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Protein

Nuclear receptor-binding protein 2

Gene

Nrbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate apoptosis of neural progenitor cells during their differentiation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of neuron apoptotic process Source: UniProtKB
  • neuron differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor-binding protein 2
Gene namesi
Name:Nrbp2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2385017. Nrbp2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Nuclear receptor-binding protein 2PRO_0000225609Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei407 – 4071PhosphothreonineCombined sources
Modified residuei409 – 4091PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91V36.
MaxQBiQ91V36.
PaxDbiQ91V36.
PRIDEiQ91V36.

PTM databases

iPTMnetiQ91V36.
PhosphoSiteiQ91V36.

Expressioni

Tissue specificityi

Expressed in Purkinje cells of the cerebellum and neurons in the CA3 region of the hippocampus. Also detected in non-neural tissues including mesenchymal layer adjacent to epithelium in developing bronchi of the lung, the epithelium of the stomach as well as cells in the liver.1 Publication

Developmental stagei

Expressed in the cerebral cortex at E14 (at protein level). Expressed in the walls of the third and fourth ventricles, and in the hippocampus during development.1 Publication

Gene expression databases

BgeeiQ91V36.
CleanExiMM_NRBP2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019516.

Structurei

3D structure databases

ProteinModelPortaliQ91V36.
SMRiQ91V36. Positions 33-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 304269Protein kinasePROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1266. Eukaryota.
ENOG410XSIC. LUCA.
HOGENOMiHOG000113848.
HOVERGENiHBG082057.
InParanoidiQ91V36.
KOiK08875.
OrthoDBiEOG7K6PTQ.
PhylomeDBiQ91V36.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91V36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPEPAPRR GREREREDES EDESDILEES PCGRWQKRRE QVNQGNMPGI
60 70 80 90 100
QSTFLAMDTE EGVEVVWNEL HFGDRKAFAA HEEKIQTMFE QLALVDHPNI
110 120 130 140 150
VKLHKYWLDA SEARARVIFI TEYVSSGSLK QFLKKTKKNH KAMNARAWKR
160 170 180 190 200
WCTQILSALS FLHACSPPII HGNLTSDTIF IQHNGLIKIG SVWYRIFSNA
210 220 230 240 250
LPDDLRSPIR AEREELRNLH FFPPEYGEVN DGTAVDIFSF GMCALEMAVL
260 270 280 290 300
EIQANGDTRV TEEAIARARH SLSDPNMREF ILSCLARDPA RRPSAHNLLF
310 320 330 340 350
HRVLFEVHSL KLLAAHCFIQ HQYLMPENVV EEKTKAMDLH AVLAEMPQPH
360 370 380 390 400
GPPMQWRYSE VSFLELDKFL EDVRNGIYPL MNFAAARPLG LPRVLAPPPE
410 420 430 440 450
EAQKAKTPTP EPFDSETRKV VQMQCNLERS EDKARWHLTL LLVLEDRLHR
460 470 480 490
QLTYDLLPTD SAQDLAAELV HYGFLHEDDR TKLAAFLETT FLKYRGTQA
Length:499
Mass (Da):57,348
Last modified:June 15, 2010 - v2
Checksum:iB46B19E047549170
GO

Sequence cautioni

The sequence AAH11468.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH12437.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti200 – 2001A → V in AAH11468 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116487 Genomic DNA. No translation available.
BC011468 mRNA. Translation: AAH11468.1. Different initiation.
BC012437 mRNA. Translation: AAH12437.1. Different initiation.
BC025042 mRNA. Translation: AAH25042.1.
RefSeqiNP_659096.1. NM_144847.1.
XP_006520835.1. XM_006520772.2.
UniGeneiMm.101946.

Genome annotation databases

GeneIDi223649.
KEGGimmu:223649.
UCSCiuc007wil.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116487 Genomic DNA. No translation available.
BC011468 mRNA. Translation: AAH11468.1. Different initiation.
BC012437 mRNA. Translation: AAH12437.1. Different initiation.
BC025042 mRNA. Translation: AAH25042.1.
RefSeqiNP_659096.1. NM_144847.1.
XP_006520835.1. XM_006520772.2.
UniGeneiMm.101946.

3D structure databases

ProteinModelPortaliQ91V36.
SMRiQ91V36. Positions 33-301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019516.

PTM databases

iPTMnetiQ91V36.
PhosphoSiteiQ91V36.

Proteomic databases

EPDiQ91V36.
MaxQBiQ91V36.
PaxDbiQ91V36.
PRIDEiQ91V36.

Protocols and materials databases

DNASUi223649.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi223649.
KEGGimmu:223649.
UCSCiuc007wil.1. mouse.

Organism-specific databases

CTDi340371.
MGIiMGI:2385017. Nrbp2.

Phylogenomic databases

eggNOGiKOG1266. Eukaryota.
ENOG410XSIC. LUCA.
HOGENOMiHOG000113848.
HOVERGENiHBG082057.
InParanoidiQ91V36.
KOiK08875.
OrthoDBiEOG7K6PTQ.
PhylomeDBiQ91V36.

Miscellaneous databases

NextBioi376780.
PROiQ91V36.
SOURCEiSearch...

Gene expression databases

BgeeiQ91V36.
CleanExiMM_NRBP2.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-499.
    Strain: Czech IIImported and FVB/NImported.
    Tissue: Mammary glandImported.
  3. "Nuclear receptor binding protein 2 is induced during neural progenitor differentiation and affects cell survival."
    Larsson J., Forsberg M., Brannvall K., Zhang X.Q., Enarsson M., Hedborg F., Forsberg-Nilsson K.
    Mol. Cell. Neurosci. 39:32-39(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-407 AND THR-409, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Lung and Testis.

Entry informationi

Entry nameiNRBP2_MOUSE
AccessioniPrimary (citable) accession number: Q91V36
Secondary accession number(s): Q8R3M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 15, 2010
Last modified: March 16, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.