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Q91V87

- FGRL1_MOUSE

UniProt

Q91V87 - FGRL1_MOUSE

Protein

Fibroblast growth factor receptor-like 1

Gene

Fgfrl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Has a negative effect on cell proliferation.By similarity

    GO - Molecular functioni

    1. fibroblast growth factor-activated receptor activity Source: UniProtKB
    2. fibroblast growth factor binding Source: MGI
    3. heparin binding Source: Ensembl
    4. non-tyrosine kinase fibroblast growth factor receptor activity Source: MGI

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: MGI
    2. diaphragm development Source: MGI
    3. fibroblast growth factor receptor signaling pathway Source: GOC
    4. heart valve morphogenesis Source: MGI
    5. negative regulation of cell proliferation Source: MGI
    6. negative regulation of fibroblast growth factor receptor signaling pathway Source: MGI
    7. skeletal system development Source: MGI
    8. ventricular septum morphogenesis Source: MGI

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor receptor-like 1
    Short name:
    FGF receptor-like protein 1
    Alternative name(s):
    Fibroblast growth factor receptor 5
    Short name:
    FGFR-5
    Gene namesi
    Name:Fgfrl1
    Synonyms:Fgfr5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2150920. Fgfrl1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 529509Fibroblast growth factor receptor-like 1PRO_0000021251Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 ↔ 95PROSITE-ProRule annotation
    Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi168 ↔ 217PROSITE-ProRule annotation
    Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi264 ↔ 334PROSITE-ProRule annotation
    Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ91V87.

    PTM databases

    PhosphoSiteiQ91V87.

    Expressioni

    Tissue specificityi

    Highly expressed in the kidney, brain and lung. Weakly expressed in the muscle, thymus, lymph node, stomach, intestine, colon and liver. Expressed in fetal cartilaginous structures like the nasal cartilage, the ribs and the sternum as well as in the cartilaginous rudiments of developing bones such as the vertebrae and the pelvic bone. High expression is found in the muscles of the tongue and the diaphragm.2 Publications

    Developmental stagei

    First detected at embryonic day 7 and became clearly visible at day 11 and increased until day 17.1 Publication

    Gene expression databases

    BgeeiQ91V87.
    CleanExiMM_FGFRL1.
    GenevestigatoriQ91V87.

    Interactioni

    Subunit structurei

    Interacts with FGF2 with a low affinity.1 Publication

    Protein-protein interaction databases

    BioGridi227959. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91V87.
    SMRiQ91V87. Positions 21-355.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 374354ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini396 – 529134CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei375 – 39521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 11187Ig-like C2-type 1Add
    BLAST
    Domaini143 – 23391Ig-like C2-type 2Add
    BLAST
    Domaini242 – 350109Ig-like C2-type 3Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG289609.
    GeneTreeiENSGT00390000008504.
    HOGENOMiHOG000112576.
    HOVERGENiHBG056473.
    InParanoidiQ91V87.
    OMAiKQWARPR.
    OrthoDBiEOG79KPF3.
    PhylomeDBiQ91V87.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF07679. I-set. 3 hits.
    [Graphical view]
    SMARTiSM00408. IGc2. 3 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q91V87-1) [UniParc]FASTAAdd to Basket

    Also known as: FGFR5beta, FGFR5b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTRSPALLLL LLGALPSAEA ARGPPRMADK VVPRQVARLG RTVRLQCPVE    50
    GDPPPLTMWT KDGRTIHSGW SRFRVLPQGL KVKEVEAEDA GVYVCKATNG 100
    FGSLSVNYTL IIMDDISPGK ESPGPGGSSG GQEDPASQQW ARPRFTQPSK 150
    MRRRVIARPV GSSVRLKCVA SGHPRPDIMW MKDDQTLTHL EASEHRKKKW 200
    TLSLKNLKPE DSGKYTCRVS NKAGAINATY KVDVIQRTRS KPVLTGTHPV 250
    NTTVDFGGTT SFQCKVRSDV KPVIQWLKRV EYGSEGRHNS TIDVGGQKFV 300
    VLPTGDVWSR PDGSYLNKLL ISRARQDDAG MYICLGANTM GYSFRSAFLT 350
    VLPDPKPPGP PMASSSSSTS LPWPVVIGIP AGAVFILGTV LLWLCQTKKK 400
    PCAPASTLPV PGHRPPGTSR ERSGDKDLPS LAVGICEEHG SAMAPQHILA 450
    SGSTAGPKLY PKLYTDVHTH THTHTCTHTL SCGGQGSSTP ACPLSVLNTA 500
    NLQALCPEVG IWGPRQQVGR IENNGGRVS 529
    Length:529
    Mass (Da):57,013
    Last modified:December 1, 2001 - v1
    Checksum:i6CE76A75BF2498DD
    GO
    Isoform 2 (identifier: Q91V87-2) [UniParc]FASTAAdd to Basket

    Also known as: FGFR5gamma, FGFR5g

    The sequence of this isoform differs from the canonical sequence as follows:
         23-113: Missing.

