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Q91V24

- ABCA7_MOUSE

UniProt

Q91V24 - ABCA7_MOUSE

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Protein

ATP-binding cassette sub-family A member 7

Gene

Abca7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi838 – 8458ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1841 – 18488ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. apolipoprotein A-I receptor activity Source: Alzheimers_University_of_Toronto
  2. ATPase activity Source: InterPro
  3. ATP binding Source: UniProtKB-KW
  4. phospholipid transporter activity Source: MGI

GO - Biological processi

  1. apolipoprotein A-I-mediated signaling pathway Source: Alzheimers_University_of_Toronto
  2. cholesterol efflux Source: Alzheimers_University_of_Toronto
  3. high-density lipoprotein particle assembly Source: Alzheimers_University_of_Toronto
  4. memory Source: Alzheimers_University_of_Toronto
  5. negative regulation of amyloid precursor protein biosynthetic process Source: Alzheimers_University_of_Toronto
  6. negative regulation of ATPase activity Source: Alzheimers_University_of_Toronto
  7. negative regulation of beta-amyloid formation Source: Alzheimers_University_of_Toronto
  8. peptide cross-linking Source: Alzheimers_University_of_Toronto
  9. phagocytosis Source: UniProtKB-KW
  10. phospholipid efflux Source: MGI
  11. phospholipid scrambling Source: Alzheimers_University_of_Toronto
  12. positive regulation of ATPase activity Source: Alzheimers_University_of_Toronto
  13. positive regulation of beta-amyloid clearance Source: Alzheimers_University_of_Toronto
  14. positive regulation of cholesterol efflux Source: Alzheimers_University_of_Toronto
  15. positive regulation of engulfment of apoptotic cell Source: Alzheimers_University_of_Toronto
  16. positive regulation of ERK1 and ERK2 cascade Source: Alzheimers_University_of_Toronto
  17. positive regulation of phagocytosis Source: Alzheimers_University_of_Toronto
  18. positive regulation of phospholipid efflux Source: Alzheimers_University_of_Toronto
  19. protein localization to nucleus Source: Alzheimers_University_of_Toronto
Complete GO annotation...

Keywords - Biological processi

Phagocytosis, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_197984. ABCA transporters in lipid homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 7
Gene namesi
Name:Abca7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1351646. Abca7.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein
Note: Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence AnalysisAdd
BLAST
Topological domaini43 – 546504ExtracellularBy similarityAdd
BLAST
Transmembranei547 – 56721HelicalSequence AnalysisAdd
BLAST
Transmembranei590 – 61021HelicalSequence AnalysisAdd
BLAST
Transmembranei623 – 64321HelicalSequence AnalysisAdd
BLAST
Transmembranei652 – 67221HelicalSequence AnalysisAdd
BLAST
Transmembranei678 – 69821HelicalSequence AnalysisAdd
BLAST
Transmembranei732 – 75221HelicalSequence AnalysisAdd
BLAST
Transmembranei846 – 86621HelicalSequence AnalysisAdd
BLAST
Transmembranei1246 – 126621HelicalSequence AnalysisAdd
BLAST
Topological domaini1267 – 1551285ExtracellularBy similarityAdd
BLAST
Transmembranei1552 – 157221HelicalSequence AnalysisAdd
BLAST
Transmembranei1598 – 161821HelicalSequence AnalysisAdd
BLAST
Transmembranei1635 – 165521HelicalSequence AnalysisAdd
BLAST
Transmembranei1663 – 168321HelicalSequence AnalysisAdd
BLAST
Transmembranei1743 – 176321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. cell surface Source: Alzheimers_University_of_Toronto
  3. endosome Source: UniProtKB-KW
  4. Golgi apparatus Source: UniProtKB-KW
  5. integral component of membrane Source: UniProtKB-KW
  6. intracellular Source: MGI
  7. phagocytic cup Source: Alzheimers_University_of_Toronto
  8. plasma membrane Source: Alzheimers_University_of_Toronto
  9. ruffle membrane Source: Alzheimers_University_of_Toronto
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

According to PubMed:16908670, mice are not viable and heterozygous knockout mice display impaired phagocytosis of apoptotic cells. Depletion of Abca7 in macrophages by RNAi reduces phagocytosis of apoptotic cells. According to PubMed:15550377, mice are viable and females have less visceral fat and lower total serum and high density lipoprotein cholesterol level.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21592159ATP-binding cassette sub-family A member 7PRO_0000250675Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi75 ↔ 222By similarity
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1359 ↔ 1373By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ91V24.
PaxDbiQ91V24.
PRIDEiQ91V24.

