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Q91V87

- FGRL1_MOUSE

UniProt

Q91V87 - FGRL1_MOUSE

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Protein

Fibroblast growth factor receptor-like 1

Gene

Fgfrl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has a negative effect on cell proliferation.By similarity

GO - Molecular functioni

  1. fibroblast growth factor-activated receptor activity Source: UniProtKB
  2. fibroblast growth factor binding Source: MGI
  3. heparin binding Source: Ensembl
  4. non-tyrosine kinase fibroblast growth factor receptor activity Source: MGI

GO - Biological processi

  1. cell surface receptor signaling pathway Source: MGI
  2. diaphragm development Source: MGI
  3. fibroblast growth factor receptor signaling pathway Source: GOC
  4. heart valve morphogenesis Source: MGI
  5. negative regulation of cell proliferation Source: MGI
  6. negative regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  7. skeletal system development Source: MGI
  8. ventricular septum morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptor-like 1
Short name:
FGF receptor-like protein 1
Alternative name(s):
Fibroblast growth factor receptor 5
Short name:
FGFR-5
Gene namesi
Name:Fgfrl1
Synonyms:Fgfr5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2150920. Fgfrl1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 529509Fibroblast growth factor receptor-like 1PRO_0000021251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 95PROSITE-ProRule annotation
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi168 ↔ 217PROSITE-ProRule annotation
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi264 ↔ 334PROSITE-ProRule annotation
Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ91V87.

PTM databases

PhosphoSiteiQ91V87.

Expressioni

Tissue specificityi

Highly expressed in the kidney, brain and lung. Weakly expressed in the muscle, thymus, lymph node, stomach, intestine, colon and liver. Expressed in fetal cartilaginous structures like the nasal cartilage, the ribs and the sternum as well as in the cartilaginous rudiments of developing bones such as the vertebrae and the pelvic bone. High expression is found in the muscles of the tongue and the diaphragm.2 Publications

Developmental stagei

First detected at embryonic day 7 and became clearly visible at day 11 and increased until day 17.1 Publication

Gene expression databases

BgeeiQ91V87.
CleanExiMM_FGFRL1.
GenevestigatoriQ91V87.

Interactioni

Subunit structurei

Interacts with FGF2 with a low affinity.1 Publication

Protein-protein interaction databases

BioGridi227959. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ91V87.
SMRiQ91V87. Positions 21-355.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 374354ExtracellularSequence AnalysisAdd
BLAST
Topological domaini396 – 529134CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei375 – 39521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 11187Ig-like C2-type 1Add
BLAST
Domaini143 – 23391Ig-like C2-type 2Add
BLAST
Domaini242 – 350109Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG289609.
GeneTreeiENSGT00390000008504.
HOGENOMiHOG000112576.
HOVERGENiHBG056473.
InParanoidiQ91V87.
OMAiKQWARPR.
OrthoDBiEOG79KPF3.
PhylomeDBiQ91V87.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00408. IGc2. 3 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91V87) [UniParc]FASTAAdd to Basket

Also known as: FGFR5beta, FGFR5b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTRSPALLLL LLGALPSAEA ARGPPRMADK VVPRQVARLG RTVRLQCPVE
60 70 80 90 100
GDPPPLTMWT KDGRTIHSGW SRFRVLPQGL KVKEVEAEDA GVYVCKATNG
110 120 130 140 150
FGSLSVNYTL IIMDDISPGK ESPGPGGSSG GQEDPASQQW ARPRFTQPSK
160 170 180 190 200
MRRRVIARPV GSSVRLKCVA SGHPRPDIMW MKDDQTLTHL EASEHRKKKW
210 220 230 240 250
TLSLKNLKPE DSGKYTCRVS NKAGAINATY KVDVIQRTRS KPVLTGTHPV
260 270 280 290 300
NTTVDFGGTT SFQCKVRSDV KPVIQWLKRV EYGSEGRHNS TIDVGGQKFV
310 320 330 340 350
VLPTGDVWSR PDGSYLNKLL ISRARQDDAG MYICLGANTM GYSFRSAFLT
360 370 380 390 400
VLPDPKPPGP PMASSSSSTS LPWPVVIGIP AGAVFILGTV LLWLCQTKKK
410 420 430 440 450
PCAPASTLPV PGHRPPGTSR ERSGDKDLPS LAVGICEEHG SAMAPQHILA
460 470 480 490 500
SGSTAGPKLY PKLYTDVHTH THTHTCTHTL SCGGQGSSTP ACPLSVLNTA
510 520
NLQALCPEVG IWGPRQQVGR IENNGGRVS
Length:529
Mass (Da):57,013
Last modified:December 1, 2001 - v1
Checksum:i6CE76A75BF2498DD
GO
Isoform 2 (identifier: Q91V87-2) [UniParc]FASTAAdd to Basket

Also known as: FGFR5gamma, FGFR5g

The sequence of this isoform differs from the canonical sequence as follows:
     23-113: Missing.

