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Q91V98 (CD248_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endosialin
Alternative name(s):
Tumor endothelial marker 1
CD_antigen=CD248
Gene names
Name:Cd248
Synonyms:Tem1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length765 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in angiogenesis or vascular function. Ref.2

Subcellular location

Membrane; Single-pass type I membrane protein Probable.

Tissue specificity

Expressed in cell lines derived from endothelial cells, embryonic fibroblasts and preadipocytes. Ref.2

Developmental stage

Detected at E19 in embryo. Ref.2

Post-translational modification

O-glycosylated by sialylated oligosaccharides By similarity.

May be N-glycosylated By similarity.

Sequence similarities

Contains 1 C-type lectin domain.

Contains 1 EGF-like domain.

Contains 1 Sushi (CCP/SCR) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 765748Endosialin
PRO_0000045800

Regions

Topological domain18 – 695678Extracellular Potential
Transmembrane696 – 71621Helical; Potential
Topological domain717 – 76549Cytoplasmic Potential
Domain30 – 156127C-type lectin
Domain162 – 23271Sushi
Domain312 – 35140EGF-like; calcium-binding Potential
Compositional bias400 – 676277Pro-rich

Amino acid modifications

Glycosylation4011O-linked (GalNAc...) Potential
Glycosylation4281O-linked (GalNAc...) Potential
Glycosylation4481O-linked (GalNAc...) Potential
Glycosylation4561O-linked (GalNAc...) Potential
Glycosylation4591O-linked (GalNAc...) Potential
Glycosylation4661O-linked (GalNAc...) Potential
Glycosylation4671O-linked (GalNAc...) Potential
Glycosylation4701O-linked (GalNAc...) Potential
Glycosylation4721O-linked (GalNAc...) Potential
Glycosylation4771O-linked (GalNAc...) Potential
Glycosylation4881O-linked (GalNAc...) Potential
Glycosylation5171O-linked (GalNAc...) Potential
Glycosylation5201O-linked (GalNAc...) Potential
Glycosylation5351O-linked (GalNAc...) Potential
Glycosylation5521O-linked (GalNAc...) Potential
Glycosylation5541O-linked (GalNAc...) Potential
Glycosylation5561O-linked (GalNAc...) Potential
Glycosylation5701O-linked (GalNAc...) Potential
Glycosylation5711O-linked (GalNAc...) Potential
Glycosylation6041O-linked (GalNAc...) Potential
Glycosylation6131O-linked (GalNAc...) Potential
Glycosylation6261O-linked (GalNAc...) Potential
Glycosylation6271O-linked (GalNAc...) Potential
Glycosylation6351O-linked (GalNAc...) Potential
Glycosylation6381O-linked (GalNAc...) Potential
Glycosylation6391O-linked (GalNAc...) Potential
Glycosylation6401O-linked (GalNAc...) Potential
Glycosylation6441O-linked (GalNAc...) Potential
Glycosylation6631O-linked (GalNAc...) Potential
Glycosylation6731O-linked (GalNAc...) Potential
Disulfide bond131 ↔ 147 By similarity
Disulfide bond164 ↔ 213 By similarity
Disulfide bond203 ↔ 230 By similarity
Disulfide bond316 ↔ 326 By similarity
Disulfide bond322 ↔ 335 By similarity
Disulfide bond337 ↔ 350 By similarity

Experimental info

Sequence conflict5251S → P in AAK84664. Ref.2
Sequence conflict7511P → T in BAE25992. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q91V98 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 572A06CC15BC8CD8

FASTA76581,813
        10         20         30         40         50         60 
MLLRLLLAWV AAVPALGQVP WTPEPRAACG PSSCYALFPR RRTFLEAWRA CRELGGNLAT 

        70         80         90        100        110        120 
PRTPEEAQRV DSLVGVGPAN GLLWIGLQRQ ARQCQPQRPL RGFIWTTGDQ DTAFTNWAQP 

       130        140        150        160        170        180 
ATEGPCPAQR CAALEASGEH RWLEGSCTLA VDGYLCQFGF EGACPALPLE VGQAGPAVYT 

