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Q91V98

- CD248_MOUSE

UniProt

Q91V98 - CD248_MOUSE

Protein

Endosialin

Gene

Cd248

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May play a role in angiogenesis or vascular function.1 Publication

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. carbohydrate binding Source: InterPro
    3. extracellular matrix binding Source: MGI

    GO - Biological processi

    1. anatomical structure regression Source: MGI
    2. cell migration Source: MGI
    3. lymph node development Source: MGI
    4. positive regulation of cell proliferation Source: MGI
    5. positive regulation of endothelial cell apoptotic process Source: MGI

    Keywords - Ligandi

    Calcium, Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endosialin
    Alternative name(s):
    Tumor endothelial marker 1
    CD_antigen: CD248
    Gene namesi
    Name:Cd248
    Synonyms:Tem1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1917695. Cd248.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 765748EndosialinPRO_0000045800Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi131 ↔ 147PROSITE-ProRule annotation
    Disulfide bondi164 ↔ 213PROSITE-ProRule annotation
    Disulfide bondi203 ↔ 230PROSITE-ProRule annotation
    Disulfide bondi316 ↔ 326PROSITE-ProRule annotation
    Disulfide bondi322 ↔ 335PROSITE-ProRule annotation
    Disulfide bondi337 ↔ 350PROSITE-ProRule annotation
    Glycosylationi401 – 4011O-linked (GalNAc...)Sequence Analysis
    Glycosylationi428 – 4281O-linked (GalNAc...)Sequence Analysis
    Glycosylationi448 – 4481O-linked (GalNAc...)Sequence Analysis
    Glycosylationi456 – 4561O-linked (GalNAc...)Sequence Analysis
    Glycosylationi459 – 4591O-linked (GalNAc...)Sequence Analysis
    Glycosylationi466 – 4661O-linked (GalNAc...)Sequence Analysis
    Glycosylationi467 – 4671O-linked (GalNAc...)Sequence Analysis
    Glycosylationi470 – 4701O-linked (GalNAc...)Sequence Analysis
    Glycosylationi472 – 4721O-linked (GalNAc...)Sequence Analysis
    Glycosylationi477 – 4771O-linked (GalNAc...)Sequence Analysis
    Glycosylationi488 – 4881O-linked (GalNAc...)Sequence Analysis
    Glycosylationi517 – 5171O-linked (GalNAc...)Sequence Analysis
    Glycosylationi520 – 5201O-linked (GalNAc...)Sequence Analysis
    Glycosylationi535 – 5351O-linked (GalNAc...)Sequence Analysis
    Glycosylationi552 – 5521O-linked (GalNAc...)Sequence Analysis
    Glycosylationi554 – 5541O-linked (GalNAc...)Sequence Analysis
    Glycosylationi556 – 5561O-linked (GalNAc...)Sequence Analysis
    Glycosylationi570 – 5701O-linked (GalNAc...)Sequence Analysis
    Glycosylationi571 – 5711O-linked (GalNAc...)Sequence Analysis
    Glycosylationi604 – 6041O-linked (GalNAc...)Sequence Analysis
    Glycosylationi613 – 6131O-linked (GalNAc...)Sequence Analysis
    Glycosylationi626 – 6261O-linked (GalNAc...)Sequence Analysis
    Glycosylationi627 – 6271O-linked (GalNAc...)Sequence Analysis
    Glycosylationi635 – 6351O-linked (GalNAc...)Sequence Analysis
    Glycosylationi638 – 6381O-linked (GalNAc...)Sequence Analysis
    Glycosylationi639 – 6391O-linked (GalNAc...)Sequence Analysis
    Glycosylationi640 – 6401O-linked (GalNAc...)Sequence Analysis
    Glycosylationi644 – 6441O-linked (GalNAc...)Sequence Analysis
    Glycosylationi663 – 6631O-linked (GalNAc...)Sequence Analysis
    Glycosylationi673 – 6731O-linked (GalNAc...)Sequence Analysis

    Post-translational modificationi

    O-glycosylated by sialylated oligosaccharides.By similarity
    May be N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ91V98.
    PRIDEiQ91V98.

    PTM databases

    PhosphoSiteiQ91V98.

    Expressioni

    Tissue specificityi

    Expressed in cell lines derived from endothelial cells, embryonic fibroblasts and preadipocytes.1 Publication

    Developmental stagei

    Detected at E19 in embryo.1 Publication

    Gene expression databases

    BgeeiQ91V98.
    CleanExiMM_CD248.
    GenevestigatoriQ91V98.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000070847.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91V98.
    SMRiQ91V98. Positions 34-159, 242-357.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 695678ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini717 – 76549CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei696 – 71621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 156127C-type lectinPROSITE-ProRule annotationAdd
    BLAST
    Domaini162 – 23271SushiAdd
    BLAST
    Domaini312 – 35140EGF-like; calcium-bindingSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi400 – 676277Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation
    Contains 1 EGF-like domain.Curated
    Contains 1 Sushi (CCP/SCR) domain.Curated

    Keywords - Domaini

    EGF-like domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG147482.
    GeneTreeiENSGT00530000063403.
    HOGENOMiHOG000111482.
    HOVERGENiHBG081065.
    InParanoidiQ91V98.
    KOiK06706.
    OMAiEASGEHR.
    OrthoDBiEOG7ZGX2D.
    PhylomeDBiQ91V98.
    TreeFamiTF330714.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view]
    PfamiPF07645. EGF_CA. 1 hit.
    PF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    SM00181. EGF. 2 hits.
    SM00179. EGF_CA. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS01187. EGF_CA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91V98-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLRLLLAWV AAVPALGQVP WTPEPRAACG PSSCYALFPR RRTFLEAWRA    50
    CRELGGNLAT PRTPEEAQRV DSLVGVGPAN GLLWIGLQRQ ARQCQPQRPL 100
    RGFIWTTGDQ DTAFTNWAQP ATEGPCPAQR CAALEASGEH RWLEGSCTLA 150
    VDGYLCQFGF EGACPALPLE VGQAGPAVYT TPFNLVSSEF EWLPFGSVAA 200
    VQCQAGRGAS LLCVKQPSGG VGWSQTGPLC PGTGCGPDNG GCEHECVEEV 250
    DGAVSCRCSE GFRLAADGHS CEDPCAQAPC EQQCEPGGPQ GYSCHCRLGF 300
    RPAEDDPHRC VDTDECQIAG VCQQMCVNYV GGFECYCSEG HELEADGISC 350
    SPAGAMGAQA SQDLRDELLD DGEEGEDEEE PWEDFDGTWT EEQGILWLAP 400
    THPPDFGLPY RPNFPQDGEP QRLHLEPTWP PPLSAPRGPY HSSVVSATRP 450
    MVISATRPTL PSAHKTSVIS ATRPPLSPVH PPAMAPATPP AVFSEHQIPK 500
    IKANYPDLPF GHKPGITSAT HPARSPPYQP PIISTNYPQV FPPHQAPMSP 550
    DTHTITYLPP VPPHLDPGDT TSKAHQHPLL PDAPGIRTQA PQLSVSALQP 600
    PLPTNSRSSV HETPVPAANQ PPAFPSSPLP PQRPTNQTSS ISPTHSYSRA 650
    PLVPREGVPS PKSVPQLPSV PSTAAPTALA ESGLAGQSQR DDRWLLVALL 700
    VPTCVFLVVL LALGIVYCTR CGSHAPNKRI TDCYRWVTHA GNKSSTEPMP 750
    PRGSLTGVQT CRTSV 765
    Length:765
    Mass (Da):81,813
    Last modified:December 1, 2001 - v1
    Checksum:i572A06CC15BC8CD8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti525 – 5251S → P in AAK84664. (PubMed:11489895)Curated
    Sequence conflicti751 – 7511P → T in BAE25992. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF378758 mRNA. Translation: AAL11995.1.
    AF388572 mRNA. Translation: AAK84664.1.
    AF388573 Genomic DNA. Translation: AAK84665.1.
    AK144655 mRNA. Translation: BAE25992.1.
    BC046318 mRNA. Translation: AAH46318.1.
    CCDSiCCDS29448.1.
    RefSeqiNP_473383.1. NM_054042.2.
    UniGeneiMm.29597.

    Genome annotation databases

    EnsembliENSMUST00000070630; ENSMUSP00000070847; ENSMUSG00000056481.
    GeneIDi70445.
    KEGGimmu:70445.
    UCSCiuc008gcb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF378758 mRNA. Translation: AAL11995.1 .
    AF388572 mRNA. Translation: AAK84664.1 .
    AF388573 Genomic DNA. Translation: AAK84665.1 .
    AK144655 mRNA. Translation: BAE25992.1 .
    BC046318 mRNA. Translation: AAH46318.1 .
    CCDSi CCDS29448.1.
    RefSeqi NP_473383.1. NM_054042.2.
    UniGenei Mm.29597.

    3D structure databases

    ProteinModelPortali Q91V98.
    SMRi Q91V98. Positions 34-159, 242-357.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000070847.

    PTM databases

    PhosphoSitei Q91V98.

    Proteomic databases

    PaxDbi Q91V98.
    PRIDEi Q91V98.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000070630 ; ENSMUSP00000070847 ; ENSMUSG00000056481 .
    GeneIDi 70445.
    KEGGi mmu:70445.
    UCSCi uc008gcb.1. mouse.

    Organism-specific databases

    CTDi 57124.
    MGIi MGI:1917695. Cd248.

    Phylogenomic databases

    eggNOGi NOG147482.
    GeneTreei ENSGT00530000063403.
    HOGENOMi HOG000111482.
    HOVERGENi HBG081065.
    InParanoidi Q91V98.
    KOi K06706.
    OMAi EASGEHR.
    OrthoDBi EOG7ZGX2D.
    PhylomeDBi Q91V98.
    TreeFami TF330714.

    Miscellaneous databases

    ChiTaRSi CD248. mouse.
    NextBioi 331635.
    PROi Q91V98.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91V98.
    CleanExi MM_CD248.
    Genevestigatori Q91V98.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view ]
    Pfami PF07645. EGF_CA. 1 hit.
    PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    SM00181. EGF. 2 hits.
    SM00179. EGF_CA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS01187. EGF_CA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cell surface tumor endothelial markers are conserved in mice and humans."
      Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W., St Croix B.
      Cancer Res. 61:6649-6655(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo."
      Opavsky R., Haviernik P., Jurkovicova D., Garin M.T., Copeland N.G., Gilbert D.J., Jenkins N.A., Bies J., Garfield S., Pastorekova S., Oue A., Wolff L.
      J. Biol. Chem. 276:38795-38807(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, FUNCTION.
      Strain: 129S6/SvEvTac.
      Tissue: Spleen and Thymus.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiCD248_MOUSE
    AccessioniPrimary (citable) accession number: Q91V98
    Secondary accession number(s): Q3UMV6, Q91ZV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3