PTM databases

PhosphoSiteiQ91V24.

Expressioni

Tissue specificityi

Widely expressed with higher expression in brain, lung, adrenal gland and spleen (at protein level). Highly expressed in spleen and hematopoietic tissues.3 Publications

Developmental stagei

Widely expressed during embryogenesis.1 Publication

Inductioni

Down-regulated by digoxin.1 Publication

Gene expression databases

BgeeiQ91V24.
ExpressionAtlasiQ91V24. baseline and differential.
GenevestigatoriQ91V24.

Structurei

3D structure databases

ProteinModelPortaliQ91V24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini804 – 1035232ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini1807 – 2039233ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1131.
GeneTreeiENSGT00760000118965.
HOVERGENiHBG050436.
InParanoidiQ91V24.
KOiK05645.
OrthoDBiEOG78D7J6.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91V24-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALGTQLMLL LWKNYTYRRR QPIQLLVELL WPLFLFFILV AVRHSHPPLE
60 70 80 90 100
HHECHFPNKP LPSAGTVPWL QGLVCNVNNS CFQHPTPGEK PGVLSNFKDS
110 120 130 140 150
LISRLLADTR TVLGGHSIQD MLDALGKLIP VLRAVGGGAR PQESDQPTSQ
160 170 180 190 200
GSVTKLLEKI LQRASLDPVL GQAQDSMRKF SDAIRDLAQE LLTLPSLMEL
210 220 230 240 250
RALLRRPRGS AGSLELVSEA LCSTKGPSSP GGLSLNWYEA NQLNEFMGPE
260 270 280 290 300
VAPALPDNSL SPACSEFVGT LDDHPVSRLL WRRLKPLILG KILFAPDTNF
310 320 330 340 350
TRKLMAQVNQ TFEELALLRD LHELWGVLGP QIFNFMNDST NVAMLQRLLD
360 370 380 390 400
VGGTGQRQQT PRAQKKLEAI KDFLDPSRGG YSWREAHADM GRLAGILGQM
410 420 430 440 450
MECVSLDKLE AVPSEEALVS RALELLGERR LWAGIVFLSP EHPLDPSELS
460 470 480 490 500
SPALSPGHLR FKIRMDIDDV TRTNKIRDKF WDPGPSADPF MDLRYVWGGF
510 520 530 540 550
VYLQDLLEQA AVRVLGGGNS RTGLYLQQMP HPCYVDDVFL RVLSRSLPLF
560 570 580 590 600
LTLAWIYSVA LTVKAVVREK ETRLRETMRA MGLSRAVLWL GWFLSCLGPF
610 620 630 640 650
LVSAALLVLV LKLGNILPYS HPVVIFLFLA AFAVATVAQS FLLSAFFSRA
660 670 680 690 700
NLAAACGGLA YFALYLPYVL CVAWRERLHL GGLLAASLLS PVAFGFGCES
710 720 730 740 750
LALLEEQGDG AQWHNLGTGP AEDVFSLAQV SAFLLLDAVI YGLALWYLEA
760 770 780 790 800
VCPGQYGIPE PWNFPFRRSY WCGPGPPKSS VLAPAPQDPK VLVEEPPLGL
810 820 830 840 850
VPGVSIRGLK KHFRGCPQPA LQGLNLDFYE GHITAFLGHN GAGKTTTLSI
860 870 880 890 900
LSGLFPPSSG SASILGHDVQ TNMAAIRPHL GICPQYNVLF DMLTVEEHVW
910 920 930 940 950
FYGRLKGVSA AAMGPERERL IRDVGLTLKR DTQTRHLSGG MQRKLSVAIA
960 970 980 990 1000
FVGGSRVVIM DEPTAGVDPA SRRGIWELLL KYREGRTLIL STHHLDEAEL
1010 1020 1030 1040 1050
