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Protein

TELO2-interacting protein 1 homolog

Gene

Tti1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
TELO2-interacting protein 1 homolog
Gene namesi
Name:Tti1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1922675. Tti1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10851085TELO2-interacting protein 1 homologPRO_0000050752Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei459 – 4591PhosphoserineBy similarity
Modified residuei823 – 8231Phosphoserine; by CK2By similarity

Post-translational modificationi

Phosphorylated at Ser-823 by CK2 following growth factor deprivation, leading to its subsequent ubiquitination by the SCF(FBXO9) complex. Phosphorylation by CK2 only takes place when TELO2 is bound to mTORC1, not mTORC2; leading to selective ubiquitination of mTORC1-associated protein (By similarity).By similarity
Ubiquitinated by the SCF(FBXO9) complex following phosphorylation by CK2 in response to growth factor deprivation, leading to its degradation by the proteasome. Only mTORC1-associated protein is ubiquitinated and degraded, leading to selective inactivation of mTORC1 to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ91V83.
MaxQBiQ91V83.
PaxDbiQ91V83.
PeptideAtlasiQ91V83.
PRIDEiQ91V83.

PTM databases

iPTMnetiQ91V83.
PhosphoSiteiQ91V83.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027650.
CleanExiMM_2610036D13RIK.
ExpressionAtlasiQ91V83. baseline and differential.
GenevisibleiQ91V83. MM.

Interactioni

Subunit structurei

Component of the TTT complex composed of TELO2, TTI1 and TTI2. Interacts with ATM, ATR, MTOR, PRKDC, SMG1, TELO2, TRRAP AND TTI2. Component of the mTORC1 and mTORC2 complexes (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029179.

Structurei

3D structure databases

ProteinModelPortaliQ91V83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tti1 family.Curated

Phylogenomic databases

eggNOGiKOG4524. Eukaryota.
ENOG410XSN6. LUCA.
GeneTreeiENSGT00390000009748.
HOGENOMiHOG000234009.
HOVERGENiHBG052183.
InParanoidiQ91V83.
OMAiEERRWNS.
OrthoDBiEOG091G06Y4.
TreeFamiTF315296.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR016441. Tti1.
[Graphical view]
PIRSFiPIRSF005250. UCP005250. 1 hit.
SUPFAMiSSF48371. SSF48371. 5 hits.

Sequencei

Sequence statusi: Complete.

Q91V83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVFDTPEEA FGVLRPVCVQ LTKTQTVENV EHLQTQLQAI SDTALQELQQ
60 70 80 90 100
YILFPLRFAL KTPGPKRERL VQSVVECLTF VLSSTCVREQ ELLQELFSEL
110 120 130 140 150
SACLYSPSSQ KPAALSEELK LAVIQGLSTL MHSAYRDIIL TFYEPSILPR
160 170 180 190 200
LGFAVSLLLG LAEQEKSKQI KIAALQCLQV LLLQCDCQDH PRPLDELEQQ
210 220 230 240 250
QLGDLLASFL PGISTALTRI ITGDFKQGHS IVVSSLKVFY KTVGFIMADE
260 270 280 290 300
QLTRIPKAQA KPVVEHRVAA LMIHREADWV KSTGDKLAIF IKKIIDCVSV
310 320 330 340 350
HPHWKVRLEL VEFVEILLLK CTQSLVESTG PLLKVLVGLV NDESPEVQAR
360 370 380 390 400
CSTVLRRLAD QKVVVGSRAL ADILSESLHS LATSLPRLMN TQDDQGKFST
410 420 430 440 450
LSLLLGYLKL LGPKVHVILN SVAHVQRLSR ALIQVLELEV TDVKMVEERR
460 470 480 490 500
WNSDNLSASA EVSAARPWSR VQRRYFRCFT DERVFLLLRK ICQLLGYYGD
510 520 530 540 550
LYLLVDHFME LYHTSVVYRK QAAMILNELV VGAAGLDVED IHNKCPSMGP
560 570 580 590 600
EELREIVKSI LEEYTSQENW YLITCFEAEE GEEVMMKQQG FQAVTSGVHT
610 620 630 640 650
CQVVSFPALS KPSPTICSMN SNIWQICIQL EGIGQFAYAL GKDFRLLLMS
660 670 680 690 700
ALYPILEKAG DPTLLISQVA TSTMVDICHA CGYNSVQHLI NQNSDYLVNG
710 720 730 740 750
ISLNLRHLAL HPHAPKVLEA MLRNADASLL PLVADVVQDV LATLDQFYDK
760 770 780 790 800
RAASFVSVLH ALLAALAHWF PDSGSTGQLQ QRSLEEEGRQ LPAAGEASTT
810 820 830 840 850
AEDIEQFVLS YLQEKDVAEG NVSDLEAEEE VQSAPPKVDE NDTLPDVEPP
860 870 880 890 900
LPTHIQIAKD VMERCIHLSA DKNLKIRLKV LDVLGLCVEV LQTHKNQLLP
910 920 930 940 950
LAHRAWPSLV HRLTSDDPLA VLRAFKVLQT LGSRCGDFLR SRFCKDVLPK
960 970 980 990 1000
LTSSLITQAP ISARAGPVYS HTLAFKLQLA VLQGLGPLCE NLDLGEGDLN
1010 1020 1030 1040 1050
KVADACVIYL STKQPVKLQE AARSVFLHLM RVDPDSTWLL LHELYCPVQQ
1060 1070 1080
FTAPHPSLHP VQLQGATQPQ NPYATNVCHL LLQLQ
Length:1,085
Mass (Da):120,814
Last modified:July 27, 2011 - v2
Checksum:iBB4CC0F849BC05E4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti216 – 2161A → V in AAK56095 (PubMed:11471062).Curated
Sequence conflicti216 – 2161A → V in AAK56096 (PubMed:11471062).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332067 mRNA. Translation: AAK56095.1.
AF332068 mRNA. Translation: AAK56096.1.
AL845511, AL663092 Genomic DNA. Translation: CAM20389.1.
AL663092, AL845511 Genomic DNA. Translation: CAM27321.1.
CH466551 Genomic DNA. Translation: EDL06248.1.
BC053067 mRNA. Translation: AAH53067.1.
AK011692 mRNA. Translation: BAB27782.1.
CCDSiCCDS16983.1.
RefSeqiNP_083558.1. NM_029282.1.
XP_006500395.1. XM_006500332.1.
XP_011238128.1. XM_011239826.1.
UniGeneiMm.29068.

