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Protein

Choline transporter-like protein 4

Gene

Slc44a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1483191. Synthesis of PC.
R-MMU-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline transporter-like protein 4
Alternative name(s):
Solute carrier family 44 member 4
Gene namesi
Name:Slc44a4
Synonyms:Ctl4, Ng22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1917379. Slc44a4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 227ExtracellularSequence analysisAdd BLAST174
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 250CytoplasmicSequence analysis2
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 307ExtracellularSequence analysisAdd BLAST36
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 356CytoplasmicSequence analysisAdd BLAST28
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Topological domaini378 – 452ExtracellularSequence analysisAdd BLAST75
Transmembranei453 – 473HelicalSequence analysisAdd BLAST21
Topological domaini474 – 498CytoplasmicSequence analysisAdd BLAST25
Transmembranei499 – 519HelicalSequence analysisAdd BLAST21
Topological domaini520 – 557ExtracellularSequence analysisAdd BLAST38
Transmembranei558 – 578HelicalSequence analysisAdd BLAST21
Topological domaini579 – 594CytoplasmicSequence analysisAdd BLAST16
Transmembranei595 – 615HelicalSequence analysisAdd BLAST21
Topological domaini616 – 635ExtracellularSequence analysisAdd BLAST20
Transmembranei636 – 656HelicalSequence analysisAdd BLAST21
Topological domaini657 – 707CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917241 – 707Choline transporter-like protein 4Add BLAST707

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Glycosylationi185N-linked (GlcNAc...)Sequence analysis1
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1
Glycosylationi196N-linked (GlcNAc...)1 Publication1
Glycosylationi201N-linked (GlcNAc...); atypical1 Publication1
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Glycosylationi391N-linked (GlcNAc...)Sequence analysis1
Glycosylationi403N-linked (GlcNAc...)Sequence analysis1
Glycosylationi413N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91VA1.
PRIDEiQ91VA1.

PTM databases

iPTMnetiQ91VA1.
PhosphoSitePlusiQ91VA1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000007034.
CleanExiMM_SLC44A4.
ExpressionAtlasiQ91VA1. baseline and differential.
GenevisibleiQ91VA1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007249.

Structurei

3D structure databases

ProteinModelPortaliQ91VA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1362. Eukaryota.
ENOG410XS0P. LUCA.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000007110.
HOVERGENiHBG062155.
InParanoidiQ91VA1.
KOiK15377.
OMAiKNVLQNQ.
OrthoDBiEOG091G04CQ.
PhylomeDBiQ91VA1.
TreeFamiTF313325.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 2 hits.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91VA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRKQNENEA HGNSAKYDPS FRGPIKNRGC TDIICCVLFL IFILGYIIVG
60 70 80 90 100
LVAWVYGDPR QVLYPRNSTG AYCGVGDNKD KPYVLYFDIL SCAAAINIIS
110 120 130 140 150
IAENGLQCPT PQVCVSSCPL APWAVEVFQF SKTVGEVYGE RRNFCLPAVS
160 170 180 190 200
PDMIVEESLQ KGLCPRFLLP STPALGRCFP LPNINFTLPE DLRINNTTVS
210 220 230 240 250
NGISGLLDSI NARDVSVKIF EDFAQSWYWI LVALGVALAL SLLFILLLRL
260 270 280 290 300
VAAPLVLLLI VGVLAVLAYG IYHCWQQYQV FRDKGASITQ LGFTTNFSAY
310 320 330 340 350
QSVKETWLAA LIVLAVLEGI LLLMLIFLRQ RIRIAIALLK EASRAVGQMM
360 370 380 390 400
STMFYPLVTF VLLVICIGYW AVTALYLATS GQPQYIYWAS NTSTPGCENV
410 420 430 440 450
PVNMTCDPMA PLNSSCPNLK CVFKGYSTTG LAQRSLFNLQ IYGVLGLFWT
460 470 480 490 500
VNWVLALGQC VLAGAFASFY WAFHKPRDIP TFPLSSAFIR TLRYHTGSLA
510 520 530 540 550
FGALILSLVQ IARVILEYID HKLRGSQNPV ARCIICCFKC CLWCLEKFIK
560 570 580 590 600
FLNRNAYIMI AIYGKNFCVS AKNAFMLLMR NVLRVVVLDK VTDLLLFFGK
610 620 630 640 650
LLVVGGVGVL SFFFFSGRIK GLGKDFENPN LNYYWLPIMT SIMGAYVIAS
660 670 680 690 700
GFFSVFGMCV DTLFLCFLED LERNDGSQER PYYMPKALLK ILGKKNEAPT

GGKTRKK
Length:707
Mass (Da):78,723
Last modified:December 1, 2001 - v1
Checksum:i544118B5B030A376
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti461V → A in AAH10808 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109906 Genomic DNA. Translation: AAC84166.1.
BC010808 mRNA. Translation: AAH10808.1.
BC052652 mRNA. Translation: AAH52652.1.
AK008864 mRNA. Translation: BAB25938.1.
CCDSiCCDS37591.1.
RefSeqiNP_076046.1. NM_023557.3.
UniGeneiMm.183126.

Genome annotation databases

EnsembliENSMUST00000007249; ENSMUSP00000007249; ENSMUSG00000007034.
GeneIDi70129.
KEGGimmu:70129.
UCSCiuc008ceh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109906 Genomic DNA. Translation: AAC84166.1.
BC010808 mRNA. Translation: AAH10808.1.
BC052652 mRNA. Translation: AAH52652.1.
AK008864 mRNA. Translation: BAB25938.1.
CCDSiCCDS37591.1.
RefSeqiNP_076046.1. NM_023557.3.
UniGeneiMm.183126.

3D structure databases

ProteinModelPortaliQ91VA1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007249.

PTM databases

iPTMnetiQ91VA1.
PhosphoSitePlusiQ91VA1.

Proteomic databases

PaxDbiQ91VA1.
PRIDEiQ91VA1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000007249; ENSMUSP00000007249; ENSMUSG00000007034.
GeneIDi70129.
KEGGimmu:70129.
UCSCiuc008ceh.2. mouse.

Organism-specific databases

CTDi80736.
MGIiMGI:1917379. Slc44a4.

Phylogenomic databases

eggNOGiKOG1362. Eukaryota.
ENOG410XS0P. LUCA.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000007110.
HOVERGENiHBG062155.
InParanoidiQ91VA1.
KOiK15377.
OMAiKNVLQNQ.
OrthoDBiEOG091G04CQ.
PhylomeDBiQ91VA1.
TreeFamiTF313325.

Enzyme and pathway databases

ReactomeiR-MMU-1483191. Synthesis of PC.
R-MMU-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

PROiQ91VA1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007034.
CleanExiMM_SLC44A4.
ExpressionAtlasiQ91VA1. baseline and differential.
GenevisibleiQ91VA1. MM.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 2 hits.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTL4_MOUSE
AccessioniPrimary (citable) accession number: Q91VA1
Secondary accession number(s): Q7TQ02, Q9CVA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.