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Protein

Sideroflexin-3

Gene

Sfxn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential iron transporter.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Protein family/group databases

TCDBi2.A.54.1.6 the mitochondrial tricarboxylate carrier (mtc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sideroflexin-3
Gene namesi
Name:Sfxn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:2137679 Sfxn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei146 – 164HelicalSequence analysisAdd BLAST19
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001770381 – 321Sideroflexin-3Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91V61
PaxDbiQ91V61
PeptideAtlasiQ91V61
PRIDEiQ91V61

PTM databases

iPTMnetiQ91V61
PhosphoSitePlusiQ91V61
SwissPalmiQ91V61

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000025212
CleanExiMM_SFXN3
ExpressionAtlasiQ91V61 baseline and differential
GenevisibleiQ91V61 MM

Interactioni

Protein-protein interaction databases

BioGridi220499, 3 interactors
IntActiQ91V61, 6 interactors
STRINGi10090.ENSMUSP00000059419

Structurei

3D structure databases

ProteinModelPortaliQ91V61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sideroflexin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3767 Eukaryota
ENOG410YU8V LUCA
GeneTreeiENSGT00390000002026
HOGENOMiHOG000203440
HOVERGENiHBG056083
InParanoidiQ91V61
OMAiRAQIHEQ
OrthoDBiEOG091G0BOU
PhylomeDBiQ91V61
TreeFamiTF313205

Family and domain databases

InterProiView protein in InterPro
IPR004686 Mtc
PANTHERiPTHR11153 PTHR11153, 1 hit
PfamiView protein in Pfam
PF03820 Mtc, 1 hit
TIGRFAMsiTIGR00798 mtc, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91V61-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDLPLNINI QEPRWDQSTF LGRARHFFTV TDPRNLLLSG EQLEASRNIV
60 70 80 90 100
QNYRAGVATP GLTEDQLWRA KYVYDSAFHP DTGEKVVLIG RMSAQVPMNM
110 120 130 140 150
TITGCMLTFY RKTPTVVFWQ WVNQSFNAIV NYSNRSGDAP ITVQQLGTAY
160 170 180 190 200
VSATTGAVAT ALGLKSLTKH LPPLVGRFVP FAAVAAANCI NIPLMRQREL
210 220 230 240 250
QVGIPVTDEA GQRLGHSVTA AKQGIFQVVI SRIGMAIPAM AIPPVIMNTL
260 270 280 290 300
EKKDFLKRRP WLGAPLQVGL VGFCLVFATP LCCALFPQRS SIHVTRLEPE
310 320
LRAQIQAQNP SIDVVYYNKG L
Length:321
Mass (Da):35,406
Last modified:December 1, 2001 - v1
Checksum:i9B9816A54B23F4EC
GO
Isoform 2 (identifier: Q91V61-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-144: Missing.

Note: No experimental confirmation available.
Show »
Length:288
Mass (Da):31,656
Checksum:iFFE4200739D6F92A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti243P → A in BAC41029 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007388112 – 144Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325262 mRNA Translation: AAK39430.1
AK034514 mRNA Translation: BAC28739.1
AK089985 mRNA Translation: BAC41029.1
BC012208 mRNA Translation: AAH12208.1
CCDSiCCDS29856.1 [Q91V61-1]
CCDS50448.1 [Q91V61-2]
RefSeqiNP_001171483.1, NM_001178012.1 [Q91V61-2]
NP_444427.1, NM_053197.4 [Q91V61-1]
XP_006527556.1, XM_006527493.2 [Q91V61-1]
UniGeneiMm.36169

Genome annotation databases

EnsembliENSMUST00000062213; ENSMUSP00000059419; ENSMUSG00000025212 [Q91V61-1]
ENSMUST00000111954; ENSMUSP00000107585; ENSMUSG00000025212 [Q91V61-2]
GeneIDi94280
KEGGimmu:94280
UCSCiuc012bml.1 mouse [Q91V61-1]
uc012bmm.1 mouse [Q91V61-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSFXN3_MOUSE
AccessioniPrimary (citable) accession number: Q91V61
Secondary accession number(s): Q544M7, Q8C1Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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