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Q91V95

- PTH2R_MOUSE

UniProt

Q91V95 - PTH2R_MOUSE

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Protein

Parathyroid hormone 2 receptor

Gene

Pth2r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor By similarity.By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone 2 receptor
Short name:
PTH2 receptor
Gene namesi
Name:Pth2r
Synonyms:Pthr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2180917. Pth2r.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 546522Parathyroid hormone 2 receptorPRO_0000012850Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91V95.
PRIDEiQ91V95.

PTM databases

PhosphoSiteiQ91V95.

Expressioni

Gene expression databases

BgeeiQ91V95.
CleanExiMM_PTH2R.
ExpressionAtlasiQ91V95. baseline and differential.
GenevestigatoriQ91V95.

Interactioni

Subunit structurei

Binds to TIPF39/TIP39.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027083.

Structurei

3D structure databases

ProteinModelPortaliQ91V95.
SMRiQ91V95. Positions 24-420.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 143117ExtracellularSequence AnalysisAdd
BLAST
Topological domaini168 – 1747CytoplasmicSequence Analysis
Topological domaini195 – 23541ExtracellularSequence AnalysisAdd
BLAST
Topological domaini259 – 27315CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini296 – 31318ExtracellularSequence AnalysisAdd
BLAST
Topological domaini335 – 36127CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini381 – 39111ExtracellularSequence AnalysisAdd
BLAST
Topological domaini415 – 546132CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei144 – 16724Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei175 – 19420Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei274 – 29522Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei314 – 33421Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei362 – 38019Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei392 – 41423Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293423.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008248.
HOVERGENiHBG008318.
InParanoidiQ91V95.
KOiK04586.
OMAiVGCKIAV.
OrthoDBiEOG7TF78W.
PhylomeDBiQ91V95.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91V95-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAWLETFTYI CGWLILSSCL LVRAQLDSDG TITIEEQIVL VMKAKMQCEL
60 70 80 90 100
NITAQLQEGE GNCFPEWDGI ICWPRGTVGK MSAVPCPPYV YDFNHKGVAF
110 120 130 140 150
RHCTPNGTWD SIHGSNKTWA NYSDCFLQPD INIGKQEFFE SLYILYTVGY
160 170 180 190 200
SISFGSLAVA ILIIGYFRRL HCTRNYIHLH LFVSFMLRAM SIFVKDRVAQ
210 220 230 240 250
AHLGVEALQS LVMQGDLQNF IGGPSVDKSQ YVGCKIAVVM FIYFLATNYY
260 270 280 290 300
WILVEGLYLH NLIFVSFFSD TKYLWGFISI GWGFPAVFVV AWAVARATLA
310 320 330 340 350
DTRCWELSAG DRWIYQAPIL AAIGLNFILF LNTVRVLATK IWETNAVGHD
360 370 380 390 400
MRKQYRKLAK STLVLVLVFG VHYIVFVCQP HSFSGLWWEI RMHCELFFNS
410 420 430 440 450
FQGFFVSIVY CYCNGEVQAE VKKMWTRWNL SIDWKRAPPC GGQRYGSVLT
460 470 480 490 500
TVTHSTSSQS QMGASTRLVL ISGKPTKNAC RQIDSHVTLP GYVWSSSEQD
510 520 530 540
CQTHSPPEET KEGHRRQGDD SPVMESSRPV AFTLDTEGCK GETHPI
Length:546
Mass (Da):61,908
Last modified:December 1, 2001 - v1
Checksum:i628051EF181A1DF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF332077 mRNA. Translation: AAK56105.1.
AF332078 mRNA. Translation: AAK56106.1.
AK045576 mRNA. Translation: BAC32420.1.
CCDSiCCDS15017.1.
RefSeqiNP_644676.1. NM_139270.2.
UniGeneiMm.294225.

Genome annotation databases

EnsembliENSMUST00000027083; ENSMUSP00000027083; ENSMUSG00000025946.
GeneIDi213527.
KEGGimmu:213527.
UCSCiuc007bhu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF332077 mRNA. Translation: AAK56105.1 .
AF332078 mRNA. Translation: AAK56106.1 .
AK045576 mRNA. Translation: BAC32420.1 .
CCDSi CCDS15017.1.
RefSeqi NP_644676.1. NM_139270.2.
UniGenei Mm.294225.

3D structure databases

ProteinModelPortali Q91V95.
SMRi Q91V95. Positions 24-420.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000027083.

Chemistry

GuidetoPHARMACOLOGYi 332.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q91V95.

Proteomic databases

PaxDbi Q91V95.
PRIDEi Q91V95.

Protocols and materials databases

DNASUi 213527.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027083 ; ENSMUSP00000027083 ; ENSMUSG00000025946 .
GeneIDi 213527.
KEGGi mmu:213527.
UCSCi uc007bhu.1. mouse.

Organism-specific databases

CTDi 5746.
MGIi MGI:2180917. Pth2r.

Phylogenomic databases

eggNOGi NOG293423.
GeneTreei ENSGT00760000118800.
HOGENOMi HOG000008248.
HOVERGENi HBG008318.
InParanoidi Q91V95.
KOi K04586.
OMAi VGCKIAV.
OrthoDBi EOG7TF78W.
PhylomeDBi Q91V95.
TreeFami TF315710.

Miscellaneous databases

NextBioi 374025.
PROi Q91V95.
SOURCEi Search...

Gene expression databases

Bgeei Q91V95.
CleanExi MM_PTH2R.
ExpressionAtlasi Q91V95. baseline and differential.
Genevestigatori Q91V95.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
    Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
    Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ILS and ISS.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues."
    John M.R., Arai M., Rubin D.A., Jonsson K.B., Jueppner H.
    Endocrinology 143:1047-1057(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TIPF39/TI39.

Entry informationi

Entry nameiPTH2R_MOUSE
AccessioniPrimary (citable) accession number: Q91V95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3