Show »
Length:438
Mass (Da):46,981
Checksum:i768D7E96126DD8AE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei23 – 11391Missing in isoform 2. 1 PublicationVSP_013976Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF321300 mRNA. Translation: AAL06295.1.
AF321301 mRNA. Translation: AAL06296.1.
AF321302 Genomic DNA. Translation: AAL06297.1.
AJ293947 mRNA. Translation: CAC82376.1.
AJ308490 Genomic DNA. Translation: CAC83768.1.
BC058745 mRNA. Translation: AAH58745.1.
CCDSiCCDS19518.1. [Q91V87-1]
CCDS51592.1. [Q91V87-2]
RefSeqiNP_001157731.1. NM_001164259.1. [Q91V87-2]
NP_473412.1. NM_054071.2. [Q91V87-1]
UniGeneiMm.35691.

Genome annotation databases

EnsembliENSMUST00000013633; ENSMUSP00000013633; ENSMUSG00000008090. [Q91V87-1]
ENSMUST00000112560; ENSMUSP00000108179; ENSMUSG00000008090. [Q91V87-2]
GeneIDi116701.
KEGGimmu:116701.
UCSCiuc008ypa.2. mouse. [Q91V87-1]
uc012eav.1. mouse. [Q91V87-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF321300 mRNA. Translation: AAL06295.1 .
AF321301 mRNA. Translation: AAL06296.1 .
AF321302 Genomic DNA. Translation: AAL06297.1 .
AJ293947 mRNA. Translation: CAC82376.1 .
AJ308490 Genomic DNA. Translation: CAC83768.1 .
BC058745 mRNA. Translation: AAH58745.1 .
CCDSi CCDS19518.1. [Q91V87-1 ]
CCDS51592.1. [Q91V87-2 ]
RefSeqi NP_001157731.1. NM_001164259.1. [Q91V87-2 ]
NP_473412.1. NM_054071.2. [Q91V87-1 ]
UniGenei Mm.35691.

3D structure databases

ProteinModelPortali Q91V87.
SMRi Q91V87. Positions 21-355.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 227959. 1 interaction.

PTM databases

PhosphoSitei Q91V87.

Proteomic databases

PRIDEi Q91V87.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000013633 ; ENSMUSP00000013633 ; ENSMUSG00000008090 . [Q91V87-1 ]
ENSMUST00000112560 ; ENSMUSP00000108179 ; ENSMUSG00000008090 . [Q91V87-2 ]
GeneIDi 116701.
KEGGi mmu:116701.
UCSCi uc008ypa.2. mouse. [Q91V87-1 ]
uc012eav.1. mouse. [Q91V87-2 ]

Organism-specific databases

CTDi 53834.
MGIi MGI:2150920. Fgfrl1.

Phylogenomic databases

eggNOGi NOG289609.
GeneTreei ENSGT00390000008504.
HOGENOMi HOG000112576.
HOVERGENi HBG056473.
InParanoidi Q91V87.
OMAi KQWARPR.
OrthoDBi EOG79KPF3.
PhylomeDBi Q91V87.

Miscellaneous databases

ChiTaRSi FGFRL1. mouse.
NextBioi 369030.
PROi Q91V87.
SOURCEi Search...

Gene expression databases

Bgeei Q91V87.
CleanExi MM_FGFRL1.
Genevestigatori Q91V87.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF07679. I-set. 3 hits.
[Graphical view ]
SMARTi SM00408. IGc2. 3 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a new fibroblast growth factor receptor, FGFR5."
    Sleeman M., Fraser J., McDonald M., Yuan S., White D., Grandison P., Kumble K., Watson J.D., Murison J.G.
    Gene 271:171-182(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH FGF2.
    Strain: BALB/cJ.
  2. "The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein."
    Wiedemann M., Trueb B.
    Biochim. Biophys. Acta 1520:247-250(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), DEVELOPMENTAL STAGE.
    Tissue: Cartilage.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  4. "Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues."
    Trueb B., Zhuang L., Taeschler S., Wiedemann M.
    J. Biol. Chem. 278:33857-33865(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFGRL1_MOUSE
AccessioniPrimary (citable) accession number: Q91V87
Secondary accession number(s): Q920C2, Q920C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3