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Q91V61 (SFXN3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sideroflexin-3
Gene names
Name:Sfxn3
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potential iron transporter.

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Widely expressed. Ref.1

Sequence similarities

Belongs to the sideroflexin family.

Ontologies

Keywords
   Biological processIon transport
Iron transport
Transport
   Cellular componentMembrane
Mitochondrion
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   LigandIron
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological processiron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncation transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q91V61-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q91V61-2)

The sequence of this isoform differs from the canonical sequence as follows:
     112-144: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Sideroflexin-3
PRO_0000177038

Regions

Transmembrane146 – 16419Helical; Potential
Transmembrane174 – 19421Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane266 – 28621Helical; Potential

Natural variations

Alternative sequence112 – 14433Missing in isoform 2.
VSP_007388

Experimental info

Sequence conflict2431P → A in BAC41029. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 9B9816A54B23F4EC

FASTA32135,406
        10         20         30         40         50         60 
MGDLPLNINI QEPRWDQSTF LGRARHFFTV TDPRNLLLSG EQLEASRNIV QNYRAGVATP 

        70         80         90        100        110        120 
GLTEDQLWRA KYVYDSAFHP DTGEKVVLIG RMSAQVPMNM TITGCMLTFY RKTPTVVFWQ 

       130        140        150        160        170        180 
WVNQSFNAIV NYSNRSGDAP ITVQQLGTAY VSATTGAVAT ALGLKSLTKH LPPLVGRFVP 

       190        200        210        220        230        240 
FAAVAAANCI NIPLMRQREL QVGIPVTDEA GQRLGHSVTA AKQGIFQVVI SRIGMAIPAM 

       250        260        270        280        290        300 
AIPPVIMNTL EKKDFLKRRP WLGAPLQVGL VGFCLVFATP LCCALFPQRS SIHVTRLEPE 

       310        320 
LRAQIQAQNP SIDVVYYNKG L

« Hide

Isoform 2 [UniParc].

Checksum: FFE4200739D6F92A
Show »

FASTA28831,656

References

« Hide 'large scale' references
[1]"A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice."
Fleming M.D., Campagna D.R., Haslett J.N., Trenor C.C. III, Andrews N.C.
Genes Dev. 15:652-657(2001) [PubMed: 11274051] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Diencephalon.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Mammary gland.
[4]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 15-23; 55-69; 72-85; 178-196; 199-213; 223-252 AND 303-319, MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF325262 mRNA. Translation: AAK39430.1.
AK034514 mRNA. Translation: BAC28739.1.
AK089985 mRNA. Translation: BAC41029.1.
BC012208 mRNA. Translation: AAH12208.1.
IPIIPI00126115.
IPI00278561.
RefSeqNP_001171483.1. NM_001178012.1.
NP_444427.1. NM_053197.4.
UniGeneMm.36169.

3D structure databases

ProteinModelPortalQ91V61.
ModBaseSearch...

Protein-protein interaction databases

IntActQ91V61. 4 interactions.
STRINGQ91V61.

Proteomic databases

PRIDEQ91V61.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000062213; ENSMUSP00000059419; ENSMUSG00000025212.
ENSMUST00000111954; ENSMUSP00000107585; ENSMUSG00000025212.
GeneID94280.
KEGGmmu:94280.
UCSCuc012bml.1. mouse.
uc012bmm.1. mouse.

Organism-specific databases

CTD81855.
MGIMGI:2137679. Sfxn3.

Phylogenomic databases

GeneTreeENSGT00390000002026.
HOGENOMHBG526141.
HOVERGENHBG056083.
InParanoidQ91V61.
OMASIHVSRL.
PhylomeDBQ91V61.

Gene expression databases

ArrayExpressQ91V61.
BgeeQ91V61.
CleanExMM_SFXN3.
GenevestigatorQ91V61.
GermOnlineENSMUSG00000025212. Mus musculus.

Family and domain databases

InterProIPR004686. Mtc.
[Graphical view]
PANTHERPTHR11153. Mtc. 1 hit.
PfamPF03820. Mtc. 1 hit.
[Graphical view]
TIGRFAMsTIGR00798. Mtc. 1 hit.
ProtoNetSearch...

Other

NextBio352287.
SOURCESearch...

Entry information

Entry nameSFXN3_MOUSE
AccessionPrimary (citable) accession number: Q91V61
Secondary accession number(s): Q544M7, Q8C1Z2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: September 21, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents