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Protein

Fibroblast growth factor receptor-like 1

Gene

Fgfrl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a negative effect on cell proliferation.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell-cell adhesion via plasma-membrane adhesion molecules Source: MGI
  • cell surface receptor signaling pathway Source: MGI
  • diaphragm development Source: MGI
  • heart valve morphogenesis Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  • protein homooligomerization Source: MGI
  • skeletal system development Source: MGI
  • ventricular septum morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-5658623. FGFRL1 modulation of FGFR1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptor-like 1
Short name:
FGF receptor-like protein 1
Alternative name(s):
Fibroblast growth factor receptor 5
Short name:
FGFR-5
Gene namesi
Name:Fgfrl1
Synonyms:Fgfr5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2150920. Fgfrl1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 374ExtracellularSequence analysisAdd BLAST354
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 529CytoplasmicSequence analysisAdd BLAST134

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000002125121 – 529Fibroblast growth factor receptor-like 1Add BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 95PROSITE-ProRule annotation
Glycosylationi107N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi168 ↔ 217PROSITE-ProRule annotation
Glycosylationi227N-linked (GlcNAc...)Sequence analysis1
Glycosylationi251N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi264 ↔ 334PROSITE-ProRule annotation
Glycosylationi289N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91V87.
PeptideAtlasiQ91V87.
PRIDEiQ91V87.

PTM databases

iPTMnetiQ91V87.
PhosphoSitePlusiQ91V87.

Expressioni

Tissue specificityi

Highly expressed in the kidney, brain and lung. Weakly expressed in the muscle, thymus, lymph node, stomach, intestine, colon and liver. Expressed in fetal cartilaginous structures like the nasal cartilage, the ribs and the sternum as well as in the cartilaginous rudiments of developing bones such as the vertebrae and the pelvic bone. High expression is found in the muscles of the tongue and the diaphragm.2 Publications

Developmental stagei

First detected at embryonic day 7 and became clearly visible at day 11 and increased until day 17.1 Publication

Gene expression databases

BgeeiENSMUSG00000008090.
CleanExiMM_FGFRL1.
ExpressionAtlasiQ91V87. baseline and differential.
GenevisibleiQ91V87. MM.

Interactioni

Subunit structurei

Interacts with FGF2 with a low affinity.1 Publication

GO - Molecular functioni

  • fibroblast growth factor binding Source: MGI

Protein-protein interaction databases

BioGridi227959. 1 interactor.
STRINGi10090.ENSMUSP00000013633.

Structurei

3D structure databases

ProteinModelPortaliQ91V87.
SMRiQ91V87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 111Ig-like C2-type 1Add BLAST87
Domaini143 – 233Ig-like C2-type 2Add BLAST91
Domaini242 – 350Ig-like C2-type 3Add BLAST109

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00390000008504.
HOGENOMiHOG000112576.
HOVERGENiHBG056473.
InParanoidiQ91V87.
OMAiKRVEYGT.
OrthoDBiEOG091G0985.
PhylomeDBiQ91V87.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91V87-1) [UniParc]FASTAAdd to basket
Also known as: FGFR5beta, FGFR5b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTRSPALLLL LLGALPSAEA ARGPPRMADK VVPRQVARLG RTVRLQCPVE
60 70 80 90 100
GDPPPLTMWT KDGRTIHSGW SRFRVLPQGL KVKEVEAEDA GVYVCKATNG
110 120 130 140 150
FGSLSVNYTL IIMDDISPGK ESPGPGGSSG GQEDPASQQW ARPRFTQPSK
160 170 180 190 200
MRRRVIARPV GSSVRLKCVA SGHPRPDIMW MKDDQTLTHL EASEHRKKKW
210 220 230 240 250
TLSLKNLKPE DSGKYTCRVS NKAGAINATY KVDVIQRTRS KPVLTGTHPV
260 270 280 290 300
NTTVDFGGTT SFQCKVRSDV KPVIQWLKRV EYGSEGRHNS TIDVGGQKFV
310 320 330 340 350
VLPTGDVWSR PDGSYLNKLL ISRARQDDAG MYICLGANTM GYSFRSAFLT
360 370 380 390 400
VLPDPKPPGP PMASSSSSTS LPWPVVIGIP AGAVFILGTV LLWLCQTKKK
410 420 430 440 450
PCAPASTLPV PGHRPPGTSR ERSGDKDLPS LAVGICEEHG SAMAPQHILA
460 470 480 490 500
SGSTAGPKLY PKLYTDVHTH THTHTCTHTL SCGGQGSSTP ACPLSVLNTA
510 520
NLQALCPEVG IWGPRQQVGR IENNGGRVS
Length:529
Mass (Da):57,013
Last modified:December 1, 2001 - v1
Checksum:i6CE76A75BF2498DD
GO
Isoform 2 (identifier: Q91V87-2) [UniParc]FASTAAdd to basket
Also known as: FGFR5gamma, FGFR5g

