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Protein

Nephronectin

Gene

Npnt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins.3 Publications

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • integrin binding Source: BHF-UCL

GO - Biological processi

  • branching involved in ureteric bud morphogenesis Source: MGI
  • cell-cell adhesion mediated by integrin Source: BHF-UCL
  • cell-matrix adhesion Source: MGI
  • cellular response to tumor necrosis factor Source: BHF-UCL
  • establishment of protein localization Source: BHF-UCL
  • extracellular matrix organization Source: MGI
  • pilomotor reflex Source: BHF-UCL
  • positive regulation of alkaline phosphatase activity Source: BHF-UCL
  • positive regulation of cell-substrate adhesion Source: MGI
  • positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  • positive regulation of osteoblast differentiation Source: BHF-UCL
  • positive regulation of smooth muscle contraction Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: BHF-UCL
  • positive regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  • ureteric bud development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion, Differentiation

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Nephronectin
Alternative name(s):
Preosteoblast EGF-like repeat protein with MAM domain
Gene namesi
Name:Npnt
Synonyms:Neph1, Poem
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2148811. Npnt.

Subcellular locationi

GO - Cellular componenti

  • basement membrane Source: BHF-UCL
  • extracellular exosome Source: MGI
  • extracellular matrix Source: BHF-UCL
  • extracellular region Source: BHF-UCL
  • membrane Source: InterPro
  • proteinaceous extracellular matrix Source: MGI
  • smooth muscle contractile fiber Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice display renal agenesis at birth due to a developmental delay. This delay is associated with a reduced expression of Gdnf and is similar to the one found in mice lacking Itga8.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi384 – 3841D → E: Reduced cell spreading- and survival-promoting activities. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 561542NephronectinPRO_0000295685Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 69PROSITE-ProRule annotation
Disulfide bondi60 ↔ 75PROSITE-ProRule annotation
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
Disulfide bondi93 ↔ 104PROSITE-ProRule annotation
Disulfide bondi100 ↔ 113PROSITE-ProRule annotation
Disulfide bondi115 ↔ 127PROSITE-ProRule annotation
Disulfide bondi173 ↔ 186PROSITE-ProRule annotation
Disulfide bondi180 ↔ 195PROSITE-ProRule annotation
Disulfide bondi197 ↔ 212PROSITE-ProRule annotation
Disulfide bondi218 ↔ 231PROSITE-ProRule annotation
Disulfide bondi225 ↔ 240PROSITE-ProRule annotation
Disulfide bondi242 ↔ 253PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ91V88.
PaxDbiQ91V88.
PRIDEiQ91V88.

PTM databases

iPTMnetiQ91V88.

Expressioni

Tissue specificityi

Expressed in kidney (at protein level).1 Publication

Developmental stagei

Expressed from 10.5 dpc onward mainly at epithelial-mesenchymal interfaces in kidney and other tissues undergoing morphogenesis (at protein level).2 Publications

Gene expression databases

BgeeiQ91V88.
CleanExiMM_NPNT.
ExpressionAtlasiQ91V88. baseline and differential.
GenevisibleiQ91V88. MM.

Interactioni

Subunit structurei

Homodimer and homotrimer.

GO - Molecular functioni

  • integrin binding Source: BHF-UCL

Protein-protein interaction databases

IntActiQ91V88. 2 interactions.
STRINGi10090.ENSMUSP00000040071.

Structurei

3D structure databases

ProteinModelPortaliQ91V88.
SMRiQ91V88. Positions 34-242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 8736EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini89 – 12840EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini132 – 16837EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini169 – 21345EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini214 – 25441EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini420 – 561142MAMPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi382 – 3843Integrin interaction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi296 – 35964Pro-richAdd
BLAST

Domaini

The MAM domain is required for localization at the cell surface.

Sequence similaritiesi

Belongs to the nephronectin family.Curated
Contains 5 EGF-like domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR6Z. Eukaryota.
ENOG411039V. LUCA.
GeneTreeiENSGT00840000129786.
HOGENOMiHOG000059638.
HOVERGENiHBG108200.
InParanoidiQ91V88.
KOiK06824.
OMAiSLKKGHC.
OrthoDBiEOG73RBB8.
PhylomeDBiQ91V88.
TreeFamiTF330819.

Family and domain databases

InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR000998. MAM_dom.
[Graphical view]
PfamiPF07645. EGF_CA. 3 hits.
PF00629. MAM. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 5 hits.
SM00179. EGF_CA. 3 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
PS50060. MAM_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91V88-1) [UniParc]FASTAAdd to basket

Also known as: Short

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVLLAAVLA SSLYLQVAAD FDGRWPRQIV SSIGLCRYGG RIDCCWGWAR
60 70 80 90 100
QSWGQCQPVC QPQCKHGECV GPNKCKCHPG FAGKTCNQDL NECGLKPRPC
110 120 130 140 150
KHRCMNTFGS YKCYCLNGYM LLPDGSCSSA LSCSMANCQY GCDVVKGQVR
160 170 180 190 200
CQCPSPGLQL APDGRTCVDI DECATGRVSC PRFRQCVNTF GSYICKCHTG
210 220 230 240 250
FDLMYIGGKY QCHDIDECSL GQHQCSSYAR CYNIHGSYKC QCRDGYEGDG
260 270 280 290 300
LNCVYIPKVM IEPSGPIHMP ERNGTISKGD GGHANRIPDA GSTRWPLKTP
310 320 330 340 350
YIPPVITNRP TSKPTTRPTP NPTPQPTPPP PPPLPTEPRT TPLPPTPERP
360 370 380 390 400
STRPTTIAPA TSTTTRVITV DNRIQTDPQK PRGDVFIPRQ PTNDLFEIFE
410 420 430 440 450
IERGVSADEE VKDDPGILIH SCNFDHGLCG WIREKDSDLH WETARDPAGG
460 470 480 490 500
QYLTVSAAKA PGGKAARLVL RLGHLMHSGD LCLSFRHKVT GLHSGTLQVF
510 520 530 540 550
VRKHGTHGAA LWGRNGGHGW RQTQITLRGA DVKSVIFKGE KRRGHTGEIG
560
LDDVSLKRGR C
Length:561
Mass (Da):61,490
Last modified:December 1, 2001 - v1
Checksum:i69E7ACAA0EE3F506
GO
Isoform 2 (identifier: Q91V88-2) [UniParc]FASTAAdd to basket

Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
     58-58: P → PFYVLRQRLARIRCQLKA

Show »
Length:578
Mass (Da):63,607
Checksum:i4757DE54CC47DA4C
GO
Isoform 3 (identifier: Q91V88-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-88: Q → QDESFHPTPLDQGSEQPLFQPPDHQATNVPSR

Show »
Length:592
Mass (Da):64,945
Checksum:i21943B9077691396
GO
Isoform 4 (identifier: Q91V88-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-58: P → PFYVLRQRLARIRCQLKA
     88-88: Q → QDESFHPTPLDQGSEQPLFQPPDHQATNVPSR

Show »
Length:609
Mass (Da):67,061
Checksum:i44C45DE3EBEC4BDC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241R → G in AAH68308 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei58 – 581P → PFYVLRQRLARIRCQLKA in isoform 2 and isoform 4. 1 PublicationVSP_026989
Alternative sequencei88 – 881Q → QDESFHPTPLDQGSEQPLFQ PPDHQATNVPSR in isoform 3 and isoform 4. 1 PublicationVSP_026990

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB059656 mRNA. Translation: BAB69692.1.
AF397007 mRNA. Translation: AAK84391.1.
AF397008 mRNA. Translation: AAK84392.1.
AY035898 mRNA. Translation: AAK96010.1.
AY035899 mRNA. Translation: AAK96011.1.
AK050484 mRNA. Translation: BAC34283.1.
BC046642 mRNA. Translation: AAH46642.1.
BC068308 mRNA. Translation: AAH68308.1.
CCDSiCCDS17845.1. [Q91V88-1]
CCDS17846.1. [Q91V88-2]
CCDS71322.1. [Q91V88-3]
CCDS71323.1. [Q91V88-4]
RefSeqiNP_001025007.1. NM_001029836.2. [Q91V88-1]
NP_001274030.1. NM_001287101.1. [Q91V88-4]
NP_001274031.1. NM_001287102.1. [Q91V88-3]
NP_277060.2. NM_033525.3. [Q91V88-2]
UniGeneiMm.279310.
Mm.440226.

Genome annotation databases

EnsembliENSMUST00000042729; ENSMUSP00000040071; ENSMUSG00000040998. [Q91V88-2]
ENSMUST00000042744; ENSMUSP00000040684; ENSMUSG00000040998. [Q91V88-1]
ENSMUST00000093971; ENSMUSP00000091505; ENSMUSG00000040998. [Q91V88-4]
ENSMUST00000117164; ENSMUSP00000113419; ENSMUSG00000040998. [Q91V88-3]
GeneIDi114249.
KEGGimmu:114249.
UCSCiuc008rkc.3. mouse. [Q91V88-2]
uc008rkd.3. mouse. [Q91V88-1]
uc008rke.3. mouse. [Q91V88-4]
uc008rkf.3. mouse. [Q91V88-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB059656 mRNA. Translation: BAB69692.1.
AF397007 mRNA. Translation: AAK84391.1.
AF397008 mRNA. Translation: AAK84392.1.
AY035898 mRNA. Translation: AAK96010.1.
AY035899 mRNA. Translation: AAK96011.1.
AK050484 mRNA. Translation: BAC34283.1.
BC046642 mRNA. Translation: AAH46642.1.
BC068308 mRNA. Translation: AAH68308.1.
CCDSiCCDS17845.1. [Q91V88-1]
CCDS17846.1. [Q91V88-2]
CCDS71322.1. [Q91V88-3]
CCDS71323.1. [Q91V88-4]
RefSeqiNP_001025007.1. NM_001029836.2. [Q91V88-1]
NP_001274030.1. NM_001287101.1. [Q91V88-4]
NP_001274031.1. NM_001287102.1. [Q91V88-3]
NP_277060.2. NM_033525.3. [Q91V88-2]
UniGeneiMm.279310.
Mm.440226.

3D structure databases

ProteinModelPortaliQ91V88.
SMRiQ91V88. Positions 34-242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91V88. 2 interactions.
STRINGi10090.ENSMUSP00000040071.

PTM databases

iPTMnetiQ91V88.

Proteomic databases

MaxQBiQ91V88.
PaxDbiQ91V88.
PRIDEiQ91V88.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042729; ENSMUSP00000040071; ENSMUSG00000040998. [Q91V88-2]
ENSMUST00000042744; ENSMUSP00000040684; ENSMUSG00000040998. [Q91V88-1]
ENSMUST00000093971; ENSMUSP00000091505; ENSMUSG00000040998. [Q91V88-4]
ENSMUST00000117164; ENSMUSP00000113419; ENSMUSG00000040998. [Q91V88-3]
GeneIDi114249.
KEGGimmu:114249.
UCSCiuc008rkc.3. mouse. [Q91V88-2]
uc008rkd.3. mouse. [Q91V88-1]
uc008rke.3. mouse. [Q91V88-4]
uc008rkf.3. mouse. [Q91V88-3]

Organism-specific databases

CTDi255743.
MGIiMGI:2148811. Npnt.

Phylogenomic databases

eggNOGiENOG410IR6Z. Eukaryota.
ENOG411039V. LUCA.
GeneTreeiENSGT00840000129786.
HOGENOMiHOG000059638.
HOVERGENiHBG108200.
InParanoidiQ91V88.
KOiK06824.
OMAiSLKKGHC.
OrthoDBiEOG73RBB8.
PhylomeDBiQ91V88.
TreeFamiTF330819.

Miscellaneous databases

PROiQ91V88.
SOURCEiSearch...

Gene expression databases

BgeeiQ91V88.
CleanExiMM_NPNT.
ExpressionAtlasiQ91V88. baseline and differential.
GenevisibleiQ91V88. MM.

Family and domain databases

InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR000998. MAM_dom.
[Graphical view]
PfamiPF07645. EGF_CA. 3 hits.
PF00629. MAM. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 5 hits.
SM00179. EGF_CA. 3 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
PS50060. MAM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of POEM: a novel adhesion molecule that interacts with alpha8beta1 integrin."
    Morimura N., Tezuka Y., Watanabe N., Yasuda M., Miyatani S., Hozumi N., Tezuka Ki K.
    J. Biol. Chem. 276:42172-42181(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, OLIGOMERIZATION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, MUTAGENESIS OF ASP-384.
    Strain: C57BL/6J.
    Tissue: Preosteoblast.
  2. "Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney."
    Brandenberger R., Schmidt A., Linton J., Wang D., Backus C., Denda S., Mueller U., Reichardt L.F.
    J. Cell Biol. 154:447-458(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: C57BL/6J and NIH Swiss.
    Tissue: Kidney.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Pancreas.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Kidney and Mammary tumor.
  5. "The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression."
    Linton J.M., Martin G.R., Reichardt L.F.
    Development 134:2501-2509(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung.

Entry informationi

Entry nameiNPNT_MOUSE
AccessioniPrimary (citable) accession number: Q91V88
Secondary accession number(s): Q6NV58
, Q80VP6, Q91XL5, Q91ZD3, Q923T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Was named nephronectin based on its potential role in kidney development.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.