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Protein

Rho-related BTB domain-containing protein 2

Gene

Rhobtb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 288GTPSequence analysis
Nucleotide bindingi84 – 885GTPSequence analysis
Nucleotide bindingi140 – 1434GTPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related BTB domain-containing protein 2
Alternative name(s):
Deleted in breast cancer 2 gene protein homolog
Gene namesi
Name:Rhobtb2
Synonyms:Dbc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2180557. Rhobtb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Rho-related BTB domain-containing protein 2PRO_0000198963Add
BLAST

Proteomic databases

MaxQBiQ91V93.
PaxDbiQ91V93.
PRIDEiQ91V93.

PTM databases

iPTMnetiQ91V93.
PhosphoSiteiQ91V93.

Expressioni

Tissue specificityi

Expressed in most tissues, with highest expression in brain.1 Publication

Gene expression databases

BgeeiQ91V93.
CleanExiMM_RHOBTB2.
GenevisibleiQ91V93. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022665.

Structurei

3D structure databases

ProteinModelPortaliQ91V93.
SMRiQ91V93. Positions 13-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini266 – 33368BTB 1PROSITE-ProRule annotationAdd
BLAST
Domaini500 – 56768BTB 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 210210Rho-likeAdd
BLAST

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated
Contains 2 BTB (POZ) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000007723.
HOVERGENiHBG054987.
InParanoidiQ91V93.
KOiK07868.
OMAiNTTRSCM.
OrthoDBiEOG7SXW2N.
TreeFamiTF323347.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027417. P-loop_NTPase.
IPR011333. SKP1/BTB/POZ.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00651. BTB. 2 hits.
PF00071. Ras. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54695. SSF54695. 3 hits.
PROSITEiPS50097. BTB. 2 hits.
PS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91V93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDMDYERP NVETIKCVVV GDNAVGKTRL ICARACNATL TQYQLLATHV
60 70 80 90 100
PTVWAIDQYR VCQEVLERSR DVVDDVSVSL RLWDTFGDHH KDRRFAYGRS
110 120 130 140 150
DVVVLCFSIA NPNSLHHVKT MWYPEIKHFC PRAPVILVGC QLDLRYADLE
160 170 180 190 200
AVNRARRPLA RPIKPNEILP PEKGREVAKE LGIPYYETSV VAQFGIKDVF
210 220 230 240 250
DNAIRAALIS RRHLQFWKSH LRNVQRPLLQ APFLPPKPPP PIIVVPDPPS
260 270 280 290 300
SSEECPAHLL EDPLCADVIL VLQERVRIFA HKIYLSTSSS KFYDLFLMDL
310 320 330 340 350
SEGELGGPSG SGGPRPEDHR SHPEQHHHHH HHHHGRDFLL RAASFDVCES
360 370 380 390 400
VDEAGGSGPA GLRASTSDGI LRGNGTGYLP GRGRVLSSWS RAFVSIQEEM
410 420 430 440 450
AEDPLTFKSR LMVVVKMDNS IQPGPFRAVL KYLYTGELGE NERDLMHIAH
460 470 480 490 500
IAELLEVFDL RMMVANILNN EAFMNQEITK AFHVRRTNRV KECLAKGTFS
510 520 530 540 550
DVTFILDDGT ISAHKPLLIS SCDWMAAMFG GPFVESSTRE VVFPYTSKSC
560 570 580 590 600
MRAVLEYLYT GMFTSSPDLD DMKLIVLANR LCLPHLVALT EQYTVTGLME
610 620 630 640 650
ATQMMVDIDG DVLVFLELAQ FHCAYQLADW CLHHICTNYN NVCRKFPRDM
660 670 680 690 700
KAMSPENQEY FEKHRWPPVW YLKEEDHYQR ARKEREKEDY LHLRRQPKRR
710 720
WLFWNSPSSP SSSAAGSASP SSSSSAVV
Length:728
Mass (Da):82,650
Last modified:July 27, 2011 - v2
Checksum:i2B7CB52380CFD6D1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1922VA → FD in AAL16061 (PubMed:12426103).Curated
Sequence conflicti191 – 1922VA → FD in AAL16063 (PubMed:12426103).Curated
Sequence conflicti222 – 2232RN → KK in AAL16061 (PubMed:12426103).Curated
Sequence conflicti222 – 2232RN → KK in AAL16063 (PubMed:12426103).Curated
Sequence conflicti226 – 2261R → K in AAL16061 (PubMed:12426103).Curated
Sequence conflicti226 – 2261R → K in AAL16063 (PubMed:12426103).Curated
Sequence conflicti234 – 2374LPPK → RNSE in AAL16061 (PubMed:12426103).Curated
Sequence conflicti234 – 2374LPPK → RNSE in AAL16063 (PubMed:12426103).Curated
Sequence conflicti363 – 3631R → G in AAH26836 (PubMed:15489334).Curated
Sequence conflicti458 – 4581F → L in AAH26836 (PubMed:15489334).Curated
Sequence conflicti503 – 5031T → A in AAL16061 (PubMed:12426103).Curated
Sequence conflicti503 – 5031T → A in AAL16063 (PubMed:12426103).Curated
Sequence conflicti570 – 5701D → G in AAL16061 (PubMed:12426103).Curated
Sequence conflicti570 – 5701D → G in AAL16063 (PubMed:12426103).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF420001 mRNA. Translation: AAL16061.1.
AF420002 Genomic DNA. Translation: AAL16063.1.
AK038196 mRNA. Translation: BAC29946.1.
BC026836 mRNA. Translation: AAH26836.1.
BC056954 mRNA. Translation: AAH56954.1.
CCDSiCCDS27244.1.
RefSeqiNP_705734.4. NM_153514.5.
UniGeneiMm.102367.

Genome annotation databases

EnsembliENSMUST00000022665; ENSMUSP00000022665; ENSMUSG00000022075.
GeneIDi246710.
KEGGimmu:246710.
UCSCiuc011znx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF420001 mRNA. Translation: AAL16061.1.
AF420002 Genomic DNA. Translation: AAL16063.1.
AK038196 mRNA. Translation: BAC29946.1.
BC026836 mRNA. Translation: AAH26836.1.
BC056954 mRNA. Translation: AAH56954.1.
CCDSiCCDS27244.1.
RefSeqiNP_705734.4. NM_153514.5.
UniGeneiMm.102367.

3D structure databases

ProteinModelPortaliQ91V93.
SMRiQ91V93. Positions 13-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022665.

PTM databases

iPTMnetiQ91V93.
PhosphoSiteiQ91V93.

Proteomic databases

MaxQBiQ91V93.
PaxDbiQ91V93.
PRIDEiQ91V93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022665; ENSMUSP00000022665; ENSMUSG00000022075.
GeneIDi246710.
KEGGimmu:246710.
UCSCiuc011znx.1. mouse.

Organism-specific databases

CTDi23221.
MGIiMGI:2180557. Rhobtb2.

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000007723.
HOVERGENiHBG054987.
InParanoidiQ91V93.
KOiK07868.
OMAiNTTRSCM.
OrthoDBiEOG7SXW2N.
TreeFamiTF323347.

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiRhobtb2. mouse.
PROiQ91V93.
SOURCEiSearch...

Gene expression databases

BgeeiQ91V93.
CleanExiMM_RHOBTB2.
GenevisibleiQ91V93. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027417. P-loop_NTPase.
IPR011333. SKP1/BTB/POZ.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00651. BTB. 2 hits.
PF00071. Ras. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54695. SSF54695. 3 hits.
PROSITEiPS50097. BTB. 2 hits.
PS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse."
    Ramos S., Khademi F., Somesh B.P., Rivero F.
    Gene 298:147-157(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiRHBT2_MOUSE
AccessioniPrimary (citable) accession number: Q91V93
Secondary accession number(s): Q8BYU3, Q8K1A8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.