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Protein

Sideroflexin-3

Gene

Sfxn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potential iron transporter.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Protein family/group databases

TCDBi2.A.54.1.6. the mitochondrial tricarboxylate carrier (mtc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sideroflexin-3
Gene namesi
Name:Sfxn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2137679. Sfxn3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei146 – 16419HelicalSequence analysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence analysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence analysisAdd
BLAST
Transmembranei266 – 28621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Sideroflexin-3PRO_0000177038Add
BLAST

Proteomic databases

EPDiQ91V61.
MaxQBiQ91V61.
PaxDbiQ91V61.
PRIDEiQ91V61.

PTM databases

iPTMnetiQ91V61.
PhosphoSiteiQ91V61.
SwissPalmiQ91V61.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ91V61.
CleanExiMM_SFXN3.
ExpressionAtlasiQ91V61. baseline and differential.
GenevisibleiQ91V61. MM.

Interactioni

Protein-protein interaction databases

BioGridi220499. 1 interaction.
IntActiQ91V61. 5 interactions.
STRINGi10090.ENSMUSP00000059419.

Structurei

3D structure databases

ProteinModelPortaliQ91V61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sideroflexin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3767. Eukaryota.
ENOG410YU8V. LUCA.
GeneTreeiENSGT00390000002026.
HOGENOMiHOG000203440.
HOVERGENiHBG056083.
InParanoidiQ91V61.
OMAiHEQNPSI.
OrthoDBiEOG70KGPJ.
PhylomeDBiQ91V61.
TreeFamiTF313205.

Family and domain databases

InterProiIPR004686. Mtc.
[Graphical view]
PANTHERiPTHR11153. PTHR11153. 1 hit.
PfamiPF03820. Mtc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00798. mtc. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91V61-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDLPLNINI QEPRWDQSTF LGRARHFFTV TDPRNLLLSG EQLEASRNIV
60 70 80 90 100
QNYRAGVATP GLTEDQLWRA KYVYDSAFHP DTGEKVVLIG RMSAQVPMNM
110 120 130 140 150
TITGCMLTFY RKTPTVVFWQ WVNQSFNAIV NYSNRSGDAP ITVQQLGTAY
160 170 180 190 200
VSATTGAVAT ALGLKSLTKH LPPLVGRFVP FAAVAAANCI NIPLMRQREL
210 220 230 240 250
QVGIPVTDEA GQRLGHSVTA AKQGIFQVVI SRIGMAIPAM AIPPVIMNTL
260 270 280 290 300
EKKDFLKRRP WLGAPLQVGL VGFCLVFATP LCCALFPQRS SIHVTRLEPE
310 320
LRAQIQAQNP SIDVVYYNKG L
Length:321
Mass (Da):35,406
Last modified:December 1, 2001 - v1
Checksum:i9B9816A54B23F4EC
GO
Isoform 2 (identifier: Q91V61-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-144: Missing.

Note: No experimental confirmation available.
Show »
Length:288
Mass (Da):31,656
Checksum:iFFE4200739D6F92A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti243 – 2431P → A in BAC41029 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei112 – 14433Missing in isoform 2. 1 PublicationVSP_007388Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325262 mRNA. Translation: AAK39430.1.
AK034514 mRNA. Translation: BAC28739.1.
AK089985 mRNA. Translation: BAC41029.1.
BC012208 mRNA. Translation: AAH12208.1.
CCDSiCCDS29856.1. [Q91V61-1]
CCDS50448.1. [Q91V61-2]
RefSeqiNP_001171483.1. NM_001178012.1. [Q91V61-2]
NP_444427.1. NM_053197.4. [Q91V61-1]
XP_006527556.1. XM_006527493.1. [Q91V61-1]
XP_006527557.1. XM_006527494.1. [Q91V61-1]
XP_011245710.1. XM_011247408.1. [Q91V61-1]
UniGeneiMm.36169.

Genome annotation databases

EnsembliENSMUST00000062213; ENSMUSP00000059419; ENSMUSG00000025212. [Q91V61-1]
ENSMUST00000111954; ENSMUSP00000107585; ENSMUSG00000025212. [Q91V61-2]
GeneIDi94280.
KEGGimmu:94280.
UCSCiuc012bml.1. mouse. [Q91V61-1]
uc012bmm.1. mouse. [Q91V61-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325262 mRNA. Translation: AAK39430.1.
AK034514 mRNA. Translation: BAC28739.1.
AK089985 mRNA. Translation: BAC41029.1.
BC012208 mRNA. Translation: AAH12208.1.
CCDSiCCDS29856.1. [Q91V61-1]
CCDS50448.1. [Q91V61-2]
RefSeqiNP_001171483.1. NM_001178012.1. [Q91V61-2]
NP_444427.1. NM_053197.4. [Q91V61-1]
XP_006527556.1. XM_006527493.1. [Q91V61-1]
XP_006527557.1. XM_006527494.1. [Q91V61-1]
XP_011245710.1. XM_011247408.1. [Q91V61-1]
UniGeneiMm.36169.

3D structure databases

ProteinModelPortaliQ91V61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220499. 1 interaction.
IntActiQ91V61. 5 interactions.
STRINGi10090.ENSMUSP00000059419.

Protein family/group databases

TCDBi2.A.54.1.6. the mitochondrial tricarboxylate carrier (mtc) family.

PTM databases

iPTMnetiQ91V61.
PhosphoSiteiQ91V61.
SwissPalmiQ91V61.

Proteomic databases

EPDiQ91V61.
MaxQBiQ91V61.
PaxDbiQ91V61.
PRIDEiQ91V61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062213; ENSMUSP00000059419; ENSMUSG00000025212. [Q91V61-1]
ENSMUST00000111954; ENSMUSP00000107585; ENSMUSG00000025212. [Q91V61-2]
GeneIDi94280.
KEGGimmu:94280.
UCSCiuc012bml.1. mouse. [Q91V61-1]
uc012bmm.1. mouse. [Q91V61-2]

Organism-specific databases

CTDi81855.
MGIiMGI:2137679. Sfxn3.

Phylogenomic databases

eggNOGiKOG3767. Eukaryota.
ENOG410YU8V. LUCA.
GeneTreeiENSGT00390000002026.
HOGENOMiHOG000203440.
HOVERGENiHBG056083.
InParanoidiQ91V61.
OMAiHEQNPSI.
OrthoDBiEOG70KGPJ.
PhylomeDBiQ91V61.
TreeFamiTF313205.

Miscellaneous databases

ChiTaRSiSfxn3. mouse.
NextBioi352287.
PROiQ91V61.
SOURCEiSearch...

Gene expression databases

BgeeiQ91V61.
CleanExiMM_SFXN3.
ExpressionAtlasiQ91V61. baseline and differential.
GenevisibleiQ91V61. MM.

Family and domain databases

InterProiIPR004686. Mtc.
[Graphical view]
PANTHERiPTHR11153. PTHR11153. 1 hit.
PfamiPF03820. Mtc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00798. mtc. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice."
    Fleming M.D., Campagna D.R., Haslett J.N., Trenor C.C. III, Andrews N.C.
    Genes Dev. 15:652-657(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Diencephalon.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary gland.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 15-23; 55-69; 72-85; 178-196; 199-213; 223-252 AND 303-319, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiSFXN3_MOUSE
AccessioniPrimary (citable) accession number: Q91V61
Secondary accession number(s): Q544M7, Q8C1Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.