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Q91V87 (FGRL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor receptor-like 1

Short name=FGF receptor-like protein 1
Alternative name(s):
Fibroblast growth factor receptor 5
Short name=FGFR-5
Gene names
Name:Fgfrl1
Synonyms:Fgfr5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has a negative effect on cell proliferation By similarity. Ref.4

Subunit structure

Interacts with FGF2 with a low affinity. Ref.1

Subcellular location

Cell membrane; Single-pass membrane protein Potential.

Tissue specificity

Highly expressed in the kidney, brain and lung. Weakly expressed in the muscle, thymus, lymph node, stomach, intestine, colon and liver. Expressed in fetal cartilaginous structures like the nasal cartilage, the ribs and the sternum as well as in the cartilaginous rudiments of developing bones such as the vertebrae and the pelvic bone. High expression is found in the muscles of the tongue and the diaphragm. Ref.1 Ref.4

Developmental stage

First detected at embryonic day 7 and became clearly visible at day 11 and increased until day 17. Ref.2

Sequence similarities

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell surface receptor signaling pathway

Inferred from sequence alignment Ref.1. Source: MGI

diaphragm development

Inferred from mutant phenotype PubMed 17986259. Source: MGI

fibroblast growth factor receptor signaling pathway

Inferred from direct assay Ref.4. Source: GOC

heart valve morphogenesis

Inferred from mutant phenotype PubMed 19383940. Source: MGI

negative regulation of cell proliferation

Inferred from direct assay Ref.4. Source: MGI

negative regulation of fibroblast growth factor receptor signaling pathway

Inferred by curator Ref.1. Source: MGI

skeletal system development

Inferred from mutant phenotype PubMed 19383940. Source: MGI

ventricular septum morphogenesis

Inferred from mutant phenotype PubMed 19383940. Source: MGI

   Cellular_componentintegral component of plasma membrane

Inferred from sequence alignment Ref.1. Source: MGI

plasma membrane

Inferred from direct assay Ref.4. Source: MGI

   Molecular_functionfibroblast growth factor binding

Inferred from physical interaction Ref.1Ref.4. Source: MGI

fibroblast growth factor-activated receptor activity

Inferred from direct assay Ref.4. Source: UniProtKB

heparin binding

Inferred from electronic annotation. Source: Ensembl

non-tyrosine kinase fibroblast growth factor receptor activity

Inferred from sequence alignment Ref.1. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q91V87-1)

Also known as: FGFR5beta; FGFR5b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q91V87-2)

Also known as: FGFR5gamma; FGFR5g;

The sequence of this isoform differs from the canonical sequence as follows:
     23-113: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 By similarity
Chain21 – 529509Fibroblast growth factor receptor-like 1
PRO_0000021251

Regions

Topological domain21 – 374354Extracellular Potential
Transmembrane375 – 39521Helical; Potential
Topological domain396 – 529134Cytoplasmic Potential
Domain25 – 11187Ig-like C2-type 1
Domain143 – 23391Ig-like C2-type 2
Domain242 – 350109Ig-like C2-type 3

Amino acid modifications

Glycosylation1071N-linked (GlcNAc...) Potential
Glycosylation2271N-linked (GlcNAc...) Potential
Glycosylation2511N-linked (GlcNAc...) Potential
Glycosylation2891N-linked (GlcNAc...) Potential
Disulfide bond47 ↔ 95 By similarity
Disulfide bond168 ↔ 217 By similarity
Disulfide bond264 ↔ 334 By similarity

Natural variations

Alternative sequence23 – 11391Missing in isoform 2.
VSP_013976

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (FGFR5beta) (FGFR5b) [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 6CE76A75BF2498DD

FASTA52957,013
        10         20         30         40         50         60 
MTRSPALLLL LLGALPSAEA ARGPPRMADK VVPRQVARLG RTVRLQCPVE GDPPPLTMWT 

        70         80         90        100        110        120 
KDGRTIHSGW SRFRVLPQGL KVKEVEAEDA GVYVCKATNG FGSLSVNYTL IIMDDISPGK 