    Show »
    Length:438
    Mass (Da):46,981
    Checksum:i768D7E96126DD8AE
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei23 – 11391Missing in isoform 2. 1 PublicationVSP_013976Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321300 mRNA. Translation: AAL06295.1.
    AF321301 mRNA. Translation: AAL06296.1.
    AF321302 Genomic DNA. Translation: AAL06297.1.
    AJ293947 mRNA. Translation: CAC82376.1.
    AJ308490 Genomic DNA. Translation: CAC83768.1.
    BC058745 mRNA. Translation: AAH58745.1.
    CCDSiCCDS19518.1. [Q91V87-1]
    CCDS51592.1. [Q91V87-2]
    RefSeqiNP_001157731.1. NM_001164259.1. [Q91V87-2]
    NP_473412.1. NM_054071.2. [Q91V87-1]
    UniGeneiMm.35691.

    Genome annotation databases

    EnsembliENSMUST00000013633; ENSMUSP00000013633; ENSMUSG00000008090. [Q91V87-1]
    ENSMUST00000112560; ENSMUSP00000108179; ENSMUSG00000008090. [Q91V87-2]
    GeneIDi116701.
    KEGGimmu:116701.
    UCSCiuc008ypa.2. mouse. [Q91V87-1]
    uc012eav.1. mouse. [Q91V87-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321300 mRNA. Translation: AAL06295.1 .
    AF321301 mRNA. Translation: AAL06296.1 .
    AF321302 Genomic DNA. Translation: AAL06297.1 .
    AJ293947 mRNA. Translation: CAC82376.1 .
    AJ308490 Genomic DNA. Translation: CAC83768.1 .
    BC058745 mRNA. Translation: AAH58745.1 .
    CCDSi CCDS19518.1. [Q91V87-1 ]
    CCDS51592.1. [Q91V87-2 ]
    RefSeqi NP_001157731.1. NM_001164259.1. [Q91V87-2 ]
    NP_473412.1. NM_054071.2. [Q91V87-1 ]
    UniGenei Mm.35691.

    3D structure databases

    ProteinModelPortali Q91V87.
    SMRi Q91V87. Positions 21-355.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 227959. 1 interaction.

    PTM databases

    PhosphoSitei Q91V87.

    Proteomic databases

    PRIDEi Q91V87.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000013633 ; ENSMUSP00000013633 ; ENSMUSG00000008090 . [Q91V87-1 ]
    ENSMUST00000112560 ; ENSMUSP00000108179 ; ENSMUSG00000008090 . [Q91V87-2 ]
    GeneIDi 116701.
    KEGGi mmu:116701.
    UCSCi uc008ypa.2. mouse. [Q91V87-1 ]
    uc012eav.1. mouse. [Q91V87-2 ]

    Organism-specific databases

    CTDi 53834.
    MGIi MGI:2150920. Fgfrl1.

    Phylogenomic databases

    eggNOGi NOG289609.
    GeneTreei ENSGT00390000008504.
    HOGENOMi HOG000112576.
    HOVERGENi HBG056473.
    InParanoidi Q91V87.
    OMAi KQWARPR.
    OrthoDBi EOG79KPF3.
    PhylomeDBi Q91V87.

    Miscellaneous databases

    ChiTaRSi FGFRL1. mouse.
    NextBioi 369030.
    PROi Q91V87.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91V87.
    CleanExi MM_FGFRL1.
    Genevestigatori Q91V87.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF07679. I-set. 3 hits.
    [Graphical view ]
    SMARTi SM00408. IGc2. 3 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a new fibroblast growth factor receptor, FGFR5."
      Sleeman M., Fraser J., McDonald M., Yuan S., White D., Grandison P., Kumble K., Watson J.D., Murison J.G.
      Gene 271:171-182(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH FGF2.
      Strain: BALB/cJ.
    2. "The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein."
      Wiedemann M., Trueb B.
      Biochim. Biophys. Acta 1520:247-250(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), DEVELOPMENTAL STAGE.
      Tissue: Cartilage.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N-3.
      Tissue: Mammary tumor.
    4. "Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues."
      Trueb B., Zhuang L., Taeschler S., Wiedemann M.
      J. Biol. Chem. 278:33857-33865(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFGRL1_MOUSE
    AccessioniPrimary (citable) accession number: Q91V87
    Secondary accession number(s): Q920C2, Q920C3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3