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Q91V48

- Q91V48_MOUSE

UniProt

Q91V48 - Q91V48_MOUSE

Protein
Submitted name:

MCG1033322

Gene

Pcdhb21

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.SAAS annotation

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. homophilic cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesionSAAS annotation

    Keywords - Ligandi

    CalciumUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    MCG1033322Imported
    Submitted name:
    Protein Pcdhb21Imported
    Submitted name:
    Protocadherin beta 21Imported
    Submitted name:
    Protocadherin-betaUImported
    Gene namesi
    Name:Pcdhb21Imported
    Synonyms:Pcdhb18Imported
    ORF Names:mCG_1033322Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:2136759. Pcdhb21.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membraneSAAS annotation, Membrane

    Expressioni

    Gene expression databases

    GenevestigatoriQ91V48.

    Family & Domainsi

    Sequence similaritiesi

    Contains cadherin domains.SAAS annotation

    Keywords - Domaini

    RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00600000084235.
    HOVERGENiHBG054878.
    InParanoidiQ91V48.
    KOiK16494.
    OMAiFEIHPIS.
    OrthoDBiEOG7KSX80.
    TreeFamiTF332299.

    Family and domain databases

    Gene3Di2.60.40.60. 5 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 5 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 6 hits.
    PROSITEiPS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91V48-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPGVGAAQH IRQVLLFFVF LEGSSVLATT WRYSVPEEME TGSSIANIIK    50
    DMDVGDLAAR GARVIFDDYQ PYLRLELETG NLLLNEKLDR EALCSSSEPC 100
    ILHFQVLLEN PLQFFQAELL IEDINDHTPT FLEKLIFLNI SESATPGTSF 150
    QMDDAQDLDI GMNGIQNYSI SPNPYFYLKL KDSGKGRRYP ELVLVRSLDR 200
    EKEASISLIL TAMDGGSLPR SGTVLVQVVV LDVNDNAPEF ERTLYEVQVP 250
    ENSSVDSLVI KVSATDLDSG INGEISYSFS HISRDVQKTF EIHPTSGEVR 300
    LKRLLDFEVI QSYTINIQAI DGGGLSGKSA IIVQVTDVND NPPEIVITSL 350
    MSSIPENGLS EMVVAVFSLR DQDSGENGRM MCSIEDKLPF LLKPTFKNFY 400
    TLVTEHPLDR ESRAEYNITV MISDLGTPRL TTQHTITVHI SDINDNAPAF 450
    TQTTYTMFVR ENNSPALHIG TISATDSDLG SNAHITYSLL PPQDQRLALT 500
    SLISINADNG QLFALRALDY ETLQAFEFRV GATDRGSPAL SSQALVRVVV 550
    LDDNDNAPFV LYPMQNASAP CTELLPRAAE PGYLVTKVVA VDRDSGQNAW 600
    LSFQLLKATE PGLFSVWAHN GEVRTTRLLS ERDVPKHRLL LLVKDNGDPP 650
    RSASVTLHLL VVDGFSQPYL PLPEVAHDST QVDEEALTLY LVIALASVSS 700
    LFLLSVLLFV GVRLCRRARA ASLSGYSEPD GHFSGHLVDV SGAGTLSQSY 750
    QYEVCLTGMS DSNDIRFLKP VSQP 774
    Length:774
    Mass (Da):85,231
    Last modified:December 1, 2001 - v1
    Checksum:iB1BCD215E09595DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC020967 Genomic DNA. No translation available.
    BC138121 mRNA. Translation: AAI38122.1.
    BC138122 mRNA. Translation: AAI38123.1.
    AY013783 mRNA. Translation: AAK26072.1.
    AF326314 mRNA. Translation: AAK53239.1.
    CH466528 Genomic DNA. Translation: EDL10150.1.
    RefSeqiNP_444376.1. NM_053146.2.
    UniGeneiMm.348053.

    Genome annotation databases

    EnsembliENSMUST00000061405; ENSMUSP00000056424; ENSMUSG00000044022.
    GeneIDi93892.
    KEGGimmu:93892.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC020967 Genomic DNA. No translation available.
    BC138121 mRNA. Translation: AAI38122.1 .
    BC138122 mRNA. Translation: AAI38123.1 .
    AY013783 mRNA. Translation: AAK26072.1 .
    AF326314 mRNA. Translation: AAK53239.1 .
    CH466528 Genomic DNA. Translation: EDL10150.1 .
    RefSeqi NP_444376.1. NM_053146.2.
    UniGenei Mm.348053.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000061405 ; ENSMUSP00000056424 ; ENSMUSG00000044022 .
    GeneIDi 93892.
    KEGGi mmu:93892.

    Organism-specific databases

    CTDi 93892.
    MGIi MGI:2136759. Pcdhb21.

    Phylogenomic databases

    GeneTreei ENSGT00600000084235.
    HOVERGENi HBG054878.
    InParanoidi Q91V48.
    KOi K16494.
    OMAi FEIHPIS.
    OrthoDBi EOG7KSX80.
    TreeFami TF332299.

    Miscellaneous databases

    NextBioi 351837.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q91V48.

    Family and domain databases

    Gene3Di 2.60.40.60. 5 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 6 hits.
    PROSITEi PS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
      Wu Q., Maniatis T.
      Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.
    2. "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes."
      Wu Q., Maniatis T.
      Proc. Natl. Acad. Sci. U.S.A. 97:3124-3129(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.
    3. "The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number."
      Vanhalst K., Kools P., Vanden Eynde E., van Roy F.
      FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/CImported.
    4. "Comparative DNA sequence analysis of mouse and human protocadherin gene clusters."
      Wu Q., Zhang T., Cheng J.-F., Kim Y., Grimwood J., Schmutz J., Dickson M., Noonan J.P., Zhang M.Q., Myers R.M., Maniatis T.
      Genome Res. 11:389-404(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.
    5. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    7. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    9. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ91V48_MOUSE
    AccessioniPrimary (citable) accession number: Q91V48
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3