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Protein

Apolipoprotein F

Gene

Apof

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII (By similarity).By similarity

GO - Biological processi

  1. cholesterol efflux Source: MGI
  2. cholesterol metabolic process Source: MGI
  3. triglyceride metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein F
Short name:
Apo-F
Alternative name(s):
Leukemia virus-inactivating factor
Short name:
LVIF
Gene namesi
Name:Apof
Synonyms:Lvif
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:104539. Apof.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. high-density lipoprotein particle Source: UniProtKB-KW
  2. low-density lipoprotein particle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

HDL, LDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Propeptidei25 – 154130Sequence AnalysisPRO_0000002053Add
BLAST
Chaini155 – 315161Apolipoprotein FPRO_0000002054Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

MaxQBiQ91V80.
PaxDbiQ91V80.
PRIDEiQ91V80.

Expressioni

Tissue specificityi

Liver.1 Publication

Gene expression databases

BgeeiQ91V80.
CleanExiMM_APOF.
GenevestigatoriQ91V80.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050300.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG68175.
HOGENOMiHOG000034007.
HOVERGENiHBG050551.
InParanoidiQ91V80.
OrthoDBiEOG7T1RC5.
PhylomeDBiQ91V80.
TreeFamiTF338778.

Family and domain databases

InterProiIPR026114. APOF.
[Graphical view]
PANTHERiPTHR15011. PTHR15011. 1 hit.
PfamiPF15148. Apolipo_F. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91V80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSLRLILMS IQLLCYLLLC PVDATSHGEA TSVSTVLPPS KLGYQMQTSD
60 70 80 90 100
KPLSCQMLLP KSLPGFTYMP PVSKFLVGLA LRNALEAAGC QAEVWALQLQ
110 120 130 140 150
LYRLGGVEAT QALIHHLQEL QKSGHTDREV SVDALSSALQ LLAWEQPGPK
160 170 180 190 200
RAKRSISNTD CDNDQEQSVH NVVDLLPAVG TYYNLGTALY YAIKNCSDKA
210 220 230 240 250
KERGRDGAID LGYDLLMAMV GASGGPAGAV ITAALKPAMK AGVQRLIQYY
260 270 280 290 300
YDEKEVTTPQ PEVTTHQPET GKDATTDIGV VEEIAMSNFV SEVESTTSNW
310
EWPLLKNYGV LAYKR
Length:315
Mass (Da):34,359
Last modified:July 18, 2005 - v2
Checksum:iFB669F792B3E90E7
GO

Sequence cautioni

The sequence AAH10815.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH22795.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH24769.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH25827.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAL06339.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAL06340.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAL06341.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411830 Genomic DNA. Translation: AAL06339.1. Different initiation.
AF411831 Genomic DNA. Translation: AAL06340.1. Different initiation.
AF411832 Genomic DNA. Translation: AAL06341.1. Different initiation.
BC010815 mRNA. Translation: AAH10815.1. Different initiation.
BC022795 mRNA. Translation: AAH22795.1. Different initiation.
BC024769 mRNA. Translation: AAH24769.1. Different initiation.
BC025827 mRNA. Translation: AAH25827.1. Different initiation.
RefSeqiNP_598758.1. NM_133997.2.
UniGeneiMm.26513.

Genome annotation databases

GeneIDi103161.
KEGGimmu:103161.
UCSCiuc007hlz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411830 Genomic DNA. Translation: AAL06339.1. Different initiation.
AF411831 Genomic DNA. Translation: AAL06340.1. Different initiation.
AF411832 Genomic DNA. Translation: AAL06341.1. Different initiation.
BC010815 mRNA. Translation: AAH10815.1. Different initiation.
BC022795 mRNA. Translation: AAH22795.1. Different initiation.
BC024769 mRNA. Translation: AAH24769.1. Different initiation.
BC025827 mRNA. Translation: AAH25827.1. Different initiation.
RefSeqiNP_598758.1. NM_133997.2.
UniGeneiMm.26513.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050300.

Proteomic databases

MaxQBiQ91V80.
PaxDbiQ91V80.
PRIDEiQ91V80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103161.
KEGGimmu:103161.
UCSCiuc007hlz.1. mouse.

Organism-specific databases

CTDi319.
MGIiMGI:104539. Apof.

Phylogenomic databases

eggNOGiNOG68175.
HOGENOMiHOG000034007.
HOVERGENiHBG050551.
InParanoidiQ91V80.
OrthoDBiEOG7T1RC5.
PhylomeDBiQ91V80.
TreeFamiTF338778.

Miscellaneous databases

ChiTaRSiApof. mouse.
NextBioi355823.
PROiQ91V80.
SOURCEiSearch...

Gene expression databases

BgeeiQ91V80.
CleanExiMM_APOF.
GenevestigatoriQ91V80.

Family and domain databases

InterProiIPR026114. APOF.
[Graphical view]
PANTHERiPTHR15011. PTHR15011. 1 hit.
PfamiPF15148. Apolipo_F. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic control of a mouse serum lipoprotein factor that inactivates murine leukemia viruses: evaluation of apolipoprotein F as a candidate."
    Wu T., Lee C.G., Buckler-White A., Kozak C.A.
    J. Virol. 76:2279-2286(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: C58/J, CAST/Ei and NFS.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiAPOF_MOUSE
AccessioniPrimary (citable) accession number: Q91V80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 18, 2005
Last sequence update: July 18, 2005
Last modified: March 3, 2015
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.