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Q91VA1

- CTL4_MOUSE

UniProt

Q91VA1 - CTL4_MOUSE

Protein

Choline transporter-like protein 4

Gene

Slc44a4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    ReactomeiREACT_207335. Synthesis of PC.
    REACT_217615. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Choline transporter-like protein 4
    Alternative name(s):
    Solute carrier family 44 member 4
    Gene namesi
    Name:Slc44a4
    Synonyms:Ctl4, Ng22
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1917379. Slc44a4.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 707707Choline transporter-like protein 4PRO_0000191724Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi196 – 1961N-linked (GlcNAc...)1 Publication
    Glycosylationi201 – 2011N-linked (GlcNAc...); atypical1 Publication
    Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ91VA1.
    PRIDEiQ91VA1.

    PTM databases

    PhosphoSiteiQ91VA1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91VA1.
    BgeeiQ91VA1.
    CleanExiMM_SLC44A4.
    GenevestigatoriQ91VA1.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini54 – 227174ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini249 – 2502CytoplasmicSequence Analysis
    Topological domaini272 – 30736ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini329 – 35628CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini378 – 45275ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini474 – 49825CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini520 – 55738ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini579 – 59416CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini616 – 63520ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini657 – 70751CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei228 – 24821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei251 – 27121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei308 – 32821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei357 – 37721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei453 – 47321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei499 – 51921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei558 – 57821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei595 – 61521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei636 – 65621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG310633.
    GeneTreeiENSGT00550000074521.
    HOGENOMiHOG000007110.
    HOVERGENiHBG062155.
    InParanoidiQ91VA1.
    KOiK15377.
    OMAiCISAKNA.
    OrthoDBiEOG7FR7G4.
    PhylomeDBiQ91VA1.
    TreeFamiTF313325.

    Family and domain databases

    InterProiIPR007603. Choline_transptr-like.
    [Graphical view]
    PANTHERiPTHR12385. PTHR12385. 1 hit.
    PfamiPF04515. Choline_transpo. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91VA1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRKQNENEA HGNSAKYDPS FRGPIKNRGC TDIICCVLFL IFILGYIIVG    50
    LVAWVYGDPR QVLYPRNSTG AYCGVGDNKD KPYVLYFDIL SCAAAINIIS 100
    IAENGLQCPT PQVCVSSCPL APWAVEVFQF SKTVGEVYGE RRNFCLPAVS 150
    PDMIVEESLQ KGLCPRFLLP STPALGRCFP LPNINFTLPE DLRINNTTVS 200
    NGISGLLDSI NARDVSVKIF EDFAQSWYWI LVALGVALAL SLLFILLLRL 250
    VAAPLVLLLI VGVLAVLAYG IYHCWQQYQV FRDKGASITQ LGFTTNFSAY 300
    QSVKETWLAA LIVLAVLEGI LLLMLIFLRQ RIRIAIALLK EASRAVGQMM 350
    STMFYPLVTF VLLVICIGYW AVTALYLATS GQPQYIYWAS NTSTPGCENV 400
    PVNMTCDPMA PLNSSCPNLK CVFKGYSTTG LAQRSLFNLQ IYGVLGLFWT 450
    VNWVLALGQC VLAGAFASFY WAFHKPRDIP TFPLSSAFIR TLRYHTGSLA 500
    FGALILSLVQ IARVILEYID HKLRGSQNPV ARCIICCFKC CLWCLEKFIK 550
    FLNRNAYIMI AIYGKNFCVS AKNAFMLLMR NVLRVVVLDK VTDLLLFFGK 600
    LLVVGGVGVL SFFFFSGRIK GLGKDFENPN LNYYWLPIMT SIMGAYVIAS 650
    GFFSVFGMCV DTLFLCFLED LERNDGSQER PYYMPKALLK ILGKKNEAPT 700
    GGKTRKK 707
    Length:707
    Mass (Da):78,723
    Last modified:December 1, 2001 - v1
    Checksum:i544118B5B030A376
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti461 – 4611V → A in AAH10808. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF109906 Genomic DNA. Translation: AAC84166.1.
    BC010808 mRNA. Translation: AAH10808.1.
    BC052652 mRNA. Translation: AAH52652.1.
    AK008864 mRNA. Translation: BAB25938.1.
    CCDSiCCDS37591.1.
    RefSeqiNP_076046.1. NM_023557.3.
    UniGeneiMm.183126.

    Genome annotation databases

    EnsembliENSMUST00000007249; ENSMUSP00000007249; ENSMUSG00000007034.
    GeneIDi70129.
    KEGGimmu:70129.
    UCSCiuc008ceh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF109906 Genomic DNA. Translation: AAC84166.1 .
    BC010808 mRNA. Translation: AAH10808.1 .
    BC052652 mRNA. Translation: AAH52652.1 .
    AK008864 mRNA. Translation: BAB25938.1 .
    CCDSi CCDS37591.1.
    RefSeqi NP_076046.1. NM_023557.3.
    UniGenei Mm.183126.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91VA1.

    Proteomic databases

    PaxDbi Q91VA1.
    PRIDEi Q91VA1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000007249 ; ENSMUSP00000007249 ; ENSMUSG00000007034 .
    GeneIDi 70129.
    KEGGi mmu:70129.
    UCSCi uc008ceh.2. mouse.

    Organism-specific databases

    CTDi 80736.
    MGIi MGI:1917379. Slc44a4.

    Phylogenomic databases

    eggNOGi NOG310633.
    GeneTreei ENSGT00550000074521.
    HOGENOMi HOG000007110.
    HOVERGENi HBG062155.
    InParanoidi Q91VA1.
    KOi K15377.
    OMAi CISAKNA.
    OrthoDBi EOG7FR7G4.
    PhylomeDBi Q91VA1.
    TreeFami TF313325.

    Enzyme and pathway databases

    Reactomei REACT_207335. Synthesis of PC.
    REACT_217615. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

    Miscellaneous databases

    NextBioi 331054.
    PROi Q91VA1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91VA1.
    Bgeei Q91VA1.
    CleanExi MM_SLC44A4.
    Genevestigatori Q91VA1.

    Family and domain databases

    InterProi IPR007603. Choline_transptr-like.
    [Graphical view ]
    PANTHERi PTHR12385. PTHR12385. 1 hit.
    Pfami PF04515. Choline_transpo. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 129.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Blastocyst and Kidney.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 340-707.
      Strain: C57BL/6J.
      Tissue: Stomach.
    4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-196 AND ASN-201.

    Entry informationi

    Entry nameiCTL4_MOUSE
    AccessioniPrimary (citable) accession number: Q91VA1
    Secondary accession number(s): Q7TQ02, Q9CVA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3