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Protein

Ras-related protein Rab-14

Gene

Rab14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26GTPBy similarity9
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi124 – 127GTPBy similarity4
Nucleotide bindingi154 – 156GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • defense response to bacterium Source: InterPro
  • embryo development Source: UniProtKB
  • endocytic recycling Source: UniProtKB
  • fibroblast growth factor receptor signaling pathway Source: UniProtKB
  • Golgi to endosome transport Source: UniProtKB
  • phagolysosome assembly involved in apoptotic cell clearance Source: GO_Central
  • protein transport Source: UniProtKB-KW
  • regulation of protein localization Source: UniProtKB
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1445148. Translocation of GLUT4 to the plasma membrane.
R-MMU-1660499. Synthesis of PIPs at the plasma membrane.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-14
Gene namesi
Name:Rab14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915615. Rab14.

Subcellular locationi

  • Recycling endosome By similarity
  • Early endosome membrane By similarity; Lipid-anchor Curated; Cytoplasmic side Curated
  • Golgi apparatus membrane By similarity; Lipid-anchor Curated; Cytoplasmic side Curated
  • Golgi apparatustrans-Golgi network membrane By similarity; Lipid-anchor Curated; Cytoplasmic side Curated
  • Cytoplasmic vesiclephagosome By similarity

  • Note: Recruited to recycling endosomes by DENND6A. Recruited to phagosomes containing S.aureus or M.tuberculosis.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001211862 – 215Ras-related protein Rab-14Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Lipidationi213S-geranylgeranyl cysteineBy similarity1
Modified residuei215Cysteine methyl esterBy similarity1
Lipidationi215S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ91V41.
MaxQBiQ91V41.
PaxDbiQ91V41.
PRIDEiQ91V41.

2D gel databases

UCD-2DPAGEQ91V41.

PTM databases

iPTMnetiQ91V41.
PhosphoSitePlusiQ91V41.
SwissPalmiQ91V41.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026878.
CleanExiMM_RAB14.
ExpressionAtlasiQ91V41. baseline and differential.
GenevisibleiQ91V41. MM.

Interactioni

Subunit structurei

Interacts with ZFYVE20 (By similarity). Interacts with KIF16B.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212822. 4 interactors.
IntActiQ91V41. 8 interactors.
MINTiMINT-1862674.
STRINGi10090.ENSMUSP00000028238.

Structurei

3D structure databases

ProteinModelPortaliQ91V41.
SMRiQ91V41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 48Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0097. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ91V41.
KOiK07881.
OMAiQRDVTFE.
OrthoDBiEOG091G0QOB.
PhylomeDBiQ91V41.
TreeFamiTF300032.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR030702. Rab14.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PANTHERiPTHR24073:SF185. PTHR24073:SF185. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91V41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAPYNYSY IFKYIIIGDM GVGKSCLLHQ FTEKKFMADC PHTIGVEFGT
60 70 80 90 100
RIIEVSGQKI KLQIWDTAGQ ERFRAVTRSY YRGAAGALMV YDITRRSTYN
110 120 130 140 150
HLSSWLTDAR NLTNPNTVII LIGNKADLEA QRDVTYEEAK QFAEENGLLF
160 170 180 190 200
LEASAKTGEN VEDAFLEAAK KIYQNIQDGS LDLNAAESGV QHKPSAPQGG
210
RLTSEPQPQR EGCGC
Length:215
Mass (Da):23,897
Last modified:January 23, 2007 - v3
Checksum:iBC8A8B98FB9944AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002704 mRNA. Translation: BAB22298.1.
BC009085 mRNA. Translation: AAH09085.1.
BC025139 mRNA. Translation: AAH25139.1.
BC056648 mRNA. Translation: AAH56648.1.
CCDSiCCDS15959.1.
RefSeqiNP_080973.1. NM_026697.3.
UniGeneiMm.198264.

Genome annotation databases

EnsembliENSMUST00000028238; ENSMUSP00000028238; ENSMUSG00000026878.
GeneIDi68365.
KEGGimmu:68365.
UCSCiuc008jjz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002704 mRNA. Translation: BAB22298.1.
BC009085 mRNA. Translation: AAH09085.1.
BC025139 mRNA. Translation: AAH25139.1.
BC056648 mRNA. Translation: AAH56648.1.
CCDSiCCDS15959.1.
RefSeqiNP_080973.1. NM_026697.3.
UniGeneiMm.198264.

3D structure databases

ProteinModelPortaliQ91V41.
SMRiQ91V41.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212822. 4 interactors.
IntActiQ91V41. 8 interactors.
MINTiMINT-1862674.
STRINGi10090.ENSMUSP00000028238.

PTM databases

iPTMnetiQ91V41.
PhosphoSitePlusiQ91V41.
SwissPalmiQ91V41.

2D gel databases

UCD-2DPAGEQ91V41.

Proteomic databases

EPDiQ91V41.
MaxQBiQ91V41.
PaxDbiQ91V41.
PRIDEiQ91V41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028238; ENSMUSP00000028238; ENSMUSG00000026878.
GeneIDi68365.
KEGGimmu:68365.
UCSCiuc008jjz.1. mouse.

Organism-specific databases

CTDi51552.
MGIiMGI:1915615. Rab14.

Phylogenomic databases

eggNOGiKOG0097. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ91V41.
KOiK07881.
OMAiQRDVTFE.
OrthoDBiEOG091G0QOB.
PhylomeDBiQ91V41.
TreeFamiTF300032.

Enzyme and pathway databases

ReactomeiR-MMU-1445148. Translocation of GLUT4 to the plasma membrane.
R-MMU-1660499. Synthesis of PIPs at the plasma membrane.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

ChiTaRSiRab14. mouse.
PROiQ91V41.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026878.
CleanExiMM_RAB14.
ExpressionAtlasiQ91V41. baseline and differential.
GenevisibleiQ91V41. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR030702. Rab14.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PANTHERiPTHR24073:SF185. PTHR24073:SF185. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB14_MOUSE
AccessioniPrimary (citable) accession number: Q91V41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.