Q91V48 (Q91V48_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
MCG1033322 EMBL EDL10150.1

Submitted name:
Protein Pcdhb21 Ensembl ENSMUSP00000056424
Submitted name:
Protocadherin beta 21 EMBL AAI38122.1
Submitted name:
Protocadherin-betaU EMBL AAK53239.1

Gene names

Name:	Pcdhb21 MGI 2136759 EMBL AAI38122.1 Ensembl ENSMUSP00000056424
Synonyms:	Pcdhb18 EMBL AAK53239.1
ORF Names:	mCG_1033322 EMBL EDL10150.1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	774 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain By similarity. SAAS SAAS020894
Sequence similarities	Contains 6 cadherin domains. SAAS SAAS020894

Ontologies

Keywords
Biological process	Cell adhesion SAAS SAAS020894
Cellular component	Cell membrane SAAS SAAS013164 Membrane
Domain	Repeat SAAS SAAS020894 Transmembrane Transmembrane helix SAAS SAAS020894
Ligand	Calcium SAAS SAAS020894 RuleBase RU000484
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q91V48 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: B1BCD215E09595DE	FASTA	774	85,231
	10 20 30 40 50 60 MEPGVGAAQH IRQVLLFFVF LEGSSVLATT WRYSVPEEME TGSSIANIIK DMDVGDLAAR 70 80 90 100 110 120 GARVIFDDYQ PYLRLELETG NLLLNEKLDR EALCSSSEPC ILHFQVLLEN PLQFFQAELL 130 140 150 160 170 180 IEDINDHTPT FLEKLIFLNI SESATPGTSF QMDDAQDLDI GMNGIQNYSI SPNPYFYLKL 190 200 210 220 230 240 KDSGKGRRYP ELVLVRSLDR EKEASISLIL TAMDGGSLPR SGTVLVQVVV LDVNDNAPEF 250 260 270 280 290 300 ERTLYEVQVP ENSSVDSLVI KVSATDLDSG INGEISYSFS HISRDVQKTF EIHPTSGEVR 310 320 330 340 350 360 LKRLLDFEVI QSYTINIQAI DGGGLSGKSA IIVQVTDVND NPPEIVITSL MSSIPENGLS 370 380 390 400 410 420 EMVVAVFSLR DQDSGENGRM MCSIEDKLPF LLKPTFKNFY TLVTEHPLDR ESRAEYNITV 430 440 450 460 470 480 MISDLGTPRL TTQHTITVHI SDINDNAPAF TQTTYTMFVR ENNSPALHIG TISATDSDLG 490 500 510 520 530 540 SNAHITYSLL PPQDQRLALT SLISINADNG QLFALRALDY ETLQAFEFRV GATDRGSPAL 550 560 570 580 590 600 SSQALVRVVV LDDNDNAPFV LYPMQNASAP CTELLPRAAE PGYLVTKVVA VDRDSGQNAW 610 620 630 640 650 660 LSFQLLKATE PGLFSVWAHN GEVRTTRLLS ERDVPKHRLL LLVKDNGDPP RSASVTLHLL 670 680 690 700 710 720 VVDGFSQPYL PLPEVAHDST QVDEEALTLY LVIALASVSS LFLLSVLLFV GVRLCRRARA 730 740 750 760 770 ASLSGYSEPD GHFSGHLVDV SGAGTLSQSY QYEVCLTGMS DSNDIRFLKP VSQP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A striking organization of a large family of human neural cadherin-like cell adhesion genes." Wu Q., Maniatis T. Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL AAK26072.1.
[2]	"Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes." Wu Q., Maniatis T. Proc. Natl. Acad. Sci. U.S.A. 97:3124-3129(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL AAK26072.1.
[3]	"The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number." Vanhalst K., Kools P., Vanden Eynde E., van Roy F. FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BALB/C EMBL AAK53239.1.
[4]	"Comparative DNA sequence analysis of mouse and human protocadherin gene clusters." Wu Q., Zhang T., Cheng J.-F., Kim Y., Grimwood J., Schmutz J., Dickson M., Noonan J.P., Zhang M.Q., Myers R.M., Maniatis T. Genome Res. 11:389-404(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL AAK26072.1.
[5]	"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome." Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D. Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL10150.1.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAI38122.1.
[7]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL10150.1.
[8]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000056424.
[9]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000056424.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC020967 Genomic DNA. No translation available. BC138121 mRNA. Translation: AAI38122.1. BC138122 mRNA. Translation: AAI38123.1. AY013783 mRNA. Translation: AAK26072.1. AF326314 mRNA. Translation: AAK53239.1. CH466528 Genomic DNA. Translation: EDL10150.1.
IPI	IPI00126049.
RefSeq	NP_444376.1. NM_053146.2.
UniGene	Mm.348053.
3D structure databases
HSSP	HSSP built from PDB template 1NCJ based on UniProtKB P15116.
SMR	Q91V48. Positions 30-656.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000061405; ENSMUSP00000056424; ENSMUSG00000044022.
GeneID	93892.
KEGG	mmu:93892.
UCSC	uc008eqg.1. mouse.
Organism-specific databases
CTD	93892.
MGI	MGI:2136759. Pcdhb21.
Phylogenomic databases
GeneTree	ENSGT00600000084235.
HOVERGEN	HBG054878.
InParanoid	Q91V48.
KO	K16494.
OMA	GVQNYTL.
Gene expression databases
Genevestigator	Q91V48.
Family and domain databases
Gene3D	2.60.40.60. 5 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR013164. Cadherin_N. [Graphical view]
Pfam	PF00028. Cadherin. 5 hits. PF08266. Cadherin_2. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 6 hits.
PROSITE	PS00232. CADHERIN_1. 5 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	351837.
SOURCE	Search...

Entry information

Entry name

Q91V48_MOUSE

Accession

Primary (citable) accession number: Q91V48

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)