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Protein

Beta-defensin 8

Gene

Defb8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

A synthetic peptide displays antimicrobial activities against S.aureus, P.aeruginosa, E.coli and B.cepacia. The antimicrobial activity against S.aureus, E.coli and B.cepacia is reduced in raised concentration of NaCl, but its action against P.aeruginosa is independent of NaCl concentration.

GO - Biological processi

  • defense response to bacterium Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 8
Short name:
BD-8
Short name:
mBD-8
Alternative name(s):
Defensin, beta 8
Defensin-related peptide
Defr1
Gene namesi
Name:Defb8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2654206. Defb8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 253PRO_0000006935
Peptidei26 – 6035Beta-defensin 8PRO_0000006936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 581 Publication
Disulfide bondi38 ↔ 521 Publication
Disulfide bondi42 ↔ 591 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ91V82.
PRIDEiQ91V82.

Expressioni

Tissue specificityi

Most highly expressed in testis and heart.

Gene expression databases

BgeeiENSMUSG00000031471.
CleanExiMM_DEFB8.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033854.

Structurei

Secondary structure

1
60
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi31 – 344Combined sources
Beta strandi37 – 404Combined sources
Beta strandi46 – 505Combined sources
Beta strandi54 – 607Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E4RNMR-A26-60[»]
ProteinModelPortaliQ91V82.
SMRiQ91V82. Positions 26-60.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ91V82.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000015465.
HOVERGENiHBG004834.
InParanoidiQ91V82.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91V82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIHYLLFTF LLVLLSPLAA FSQKINEPVS CIRNGGICQY RCIGLRHKIG
60
TCGSPFKCCK
Length:60
Mass (Da):6,760
Last modified:December 1, 2001 - v1
Checksum:i7213024CF909A59B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271E → D in CAC86998 (PubMed:12226710).Curated
Sequence conflicti30 – 312SC → TY in CAC86998 (PubMed:12226710).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344114 Genomic DNA. Translation: CAC86998.1.
AJ300674 mRNA. Translation: CAC44635.1.
AJ300673 Genomic DNA. Translation: CAC44634.1.
RefSeqiNP_694748.3. NM_153108.4.
UniGeneiMm.390008.

Genome annotation databases

GeneIDi244334.
KEGGimmu:244334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344114 Genomic DNA. Translation: CAC86998.1.
AJ300674 mRNA. Translation: CAC44635.1.
AJ300673 Genomic DNA. Translation: CAC44634.1.
RefSeqiNP_694748.3. NM_153108.4.
UniGeneiMm.390008.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E4RNMR-A26-60[»]
ProteinModelPortaliQ91V82.
SMRiQ91V82. Positions 26-60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033854.

Proteomic databases

PaxDbiQ91V82.
PRIDEiQ91V82.

Protocols and materials databases

DNASUi244334.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi244334.
KEGGimmu:244334.

Organism-specific databases

CTDi244334.
MGIiMGI:2654206. Defb8.

Phylogenomic databases

HOGENOMiHOG000015465.
HOVERGENiHBG004834.
InParanoidiQ91V82.

Miscellaneous databases

EvolutionaryTraceiQ91V82.
PROiQ91V82.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031471.
CleanExiMM_DEFB8.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEFB8_MOUSE
AccessioniPrimary (citable) accession number: Q91V82
Secondary accession number(s): Q8R556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.