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Q91V37

- VATO_MOUSE

UniProt

Q91V37 - VATO_MOUSE

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Protein

V-type proton ATPase 21 kDa proteolipid subunit

Gene
Atp6v0b, Atp6f
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei98 – 981Essential for proton translocation By similarity

GO - Molecular functioni

  1. hydrogen-exporting ATPase activity, phosphorylative mechanism Source: MGI

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).
REACT_198515. Transferrin endocytosis and recycling.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase 21 kDa proteolipid subunit
Short name:
V-ATPase 21 kDa proteolipid subunit
Alternative name(s):
23 kDa subunit of V-ATPase
Vacuolar proton pump 21 kDa proteolipid subunit
Gene namesi
Name:Atp6v0b
Synonyms:Atp6f
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1890510. Atp6v0b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33Lumenal Reviewed prediction
Transmembranei4 – 2421Helical; Reviewed predictionAdd
BLAST
Topological domaini25 – 5127Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei52 – 7221Helical; Reviewed predictionAdd
BLAST
Topological domaini73 – 9018Lumenal Reviewed predictionAdd
BLAST
Transmembranei91 – 11121Helical; Reviewed predictionAdd
BLAST
Topological domaini112 – 13726Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei138 – 15821Helical; Reviewed predictionAdd
BLAST
Topological domaini159 – 17517Lumenal Reviewed predictionAdd
BLAST
Transmembranei176 – 19621Helical; Reviewed predictionAdd
BLAST
Topological domaini197 – 2059Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. endosome Source: MGI
  2. integral component of membrane Source: MGI
  3. proton-transporting V-type ATPase, V0 domain Source: InterPro
  4. vacuolar proton-transporting V-type ATPase complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205V-type proton ATPase 21 kDa proteolipid subunitPRO_0000071778Add
BLAST

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

ArrayExpressiQ91V37.
BgeeiQ91V37.
CleanExiMM_ATP6V0B.
GenevestigatoriQ91V37.

Interactioni

Subunit structurei

Interacts with IFITM3.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ91V37.
SMRiQ91V37. Positions 49-112.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0636.
GeneTreeiENSGT00550000075120.
HOGENOMiHOG000056522.
HOVERGENiHBG105033.
InParanoidiQ91V37.
KOiK03661.
OMAiGYSLFWA.
OrthoDBiEOG7MD4RZ.
PhylomeDBiQ91V37.
TreeFamiTF314946.

Family and domain databases

InterProiIPR002379. ATPase_proteolipid_c_like_dom.
IPR000245. ATPase_proteolipid_csu.
[Graphical view]
PfamiPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSiPR00122. VACATPASE.
SUPFAMiSSF81333. SSF81333. 2 hits.

Sequencei

Sequence statusi: Complete.

Q91V37-1 [UniParc]FASTAAdd to Basket

« Hide

MTGLELLYLG IFVAFWACMV VVGICYTIFD LGFRFDVAWF LTETSPFMWS    50
NLGIGLAISL SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV 100
AIYGIIMAIV ISNMAEPFSA TEPKAIGHRN YHAGYSMFGA GLTVGLSNLF 150
CGVCVGIVGS GAALADAQNP SLFVKILIVE IFGSAIGLFG VIVAILQTSR 200
VKMGD 205
Length:205
Mass (Da):21,607
Last modified:December 1, 2001 - v1
Checksum:iC1B05E87B53C076E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB060654 mRNA. Translation: BAB61954.1.
AB060655 Genomic DNA. Translation: BAB61955.1.
AF356006 mRNA. Translation: AAL02096.1.
AF356007 Genomic DNA. Translation: AAL02097.1.
CCDSiCCDS18540.1.
RefSeqiNP_291095.1. NM_033617.3.
UniGeneiMm.207052.

Genome annotation databases

EnsembliENSMUST00000036380; ENSMUSP00000047682; ENSMUSG00000033379.
GeneIDi114143.
KEGGimmu:114143.
UCSCiuc008ujc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB060654 mRNA. Translation: BAB61954.1 .
AB060655 Genomic DNA. Translation: BAB61955.1 .
AF356006 mRNA. Translation: AAL02096.1 .
AF356007 Genomic DNA. Translation: AAL02097.1 .
CCDSi CCDS18540.1.
RefSeqi NP_291095.1. NM_033617.3.
UniGenei Mm.207052.

3D structure databases

ProteinModelPortali Q91V37.
SMRi Q91V37. Positions 49-112.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036380 ; ENSMUSP00000047682 ; ENSMUSG00000033379 .
GeneIDi 114143.
KEGGi mmu:114143.
UCSCi uc008ujc.1. mouse.

Organism-specific databases

CTDi 533.
MGIi MGI:1890510. Atp6v0b.

Phylogenomic databases

eggNOGi COG0636.
GeneTreei ENSGT00550000075120.
HOGENOMi HOG000056522.
HOVERGENi HBG105033.
InParanoidi Q91V37.
KOi K03661.
OMAi GYSLFWA.
OrthoDBi EOG7MD4RZ.
PhylomeDBi Q91V37.
TreeFami TF314946.

Enzyme and pathway databases

Reactomei REACT_198345. Phagosomal maturation (early endosomal stage).
REACT_198515. Transferrin endocytosis and recycling.

Miscellaneous databases

ChiTaRSi ATP6V0B. mouse.
NextBioi 368143.
PROi Q91V37.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91V37.
Bgeei Q91V37.
CleanExi MM_ATP6V0B.
Genevestigatori Q91V37.

Family and domain databases

InterProi IPR002379. ATPase_proteolipid_c_like_dom.
IPR000245. ATPase_proteolipid_csu.
[Graphical view ]
Pfami PF00137. ATP-synt_C. 2 hits.
[Graphical view ]
PRINTSi PR00122. VACATPASE.
SUPFAMi SSF81333. SSF81333. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Mouse Atp6f, the gene encoding the 23-kDa proteolipid of vacuolar proton translocating ATPase."
    Sun-Wada G.H., Murakami H., Nakai H., Wada Y., Futai M.
    Gene 274:93-99(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv and C57BL/6.
  2. "Expression and localization of the mouse homolog of the yeast V-ATPase 21-kDa subunit c' (Vma16p)."
    Nishi T., Kawasaki-Nishi S., Forgac M.
    J. Biol. Chem. 276:34122-34130(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Strain: BALB/c and C57BL/6J.
  3. "Interferon-inducible transmembrane proteins of the innate immune response act as membrane organizers by influencing clathrin and v-ATPase localization and function."
    Wee Y.S., Roundy K.M., Weis J.J., Weis J.H.
    Inn. Immun. 18:834-845(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IFITM3.

Entry informationi

Entry nameiVATO_MOUSE
AccessioniPrimary (citable) accession number: Q91V37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi