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Protein

KiSS-1 receptor

Gene

Kiss1r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for metastin (kisspeptin-52 or kp-52), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
KiSS-1 receptor
Short name:
KiSS-1R
Alternative name(s):
G-protein coupled receptor 54
G-protein coupled receptor OT7T175
Short name:
mOT7T175
Kisspeptins receptor
Metastin receptor
Gene namesi
Name:Kiss1r
Synonyms:Gpr54
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2148793. Kiss1r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence analysisAdd
BLAST
Transmembranei44 – 6623Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini67 – 7812CytoplasmicSequence analysisAdd
BLAST
Transmembranei79 – 10123Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini102 – 11615ExtracellularSequence analysisAdd
BLAST
Transmembranei117 – 13822Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini139 – 15719CytoplasmicSequence analysisAdd
BLAST
Transmembranei158 – 18023Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini181 – 20323ExtracellularSequence analysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini225 – 26036CytoplasmicSequence analysisAdd
BLAST
Transmembranei261 – 28323Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini284 – 30522ExtracellularSequence analysisAdd
BLAST
Transmembranei306 – 33025Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini331 – 39666CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi266.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396KiSS-1 receptorPRO_0000069696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence analysis
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence analysis
Disulfide bondi115 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91V45.
PRIDEiQ91V45.

PTM databases

PhosphoSiteiQ91V45.

Expressioni

Tissue specificityi

Highest level in the heart and 15- and 17-day embryos. Low level in other tissues. Colocalized with gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus.3 Publications

Gene expression databases

BgeeiENSMUSG00000035773.
CleanExiMM_KISS1R.
ExpressionAtlasiQ91V45. baseline and differential.
GenevisibleiQ91V45. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040516.

Structurei

3D structure databases

ProteinModelPortaliQ91V45.
SMRiQ91V45. Positions 16-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230487.
HOVERGENiHBG106952.
InParanoidiQ91V45.
KOiK08374.
OMAiFVICRHK.
OrthoDBiEOG091G0HEN.
PhylomeDBiQ91V45.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008103. KiSS_1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01728. KISS1RECEPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91V45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATEATLAPN VTWWAPSNAS GCPGCGVNAS DDPGSAPRPL DAWLVPLFFA
60 70 80 90 100
TLMLLGLVGN SLVIYVICRH KHMQTVTNFY IANLAATDVT FLLCCVPFTA
110 120 130 140 150
LLYPLPAWVL GDFMCKFVNY IQQVSVQATC ATLTAMSVDR WYVTVFPLRA
160 170 180 190 200
LHRRTPRLAL AVSLSIWVGS AAVSAPVLAL HRLSPGPRTY CSEAFPSRAL
210 220 230 240 250
ERAFALYNLL ALYLLPLLAT CACYGAMLRH LGRAAVRPAP TDGALQGQLL
260 270 280 290 300
AQRAGAVRTK VSRLVAAVVL LFAACWGPIQ LFLVLQALGP SGAWHPRSYA
310 320 330 340 350
AYAVKIWAHC MSYSNSALNP LLYAFLGSHF RQAFCRVCPC CRQRQRRPHT
360 370 380 390
SAHSDRAATH TVPHSRAAHP VRIRSPEPGN PVVRSPCAQS ERTASL
Length:396
Mass (Da):43,061
Last modified:December 1, 2001 - v1
Checksum:iB5354E739A1F185B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821Missing in AAK95814 (PubMed:12359743).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343726 mRNA. Translation: AAK83236.1.
AY044228 mRNA. Translation: AAK95814.1.
AK039628 mRNA. Translation: BAC30404.1.
BC016531 mRNA. Translation: AAH16531.1.
CCDSiCCDS23998.1.
RefSeqiNP_444474.1. NM_053244.5.
XP_006513139.1. XM_006513076.2.
XP_006513140.1. XM_006513077.2.
UniGeneiMm.191035.

Genome annotation databases

EnsembliENSMUST00000045529; ENSMUSP00000040516; ENSMUSG00000035773.
GeneIDi114229.
KEGGimmu:114229.
UCSCiuc007gao.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343726 mRNA. Translation: AAK83236.1.
AY044228 mRNA. Translation: AAK95814.1.
AK039628 mRNA. Translation: BAC30404.1.
BC016531 mRNA. Translation: AAH16531.1.
CCDSiCCDS23998.1.
RefSeqiNP_444474.1. NM_053244.5.
XP_006513139.1. XM_006513076.2.
XP_006513140.1. XM_006513077.2.
UniGeneiMm.191035.

3D structure databases

ProteinModelPortaliQ91V45.
SMRiQ91V45. Positions 16-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040516.

Chemistry

GuidetoPHARMACOLOGYi266.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ91V45.

Proteomic databases

PaxDbiQ91V45.
PRIDEiQ91V45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045529; ENSMUSP00000040516; ENSMUSG00000035773.
GeneIDi114229.
KEGGimmu:114229.
UCSCiuc007gao.2. mouse.

Organism-specific databases

CTDi84634.
MGIiMGI:2148793. Kiss1r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230487.
HOVERGENiHBG106952.
InParanoidiQ91V45.
KOiK08374.
OMAiFVICRHK.
OrthoDBiEOG091G0HEN.
PhylomeDBiQ91V45.
TreeFamiTF315737.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ91V45.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035773.
CleanExiMM_KISS1R.
ExpressionAtlasiQ91V45. baseline and differential.
GenevisibleiQ91V45. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008103. KiSS_1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01728. KISS1RECEPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKISSR_MOUSE
AccessioniPrimary (citable) accession number: Q91V45
Secondary accession number(s): Q8K3P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.