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Q91V37

- VATO_MOUSE

UniProt

Q91V37 - VATO_MOUSE

Protein

V-type proton ATPase 21 kDa proteolipid subunit

Gene

Atp6v0b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei98 – 981Essential for proton translocationBy similarity

    GO - Molecular functioni

    1. hydrogen-exporting ATPase activity, phosphorylative mechanism Source: MGI

    GO - Biological processi

    1. ATP hydrolysis coupled proton transport Source: MGI

    Keywords - Biological processi

    Hydrogen ion transport, Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198345. Phagosomal maturation (early endosomal stage).
    REACT_198515. Transferrin endocytosis and recycling.

    Protein family/group databases

    TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase 21 kDa proteolipid subunit
    Short name:
    V-ATPase 21 kDa proteolipid subunit
    Alternative name(s):
    23 kDa subunit of V-ATPase
    Vacuolar proton pump 21 kDa proteolipid subunit
    Gene namesi
    Name:Atp6v0b
    Synonyms:Atp6f
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1890510. Atp6v0b.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome Source: MGI
    2. integral component of membrane Source: MGI
    3. proton-transporting V-type ATPase, V0 domain Source: InterPro
    4. vacuolar proton-transporting V-type ATPase complex Source: MGI

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 205205V-type proton ATPase 21 kDa proteolipid subunitPRO_0000071778Add
    BLAST

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiQ91V37.
    BgeeiQ91V37.
    CleanExiMM_ATP6V0B.
    GenevestigatoriQ91V37.

    Interactioni

    Subunit structurei

    Interacts with IFITM3.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ91V37.
    SMRiQ91V37. Positions 49-112.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 33LumenalSequence Analysis
    Topological domaini25 – 5127CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini73 – 9018LumenalSequence AnalysisAdd
    BLAST
    Topological domaini112 – 13726CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 17517LumenalSequence AnalysisAdd
    BLAST
    Topological domaini197 – 2059CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei91 – 11121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0636.
    GeneTreeiENSGT00550000075120.
    HOGENOMiHOG000056522.
    HOVERGENiHBG105033.
    InParanoidiQ91V37.
    KOiK03661.
    OMAiGYSLFWA.
    OrthoDBiEOG7MD4RZ.
    PhylomeDBiQ91V37.
    TreeFamiTF314946.

    Family and domain databases

    InterProiIPR002379. ATPase_proteolipid_c_like_dom.
    IPR000245. ATPase_proteolipid_csu.
    [Graphical view]
    PfamiPF00137. ATP-synt_C. 2 hits.
    [Graphical view]
    PRINTSiPR00122. VACATPASE.
    SUPFAMiSSF81333. SSF81333. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q91V37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGLELLYLG IFVAFWACMV VVGICYTIFD LGFRFDVAWF LTETSPFMWS    50
    NLGIGLAISL SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV 100
    AIYGIIMAIV ISNMAEPFSA TEPKAIGHRN YHAGYSMFGA GLTVGLSNLF 150
    CGVCVGIVGS GAALADAQNP SLFVKILIVE IFGSAIGLFG VIVAILQTSR 200
    VKMGD 205
    Length:205
    Mass (Da):21,607
    Last modified:December 1, 2001 - v1
    Checksum:iC1B05E87B53C076E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB060654 mRNA. Translation: BAB61954.1.
    AB060655 Genomic DNA. Translation: BAB61955.1.
    AF356006 mRNA. Translation: AAL02096.1.
    AF356007 Genomic DNA. Translation: AAL02097.1.
    CCDSiCCDS18540.1.
    RefSeqiNP_291095.1. NM_033617.3.
    UniGeneiMm.207052.

    Genome annotation databases

    EnsembliENSMUST00000036380; ENSMUSP00000047682; ENSMUSG00000033379.
    GeneIDi114143.
    KEGGimmu:114143.
    UCSCiuc008ujc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB060654 mRNA. Translation: BAB61954.1 .
    AB060655 Genomic DNA. Translation: BAB61955.1 .
    AF356006 mRNA. Translation: AAL02096.1 .
    AF356007 Genomic DNA. Translation: AAL02097.1 .
    CCDSi CCDS18540.1.
    RefSeqi NP_291095.1. NM_033617.3.
    UniGenei Mm.207052.

    3D structure databases

    ProteinModelPortali Q91V37.
    SMRi Q91V37. Positions 49-112.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036380 ; ENSMUSP00000047682 ; ENSMUSG00000033379 .
    GeneIDi 114143.
    KEGGi mmu:114143.
    UCSCi uc008ujc.1. mouse.

    Organism-specific databases

    CTDi 533.
    MGIi MGI:1890510. Atp6v0b.

    Phylogenomic databases

    eggNOGi COG0636.
    GeneTreei ENSGT00550000075120.
    HOGENOMi HOG000056522.
    HOVERGENi HBG105033.
    InParanoidi Q91V37.
    KOi K03661.
    OMAi GYSLFWA.
    OrthoDBi EOG7MD4RZ.
    PhylomeDBi Q91V37.
    TreeFami TF314946.

    Enzyme and pathway databases

    Reactomei REACT_198345. Phagosomal maturation (early endosomal stage).
    REACT_198515. Transferrin endocytosis and recycling.

    Miscellaneous databases

    ChiTaRSi ATP6V0B. mouse.
    NextBioi 368143.
    PROi Q91V37.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91V37.
    Bgeei Q91V37.
    CleanExi MM_ATP6V0B.
    Genevestigatori Q91V37.

    Family and domain databases

    InterProi IPR002379. ATPase_proteolipid_c_like_dom.
    IPR000245. ATPase_proteolipid_csu.
    [Graphical view ]
    Pfami PF00137. ATP-synt_C. 2 hits.
    [Graphical view ]
    PRINTSi PR00122. VACATPASE.
    SUPFAMi SSF81333. SSF81333. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Mouse Atp6f, the gene encoding the 23-kDa proteolipid of vacuolar proton translocating ATPase."
      Sun-Wada G.H., Murakami H., Nakai H., Wada Y., Futai M.
      Gene 274:93-99(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: 129/Sv and C57BL/6.
    2. "Expression and localization of the mouse homolog of the yeast V-ATPase 21-kDa subunit c' (Vma16p)."
      Nishi T., Kawasaki-Nishi S., Forgac M.
      J. Biol. Chem. 276:34122-34130(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
      Strain: BALB/c and C57BL/6J.
    3. "Interferon-inducible transmembrane proteins of the innate immune response act as membrane organizers by influencing clathrin and v-ATPase localization and function."
      Wee Y.S., Roundy K.M., Weis J.J., Weis J.H.
      Inn. Immun. 18:834-845(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IFITM3.

    Entry informationi

    Entry nameiVATO_MOUSE
    AccessioniPrimary (citable) accession number: Q91V37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3