The sequence of this isoform differs from the canonical sequence as follows:
     23-113: Missing.

Show »
Length:438
Mass (Da):46,981
Checksum:i768D7E96126DD8AE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01397623 – 113Missing in isoform 2. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321300 mRNA. Translation: AAL06295.1.
AF321301 mRNA. Translation: AAL06296.1.
AF321302 Genomic DNA. Translation: AAL06297.1.
AJ293947 mRNA. Translation: CAC82376.1.
AJ308490 Genomic DNA. Translation: CAC83768.1.
BC058745 mRNA. Translation: AAH58745.1.
CCDSiCCDS19518.1. [Q91V87-1]
CCDS51592.1. [Q91V87-2]
RefSeqiNP_001157731.1. NM_001164259.1. [Q91V87-2]
NP_473412.1. NM_054071.2. [Q91V87-1]
XP_017176107.1. XM_017320618.1. [Q91V87-1]
UniGeneiMm.35691.

Genome annotation databases

EnsembliENSMUST00000013633; ENSMUSP00000013633; ENSMUSG00000008090. [Q91V87-1]
ENSMUST00000112560; ENSMUSP00000108179; ENSMUSG00000008090. [Q91V87-2]
GeneIDi116701.
KEGGimmu:116701.
UCSCiuc008ypa.2. mouse. [Q91V87-1]
uc012eav.1. mouse. [Q91V87-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321300 mRNA. Translation: AAL06295.1.
AF321301 mRNA. Translation: AAL06296.1.
AF321302 Genomic DNA. Translation: AAL06297.1.
AJ293947 mRNA. Translation: CAC82376.1.
AJ308490 Genomic DNA. Translation: CAC83768.1.
BC058745 mRNA. Translation: AAH58745.1.
CCDSiCCDS19518.1. [Q91V87-1]
CCDS51592.1. [Q91V87-2]
RefSeqiNP_001157731.1. NM_001164259.1. [Q91V87-2]
NP_473412.1. NM_054071.2. [Q91V87-1]
XP_017176107.1. XM_017320618.1. [Q91V87-1]
UniGeneiMm.35691.

3D structure databases

ProteinModelPortaliQ91V87.
SMRiQ91V87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi227959. 1 interactor.
STRINGi10090.ENSMUSP00000013633.

PTM databases

iPTMnetiQ91V87.
PhosphoSitePlusiQ91V87.

Proteomic databases

PaxDbiQ91V87.
PeptideAtlasiQ91V87.
PRIDEiQ91V87.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000013633; ENSMUSP00000013633; ENSMUSG00000008090. [Q91V87-1]
ENSMUST00000112560; ENSMUSP00000108179; ENSMUSG00000008090. [Q91V87-2]
GeneIDi116701.
KEGGimmu:116701.
UCSCiuc008ypa.2. mouse. [Q91V87-1]
uc012eav.1. mouse. [Q91V87-2]

Organism-specific databases

CTDi53834.
MGIiMGI:2150920. Fgfrl1.

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00390000008504.
HOGENOMiHOG000112576.
HOVERGENiHBG056473.
InParanoidiQ91V87.
OMAiKRVEYGT.
OrthoDBiEOG091G0985.
PhylomeDBiQ91V87.

Enzyme and pathway databases

ReactomeiR-MMU-5658623. FGFRL1 modulation of FGFR1 signaling.

Miscellaneous databases

ChiTaRSiFgfrl1. mouse.
PROiQ91V87.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008090.
CleanExiMM_FGFRL1.
ExpressionAtlasiQ91V87. baseline and differential.
GenevisibleiQ91V87. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGRL1_MOUSE
AccessioniPrimary (citable) accession number: Q91V87
Secondary accession number(s): Q920C2, Q920C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.