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Protein

Protein S100

Gene

S100a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi63 – 74PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumPROSITE-ProRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-5686938. Regulation of TLR by endogenous ligand.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100UniRule annotation
Alternative name(s):
S100 calcium-binding proteinUniRule annotation
Gene namesi
Name:S100a1Imported
ORF Names:mCG_68132Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1338917. S100a1.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

TopDownProteomicsiQ91V77.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044080.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91V77. 1 interactor.
MINTiMINT-4120797.
STRINGi10090.ENSMUSP00000058237.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 85EF-handInterPro annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiENOG410IXZ2. Eukaryota.
ENOG4111987. LUCA.
GeneTreeiENSGT00760000119034.
HOVERGENiHBG001479.
OMAiTAAMGSE.
OrthoDBiEOG091G10JX.
TreeFamiTF332727.

Family and domain databases

CDDicd05025. S-100A1. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028486. S100-A1.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
PANTHERiPTHR11639:SF86. PTHR11639:SF86. 1 hit.
PfamiView protein in Pfam
PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91V77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSELESAME TLINVFHAHS GKEGDKYKLS KKELKDLLQT ELSGFLDVQK
60 70 80 90
DADAVDKVMK ELDENGDGEV DFKEYVVLVA ALTVACNNFF WETS
Length:94
Mass (Da):10,505
Last modified:December 1, 2001 - v1
Checksum:i7C8E817BBF36ED15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC160552 Genomic DNA. No translation available.
BC005590 mRNA. Translation: AAH05590.1.
AF368423 Genomic DNA. Translation: AAL14436.1.
AK002721 mRNA. Translation: BAB22308.1.
AK012578 mRNA. Translation: BAB28330.1.
AK168822 mRNA. Translation: BAE40649.1.
CH466547 Genomic DNA. Translation: EDL15127.1.
RefSeqiNP_035439.1. NM_011309.3.
UniGeneiMm.24662.

Genome annotation databases

EnsembliENSMUST00000060738; ENSMUSP00000058237; ENSMUSG00000044080.
GeneIDi20193.
KEGGimmu:20193.
UCSCiuc008qct.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC160552 Genomic DNA. No translation available.
BC005590 mRNA. Translation: AAH05590.1.
AF368423 Genomic DNA. Translation: AAL14436.1.
AK002721 mRNA. Translation: BAB22308.1.
AK012578 mRNA. Translation: BAB28330.1.
AK168822 mRNA. Translation: BAE40649.1.
CH466547 Genomic DNA. Translation: EDL15127.1.
RefSeqiNP_035439.1. NM_011309.3.
UniGeneiMm.24662.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91V77. 1 interactor.
MINTiMINT-4120797.
STRINGi10090.ENSMUSP00000058237.

Proteomic databases

TopDownProteomicsiQ91V77.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060738; ENSMUSP00000058237; ENSMUSG00000044080.
GeneIDi20193.
KEGGimmu:20193.
UCSCiuc008qct.1. mouse.

Organism-specific databases

CTDi6271.
MGIiMGI:1338917. S100a1.

Phylogenomic databases

eggNOGiENOG410IXZ2. Eukaryota.
ENOG4111987. LUCA.
GeneTreeiENSGT00760000119034.
HOVERGENiHBG001479.
OMAiTAAMGSE.
OrthoDBiEOG091G10JX.
TreeFamiTF332727.

Enzyme and pathway databases

ReactomeiR-MMU-5686938. Regulation of TLR by endogenous ligand.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044080.

Family and domain databases

CDDicd05025. S-100A1. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028486. S100-A1.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
PANTHERiPTHR11639:SF86. PTHR11639:SF86. 1 hit.
PfamiView protein in Pfam
PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ91V77_MOUSE
AccessioniPrimary (citable) accession number: Q91V77
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.