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Q91V95

- PTH2R_MOUSE

UniProt

Q91V95 - PTH2R_MOUSE

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Protein
Parathyroid hormone 2 receptor
Gene
Pth2r, Pthr2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor By similarity.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Parathyroid hormone 2 receptor
    Short name:
    PTH2 receptor
    Gene namesi
    Name:Pth2r
    Synonyms:Pthr2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2180917. Pth2r.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 143117Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei144 – 16724Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini168 – 1747Cytoplasmic Reviewed prediction
    Transmembranei175 – 19420Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini195 – 23541Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei236 – 25823Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini259 – 27315Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei274 – 29522Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini296 – 31318Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei314 – 33421Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini335 – 36127Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei362 – 38019Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini381 – 39111Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei392 – 41423Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini415 – 546132Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424 Reviewed prediction
    Add
    BLAST
    Chaini25 – 546522Parathyroid hormone 2 receptor
    PRO_0000012850Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi51 – 511N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi106 – 1061N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi121 – 1211N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ91V95.
    PRIDEiQ91V95.

    PTM databases

    PhosphoSiteiQ91V95.

    Expressioni

    Gene expression databases

    BgeeiQ91V95.
    CleanExiMM_PTH2R.
    GenevestigatoriQ91V95.

    Interactioni

    Subunit structurei

    Binds to TIPF39/TIP39.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000027083.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91V95.
    SMRiQ91V95. Positions 24-420.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293423.
    GeneTreeiENSGT00750000117453.
    HOGENOMiHOG000008248.
    HOVERGENiHBG008318.
    InParanoidiQ91V95.
    KOiK04586.
    OMAiVGCKIAV.
    OrthoDBiEOG7TF78W.
    PhylomeDBiQ91V95.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91V95-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAWLETFTYI CGWLILSSCL LVRAQLDSDG TITIEEQIVL VMKAKMQCEL    50
    NITAQLQEGE GNCFPEWDGI ICWPRGTVGK MSAVPCPPYV YDFNHKGVAF 100
    RHCTPNGTWD SIHGSNKTWA NYSDCFLQPD INIGKQEFFE SLYILYTVGY 150
    SISFGSLAVA ILIIGYFRRL HCTRNYIHLH LFVSFMLRAM SIFVKDRVAQ 200
    AHLGVEALQS LVMQGDLQNF IGGPSVDKSQ YVGCKIAVVM FIYFLATNYY 250
    WILVEGLYLH NLIFVSFFSD TKYLWGFISI GWGFPAVFVV AWAVARATLA 300
    DTRCWELSAG DRWIYQAPIL AAIGLNFILF LNTVRVLATK IWETNAVGHD 350
    MRKQYRKLAK STLVLVLVFG VHYIVFVCQP HSFSGLWWEI RMHCELFFNS 400
    FQGFFVSIVY CYCNGEVQAE VKKMWTRWNL SIDWKRAPPC GGQRYGSVLT 450
    TVTHSTSSQS QMGASTRLVL ISGKPTKNAC RQIDSHVTLP GYVWSSSEQD 500
    CQTHSPPEET KEGHRRQGDD SPVMESSRPV AFTLDTEGCK GETHPI 546
    Length:546
    Mass (Da):61,908
    Last modified:December 1, 2001 - v1
    Checksum:i628051EF181A1DF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF332077 mRNA. Translation: AAK56105.1.
    AF332078 mRNA. Translation: AAK56106.1.
    AK045576 mRNA. Translation: BAC32420.1.
    CCDSiCCDS15017.1.
    RefSeqiNP_644676.1. NM_139270.2.
    UniGeneiMm.294225.

    Genome annotation databases

    EnsembliENSMUST00000027083; ENSMUSP00000027083; ENSMUSG00000025946.
    GeneIDi213527.
    KEGGimmu:213527.
    UCSCiuc007bhu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF332077 mRNA. Translation: AAK56105.1 .
    AF332078 mRNA. Translation: AAK56106.1 .
    AK045576 mRNA. Translation: BAC32420.1 .
    CCDSi CCDS15017.1.
    RefSeqi NP_644676.1. NM_139270.2.
    UniGenei Mm.294225.

    3D structure databases

    ProteinModelPortali Q91V95.
    SMRi Q91V95. Positions 24-420.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000027083.

    Chemistry

    GuidetoPHARMACOLOGYi 332.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q91V95.

    Proteomic databases

    PaxDbi Q91V95.
    PRIDEi Q91V95.

    Protocols and materials databases

    DNASUi 213527.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027083 ; ENSMUSP00000027083 ; ENSMUSG00000025946 .
    GeneIDi 213527.
    KEGGi mmu:213527.
    UCSCi uc007bhu.1. mouse.

    Organism-specific databases

    CTDi 5746.
    MGIi MGI:2180917. Pth2r.

    Phylogenomic databases

    eggNOGi NOG293423.
    GeneTreei ENSGT00750000117453.
    HOGENOMi HOG000008248.
    HOVERGENi HBG008318.
    InParanoidi Q91V95.
    KOi K04586.
    OMAi VGCKIAV.
    OrthoDBi EOG7TF78W.
    PhylomeDBi Q91V95.
    TreeFami TF315710.

    Miscellaneous databases

    NextBioi 374025.
    PROi Q91V95.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91V95.
    CleanExi MM_PTH2R.
    Genevestigatori Q91V95.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
      Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
      Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ILS and ISS.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain.
    3. "Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues."
      John M.R., Arai M., Rubin D.A., Jonsson K.B., Jueppner H.
      Endocrinology 143:1047-1057(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TIPF39/TI39.

    Entry informationi

    Entry nameiPTH2R_MOUSE
    AccessioniPrimary (citable) accession number: Q91V95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: December 1, 2001
    Last modified: July 9, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi