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Q91V80

- APOF_MOUSE

UniProt

Q91V80 - APOF_MOUSE

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Protein

Apolipoprotein F

Gene
Apof, Lvif
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII By similarity.

GO - Biological processi

  1. cholesterol efflux Source: MGI
  2. cholesterol metabolic process Source: MGI
  3. triglyceride metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein F
Short name:
Apo-F
Alternative name(s):
Leukemia virus-inactivating factor
Short name:
LVIF
Gene namesi
Name:Apof
Synonyms:Lvif
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:104539. Apof.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. high-density lipoprotein particle Source: UniProtKB-KW
  2. low-density lipoprotein particle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

HDL, LDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Propeptidei25 – 154130 Reviewed predictionPRO_0000002053Add
BLAST
Chaini155 – 315161Apolipoprotein FPRO_0000002054Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ91V80.
PRIDEiQ91V80.

Expressioni

Tissue specificityi

Liver.1 Publication

Gene expression databases

BgeeiQ91V80.
CleanExiMM_APOF.
GenevestigatoriQ91V80.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050300.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG68175.
GeneTreeiENSGT00500000045104.
HOGENOMiHOG000034007.
HOVERGENiHBG050551.
InParanoidiQ91V80.
OrthoDBiEOG7T1RC5.
PhylomeDBiQ91V80.
TreeFamiTF338778.

Family and domain databases

InterProiIPR026114. APOF.
[Graphical view]
PANTHERiPTHR15011. PTHR15011. 1 hit.
PfamiPF15148. Apolipo_F. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91V80-1 [UniParc]FASTAAdd to Basket

« Hide

MHSLRLILMS IQLLCYLLLC PVDATSHGEA TSVSTVLPPS KLGYQMQTSD    50
KPLSCQMLLP KSLPGFTYMP PVSKFLVGLA LRNALEAAGC QAEVWALQLQ 100
LYRLGGVEAT QALIHHLQEL QKSGHTDREV SVDALSSALQ LLAWEQPGPK 150
RAKRSISNTD CDNDQEQSVH NVVDLLPAVG TYYNLGTALY YAIKNCSDKA 200
KERGRDGAID LGYDLLMAMV GASGGPAGAV ITAALKPAMK AGVQRLIQYY 250
YDEKEVTTPQ PEVTTHQPET GKDATTDIGV VEEIAMSNFV SEVESTTSNW 300
EWPLLKNYGV LAYKR 315
Length:315
Mass (Da):34,359
Last modified:July 19, 2005 - v2
Checksum:iFB669F792B3E90E7
GO

Sequence cautioni

The sequence AAH10815.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH22795.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH24769.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH25827.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAL06339.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAL06340.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAL06341.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF411830 Genomic DNA. Translation: AAL06339.1. Different initiation.
AF411831 Genomic DNA. Translation: AAL06340.1. Different initiation.
AF411832 Genomic DNA. Translation: AAL06341.1. Different initiation.
BC010815 mRNA. Translation: AAH10815.1. Different initiation.
BC022795 mRNA. Translation: AAH22795.1. Different initiation.
BC024769 mRNA. Translation: AAH24769.1. Different initiation.
BC025827 mRNA. Translation: AAH25827.1. Different initiation.
RefSeqiNP_598758.1. NM_133997.2.
UniGeneiMm.26513.

Genome annotation databases

EnsembliENSMUST00000050901; ENSMUSP00000050300; ENSMUSG00000047631.
GeneIDi103161.
KEGGimmu:103161.
UCSCiuc007hlz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF411830 Genomic DNA. Translation: AAL06339.1 . Different initiation.
AF411831 Genomic DNA. Translation: AAL06340.1 . Different initiation.
AF411832 Genomic DNA. Translation: AAL06341.1 . Different initiation.
BC010815 mRNA. Translation: AAH10815.1 . Different initiation.
BC022795 mRNA. Translation: AAH22795.1 . Different initiation.
BC024769 mRNA. Translation: AAH24769.1 . Different initiation.
BC025827 mRNA. Translation: AAH25827.1 . Different initiation.
RefSeqi NP_598758.1. NM_133997.2.
UniGenei Mm.26513.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000050300.

Proteomic databases

PaxDbi Q91V80.
PRIDEi Q91V80.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050901 ; ENSMUSP00000050300 ; ENSMUSG00000047631 .
GeneIDi 103161.
KEGGi mmu:103161.
UCSCi uc007hlz.1. mouse.

Organism-specific databases

CTDi 319.
MGIi MGI:104539. Apof.

Phylogenomic databases

eggNOGi NOG68175.
GeneTreei ENSGT00500000045104.
HOGENOMi HOG000034007.
HOVERGENi HBG050551.
InParanoidi Q91V80.
OrthoDBi EOG7T1RC5.
PhylomeDBi Q91V80.
TreeFami TF338778.

Miscellaneous databases

ChiTaRSi APOF. mouse.
NextBioi 355823.
PROi Q91V80.
SOURCEi Search...

Gene expression databases

Bgeei Q91V80.
CleanExi MM_APOF.
Genevestigatori Q91V80.

Family and domain databases

InterProi IPR026114. APOF.
[Graphical view ]
PANTHERi PTHR15011. PTHR15011. 1 hit.
Pfami PF15148. Apolipo_F. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic control of a mouse serum lipoprotein factor that inactivates murine leukemia viruses: evaluation of apolipoprotein F as a candidate."
    Wu T., Lee C.G., Buckler-White A., Kozak C.A.
    J. Virol. 76:2279-2286(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: C58/J, CAST/Ei and NFS.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiAPOF_MOUSE
AccessioniPrimary (citable) accession number: Q91V80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: April 16, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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