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Protein

KiSS-1 receptor

Gene

Kiss1r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for metastin (kisspeptin-52 or kp-52), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
KiSS-1 receptor
Short name:
KiSS-1R
Alternative name(s):
G-protein coupled receptor 54
G-protein coupled receptor OT7T175
Short name:
mOT7T175
Kisspeptins receptor
Metastin receptor
Gene namesi
Name:Kiss1r
Synonyms:Gpr54
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2148793 Kiss1r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 66Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini67 – 78CytoplasmicSequence analysisAdd BLAST12
Transmembranei79 – 101Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini102 – 116ExtracellularSequence analysisAdd BLAST15
Transmembranei117 – 138Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini139 – 157CytoplasmicSequence analysisAdd BLAST19
Transmembranei158 – 180Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini181 – 203ExtracellularSequence analysisAdd BLAST23
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini225 – 260CytoplasmicSequence analysisAdd BLAST36
Transmembranei261 – 283Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini284 – 305ExtracellularSequence analysisAdd BLAST22
Transmembranei306 – 330Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini331 – 396CytoplasmicSequence analysisAdd BLAST66

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi266

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696961 – 396KiSS-1 receptorAdd BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi115 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91V45
PRIDEiQ91V45

PTM databases

PhosphoSitePlusiQ91V45

Expressioni

Tissue specificityi

Highest level in the heart and 15- and 17-day embryos. Low level in other tissues. Colocalized with gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus.3 Publications

Gene expression databases

BgeeiENSMUSG00000035773
CleanExiMM_KISS1R
ExpressionAtlasiQ91V45 baseline and differential
GenevisibleiQ91V45 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040516

Structurei

3D structure databases

ProteinModelPortaliQ91V45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00920000148959
HOGENOMiHOG000230487
HOVERGENiHBG106952
InParanoidiQ91V45
KOiK08374
OMAiIEEGYWY
OrthoDBiEOG091G0HEN
PhylomeDBiQ91V45
TreeFamiTF315737

Family and domain databases

CDDicd15095 7tmA_KiSS1R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008103 KiSS_1_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01728 KISS1RECEPTR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q91V45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATEATLAPN VTWWAPSNAS GCPGCGVNAS DDPGSAPRPL DAWLVPLFFA
60 70 80 90 100
TLMLLGLVGN SLVIYVICRH KHMQTVTNFY IANLAATDVT FLLCCVPFTA
110 120 130 140 150
LLYPLPAWVL GDFMCKFVNY IQQVSVQATC ATLTAMSVDR WYVTVFPLRA
160 170 180 190 200
LHRRTPRLAL AVSLSIWVGS AAVSAPVLAL HRLSPGPRTY CSEAFPSRAL
210 220 230 240 250
ERAFALYNLL ALYLLPLLAT CACYGAMLRH LGRAAVRPAP TDGALQGQLL
260 270 280 290 300
AQRAGAVRTK VSRLVAAVVL LFAACWGPIQ LFLVLQALGP SGAWHPRSYA
310 320 330 340 350
AYAVKIWAHC MSYSNSALNP LLYAFLGSHF RQAFCRVCPC CRQRQRRPHT
360 370 380 390
SAHSDRAATH TVPHSRAAHP VRIRSPEPGN PVVRSPCAQS ERTASL
Length:396
Mass (Da):43,061
Last modified:December 1, 2001 - v1
Checksum:iB5354E739A1F185B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82Missing in AAK95814 (PubMed:12359743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343726 mRNA Translation: AAK83236.1
AY044228 mRNA Translation: AAK95814.1
AK039628 mRNA Translation: BAC30404.1
BC016531 mRNA Translation: AAH16531.1
CCDSiCCDS23998.1
RefSeqiNP_444474.1, NM_053244.5
XP_006513139.1, XM_006513076.3
XP_006513140.1, XM_006513077.3
UniGeneiMm.191035

Genome annotation databases

EnsembliENSMUST00000045529; ENSMUSP00000040516; ENSMUSG00000035773
GeneIDi114229
KEGGimmu:114229
UCSCiuc007gao.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKISSR_MOUSE
AccessioniPrimary (citable) accession number: Q91V45
Secondary accession number(s): Q8K3P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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