Genome annotation databases

EnsembliENSMUST00000029179; ENSMUSP00000029179; ENSMUSG00000027650.
ENSMUST00000109522; ENSMUSP00000105148; ENSMUSG00000027650.
GeneIDi75425.
KEGGimmu:75425.
UCSCiuc008npj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332067 mRNA. Translation: AAK56095.1.
AF332068 mRNA. Translation: AAK56096.1.
AL845511, AL663092 Genomic DNA. Translation: CAM20389.1.
AL663092, AL845511 Genomic DNA. Translation: CAM27321.1.
CH466551 Genomic DNA. Translation: EDL06248.1.
BC053067 mRNA. Translation: AAH53067.1.
AK011692 mRNA. Translation: BAB27782.1.
CCDSiCCDS16983.1.
RefSeqiNP_083558.1. NM_029282.1.
XP_006500395.1. XM_006500332.1.
XP_011238128.1. XM_011239826.1.
UniGeneiMm.29068.

3D structure databases

ProteinModelPortaliQ91V83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029179.

PTM databases

iPTMnetiQ91V83.
PhosphoSiteiQ91V83.

Proteomic databases

EPDiQ91V83.
MaxQBiQ91V83.
PaxDbiQ91V83.
PeptideAtlasiQ91V83.
PRIDEiQ91V83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029179; ENSMUSP00000029179; ENSMUSG00000027650.
ENSMUST00000109522; ENSMUSP00000105148; ENSMUSG00000027650.
GeneIDi75425.
KEGGimmu:75425.
UCSCiuc008npj.1. mouse.

Organism-specific databases

CTDi9675.
MGIiMGI:1922675. Tti1.

Phylogenomic databases

eggNOGiKOG4524. Eukaryota.
ENOG410XSN6. LUCA.
GeneTreeiENSGT00390000009748.
HOGENOMiHOG000234009.
HOVERGENiHBG052183.
InParanoidiQ91V83.
OMAiEERRWNS.
OrthoDBiEOG091G06Y4.
TreeFamiTF315296.

Miscellaneous databases

PROiQ91V83.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027650.
CleanExiMM_2610036D13RIK.
ExpressionAtlasiQ91V83. baseline and differential.
GenevisibleiQ91V83. MM.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR016441. Tti1.
[Graphical view]
PIRSFiPIRSF005250. UCP005250. 1 hit.
SUPFAMiSSF48371. SSF48371. 5 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiTTI1_MOUSE
AccessioniPrimary (citable) accession number: Q91V83
Secondary accession number(s): Q7TS79, Q9CSY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.