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Q91VA1

- CTL4_MOUSE

UniProt

Q91VA1 - CTL4_MOUSE

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Protein
Choline transporter-like protein 4
Gene
Slc44a4, Ctl4, Ng22
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiREACT_207335. Synthesis of PC.
REACT_217615. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline transporter-like protein 4
Alternative name(s):
Solute carrier family 44 member 4
Gene namesi
Name:Slc44a4
Synonyms:Ctl4, Ng22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1917379. Slc44a4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei33 – 5321Helical; Reviewed prediction
Add
BLAST
Topological domaini54 – 227174Extracellular Reviewed prediction
Add
BLAST
Transmembranei228 – 24821Helical; Reviewed prediction
Add
BLAST
Topological domaini249 – 2502Cytoplasmic Reviewed prediction
Transmembranei251 – 27121Helical; Reviewed prediction
Add
BLAST
Topological domaini272 – 30736Extracellular Reviewed prediction
Add
BLAST
Transmembranei308 – 32821Helical; Reviewed prediction
Add
BLAST
Topological domaini329 – 35628Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei357 – 37721Helical; Reviewed prediction
Add
BLAST
Topological domaini378 – 45275Extracellular Reviewed prediction
Add
BLAST
Transmembranei453 – 47321Helical; Reviewed prediction
Add
BLAST
Topological domaini474 – 49825Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei499 – 51921Helical; Reviewed prediction
Add
BLAST
Topological domaini520 – 55738Extracellular Reviewed prediction
Add
BLAST
Transmembranei558 – 57821Helical; Reviewed prediction
Add
BLAST
Topological domaini579 – 59416Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei595 – 61521Helical; Reviewed prediction
Add
BLAST
Topological domaini616 – 63520Extracellular Reviewed prediction
Add
BLAST
Transmembranei636 – 65621Helical; Reviewed prediction
Add
BLAST
Topological domaini657 – 70751Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707Choline transporter-like protein 4
PRO_0000191724Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi185 – 1851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi195 – 1951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi196 – 1961N-linked (GlcNAc...)1 Publication
Glycosylationi201 – 2011N-linked (GlcNAc...); atypical1 Publication
Glycosylationi296 – 2961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi391 – 3911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi403 – 4031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi413 – 4131N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91VA1.
PRIDEiQ91VA1.

PTM databases

PhosphoSiteiQ91VA1.

Expressioni

Gene expression databases

ArrayExpressiQ91VA1.
BgeeiQ91VA1.
CleanExiMM_SLC44A4.
GenevestigatoriQ91VA1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG310633.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000007110.
HOVERGENiHBG062155.
InParanoidiQ91VA1.
KOiK15377.
OMAiCISAKNA.
OrthoDBiEOG7FR7G4.
PhylomeDBiQ91VA1.
TreeFamiTF313325.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 1 hit.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91VA1-1 [UniParc]FASTAAdd to Basket

« Hide

MGRKQNENEA HGNSAKYDPS FRGPIKNRGC TDIICCVLFL IFILGYIIVG    50
LVAWVYGDPR QVLYPRNSTG AYCGVGDNKD KPYVLYFDIL SCAAAINIIS 100
IAENGLQCPT PQVCVSSCPL APWAVEVFQF SKTVGEVYGE RRNFCLPAVS 150
PDMIVEESLQ KGLCPRFLLP STPALGRCFP LPNINFTLPE DLRINNTTVS 200
NGISGLLDSI NARDVSVKIF EDFAQSWYWI LVALGVALAL SLLFILLLRL 250
VAAPLVLLLI VGVLAVLAYG IYHCWQQYQV FRDKGASITQ LGFTTNFSAY 300
QSVKETWLAA LIVLAVLEGI LLLMLIFLRQ RIRIAIALLK EASRAVGQMM 350
STMFYPLVTF VLLVICIGYW AVTALYLATS GQPQYIYWAS NTSTPGCENV 400
PVNMTCDPMA PLNSSCPNLK CVFKGYSTTG LAQRSLFNLQ IYGVLGLFWT 450
VNWVLALGQC VLAGAFASFY WAFHKPRDIP TFPLSSAFIR TLRYHTGSLA 500
FGALILSLVQ IARVILEYID HKLRGSQNPV ARCIICCFKC CLWCLEKFIK 550
FLNRNAYIMI AIYGKNFCVS AKNAFMLLMR NVLRVVVLDK VTDLLLFFGK 600
LLVVGGVGVL SFFFFSGRIK GLGKDFENPN LNYYWLPIMT SIMGAYVIAS 650
GFFSVFGMCV DTLFLCFLED LERNDGSQER PYYMPKALLK ILGKKNEAPT 700
GGKTRKK 707
Length:707
Mass (Da):78,723
Last modified:December 1, 2001 - v1
Checksum:i544118B5B030A376
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti461 – 4611V → A in AAH10808. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109906 Genomic DNA. Translation: AAC84166.1.
BC010808 mRNA. Translation: AAH10808.1.
BC052652 mRNA. Translation: AAH52652.1.
AK008864 mRNA. Translation: BAB25938.1.
CCDSiCCDS37591.1.
RefSeqiNP_076046.1. NM_023557.3.
UniGeneiMm.183126.

Genome annotation databases

EnsembliENSMUST00000007249; ENSMUSP00000007249; ENSMUSG00000007034.
GeneIDi70129.
KEGGimmu:70129.
UCSCiuc008ceh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109906 Genomic DNA. Translation: AAC84166.1 .
BC010808 mRNA. Translation: AAH10808.1 .
BC052652 mRNA. Translation: AAH52652.1 .
AK008864 mRNA. Translation: BAB25938.1 .
CCDSi CCDS37591.1.
RefSeqi NP_076046.1. NM_023557.3.
UniGenei Mm.183126.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91VA1.

Proteomic databases

PaxDbi Q91VA1.
PRIDEi Q91VA1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000007249 ; ENSMUSP00000007249 ; ENSMUSG00000007034 .
GeneIDi 70129.
KEGGi mmu:70129.
UCSCi uc008ceh.2. mouse.

Organism-specific databases

CTDi 80736.
MGIi MGI:1917379. Slc44a4.

Phylogenomic databases

eggNOGi NOG310633.
GeneTreei ENSGT00550000074521.
HOGENOMi HOG000007110.
HOVERGENi HBG062155.
InParanoidi Q91VA1.
KOi K15377.
OMAi CISAKNA.
OrthoDBi EOG7FR7G4.
PhylomeDBi Q91VA1.
TreeFami TF313325.

Enzyme and pathway databases

Reactomei REACT_207335. Synthesis of PC.
REACT_217615. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

NextBioi 331054.
PROi Q91VA1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91VA1.
Bgeei Q91VA1.
CleanExi MM_SLC44A4.
Genevestigatori Q91VA1.

Family and domain databases

InterProi IPR007603. Choline_transptr-like.
[Graphical view ]
PANTHERi PTHR12385. PTHR12385. 1 hit.
Pfami PF04515. Choline_transpo. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Blastocyst and Kidney.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 340-707.
    Strain: C57BL/6J.
    Tissue: Stomach.
  4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-196 AND ASN-201.

Entry informationi

Entry nameiCTL4_MOUSE
AccessioniPrimary (citable) accession number: Q91VA1
Secondary accession number(s): Q7TQ02, Q9CVA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi