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Q91VA1

- CTL4_MOUSE

UniProt

Q91VA1 - CTL4_MOUSE

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Protein

Choline transporter-like protein 4

Gene

Slc44a4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. acetylcholine biosynthetic process Source: Ensembl
  2. acetylcholine secretion Source: Ensembl
  3. positive regulation of cell growth Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_207335. Synthesis of PC.
REACT_217615. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline transporter-like protein 4
Alternative name(s):
Solute carrier family 44 member 4
Gene namesi
Name:Slc44a4
Synonyms:Ctl4, Ng22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1917379. Slc44a4.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707Choline transporter-like protein 4PRO_0000191724Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi196 – 1961N-linked (GlcNAc...)1 Publication
Glycosylationi201 – 2011N-linked (GlcNAc...); atypical1 Publication
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91VA1.
PRIDEiQ91VA1.

PTM databases

PhosphoSiteiQ91VA1.

Expressioni

Gene expression databases

BgeeiQ91VA1.
CleanExiMM_SLC44A4.
ExpressionAtlasiQ91VA1. baseline and differential.
GenevestigatoriQ91VA1.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini54 – 227174ExtracellularSequence AnalysisAdd
BLAST
Topological domaini249 – 2502CytoplasmicSequence Analysis
Topological domaini272 – 30736ExtracellularSequence AnalysisAdd
BLAST
Topological domaini329 – 35628CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini378 – 45275ExtracellularSequence AnalysisAdd
BLAST
Topological domaini474 – 49825CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini520 – 55738ExtracellularSequence AnalysisAdd
BLAST
Topological domaini579 – 59416CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini616 – 63520ExtracellularSequence AnalysisAdd
BLAST
Topological domaini657 – 70751CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321HelicalSequence AnalysisAdd
BLAST
Transmembranei228 – 24821HelicalSequence AnalysisAdd
BLAST
Transmembranei251 – 27121HelicalSequence AnalysisAdd
BLAST
Transmembranei308 – 32821HelicalSequence AnalysisAdd
BLAST
Transmembranei357 – 37721HelicalSequence AnalysisAdd
BLAST
Transmembranei453 – 47321HelicalSequence AnalysisAdd
BLAST
Transmembranei499 – 51921HelicalSequence AnalysisAdd
BLAST
Transmembranei558 – 57821HelicalSequence AnalysisAdd
BLAST
Transmembranei595 – 61521HelicalSequence AnalysisAdd
BLAST
Transmembranei636 – 65621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG310633.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000007110.
HOVERGENiHBG062155.
InParanoidiQ91VA1.
KOiK15377.
OMAiCISAKNA.
OrthoDBiEOG7FR7G4.
PhylomeDBiQ91VA1.
TreeFamiTF313325.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 1 hit.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91VA1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRKQNENEA HGNSAKYDPS FRGPIKNRGC TDIICCVLFL IFILGYIIVG
60 70 80 90 100
LVAWVYGDPR QVLYPRNSTG AYCGVGDNKD KPYVLYFDIL SCAAAINIIS
110 120 130 140 150
IAENGLQCPT PQVCVSSCPL APWAVEVFQF SKTVGEVYGE RRNFCLPAVS
160 170 180 190 200
PDMIVEESLQ KGLCPRFLLP STPALGRCFP LPNINFTLPE DLRINNTTVS
210 220 230 240 250
NGISGLLDSI NARDVSVKIF EDFAQSWYWI LVALGVALAL SLLFILLLRL
260 270 280 290 300
VAAPLVLLLI VGVLAVLAYG IYHCWQQYQV FRDKGASITQ LGFTTNFSAY
310 320 330 340 350
QSVKETWLAA LIVLAVLEGI LLLMLIFLRQ RIRIAIALLK EASRAVGQMM
360 370 380 390 400
STMFYPLVTF VLLVICIGYW AVTALYLATS GQPQYIYWAS NTSTPGCENV
410 420 430 440 450
PVNMTCDPMA PLNSSCPNLK CVFKGYSTTG LAQRSLFNLQ IYGVLGLFWT
460 470 480 490 500
VNWVLALGQC VLAGAFASFY WAFHKPRDIP TFPLSSAFIR TLRYHTGSLA
510 520 530 540 550
FGALILSLVQ IARVILEYID HKLRGSQNPV ARCIICCFKC CLWCLEKFIK
560 570 580 590 600
FLNRNAYIMI AIYGKNFCVS AKNAFMLLMR NVLRVVVLDK VTDLLLFFGK
610 620 630 640 650
LLVVGGVGVL SFFFFSGRIK GLGKDFENPN LNYYWLPIMT SIMGAYVIAS
660 670 680 690 700
GFFSVFGMCV DTLFLCFLED LERNDGSQER PYYMPKALLK ILGKKNEAPT

GGKTRKK
Length:707
Mass (Da):78,723
Last modified:December 1, 2001 - v1
Checksum:i544118B5B030A376
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti461 – 4611V → A in AAH10808. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109906 Genomic DNA. Translation: AAC84166.1.
BC010808 mRNA. Translation: AAH10808.1.
BC052652 mRNA. Translation: AAH52652.1.
AK008864 mRNA. Translation: BAB25938.1.
CCDSiCCDS37591.1.
RefSeqiNP_076046.1. NM_023557.3.
UniGeneiMm.183126.

Genome annotation databases

EnsembliENSMUST00000007249; ENSMUSP00000007249; ENSMUSG00000007034.
GeneIDi70129.
KEGGimmu:70129.
UCSCiuc008ceh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109906 Genomic DNA. Translation: AAC84166.1 .
BC010808 mRNA. Translation: AAH10808.1 .
BC052652 mRNA. Translation: AAH52652.1 .
AK008864 mRNA. Translation: BAB25938.1 .
CCDSi CCDS37591.1.
RefSeqi NP_076046.1. NM_023557.3.
UniGenei Mm.183126.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91VA1.

Proteomic databases

PaxDbi Q91VA1.
PRIDEi Q91VA1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000007249 ; ENSMUSP00000007249 ; ENSMUSG00000007034 .
GeneIDi 70129.
KEGGi mmu:70129.
UCSCi uc008ceh.2. mouse.

Organism-specific databases

CTDi 80736.
MGIi MGI:1917379. Slc44a4.

Phylogenomic databases

eggNOGi NOG310633.
GeneTreei ENSGT00550000074521.
HOGENOMi HOG000007110.
HOVERGENi HBG062155.
InParanoidi Q91VA1.
KOi K15377.
OMAi CISAKNA.
OrthoDBi EOG7FR7G4.
PhylomeDBi Q91VA1.
TreeFami TF313325.

Enzyme and pathway databases

Reactomei REACT_207335. Synthesis of PC.
REACT_217615. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

NextBioi 331054.
PROi Q91VA1.
SOURCEi Search...

Gene expression databases

Bgeei Q91VA1.
CleanExi MM_SLC44A4.
ExpressionAtlasi Q91VA1. baseline and differential.
Genevestigatori Q91VA1.

Family and domain databases

InterProi IPR007603. Choline_transptr-like.
[Graphical view ]
PANTHERi PTHR12385. PTHR12385. 1 hit.
Pfami PF04515. Choline_transpo. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Blastocyst and Kidney.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 340-707.
    Strain: C57BL/6J.
    Tissue: Stomach.
  4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-196 AND ASN-201.

Entry informationi

Entry nameiCTL4_MOUSE
AccessioniPrimary (citable) accession number: Q91VA1
Secondary accession number(s): Q7TQ02, Q9CVA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3