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Q91V87

- FGRL1_MOUSE

UniProt

Q91V87 - FGRL1_MOUSE

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Protein
Fibroblast growth factor receptor-like 1
Gene
Fgfrl1, Fgfr5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Has a negative effect on cell proliferation By similarity.1 Publication

GO - Molecular functioni

  1. fibroblast growth factor binding Source: MGI
  2. fibroblast growth factor-activated receptor activity Source: UniProtKB
  3. heparin binding Source: Ensembl
  4. non-tyrosine kinase fibroblast growth factor receptor activity Source: MGI

GO - Biological processi

  1. cell surface receptor signaling pathway Source: MGI
  2. diaphragm development Source: MGI
  3. fibroblast growth factor receptor signaling pathway Source: GOC
  4. heart valve morphogenesis Source: MGI
  5. negative regulation of cell proliferation Source: MGI
  6. negative regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  7. skeletal system development Source: MGI
  8. ventricular septum morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptor-like 1
Short name:
FGF receptor-like protein 1
Alternative name(s):
Fibroblast growth factor receptor 5
Short name:
FGFR-5
Gene namesi
Name:Fgfrl1
Synonyms:Fgfr5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2150920. Fgfrl1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 374354Extracellular Reviewed prediction
Add
BLAST
Transmembranei375 – 39521Helical; Reviewed prediction
Add
BLAST
Topological domaini396 – 529134Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 By similarity
Add
BLAST
Chaini21 – 529509Fibroblast growth factor receptor-like 1
PRO_0000021251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 95 By similarity
Glycosylationi107 – 1071N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi168 ↔ 217 By similarity
Glycosylationi227 – 2271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi251 – 2511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi264 ↔ 334 By similarity
Glycosylationi289 – 2891N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ91V87.

PTM databases

PhosphoSiteiQ91V87.

Expressioni

Tissue specificityi

Highly expressed in the kidney, brain and lung. Weakly expressed in the muscle, thymus, lymph node, stomach, intestine, colon and liver. Expressed in fetal cartilaginous structures like the nasal cartilage, the ribs and the sternum as well as in the cartilaginous rudiments of developing bones such as the vertebrae and the pelvic bone. High expression is found in the muscles of the tongue and the diaphragm.2 Publications

Developmental stagei

First detected at embryonic day 7 and became clearly visible at day 11 and increased until day 17.1 Publication

Gene expression databases

BgeeiQ91V87.
CleanExiMM_FGFRL1.
GenevestigatoriQ91V87.

Interactioni

Subunit structurei

Interacts with FGF2 with a low affinity.1 Publication

Protein-protein interaction databases

BioGridi227959. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ91V87.
SMRiQ91V87. Positions 21-355.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 11187Ig-like C2-type 1
Add
BLAST
Domaini143 – 23391Ig-like C2-type 2
Add
BLAST
Domaini242 – 350109Ig-like C2-type 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG289609.
GeneTreeiENSGT00390000008504.
HOGENOMiHOG000112576.
HOVERGENiHBG056473.
InParanoidiQ91V87.
OMAiKQWARPR.
OrthoDBiEOG79KPF3.
PhylomeDBiQ91V87.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00408. IGc2. 3 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91V87-1) [UniParc]FASTAAdd to Basket

Also known as: FGFR5beta, FGFR5b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTRSPALLLL LLGALPSAEA ARGPPRMADK VVPRQVARLG RTVRLQCPVE    50
GDPPPLTMWT KDGRTIHSGW SRFRVLPQGL KVKEVEAEDA GVYVCKATNG 100
FGSLSVNYTL IIMDDISPGK ESPGPGGSSG GQEDPASQQW ARPRFTQPSK 150
MRRRVIARPV GSSVRLKCVA SGHPRPDIMW MKDDQTLTHL EASEHRKKKW 200
TLSLKNLKPE DSGKYTCRVS NKAGAINATY KVDVIQRTRS KPVLTGTHPV 250
NTTVDFGGTT SFQCKVRSDV KPVIQWLKRV EYGSEGRHNS TIDVGGQKFV 300
VLPTGDVWSR PDGSYLNKLL ISRARQDDAG MYICLGANTM GYSFRSAFLT 350
VLPDPKPPGP PMASSSSSTS LPWPVVIGIP AGAVFILGTV LLWLCQTKKK 400
PCAPASTLPV PGHRPPGTSR ERSGDKDLPS LAVGICEEHG SAMAPQHILA 450
SGSTAGPKLY PKLYTDVHTH THTHTCTHTL SCGGQGSSTP ACPLSVLNTA 500
NLQALCPEVG IWGPRQQVGR IENNGGRVS 529
Length:529
Mass (Da):57,013
Last modified:December 1, 2001 - v1
Checksum:i6CE76A75BF2498DD
GO
Isoform 2 (identifier: Q91V87-2) [UniParc]FASTAAdd to Basket

Also known as: FGFR5gamma, FGFR5g

The sequence of this isoform differs from the canonical sequence as follows:
     23-113: Missing.