LGDRVAMVAG GSLCCCGSPL FLRRHLGCGY YLTLVKSSQS LVTHDAKGDS
1060 1070 1080 1090 1100
EDPRREKKSD GNGRTSDTAF TRGTSDKSNQ APAPGAVPIT PSTARILELV
1110 1120 1130 1140 1150
QQHVPGAQLV EDLPHELLLV LPYAGALDGS FAMVFQELDQ QLELLGLTGY
1160 1170 1180 1190 1200
GISDTNLEEI FLKVVEDAHR EGGDSRPQLH LRTCTPQPPT GPEASVLENG
1210 1220 1230 1240 1250
ELAPQGLAPN AAQVQGWTLT CQQLRALLHK RFLLARRSRR GLFAQVVLPA
1260 1270 1280 1290 1300
LFVGLALFFS LIVPPFGQYP PLQLSPAMYG PQVSFFSEDA PGDPNRMKLL
1310 1320 1330 1340 1350
EALLGEAGLQ EPSMQDKDAR GSECTHSLAC YFTVPEVPPD VASILASGNW
1360 1370 1380 1390 1400
TPESPSPACQ CSQPGARRLL PDCPAGAGGP PPPQAVAGLG EVVQNLTGRN
1410 1420 1430 1440 1450
VSDFLVKTYP SLVRRGLKTK KWVDEVRYGG FSLGGRDPDL PTGHEVVRTL
1460 1470 1480 1490 1500
AEIRALLSPQ PGNALDRILN NLTQWALGLD ARNSLKIWFN NKGWHAMVAF
1510 1520 1530 1540 1550
VNRANNGLLH ALLPSGPVRH AHSITTLNHP LNLTKEQLSE ATLIASSVDV
1560 1570 1580 1590 1600
LVSICVVFAM SFVPASFTLV LIEERITRAK HLQLVSGLPQ TLYWLGNFLW
1610 1620 1630 1640 1650
DMCNYLVAVC IVVFIFLAFQ QRAYVAPENL PALLLLLLLY GWSITPLMYP
1660 1670 1680 1690 1700
ASFFFSVPST AYVVLTCINL FIGINSSMAT FVLELLSDQN LQEVSRILKQ
1710 1720 1730 1740 1750
VFLIFPHFCL GRGLIDMVRN QAMADAFERL GDKQFQSPLR WDIIGKNLLA
1760 1770 1780 1790 1800
MMAQGPLFLL ITLLLQHRNR LLPQSKPRLL PPLGEEDEDV AQERERVTKG
1810 1820 1830 1840 1850
ATQGDVLVLR DLTKVYRGQR NPAVDRLCLG IPPGECFGLL GVNGAGKTST
1860 1870 1880 1890 1900
FRMVTGDTLP SSGEAVLAGH NVAQERSAAH RSMGYCPQSD AIFDLLTGRE
1910 1920 1930 1940 1950
HLELFARLRG VPEAQVAQTA LSGLVRLGLP SYADRPAGTY SGGNKRKLAT
1960 1970 1980 1990 2000
ALALVGDPAV VFLDEPTTGM DPSARRFLWN SLLSVVREGR SVVLTSHSME
2010 2020 2030 2040 2050
ECEALCTRLA IMVNGRFRCL GSSQHLKGRF GAGHTLTLRV PPDQPEPAIA
2060 2070 2080 2090 2100
FIRITFPGAE LREVHGSRLR FQLPPGGRCT LTRVFRELAA QGRAHGVEDF
2110 2120 2130 2140 2150
SVSQTTLEEV FLYFSKDQGE EEESSRQEAE EEEVSKPGRQ HPKRVSRFLE

DPSSVETMI
Length:2,159
Mass (Da):236,884
Last modified:December 1, 2001 - v1
Checksum:iCD2BE3FE0D8B822B
GO

Sequence cautioni

The sequence AAF31434.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1944 – 19441N → D in AAF31434. (PubMed:10708515)Curated
Sequence conflicti2004 – 20041A → R in AAF31434. (PubMed:10708515)Curated
Sequence conflicti2069 – 20691L → M in AAF31434. (PubMed:10708515)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287141 mRNA. Translation: AAK56862.1.
AF287142 Genomic DNA. Translation: AAK56863.1.
AF213395 mRNA. Translation: AAF31434.1. Frameshift.
CCDSiCCDS24004.1.
RefSeqiNP_038878.1. NM_013850.1.
UniGeneiMm.103351.

Genome annotation databases

EnsembliENSMUST00000043866; ENSMUSP00000043090; ENSMUSG00000035722.
ENSMUST00000132517; ENSMUSP00000115111; ENSMUSG00000035722.
GeneIDi27403.
KEGGimmu:27403.
UCSCiuc007gba.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287141 mRNA. Translation: AAK56862.1 .
AF287142 Genomic DNA. Translation: AAK56863.1 .
AF213395 mRNA. Translation: AAF31434.1 . Frameshift.
CCDSi CCDS24004.1.
RefSeqi NP_038878.1. NM_013850.1.
UniGenei Mm.103351.

3D structure databases

ProteinModelPortali Q91V24.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91V24.

Proteomic databases

MaxQBi Q91V24.
PaxDbi Q91V24.
PRIDEi Q91V24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043866 ; ENSMUSP00000043090 ; ENSMUSG00000035722 .
ENSMUST00000132517 ; ENSMUSP00000115111 ; ENSMUSG00000035722 .
GeneIDi 27403.
KEGGi mmu:27403.
UCSCi uc007gba.1. mouse.

Organism-specific databases

CTDi 10347.
MGIi MGI:1351646. Abca7.

Phylogenomic databases

eggNOGi COG1131.
GeneTreei ENSGT00760000118965.
HOVERGENi HBG050436.
InParanoidi Q91V24.
KOi K05645.
OrthoDBi EOG78D7J6.

Enzyme and pathway databases

Reactomei REACT_197984. ABCA transporters in lipid homeostasis.

Miscellaneous databases

NextBioi 305402.
PROi Q91V24.
SOURCEi Search...

Gene expression databases

Bgeei Q91V24.
ExpressionAtlasi Q91V24. baseline and differential.
Genevestigatori Q91V24.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR19229. PTHR19229. 1 hit.
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter."
    Broccardo C., Osorio J., Luciani M.-F., Schriml L.M., Prades C., Shulenin S., Arnould I., Naudin L., Lafargue C., Rosier M., Jordan B., Mattei M.-G., Dean M., Denefle P., Chimini G.
    Cytogenet. Cell Genet. 92:264-270(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: DBA/2.
    Tissue: Lymphoma.
  2. "Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus."
    Schriml L.M., Dean M.
    Genomics 64:24-31(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1920-2159.
    Strain: C57BL/6J.
  3. "ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux."
    Wang N., Lan D., Gerbod-Giannone M., Linsel-Nitschke P., Jehle A.W., Chen W., Martinez L.O., Tall A.R.
    J. Biol. Chem. 278:42906-42912(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  4. "Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver."
    Wakaumi M., Ishibashi K., Ando H., Kasanuki H., Tsuruoka S.
    Clin. Exp. Pharmacol. Physiol. 32:1034-1041(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. "Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels."
    Kim W.S., Fitzgerald M.L., Kang K., Okuhira K., Bell S.A., Manning J.J., Koehn S.L., Lu N., Moore K.J., Freeman M.W.
    J. Biol. Chem. 280:3989-3995(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  6. "ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages."
    Jehle A.W., Gardai S.J., Li S., Linsel-Nitschke P., Morimoto K., Janssen W.J., Vandivier R.W., Wang N., Greenberg S., Dale B.M., Qin C., Henson P.M., Tall A.R.
    J. Cell Biol. 174:547-556(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  7. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiABCA7_MOUSE
AccessioniPrimary (citable) accession number: Q91V24
Secondary accession number(s): Q9JL36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3