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Protein

Apolipoprotein F

Gene

Apof

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.By similarity

GO - Biological processi

  • cholesterol efflux Source: MGI
  • cholesterol metabolic process Source: MGI
  • triglyceride metabolic process Source: MGI

Keywordsi

Biological processCholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein F
Short name:
Apo-F
Alternative name(s):
Leukemia virus-inactivating factor
Short name:
LVIF
Gene namesi
Name:Apof
Synonyms:Lvif
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104539 Apof

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, LDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000000205325 – 154Sequence analysisAdd BLAST130
ChainiPRO_0000002054155 – 315Apolipoprotein FAdd BLAST161

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

MaxQBiQ91V80
PaxDbiQ91V80
PeptideAtlasiQ91V80
PRIDEiQ91V80

PTM databases

iPTMnetiQ91V80
PhosphoSitePlusiQ91V80

Expressioni

Tissue specificityi

Liver.1 Publication

Gene expression databases

CleanExiMM_APOF

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050300

Structurei

3D structure databases

SMRiQ91V80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein F family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2UW Eukaryota
ENOG4112458 LUCA
HOGENOMiHOG000034007
HOVERGENiHBG050551
InParanoidiQ91V80
PhylomeDBiQ91V80
TreeFamiTF338778

Family and domain databases

InterProiView protein in InterPro
IPR026114 APOF
PANTHERiPTHR15011 PTHR15011, 1 hit
PfamiView protein in Pfam
PF15148 Apolipo_F, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91V80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSLRLILMS IQLLCYLLLC PVDATSHGEA TSVSTVLPPS KLGYQMQTSD
60 70 80 90 100
KPLSCQMLLP KSLPGFTYMP PVSKFLVGLA LRNALEAAGC QAEVWALQLQ
110 120 130 140 150
LYRLGGVEAT QALIHHLQEL QKSGHTDREV SVDALSSALQ LLAWEQPGPK
160 170 180 190 200
RAKRSISNTD CDNDQEQSVH NVVDLLPAVG TYYNLGTALY YAIKNCSDKA
210 220 230 240 250
KERGRDGAID LGYDLLMAMV GASGGPAGAV ITAALKPAMK AGVQRLIQYY
260 270 280 290 300
YDEKEVTTPQ PEVTTHQPET GKDATTDIGV VEEIAMSNFV SEVESTTSNW
310
EWPLLKNYGV LAYKR
Length:315
Mass (Da):34,359
Last modified:July 19, 2005 - v2
Checksum:iFB669F792B3E90E7
GO

Sequence cautioni

The sequence AAH10815 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH22795 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH24769 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH25827 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL06339 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL06340 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL06341 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411830 Genomic DNA Translation: AAL06339.1 Different initiation.
AF411831 Genomic DNA Translation: AAL06340.1 Different initiation.
AF411832 Genomic DNA Translation: AAL06341.1 Different initiation.
BC010815 mRNA Translation: AAH10815.1 Different initiation.
BC022795 mRNA Translation: AAH22795.1 Different initiation.
BC024769 mRNA Translation: AAH24769.1 Different initiation.
BC025827 mRNA Translation: AAH25827.1 Different initiation.
RefSeqiNP_598758.1, NM_133997.2
UniGeneiMm.26513

Genome annotation databases

GeneIDi103161
KEGGimmu:103161
UCSCiuc007hlz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAPOF_MOUSE
AccessioniPrimary (citable) accession number: Q91V80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: December 20, 2017
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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