VA1.
TreeFamTF313325.

Gene expression databases

ArrayExpressQ91VA1.
BgeeQ91VA1.
CleanExMM_SLC44A4.
GenevestigatorQ91VA1.

Family and domain databases

InterProIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERPTHR12385. PTHR12385. 1 hit.
PfamPF04515. Choline_transpo. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio331054.
PROQ91VA1.
SOURCESearch...

Entry information

Entry nameCTL4_MOUSE
AccessionPrimary (citable) accession number: Q91VA1
Secondary accession number(s): Q7TQ02, Q9CVA7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot