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Protein

V-type proton ATPase 21 kDa proteolipid subunit

Gene

Atp6v0b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei98 – 981Essential for proton translocationBy similarity

GO - Molecular functioni

  1. hydrogen-exporting ATPase activity, phosphorylative mechanism Source: MGI

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).
REACT_198515. Transferrin endocytosis and recycling.
REACT_233181. Insulin receptor recycling.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase 21 kDa proteolipid subunit
Short name:
V-ATPase 21 kDa proteolipid subunit
Alternative name(s):
23 kDa subunit of V-ATPase
Vacuolar proton pump 21 kDa proteolipid subunit
Gene namesi
Name:Atp6v0b
Synonyms:Atp6f
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1890510. Atp6v0b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33LumenalSequence Analysis
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST
Topological domaini25 – 5127CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Topological domaini73 – 9018LumenalSequence AnalysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence AnalysisAdd
BLAST
Topological domaini112 – 13726CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence AnalysisAdd
BLAST
Topological domaini159 – 17517LumenalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Topological domaini197 – 2059CytoplasmicSequence Analysis

GO - Cellular componenti

  1. endosome Source: MGI
  2. integral component of membrane Source: MGI
  3. proton-transporting V-type ATPase, V0 domain Source: InterPro
  4. vacuolar proton-transporting V-type ATPase complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205V-type proton ATPase 21 kDa proteolipid subunitPRO_0000071778Add
BLAST

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ91V37.
CleanExiMM_ATP6V0B.
ExpressionAtlasiQ91V37. baseline and differential.
GenevestigatoriQ91V37.

Interactioni

Subunit structurei

Interacts with IFITM3.1 Publication

Protein-protein interaction databases

BioGridi227579. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ91V37.
SMRiQ91V37. Positions 50-112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0636.
GeneTreeiENSGT00550000075120.
HOGENOMiHOG000056522.
HOVERGENiHBG105033.
InParanoidiQ91V37.
KOiK03661.
OMAiGYSLFWA.
OrthoDBiEOG7MD4RZ.
PhylomeDBiQ91V37.
TreeFamiTF314946.

Family and domain databases

InterProiIPR002379. ATPase_proteolipid_c_like_dom.
IPR000245. ATPase_proteolipid_csu.
[Graphical view]
PfamiPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSiPR00122. VACATPASE.
SUPFAMiSSF81333. SSF81333. 2 hits.

Sequencei

Sequence statusi: Complete.

Q91V37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGLELLYLG IFVAFWACMV VVGICYTIFD LGFRFDVAWF LTETSPFMWS
60 70 80 90 100
NLGIGLAISL SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV
110 120 130 140 150
AIYGIIMAIV ISNMAEPFSA TEPKAIGHRN YHAGYSMFGA GLTVGLSNLF
160 170 180 190 200
CGVCVGIVGS GAALADAQNP SLFVKILIVE IFGSAIGLFG VIVAILQTSR

VKMGD
Length:205
Mass (Da):21,607
Last modified:December 1, 2001 - v1
Checksum:iC1B05E87B53C076E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060654 mRNA. Translation: BAB61954.1.
AB060655 Genomic DNA. Translation: BAB61955.1.
AF356006 mRNA. Translation: AAL02096.1.
AF356007 Genomic DNA. Translation: AAL02097.1.
CCDSiCCDS18540.1.
RefSeqiNP_291095.1. NM_033617.3.
UniGeneiMm.207052.

Genome annotation databases

EnsembliENSMUST00000036380; ENSMUSP00000047682; ENSMUSG00000033379.
GeneIDi114143.
KEGGimmu:114143.
UCSCiuc008ujc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060654 mRNA. Translation: BAB61954.1.
AB060655 Genomic DNA. Translation: BAB61955.1.
AF356006 mRNA. Translation: AAL02096.1.
AF356007 Genomic DNA. Translation: AAL02097.1.
CCDSiCCDS18540.1.
RefSeqiNP_291095.1. NM_033617.3.
UniGeneiMm.207052.

3D structure databases

ProteinModelPortaliQ91V37.
SMRiQ91V37. Positions 50-112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi227579. 1 interaction.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036380; ENSMUSP00000047682; ENSMUSG00000033379.
GeneIDi114143.
KEGGimmu:114143.
UCSCiuc008ujc.1. mouse.

Organism-specific databases

CTDi533.
MGIiMGI:1890510. Atp6v0b.

Phylogenomic databases

eggNOGiCOG0636.
GeneTreeiENSGT00550000075120.
HOGENOMiHOG000056522.
HOVERGENiHBG105033.
InParanoidiQ91V37.
KOiK03661.
OMAiGYSLFWA.
OrthoDBiEOG7MD4RZ.
PhylomeDBiQ91V37.
TreeFamiTF314946.

Enzyme and pathway databases

ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).
REACT_198515. Transferrin endocytosis and recycling.
REACT_233181. Insulin receptor recycling.

Miscellaneous databases

ChiTaRSiAtp6v0b. mouse.
NextBioi368143.
PROiQ91V37.
SOURCEiSearch...

Gene expression databases

BgeeiQ91V37.
CleanExiMM_ATP6V0B.
ExpressionAtlasiQ91V37. baseline and differential.
GenevestigatoriQ91V37.

Family and domain databases

InterProiIPR002379. ATPase_proteolipid_c_like_dom.
IPR000245. ATPase_proteolipid_csu.
[Graphical view]
PfamiPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSiPR00122. VACATPASE.
SUPFAMiSSF81333. SSF81333. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Mouse Atp6f, the gene encoding the 23-kDa proteolipid of vacuolar proton translocating ATPase."
    Sun-Wada G.H., Murakami H., Nakai H., Wada Y., Futai M.
    Gene 274:93-99(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv and C57BL/6.
  2. "Expression and localization of the mouse homolog of the yeast V-ATPase 21-kDa subunit c' (Vma16p)."
    Nishi T., Kawasaki-Nishi S., Forgac M.
    J. Biol. Chem. 276:34122-34130(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Strain: BALB/c and C57BL/6J.
  3. "Interferon-inducible transmembrane proteins of the innate immune response act as membrane organizers by influencing clathrin and v-ATPase localization and function."
    Wee Y.S., Roundy K.M., Weis J.J., Weis J.H.
    Inn. Immun. 18:834-845(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IFITM3.

Entry informationi

Entry nameiVATO_MOUSE
AccessioniPrimary (citable) accession number: Q91V37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: February 4, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.