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Q91V48

- Q91V48_MOUSE

UniProt

Q91V48 - Q91V48_MOUSE

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Protein
Submitted name:

MCG1033322

Gene

Pcdhb21

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.SAAS annotation

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesionSAAS annotation

Keywords - Ligandi

CalciumUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
MCG1033322Imported
Submitted name:
Protein Pcdhb21Imported
Submitted name:
Protocadherin beta 21Imported
Submitted name:
Protocadherin-betaUImported
Gene namesi
Name:Pcdhb21Imported
Synonyms:Pcdhb18Imported
ORF Names:mCG_1033322Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:2136759. Pcdhb21.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Expressioni

Gene expression databases

GenevestigatoriQ91V48.

Family & Domainsi

Sequence similaritiesi

Contains cadherin domains.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118847.
HOVERGENiHBG054878.
KOiK16494.
OMAiFEIHPIS.
OrthoDBiEOG7KSX80.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91V48-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPGVGAAQH IRQVLLFFVF LEGSSVLATT WRYSVPEEME TGSSIANIIK
60 70 80 90 100
DMDVGDLAAR GARVIFDDYQ PYLRLELETG NLLLNEKLDR EALCSSSEPC
110 120 130 140 150
ILHFQVLLEN PLQFFQAELL IEDINDHTPT FLEKLIFLNI SESATPGTSF
160 170 180 190 200
QMDDAQDLDI GMNGIQNYSI SPNPYFYLKL KDSGKGRRYP ELVLVRSLDR
210 220 230 240 250
EKEASISLIL TAMDGGSLPR SGTVLVQVVV LDVNDNAPEF ERTLYEVQVP
260 270 280 290 300
ENSSVDSLVI KVSATDLDSG INGEISYSFS HISRDVQKTF EIHPTSGEVR
310 320 330 340 350
LKRLLDFEVI QSYTINIQAI DGGGLSGKSA IIVQVTDVND NPPEIVITSL
360 370 380 390 400
MSSIPENGLS EMVVAVFSLR DQDSGENGRM MCSIEDKLPF LLKPTFKNFY
410 420 430 440 450
TLVTEHPLDR ESRAEYNITV MISDLGTPRL TTQHTITVHI SDINDNAPAF
460 470 480 490 500
TQTTYTMFVR ENNSPALHIG TISATDSDLG SNAHITYSLL PPQDQRLALT
510 520 530 540 550
SLISINADNG QLFALRALDY ETLQAFEFRV GATDRGSPAL SSQALVRVVV
560 570 580 590 600
LDDNDNAPFV LYPMQNASAP CTELLPRAAE PGYLVTKVVA VDRDSGQNAW
610 620 630 640 650
LSFQLLKATE PGLFSVWAHN GEVRTTRLLS ERDVPKHRLL LLVKDNGDPP
660 670 680 690 700
RSASVTLHLL VVDGFSQPYL PLPEVAHDST QVDEEALTLY LVIALASVSS
710 720 730 740 750
LFLLSVLLFV GVRLCRRARA ASLSGYSEPD GHFSGHLVDV SGAGTLSQSY
760 770
QYEVCLTGMS DSNDIRFLKP VSQP
Length:774
Mass (Da):85,231
Last modified:December 1, 2001 - v1
Checksum:iB1BCD215E09595DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020967 Genomic DNA. No translation available.
BC138121 mRNA. Translation: AAI38122.1.
BC138122 mRNA. Translation: AAI38123.1.
AY013783 mRNA. Translation: AAK26072.1.
AF326314 mRNA. Translation: AAK53239.1.
CH466528 Genomic DNA. Translation: EDL10150.1.
RefSeqiNP_444376.1. NM_053146.2.
UniGeneiMm.348053.

Genome annotation databases

EnsembliENSMUST00000061405; ENSMUSP00000056424; ENSMUSG00000044022.
GeneIDi93892.
KEGGimmu:93892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020967 Genomic DNA. No translation available.
BC138121 mRNA. Translation: AAI38122.1 .
BC138122 mRNA. Translation: AAI38123.1 .
AY013783 mRNA. Translation: AAK26072.1 .
AF326314 mRNA. Translation: AAK53239.1 .
CH466528 Genomic DNA. Translation: EDL10150.1 .
RefSeqi NP_444376.1. NM_053146.2.
UniGenei Mm.348053.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000061405 ; ENSMUSP00000056424 ; ENSMUSG00000044022 .
GeneIDi 93892.
KEGGi mmu:93892.

Organism-specific databases

CTDi 93892.
MGIi MGI:2136759. Pcdhb21.

Phylogenomic databases

GeneTreei ENSGT00760000118847.
HOVERGENi HBG054878.
KOi K16494.
OMAi FEIHPIS.
OrthoDBi EOG7KSX80.
TreeFami TF332299.

Miscellaneous databases

NextBioi 351837.
SOURCEi Search...

Gene expression databases

Genevestigatori Q91V48.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 5 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  2. "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes."
    Wu Q., Maniatis T.
    Proc. Natl. Acad. Sci. U.S.A. 97:3124-3129(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  3. "The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number."
    Vanhalst K., Kools P., Vanden Eynde E., van Roy F.
    FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/CImported.
  4. "Comparative DNA sequence analysis of mouse and human protocadherin gene clusters."
    Wu Q., Zhang T., Cheng J.-F., Kim Y., Grimwood J., Schmutz J., Dickson M., Noonan J.P., Zhang M.Q., Myers R.M., Maniatis T.
    Genome Res. 11:389-404(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  5. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  7. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  9. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ91V48_MOUSE
AccessioniPrimary (citable) accession number: Q91V48
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3