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Protein

Rho-related BTB domain-containing protein 2

Gene

Rhobtb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 28GTPSequence analysis8
Nucleotide bindingi84 – 88GTPSequence analysis5
Nucleotide bindingi140 – 143GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related BTB domain-containing protein 2
Alternative name(s):
Deleted in breast cancer 2 gene protein homolog
Gene namesi
Name:Rhobtb2
Synonyms:Dbc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2180557 Rhobtb2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001989631 – 728Rho-related BTB domain-containing protein 2Add BLAST728

Proteomic databases

MaxQBiQ91V93
PaxDbiQ91V93
PRIDEiQ91V93

PTM databases

iPTMnetiQ91V93
PhosphoSitePlusiQ91V93

Expressioni

Tissue specificityi

Expressed in most tissues, with highest expression in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000022075
CleanExiMM_RHOBTB2
GenevisibleiQ91V93 MM

Interactioni

Subunit structurei

Interacts with HSP90AA1 and HSP90AB1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022665

Structurei

3D structure databases

ProteinModelPortaliQ91V93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini266 – 333BTB 1PROSITE-ProRule annotationAdd BLAST68
Domaini500 – 567BTB 2PROSITE-ProRule annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 210Rho-likeAdd BLAST210

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000119020
HOGENOMiHOG000007723
HOVERGENiHBG054987
InParanoidiQ91V93
KOiK07868
OMAiHYRQDIY
OrthoDBiEOG091G03I3
TreeFamiTF323347

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR027417 P-loop_NTPase
IPR011333 SKP1/BTB/POZ_sf
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00651 BTB, 2 hits
PF00071 Ras, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 2 hits
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54695 SSF54695, 3 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 2 hits
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Q91V93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDMDYERP NVETIKCVVV GDNAVGKTRL ICARACNATL TQYQLLATHV
60 70 80 90 100
PTVWAIDQYR VCQEVLERSR DVVDDVSVSL RLWDTFGDHH KDRRFAYGRS
110 120 130 140 150
DVVVLCFSIA NPNSLHHVKT MWYPEIKHFC PRAPVILVGC QLDLRYADLE
160 170 180 190 200
AVNRARRPLA RPIKPNEILP PEKGREVAKE LGIPYYETSV VAQFGIKDVF
210 220 230 240 250
DNAIRAALIS RRHLQFWKSH LRNVQRPLLQ APFLPPKPPP PIIVVPDPPS
260 270 280 290 300
SSEECPAHLL EDPLCADVIL VLQERVRIFA HKIYLSTSSS KFYDLFLMDL
310 320 330 340 350
SEGELGGPSG SGGPRPEDHR SHPEQHHHHH HHHHGRDFLL RAASFDVCES
360 370 380 390 400
VDEAGGSGPA GLRASTSDGI LRGNGTGYLP GRGRVLSSWS RAFVSIQEEM
410 420 430 440 450
AEDPLTFKSR LMVVVKMDNS IQPGPFRAVL KYLYTGELGE NERDLMHIAH
460 470 480 490 500
IAELLEVFDL RMMVANILNN EAFMNQEITK AFHVRRTNRV KECLAKGTFS
510 520 530 540 550
DVTFILDDGT ISAHKPLLIS SCDWMAAMFG GPFVESSTRE VVFPYTSKSC
560 570 580 590 600
MRAVLEYLYT GMFTSSPDLD DMKLIVLANR LCLPHLVALT EQYTVTGLME
610 620 630 640 650
ATQMMVDIDG DVLVFLELAQ FHCAYQLADW CLHHICTNYN NVCRKFPRDM
660 670 680 690 700
KAMSPENQEY FEKHRWPPVW YLKEEDHYQR ARKEREKEDY LHLRRQPKRR
710 720
WLFWNSPSSP SSSAAGSASP SSSSSAVV
Length:728
Mass (Da):82,650
Last modified:July 27, 2011 - v2
Checksum:i2B7CB52380CFD6D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191 – 192VA → FD in AAL16061 (PubMed:12426103).Curated2
Sequence conflicti191 – 192VA → FD in AAL16063 (PubMed:12426103).Curated2
Sequence conflicti222 – 223RN → KK in AAL16061 (PubMed:12426103).Curated2
Sequence conflicti222 – 223RN → KK in AAL16063 (PubMed:12426103).Curated2
Sequence conflicti226R → K in AAL16061 (PubMed:12426103).Curated1
Sequence conflicti226R → K in AAL16063 (PubMed:12426103).Curated1
Sequence conflicti234 – 237LPPK → RNSE in AAL16061 (PubMed:12426103).Curated4
Sequence conflicti234 – 237LPPK → RNSE in AAL16063 (PubMed:12426103).Curated4
Sequence conflicti363R → G in AAH26836 (PubMed:15489334).Curated1
Sequence conflicti458F → L in AAH26836 (PubMed:15489334).Curated1
Sequence conflicti503T → A in AAL16061 (PubMed:12426103).Curated1
Sequence conflicti503T → A in AAL16063 (PubMed:12426103).Curated1
Sequence conflicti570D → G in AAL16061 (PubMed:12426103).Curated1
Sequence conflicti570D → G in AAL16063 (PubMed:12426103).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF420001 mRNA Translation: AAL16061.1
AF420002 Genomic DNA Translation: AAL16063.1
AK038196 mRNA Translation: BAC29946.1
BC026836 mRNA Translation: AAH26836.1
BC056954 mRNA Translation: AAH56954.1
CCDSiCCDS27244.1
RefSeqiNP_705734.4, NM_153514.5
UniGeneiMm.102367

Genome annotation databases

EnsembliENSMUST00000022665; ENSMUSP00000022665; ENSMUSG00000022075
GeneIDi246710
KEGGimmu:246710
UCSCiuc011znx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRHBT2_MOUSE
AccessioniPrimary (citable) accession number: Q91V93
Secondary accession number(s): Q8BYU3, Q8K1A8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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