Show »
Length:438
Mass (Da):46,981
Checksum:i768D7E96126DD8AE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei23 – 11391Missing in isoform 2.
VSP_013976Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF321300 mRNA. Translation: AAL06295.1.
AF321301 mRNA. Translation: AAL06296.1.
AF321302 Genomic DNA. Translation: AAL06297.1.
AJ293947 mRNA. Translation: CAC82376.1.
AJ308490 Genomic DNA. Translation: CAC83768.1.
BC058745 mRNA. Translation: AAH58745.1.
CCDSiCCDS19518.1. [Q91V87-1]
CCDS51592.1. [Q91V87-2]
RefSeqiNP_001157731.1. NM_001164259.1. [Q91V87-2]
NP_473412.1. NM_054071.2. [Q91V87-1]
UniGeneiMm.35691.

Genome annotation databases

EnsembliENSMUST00000013633; ENSMUSP00000013633; ENSMUSG00000008090. [Q91V87-1]
ENSMUST00000112560; ENSMUSP00000108179; ENSMUSG00000008090. [Q91V87-2]
GeneIDi116701.
KEGGimmu:116701.
UCSCiuc008ypa.2. mouse. [Q91V87-1]
uc012eav.1. mouse. [Q91V87-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF321300 mRNA. Translation: AAL06295.1 .
AF321301 mRNA. Translation: AAL06296.1 .
AF321302 Genomic DNA. Translation: AAL06297.1 .
AJ293947 mRNA. Translation: CAC82376.1 .
AJ308490 Genomic DNA. Translation: CAC83768.1 .
BC058745 mRNA. Translation: AAH58745.1 .
CCDSi CCDS19518.1. [Q91V87-1 ]
CCDS51592.1. [Q91V87-2 ]
RefSeqi NP_001157731.1. NM_001164259.1. [Q91V87-2 ]
NP_473412.1. NM_054071.2. [Q91V87-1 ]
UniGenei Mm.35691.

3D structure databases

ProteinModelPortali Q91V87.
SMRi Q91V87. Positions 21-355.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 227959. 1 interaction.

PTM databases

PhosphoSitei Q91V87.

Proteomic databases

PRIDEi Q91V87.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000013633 ; ENSMUSP00000013633 ; ENSMUSG00000008090 . [Q91V87-1 ]
ENSMUST00000112560 ; ENSMUSP00000108179 ; ENSMUSG00000008090 . [Q91V87-2 ]
GeneIDi 116701.
KEGGi mmu:116701.
UCSCi uc008ypa.2. mouse. [Q91V87-1 ]
uc012eav.1. mouse. [Q91V87-2 ]

Organism-specific databases

CTDi 53834.
MGIi MGI:2150920. Fgfrl1.

Phylogenomic databases

eggNOGi NOG289609.
GeneTreei ENSGT00390000008504.
HOGENOMi HOG000112576.
HOVERGENi HBG056473.
InParanoidi Q91V87.
OMAi KQWARPR.
OrthoDBi EOG79KPF3.
PhylomeDBi Q91V87.

Miscellaneous databases

ChiTaRSi FGFRL1. mouse.
NextBioi 369030.
PROi Q91V87.
SOURCEi Search...

Gene expression databases

Bgeei Q91V87.
CleanExi MM_FGFRL1.
Genevestigatori Q91V87.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF07679. I-set. 3 hits.
[Graphical view ]
SMARTi SM00408. IGc2. 3 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a new fibroblast growth factor receptor, FGFR5."
    Sleeman M., Fraser J., McDonald M., Yuan S., White D., Grandison P., Kumble K., Watson J.D., Murison J.G.
    Gene 271:171-182(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH FGF2.
    Strain: BALB/cJ.
  2. "The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein."
    Wiedemann M., Trueb B.
    Biochim. Biophys. Acta 1520:247-250(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), DEVELOPMENTAL STAGE.
    Tissue: Cartilage.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  4. "Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues."
    Trueb B., Zhuang L., Taeschler S., Wiedemann M.
    J. Biol. Chem. 278:33857-33865(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFGRL1_MOUSE
AccessioniPrimary (citable) accession number: Q91V87
Secondary accession number(s): Q920C2, Q920C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi