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Q91V37 (VATO_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
V-type proton ATPase 21 kDa proteolipid subunit

Short name=V-ATPase 21 kDa proteolipid subunit
Alternative name(s):
23 kDa subunit of V-ATPase
Vacuolar proton pump 21 kDa proteolipid subunit
Gene names
Name:Atp6v0b
Synonyms:Atp6f
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subunit structure

Interacts with IFITM3. Ref.3

Subcellular location

Vacuole membrane; Multi-pass membrane protein.

Tissue specificity

Ubiquitous. Ref.2

Sequence similarities

Belongs to the V-ATPase proteolipid subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 205205V-type proton ATPase 21 kDa proteolipid subunit
PRO_0000071778

Regions

Topological domain1 – 33Lumenal Potential
Transmembrane4 – 2421Helical; Potential
Topological domain25 – 5127Cytoplasmic Potential
Transmembrane52 – 7221Helical; Potential
Topological domain73 – 9018Lumenal Potential
Transmembrane91 – 11121Helical; Potential
Topological domain112 – 13726Cytoplasmic Potential
Transmembrane138 – 15821Helical; Potential
Topological domain159 – 17517Lumenal Potential
Transmembrane176 – 19621Helical; Potential
Topological domain197 – 2059Cytoplasmic Potential

Sites

Site981Essential for proton translocation By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91V37 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: C1B05E87B53C076E

FASTA20521,607
        10         20         30         40         50         60 
MTGLELLYLG IFVAFWACMV VVGICYTIFD LGFRFDVAWF LTETSPFMWS NLGIGLAISL 

        70         80         90        100        110        120 
SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV AIYGIIMAIV ISNMAEPFSA 

       130        140        150        160        170        180 
TEPKAIGHRN YHAGYSMFGA GLTVGLSNLF CGVCVGIVGS GAALADAQNP SLFVKILIVE 

       190        200 
IFGSAIGLFG VIVAILQTSR VKMGD 

« Hide

References

[1]"Mouse Atp6f, the gene encoding the 23-kDa proteolipid of vacuolar proton translocating ATPase."
Sun-Wada G.H., Murakami H., Nakai H., Wada Y., Futai M.
Gene 274:93-99(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: 129/Sv and C57BL/6.
[2]"Expression and localization of the mouse homolog of the yeast V-ATPase 21-kDa subunit c' (Vma16p)."
Nishi T., Kawasaki-Nishi S., Forgac M.
J. Biol. Chem. 276:34122-34130(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
Strain: BALB/c and C57BL/6J.
[3]"Interferon-inducible transmembrane proteins of the innate immune response act as membrane organizers by influencing clathrin and v-ATPase localization and function."
Wee Y.S., Roundy K.M., Weis J.J., Weis J.H.
Inn. Immun. 18:834-845(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH IFITM3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB060654 mRNA. Translation: BAB61954.1.
AB060655 Genomic DNA. Translation: BAB61955.1.
AF356006 mRNA. Translation: AAL02096.1.
AF356007 Genomic DNA. Translation: AAL02097.1.
CCDSCCDS18540.1.
RefSeqNP_291095.1. NM_033617.3.
UniGeneMm.207052.

3D structure databases

ProteinModelPortalQ91V37.
SMRQ91V37. Positions 49-112.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000036380; ENSMUSP00000047682; ENSMUSG00000033379.
GeneID114143.
KEGGmmu:114143.
UCSCuc008ujc.1. mouse.

Organism-specific databases

CTD533.
MGIMGI:1890510. Atp6v0b.

Phylogenomic databases

eggNOGCOG0636.
GeneTreeENSGT00550000075120.
HOGENOMHOG000056522.
HOVERGENHBG105033.
InParanoidQ91V37.
KOK03661.
OMAGYSLFWA.
OrthoDBEOG7MD4RZ.
PhylomeDBQ91V37.
TreeFamTF314946.

Gene expression databases

ArrayExpressQ91V37.
BgeeQ91V37.
CleanExMM_ATP6V0B.
GenevestigatorQ91V37.

Family and domain databases

InterProIPR002379. ATPase_proteolipid_c_like_dom.
IPR000245. ATPase_proteolipid_csu.
[Graphical view]
PfamPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSPR00122. VACATPASE.
SUPFAMSSF81333. SSF81333. 2 hits.
ProtoNetSearch...

Other

ChiTaRSATP6V0B. mouse.
NextBio368143.
PROQ91V37.
SOURCESearch...

Entry information

Entry nameVATO_MOUSE
AccessionPrimary (citable) accession number: Q91V37
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot