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Q91V37

- VATO_MOUSE

UniProt

Q91V37 - VATO_MOUSE

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Protein

V-type proton ATPase 21 kDa proteolipid subunit

Gene

Atp6v0b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei98 – 981Essential for proton translocationBy similarity

GO - Molecular functioni

  1. hydrogen-exporting ATPase activity, phosphorylative mechanism Source: MGI

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).
REACT_198515. Transferrin endocytosis and recycling.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase 21 kDa proteolipid subunit
Short name:
V-ATPase 21 kDa proteolipid subunit
Alternative name(s):
23 kDa subunit of V-ATPase
Vacuolar proton pump 21 kDa proteolipid subunit
Gene namesi
Name:Atp6v0b
Synonyms:Atp6f
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1890510. Atp6v0b.

Subcellular locationi

GO - Cellular componenti

  1. endosome Source: MGI
  2. integral component of membrane Source: MGI
  3. proton-transporting V-type ATPase, V0 domain Source: InterPro
  4. vacuolar proton-transporting V-type ATPase complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205V-type proton ATPase 21 kDa proteolipid subunitPRO_0000071778Add
BLAST

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ91V37.
CleanExiMM_ATP6V0B.
ExpressionAtlasiQ91V37. baseline and differential.
GenevestigatoriQ91V37.

Interactioni

Subunit structurei

Interacts with IFITM3.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ91V37.
SMRiQ91V37. Positions 50-112.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33LumenalSequence Analysis
Topological domaini25 – 5127CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini73 – 9018LumenalSequence AnalysisAdd
BLAST
Topological domaini112 – 13726CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini159 – 17517LumenalSequence AnalysisAdd
BLAST
Topological domaini197 – 2059CytoplasmicSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence AnalysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0636.
GeneTreeiENSGT00550000075120.
HOGENOMiHOG000056522.
HOVERGENiHBG105033.
InParanoidiQ91V37.
KOiK03661.
OMAiGYSLFWA.
OrthoDBiEOG7MD4RZ.
PhylomeDBiQ91V37.
TreeFamiTF314946.

Family and domain databases

InterProiIPR002379. ATPase_proteolipid_c_like_dom.
IPR000245. ATPase_proteolipid_csu.
[Graphical view]
PfamiPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSiPR00122. VACATPASE.
SUPFAMiSSF81333. SSF81333. 2 hits.

Sequencei

Sequence statusi: Complete.

Q91V37-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTGLELLYLG IFVAFWACMV VVGICYTIFD LGFRFDVAWF LTETSPFMWS
60 70 80 90 100
NLGIGLAISL SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV
110 120 130 140 150
AIYGIIMAIV ISNMAEPFSA TEPKAIGHRN YHAGYSMFGA GLTVGLSNLF
160 170 180 190 200
CGVCVGIVGS GAALADAQNP SLFVKILIVE IFGSAIGLFG VIVAILQTSR

VKMGD
Length:205
Mass (Da):21,607
Last modified:December 1, 2001 - v1
Checksum:iC1B05E87B53C076E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB060654 mRNA. Translation: BAB61954.1.
AB060655 Genomic DNA. Translation: BAB61955.1.
AF356006 mRNA. Translation: AAL02096.1.
AF356007 Genomic DNA. Translation: AAL02097.1.
CCDSiCCDS18540.1.
RefSeqiNP_291095.1. NM_033617.3.
UniGeneiMm.207052.

Genome annotation databases

EnsembliENSMUST00000036380; ENSMUSP00000047682; ENSMUSG00000033379.
GeneIDi114143.
KEGGimmu:114143.
UCSCiuc008ujc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB060654 mRNA. Translation: BAB61954.1 .
AB060655 Genomic DNA. Translation: BAB61955.1 .
AF356006 mRNA. Translation: AAL02096.1 .
AF356007 Genomic DNA. Translation: AAL02097.1 .
CCDSi CCDS18540.1.
RefSeqi NP_291095.1. NM_033617.3.
UniGenei Mm.207052.

3D structure databases

ProteinModelPortali Q91V37.
SMRi Q91V37. Positions 50-112.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036380 ; ENSMUSP00000047682 ; ENSMUSG00000033379 .
GeneIDi 114143.
KEGGi mmu:114143.
UCSCi uc008ujc.1. mouse.

Organism-specific databases

CTDi 533.
MGIi MGI:1890510. Atp6v0b.

Phylogenomic databases

eggNOGi COG0636.
GeneTreei ENSGT00550000075120.
HOGENOMi HOG000056522.
HOVERGENi HBG105033.
InParanoidi Q91V37.
KOi K03661.
OMAi GYSLFWA.
OrthoDBi EOG7MD4RZ.
PhylomeDBi Q91V37.
TreeFami TF314946.

Enzyme and pathway databases

Reactomei REACT_198345. Phagosomal maturation (early endosomal stage).
REACT_198515. Transferrin endocytosis and recycling.

Miscellaneous databases

ChiTaRSi ATP6V0B. mouse.
NextBioi 368143.
PROi Q91V37.
SOURCEi Search...

Gene expression databases

Bgeei Q91V37.
CleanExi MM_ATP6V0B.
ExpressionAtlasi Q91V37. baseline and differential.
Genevestigatori Q91V37.

Family and domain databases

InterProi IPR002379. ATPase_proteolipid_c_like_dom.
IPR000245. ATPase_proteolipid_csu.
[Graphical view ]
Pfami PF00137. ATP-synt_C. 2 hits.
[Graphical view ]
PRINTSi PR00122. VACATPASE.
SUPFAMi SSF81333. SSF81333. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Mouse Atp6f, the gene encoding the 23-kDa proteolipid of vacuolar proton translocating ATPase."
    Sun-Wada G.H., Murakami H., Nakai H., Wada Y., Futai M.
    Gene 274:93-99(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv and C57BL/6.
  2. "Expression and localization of the mouse homolog of the yeast V-ATPase 21-kDa subunit c' (Vma16p)."
    Nishi T., Kawasaki-Nishi S., Forgac M.
    J. Biol. Chem. 276:34122-34130(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Strain: BALB/c and C57BL/6J.
  3. "Interferon-inducible transmembrane proteins of the innate immune response act as membrane organizers by influencing clathrin and v-ATPase localization and function."
    Wee Y.S., Roundy K.M., Weis J.J., Weis J.H.
    Inn. Immun. 18:834-845(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IFITM3.

Entry informationi

Entry nameiVATO_MOUSE
AccessioniPrimary (citable) accession number: Q91V37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3