       130        140        150        160        170        180 
ESPGPGGSSG GQEDPASQQW ARPRFTQPSK MRRRVIARPV GSSVRLKCVA SGHPRPDIMW 

       190        200        210        220        230        240 
MKDDQTLTHL EASEHRKKKW TLSLKNLKPE DSGKYTCRVS NKAGAINATY KVDVIQRTRS 

       250        260        270        280        290        300 
KPVLTGTHPV NTTVDFGGTT SFQCKVRSDV KPVIQWLKRV EYGSEGRHNS TIDVGGQKFV 

       310        320        330        340        350        360 
VLPTGDVWSR PDGSYLNKLL ISRARQDDAG MYICLGANTM GYSFRSAFLT VLPDPKPPGP 

       370        380        390        400        410        420 
PMASSSSSTS LPWPVVIGIP AGAVFILGTV LLWLCQTKKK PCAPASTLPV PGHRPPGTSR 

       430        440        450        460        470        480 
ERSGDKDLPS LAVGICEEHG SAMAPQHILA SGSTAGPKLY PKLYTDVHTH THTHTCTHTL 

       490        500        510        520 
SCGGQGSSTP ACPLSVLNTA NLQALCPEVG IWGPRQQVGR IENNGGRVS 

« Hide

Isoform 2 (FGFR5gamma) (FGFR5g) [UniParc].

Checksum: 768D7E96126DD8AE
Show »

FASTA43846,981

References

« Hide 'large scale' references
[1]"Identification of a new fibroblast growth factor receptor, FGFR5."
Sleeman M., Fraser J., McDonald M., Yuan S., White D., Grandison P., Kumble K., Watson J.D., Murison J.G.
Gene 271:171-182(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH FGF2.
Strain: BALB/cJ.
[2]"The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein."
Wiedemann M., Trueb B.
Biochim. Biophys. Acta 1520:247-250(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), DEVELOPMENTAL STAGE.
Tissue: Cartilage.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N-3.
Tissue: Mammary tumor.
[4]"Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues."
Trueb B., Zhuang L., Taeschler S., Wiedemann M.
J. Biol. Chem. 278:33857-33865(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF321300 mRNA. Translation: AAL06295.1.
AF321301 mRNA. Translation: AAL06296.1.
AF321302 Genomic DNA. Translation: AAL06297.1.
AJ293947 mRNA. Translation: CAC82376.1.
AJ308490 Genomic DNA. Translation: CAC83768.1.
BC058745 mRNA. Translation: AAH58745.1.
RefSeqNP_001157731.1. NM_001164259.1.
NP_473412.1. NM_054071.2.
UniGeneMm.35691.

3D structure databases

ProteinModelPortalQ91V87.
SMRQ91V87. Positions 21-415.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid227959. 1 interaction.

PTM databases

PhosphoSiteQ91V87.

Proteomic databases

PRIDEQ91V87.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000013633; ENSMUSP00000013633; ENSMUSG00000008090. [Q91V87-1]
ENSMUST00000112560; ENSMUSP00000108179; ENSMUSG00000008090. [Q91V87-2]
GeneID116701.
KEGGmmu:116701.
UCSCuc008ypa.2. mouse. [Q91V87-1]
uc012eav.1. mouse. [Q91V87-2]

Organism-specific databases

CTD53834.
MGIMGI:2150920. Fgfrl1.

Phylogenomic databases

eggNOGNOG289609.
GeneTreeENSGT00390000008504.
HOGENOMHOG000112576.
HOVERGENHBG056473.
InParanoidQ91V87.
OMAKQWARPR.
OrthoDBEOG79KPF3.
PhylomeDBQ91V87.

Gene expression databases

BgeeQ91V87.
CleanExMM_FGFRL1.
GenevestigatorQ91V87.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
[Graphical view]
PfamPF07679. I-set. 3 hits.
[Graphical view]
SMARTSM00408. IGc2. 3 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFGFRL1. mouse.
NextBio369030.
PROQ91V87.
SOURCESearch...

Entry information

Entry nameFGRL1_MOUSE
AccessionPrimary (citable) accession number: Q91V87
Secondary accession number(s): Q920C2, Q920C3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot