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Q91V80

- APOF_MOUSE

UniProt

Q91V80 - APOF_MOUSE

Protein

Apolipoprotein F

Gene

Apof

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII By similarity.By similarity

    GO - Biological processi

    1. cholesterol efflux Source: MGI
    2. cholesterol metabolic process Source: MGI
    3. triglyceride metabolic process Source: MGI

    Keywords - Biological processi

    Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein F
    Short name:
    Apo-F
    Alternative name(s):
    Leukemia virus-inactivating factor
    Short name:
    LVIF
    Gene namesi
    Name:Apof
    Synonyms:Lvif
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:104539. Apof.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. high-density lipoprotein particle Source: UniProtKB-KW
    2. low-density lipoprotein particle Source: UniProtKB-KW

    Keywords - Cellular componenti

    HDL, LDL, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Propeptidei25 – 154130Sequence AnalysisPRO_0000002053Add
    BLAST
    Chaini155 – 315161Apolipoprotein FPRO_0000002054Add
    BLAST

    Keywords - PTMi

    Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiQ91V80.
    PRIDEiQ91V80.

    Expressioni

    Tissue specificityi

    Liver.1 Publication

    Gene expression databases

    BgeeiQ91V80.
    CleanExiMM_APOF.
    GenevestigatoriQ91V80.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000050300.

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG68175.
    GeneTreeiENSGT00500000045104.
    HOGENOMiHOG000034007.
    HOVERGENiHBG050551.
    InParanoidiQ91V80.
    OrthoDBiEOG7T1RC5.
    PhylomeDBiQ91V80.
    TreeFamiTF338778.

    Family and domain databases

    InterProiIPR026114. APOF.
    [Graphical view]
    PANTHERiPTHR15011. PTHR15011. 1 hit.
    PfamiPF15148. Apolipo_F. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91V80-1 [UniParc]FASTAAdd to Basket

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    MHSLRLILMS IQLLCYLLLC PVDATSHGEA TSVSTVLPPS KLGYQMQTSD    50
    KPLSCQMLLP KSLPGFTYMP PVSKFLVGLA LRNALEAAGC QAEVWALQLQ 100
    LYRLGGVEAT QALIHHLQEL QKSGHTDREV SVDALSSALQ LLAWEQPGPK 150
    RAKRSISNTD CDNDQEQSVH NVVDLLPAVG TYYNLGTALY YAIKNCSDKA 200
    KERGRDGAID LGYDLLMAMV GASGGPAGAV ITAALKPAMK AGVQRLIQYY 250
    YDEKEVTTPQ PEVTTHQPET GKDATTDIGV VEEIAMSNFV SEVESTTSNW 300
    EWPLLKNYGV LAYKR 315
    Length:315
    Mass (Da):34,359
    Last modified:July 19, 2005 - v2
    Checksum:iFB669F792B3E90E7
    GO

    Sequence cautioni

    The sequence AAH10815.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH22795.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH24769.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH25827.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAL06339.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAL06340.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAL06341.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411830 Genomic DNA. Translation: AAL06339.1. Different initiation.
    AF411831 Genomic DNA. Translation: AAL06340.1. Different initiation.
    AF411832 Genomic DNA. Translation: AAL06341.1. Different initiation.
    BC010815 mRNA. Translation: AAH10815.1. Different initiation.
    BC022795 mRNA. Translation: AAH22795.1. Different initiation.
    BC024769 mRNA. Translation: AAH24769.1. Different initiation.
    BC025827 mRNA. Translation: AAH25827.1. Different initiation.
    RefSeqiNP_598758.1. NM_133997.2.
    UniGeneiMm.26513.

    Genome annotation databases

    EnsembliENSMUST00000050901; ENSMUSP00000050300; ENSMUSG00000047631.
    GeneIDi103161.
    KEGGimmu:103161.
    UCSCiuc007hlz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF411830 Genomic DNA. Translation: AAL06339.1 . Different initiation.
    AF411831 Genomic DNA. Translation: AAL06340.1 . Different initiation.
    AF411832 Genomic DNA. Translation: AAL06341.1 . Different initiation.
    BC010815 mRNA. Translation: AAH10815.1 . Different initiation.
    BC022795 mRNA. Translation: AAH22795.1 . Different initiation.
    BC024769 mRNA. Translation: AAH24769.1 . Different initiation.
    BC025827 mRNA. Translation: AAH25827.1 . Different initiation.
    RefSeqi NP_598758.1. NM_133997.2.
    UniGenei Mm.26513.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000050300.

    Proteomic databases

    PaxDbi Q91V80.
    PRIDEi Q91V80.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050901 ; ENSMUSP00000050300 ; ENSMUSG00000047631 .
    GeneIDi 103161.
    KEGGi mmu:103161.
    UCSCi uc007hlz.1. mouse.

    Organism-specific databases

    CTDi 319.
    MGIi MGI:104539. Apof.

    Phylogenomic databases

    eggNOGi NOG68175.
    GeneTreei ENSGT00500000045104.
    HOGENOMi HOG000034007.
    HOVERGENi HBG050551.
    InParanoidi Q91V80.
    OrthoDBi EOG7T1RC5.
    PhylomeDBi Q91V80.
    TreeFami TF338778.

    Miscellaneous databases

    ChiTaRSi APOF. mouse.
    NextBioi 355823.
    PROi Q91V80.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91V80.
    CleanExi MM_APOF.
    Genevestigatori Q91V80.

    Family and domain databases

    InterProi IPR026114. APOF.
    [Graphical view ]
    PANTHERi PTHR15011. PTHR15011. 1 hit.
    Pfami PF15148. Apolipo_F. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic control of a mouse serum lipoprotein factor that inactivates murine leukemia viruses: evaluation of apolipoprotein F as a candidate."
      Wu T., Lee C.G., Buckler-White A., Kozak C.A.
      J. Virol. 76:2279-2286(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Strain: C58/J, CAST/Ei and NFS.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.

    Entry informationi

    Entry nameiAPOF_MOUSE
    AccessioniPrimary (citable) accession number: Q91V80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3