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Protein

Nuclear receptor-binding protein 2

Gene

Nrbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate apoptosis of neural progenitor cells during their differentiation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: GO_Central
  • intracellular signal transduction Source: GO_Central
  • negative regulation of neuron apoptotic process Source: UniProtKB
  • neuron differentiation Source: UniProtKB
  • protein phosphorylation Source: GO_Central

Keywordsi

Biological processNeurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor-binding protein 2
Gene namesi
Name:Nrbp2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2385017. Nrbp2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002256091 – 499Nuclear receptor-binding protein 2Add BLAST499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei407PhosphothreonineCombined sources1
Modified residuei409PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91V36.
PaxDbiQ91V36.
PeptideAtlasiQ91V36.
PRIDEiQ91V36.

PTM databases

iPTMnetiQ91V36.
PhosphoSitePlusiQ91V36.

Expressioni

Tissue specificityi

Expressed in Purkinje cells of the cerebellum and neurons in the CA3 region of the hippocampus. Also detected in non-neural tissues including mesenchymal layer adjacent to epithelium in developing bronchi of the lung, the epithelium of the stomach as well as cells in the liver.1 Publication

Developmental stagei

Expressed in the cerebral cortex at E14 (at protein level). Expressed in the walls of the third and fourth ventricles, and in the hippocampus during development.1 Publication

Gene expression databases

CleanExiMM_NRBP2.

Structurei

3D structure databases

ProteinModelPortaliQ91V36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 304Protein kinasePROSITE-ProRule annotationAdd BLAST269

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1266. Eukaryota.
ENOG410XSIC. LUCA.
HOGENOMiHOG000113848.
HOVERGENiHBG082057.
InParanoidiQ91V36.
KOiK08875.
PhylomeDBiQ91V36.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91V36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPEPAPRR GREREREDES EDESDILEES PCGRWQKRRE QVNQGNMPGI
60 70 80 90 100
QSTFLAMDTE EGVEVVWNEL HFGDRKAFAA HEEKIQTMFE QLALVDHPNI
110 120 130 140 150
VKLHKYWLDA SEARARVIFI TEYVSSGSLK QFLKKTKKNH KAMNARAWKR
160 170 180 190 200
WCTQILSALS FLHACSPPII HGNLTSDTIF IQHNGLIKIG SVWYRIFSNA
210 220 230 240 250
LPDDLRSPIR AEREELRNLH FFPPEYGEVN DGTAVDIFSF GMCALEMAVL
260 270 280 290 300
EIQANGDTRV TEEAIARARH SLSDPNMREF ILSCLARDPA RRPSAHNLLF
310 320 330 340 350
HRVLFEVHSL KLLAAHCFIQ HQYLMPENVV EEKTKAMDLH AVLAEMPQPH
360 370 380 390 400
GPPMQWRYSE VSFLELDKFL EDVRNGIYPL MNFAAARPLG LPRVLAPPPE
410 420 430 440 450
EAQKAKTPTP EPFDSETRKV VQMQCNLERS EDKARWHLTL LLVLEDRLHR
460 470 480 490
QLTYDLLPTD SAQDLAAELV HYGFLHEDDR TKLAAFLETT FLKYRGTQA
Length:499
Mass (Da):57,348
Last modified:June 15, 2010 - v2
Checksum:iB46B19E047549170
GO

Sequence cautioni

Q91V36: The sequence AAH11468 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Q91V36: The sequence AAH12437 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200A → V in AAH11468 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116487 Genomic DNA. No translation available.
BC011468 mRNA. Translation: AAH11468.1. Different initiation.
BC012437 mRNA. Translation: AAH12437.1. Different initiation.
BC025042 mRNA. Translation: AAH25042.1.
RefSeqiNP_659096.1. NM_144847.1.
XP_006520835.1. XM_006520772.3.
UniGeneiMm.101946.

Genome annotation databases

GeneIDi223649.
KEGGimmu:223649.
UCSCiuc007wil.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiNRBP2_MOUSE
AccessioniPrimary (citable) accession number: Q91V36
Secondary accession number(s): Q8R3M0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 15, 2010
Last modified: September 27, 2017
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families