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Protein

Parathyroid hormone 2 receptor

Gene

Pth2r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-373080. Class B/2 (Secretin family receptors).
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone 2 receptor
Short name:
PTH2 receptor
Gene namesi
Name:Pth2r
Synonyms:Pthr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2180917. Pth2r.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 143ExtracellularSequence analysisAdd BLAST117
Transmembranei144 – 167Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini168 – 174CytoplasmicSequence analysis7
Transmembranei175 – 194Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini195 – 235ExtracellularSequence analysisAdd BLAST41
Transmembranei236 – 258Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini259 – 273CytoplasmicSequence analysisAdd BLAST15
Transmembranei274 – 295Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini296 – 313ExtracellularSequence analysisAdd BLAST18
Transmembranei314 – 334Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini335 – 361CytoplasmicSequence analysisAdd BLAST27
Transmembranei362 – 380Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini381 – 391ExtracellularSequence analysisAdd BLAST11
Transmembranei392 – 414Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini415 – 546CytoplasmicSequence analysisAdd BLAST132

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001285025 – 546Parathyroid hormone 2 receptorAdd BLAST522

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91V95.
PRIDEiQ91V95.

PTM databases

PhosphoSitePlusiQ91V95.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025946.
CleanExiMM_PTH2R.
ExpressionAtlasiQ91V95. baseline and differential.
GenevisibleiQ91V95. MM.

Interactioni

Subunit structurei

Binds to TIPF39/TIP39.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027083.

Structurei

3D structure databases

ProteinModelPortaliQ91V95.
SMRiQ91V95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008248.
HOVERGENiHBG008318.
InParanoidiQ91V95.
KOiK04586.
OMAiCGGHRYG.
OrthoDBiEOG091G0NF8.
PhylomeDBiQ91V95.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91V95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWLETFTYI CGWLILSSCL LVRAQLDSDG TITIEEQIVL VMKAKMQCEL
60 70 80 90 100
NITAQLQEGE GNCFPEWDGI ICWPRGTVGK MSAVPCPPYV YDFNHKGVAF
110 120 130 140 150
RHCTPNGTWD SIHGSNKTWA NYSDCFLQPD INIGKQEFFE SLYILYTVGY
160 170 180 190 200
SISFGSLAVA ILIIGYFRRL HCTRNYIHLH LFVSFMLRAM SIFVKDRVAQ
210 220 230 240 250
AHLGVEALQS LVMQGDLQNF IGGPSVDKSQ YVGCKIAVVM FIYFLATNYY
260 270 280 290 300
WILVEGLYLH NLIFVSFFSD TKYLWGFISI GWGFPAVFVV AWAVARATLA
310 320 330 340 350
DTRCWELSAG DRWIYQAPIL AAIGLNFILF LNTVRVLATK IWETNAVGHD
360 370 380 390 400
MRKQYRKLAK STLVLVLVFG VHYIVFVCQP HSFSGLWWEI RMHCELFFNS
410 420 430 440 450
FQGFFVSIVY CYCNGEVQAE VKKMWTRWNL SIDWKRAPPC GGQRYGSVLT
460 470 480 490 500
TVTHSTSSQS QMGASTRLVL ISGKPTKNAC RQIDSHVTLP GYVWSSSEQD
510 520 530 540
CQTHSPPEET KEGHRRQGDD SPVMESSRPV AFTLDTEGCK GETHPI
Length:546
Mass (Da):61,908
Last modified:December 1, 2001 - v1
Checksum:i628051EF181A1DF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332077 mRNA. Translation: AAK56105.1.
AF332078 mRNA. Translation: AAK56106.1.
AK045576 mRNA. Translation: BAC32420.1.
CCDSiCCDS15017.1.
RefSeqiNP_644676.1. NM_139270.2.
UniGeneiMm.294225.

Genome annotation databases

EnsembliENSMUST00000027083; ENSMUSP00000027083; ENSMUSG00000025946.
GeneIDi213527.
KEGGimmu:213527.
UCSCiuc007bhu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332077 mRNA. Translation: AAK56105.1.
AF332078 mRNA. Translation: AAK56106.1.
AK045576 mRNA. Translation: BAC32420.1.
CCDSiCCDS15017.1.
RefSeqiNP_644676.1. NM_139270.2.
UniGeneiMm.294225.

3D structure databases

ProteinModelPortaliQ91V95.
SMRiQ91V95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027083.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ91V95.

Proteomic databases

PaxDbiQ91V95.
PRIDEiQ91V95.

Protocols and materials databases

DNASUi213527.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027083; ENSMUSP00000027083; ENSMUSG00000025946.
GeneIDi213527.
KEGGimmu:213527.
UCSCiuc007bhu.1. mouse.

Organism-specific databases

CTDi5746.
MGIiMGI:2180917. Pth2r.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008248.
HOVERGENiHBG008318.
InParanoidiQ91V95.
KOiK04586.
OMAiCGGHRYG.
OrthoDBiEOG091G0NF8.
PhylomeDBiQ91V95.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiR-MMU-373080. Class B/2 (Secretin family receptors).
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiQ91V95.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025946.
CleanExiMM_PTH2R.
ExpressionAtlasiQ91V95. baseline and differential.
GenevisibleiQ91V95. MM.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTH2R_MOUSE
AccessioniPrimary (citable) accession number: Q91V95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.