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Protein

Parathyroid hormone 2 receptor

Gene

Pth2r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-373080 Class B/2 (Secretin family receptors)
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone 2 receptor
Short name:
PTH2 receptor
Gene namesi
Name:Pth2r
Synonyms:Pthr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2180917 Pth2r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 143ExtracellularSequence analysisAdd BLAST117
Transmembranei144 – 167Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini168 – 174CytoplasmicSequence analysis7
Transmembranei175 – 194Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini195 – 235ExtracellularSequence analysisAdd BLAST41
Transmembranei236 – 258Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini259 – 273CytoplasmicSequence analysisAdd BLAST15
Transmembranei274 – 295Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini296 – 313ExtracellularSequence analysisAdd BLAST18
Transmembranei314 – 334Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini335 – 361CytoplasmicSequence analysisAdd BLAST27
Transmembranei362 – 380Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini381 – 391ExtracellularSequence analysisAdd BLAST11
Transmembranei392 – 414Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini415 – 546CytoplasmicSequence analysisAdd BLAST132

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001285025 – 546Parathyroid hormone 2 receptorAdd BLAST522

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91V95
PRIDEiQ91V95

PTM databases

PhosphoSitePlusiQ91V95

Expressioni

Gene expression databases

BgeeiENSMUSG00000025946
CleanExiMM_PTH2R
ExpressionAtlasiQ91V95 baseline and differential
GenevisibleiQ91V95 MM

Interactioni

Subunit structurei

Binds to TIPF39/TIP39.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027083

Structurei

3D structure databases

ProteinModelPortaliQ91V95
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008248
HOVERGENiHBG008318
InParanoidiQ91V95
KOiK04586
OMAiCGGHRYG
OrthoDBiEOG091G0NF8
PhylomeDBiQ91V95
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91V95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWLETFTYI CGWLILSSCL LVRAQLDSDG TITIEEQIVL VMKAKMQCEL
60 70 80 90 100
NITAQLQEGE GNCFPEWDGI ICWPRGTVGK MSAVPCPPYV YDFNHKGVAF
110 120 130 140 150
RHCTPNGTWD SIHGSNKTWA NYSDCFLQPD INIGKQEFFE SLYILYTVGY
160 170 180 190 200
SISFGSLAVA ILIIGYFRRL HCTRNYIHLH LFVSFMLRAM SIFVKDRVAQ
210 220 230 240 250
AHLGVEALQS LVMQGDLQNF IGGPSVDKSQ YVGCKIAVVM FIYFLATNYY
260 270 280 290 300
WILVEGLYLH NLIFVSFFSD TKYLWGFISI GWGFPAVFVV AWAVARATLA
310 320 330 340 350
DTRCWELSAG DRWIYQAPIL AAIGLNFILF LNTVRVLATK IWETNAVGHD
360 370 380 390 400
MRKQYRKLAK STLVLVLVFG VHYIVFVCQP HSFSGLWWEI RMHCELFFNS
410 420 430 440 450
FQGFFVSIVY CYCNGEVQAE VKKMWTRWNL SIDWKRAPPC GGQRYGSVLT
460 470 480 490 500
TVTHSTSSQS QMGASTRLVL ISGKPTKNAC RQIDSHVTLP GYVWSSSEQD
510 520 530 540
CQTHSPPEET KEGHRRQGDD SPVMESSRPV AFTLDTEGCK GETHPI
Length:546
Mass (Da):61,908
Last modified:December 1, 2001 - v1
Checksum:i628051EF181A1DF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332077 mRNA Translation: AAK56105.1
AF332078 mRNA Translation: AAK56106.1
AK045576 mRNA Translation: BAC32420.1
CCDSiCCDS15017.1
RefSeqiNP_644676.1, NM_139270.2
UniGeneiMm.294225

Genome annotation databases

EnsembliENSMUST00000027083; ENSMUSP00000027083; ENSMUSG00000025946
GeneIDi213527
KEGGimmu:213527
UCSCiuc007bhu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPTH2R_MOUSE
AccessioniPrimary (citable) accession number: Q91V95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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