       190        200        210        220        230        240 
TPFNLVSSEF EWLPFGSVAA VQCQAGRGAS LLCVKQPSGG VGWSQTGPLC PGTGCGPDNG 

       250        260        270        280        290        300 
GCEHECVEEV DGAVSCRCSE GFRLAADGHS CEDPCAQAPC EQQCEPGGPQ GYSCHCRLGF 

       310        320        330        340        350        360 
RPAEDDPHRC VDTDECQIAG VCQQMCVNYV GGFECYCSEG HELEADGISC SPAGAMGAQA 

       370        380        390        400        410        420 
SQDLRDELLD DGEEGEDEEE PWEDFDGTWT EEQGILWLAP THPPDFGLPY RPNFPQDGEP 

       430        440        450        460        470        480 
QRLHLEPTWP PPLSAPRGPY HSSVVSATRP MVISATRPTL PSAHKTSVIS ATRPPLSPVH 

       490        500        510        520        530        540 
PPAMAPATPP AVFSEHQIPK IKANYPDLPF GHKPGITSAT HPARSPPYQP PIISTNYPQV 

       550        560        570        580        590        600 
FPPHQAPMSP DTHTITYLPP VPPHLDPGDT TSKAHQHPLL PDAPGIRTQA PQLSVSALQP 

       610        620        630        640        650        660 
PLPTNSRSSV HETPVPAANQ PPAFPSSPLP PQRPTNQTSS ISPTHSYSRA PLVPREGVPS 

       670        680        690        700        710        720 
PKSVPQLPSV PSTAAPTALA ESGLAGQSQR DDRWLLVALL VPTCVFLVVL LALGIVYCTR 

       730        740        750        760 
CGSHAPNKRI TDCYRWVTHA GNKSSTEPMP PRGSLTGVQT CRTSV 

« Hide

References

« Hide 'large scale' references
[1]"Cell surface tumor endothelial markers are conserved in mice and humans."
Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W., St Croix B.
Cancer Res. 61:6649-6655(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo."
Opavsky R., Haviernik P., Jurkovicova D., Garin M.T., Copeland N.G., Gilbert D.J., Jenkins N.A., Bies J., Garfield S., Pastorekova S., Oue A., Wolff L.
J. Biol. Chem. 276:38795-38807(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, FUNCTION.
Strain: 129S6/SvEvTac.
Tissue: Spleen and Thymus.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF378758 mRNA. Translation: AAL11995.1.
AF388572 mRNA. Translation: AAK84664.1.
AF388573 Genomic DNA. Translation: AAK84665.1.
AK144655 mRNA. Translation: BAE25992.1.
BC046318 mRNA. Translation: AAH46318.1.
CCDSCCDS29448.1.
RefSeqNP_473383.1. NM_054042.2.
UniGeneMm.29597.

3D structure databases

ProteinModelPortalQ91V98.
SMRQ91V98. Positions 34-159, 242-357.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000070847.

PTM databases

PhosphoSiteQ91V98.

Proteomic databases

PaxDbQ91V98.
PRIDEQ91V98.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000070630; ENSMUSP00000070847; ENSMUSG00000056481.
GeneID70445.
KEGGmmu:70445.
UCSCuc008gcb.1. mouse.

Organism-specific databases

CTD57124.
MGIMGI:1917695. Cd248.

Phylogenomic databases

eggNOGNOG147482.
GeneTreeENSGT00530000063403.
HOGENOMHOG000111482.
HOVERGENHBG081065.
InParanoidQ91V98.
KOK06706.
OMAEASGEHR.
OrthoDBEOG7ZGX2D.
PhylomeDBQ91V98.
TreeFamTF330714.

Gene expression databases

BgeeQ91V98.
CleanExMM_CD248.
GenevestigatorQ91V98.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamPF07645. EGF_CA. 1 hit.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
PS01187. EGF_CA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCD248. mouse.
NextBio331635.
PROQ91V98.
SOURCESearch...

Entry information

Entry nameCD248_MOUSE
AccessionPrimary (citable) accession number: Q91V98
Secondary accession number(s): Q3UMV6, Q91ZV1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot