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Q91V80 (APOF_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apolipoprotein F

Short name=Apo-F
Alternative name(s):
Leukemia virus-inactivating factor
Short name=LVIF
Gene names
Name:Apof
Synonyms:Lvif
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Liver. Ref.1

Sequence caution

The sequence AAH10815.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH22795.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH24769.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH25827.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAL06339.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAL06340.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAL06341.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Propeptide25 – 154130 Potential
PRO_0000002053
Chain155 – 315161Apolipoprotein F
PRO_0000002054

Sequences

Sequence LengthMass (Da)Tools
Q91V80 [UniParc].

Last modified July 19, 2005. Version 2.
Checksum: FB669F792B3E90E7

FASTA31534,359
        10         20         30         40         50         60 
MHSLRLILMS IQLLCYLLLC PVDATSHGEA TSVSTVLPPS KLGYQMQTSD KPLSCQMLLP 

        70         80         90        100        110        120 
KSLPGFTYMP PVSKFLVGLA LRNALEAAGC QAEVWALQLQ LYRLGGVEAT QALIHHLQEL 

       130        140        150        160        170        180 
QKSGHTDREV SVDALSSALQ LLAWEQPGPK RAKRSISNTD CDNDQEQSVH NVVDLLPAVG 

       190        200        210        220        230        240 
TYYNLGTALY YAIKNCSDKA KERGRDGAID LGYDLLMAMV GASGGPAGAV ITAALKPAMK 

       250        260        270        280        290        300 
AGVQRLIQYY YDEKEVTTPQ PEVTTHQPET GKDATTDIGV VEEIAMSNFV SEVESTTSNW 

       310 
EWPLLKNYGV LAYKR 

« Hide

References

« Hide 'large scale' references
[1]"Genetic control of a mouse serum lipoprotein factor that inactivates murine leukemia viruses: evaluation of apolipoprotein F as a candidate."
Wu T., Lee C.G., Buckler-White A., Kozak C.A.
J. Virol. 76:2279-2286(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
Strain: C58/J, CAST/Ei and NFS.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF411830 Genomic DNA. Translation: AAL06339.1. Different initiation.
AF411831 Genomic DNA. Translation: AAL06340.1. Different initiation.
AF411832 Genomic DNA. Translation: AAL06341.1. Different initiation.
BC010815 mRNA. Translation: AAH10815.1. Different initiation.
BC022795 mRNA. Translation: AAH22795.1. Different initiation.
BC024769 mRNA. Translation: AAH24769.1. Different initiation.
BC025827 mRNA. Translation: AAH25827.1. Different initiation.
RefSeqNP_598758.1. NM_133997.2.
UniGeneMm.26513.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000050300.

Proteomic databases

PaxDbQ91V80.
PRIDEQ91V80.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000050901; ENSMUSP00000050300; ENSMUSG00000047631.
GeneID103161.
KEGGmmu:103161.
UCSCuc007hlz.1. mouse.

Organism-specific databases

CTD319.
MGIMGI:104539. Apof.

Phylogenomic databases

eggNOGNOG68175.
GeneTreeENSGT00500000045104.
HOGENOMHOG000034007.
HOVERGENHBG050551.
InParanoidQ91V80.
OrthoDBEOG7T1RC5.
PhylomeDBQ91V80.
TreeFamTF338778.

Gene expression databases

BgeeQ91V80.
CleanExMM_APOF.
GenevestigatorQ91V80.

Family and domain databases

InterProIPR026114. APOF.
[Graphical view]
PANTHERPTHR15011. PTHR15011. 1 hit.
PfamPF15148. Apolipo_F. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAPOF. mouse.
NextBio355823.
PROQ91V80.
SOURCESearch...

Entry information

Entry nameAPOF_MOUSE
AccessionPrimary (citable) accession number: Q91V80
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: April 16, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot