Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q91V24

- ABCA7_MOUSE

UniProt

Q91V24 - ABCA7_MOUSE

Protein

ATP-binding cassette sub-family A member 7

Gene

Abca7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi838 – 8458ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1841 – 18488ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. apolipoprotein A-I receptor activity Source: Alzheimers_University_of_Toronto
    2. ATPase activity Source: InterPro
    3. ATP binding Source: UniProtKB-KW
    4. phospholipid transporter activity Source: MGI
    5. protein binding Source: Alzheimers_University_of_Toronto

    GO - Biological processi

    1. apolipoprotein A-I-mediated signaling pathway Source: Alzheimers_University_of_Toronto
    2. cholesterol efflux Source: Alzheimers_University_of_Toronto
    3. high-density lipoprotein particle assembly Source: Alzheimers_University_of_Toronto
    4. memory Source: Alzheimers_University_of_Toronto
    5. negative regulation of amyloid precursor protein biosynthetic process Source: Alzheimers_University_of_Toronto
    6. negative regulation of ATPase activity Source: Alzheimers_University_of_Toronto
    7. negative regulation of beta-amyloid formation Source: Alzheimers_University_of_Toronto
    8. peptide cross-linking Source: Alzheimers_University_of_Toronto
    9. phagocytosis Source: UniProtKB-KW
    10. phospholipid efflux Source: MGI
    11. phospholipid scrambling Source: Alzheimers_University_of_Toronto
    12. positive regulation of ATPase activity Source: Alzheimers_University_of_Toronto
    13. positive regulation of beta-amyloid clearance Source: Alzheimers_University_of_Toronto
    14. positive regulation of cholesterol efflux Source: Alzheimers_University_of_Toronto
    15. positive regulation of engulfment of apoptotic cell Source: Alzheimers_University_of_Toronto
    16. positive regulation of ERK1 and ERK2 cascade Source: Alzheimers_University_of_Toronto
    17. positive regulation of phagocytosis Source: Alzheimers_University_of_Toronto
    18. positive regulation of phospholipid efflux Source: Alzheimers_University_of_Toronto
    19. protein localization to nucleus Source: Alzheimers_University_of_Toronto

    Keywords - Biological processi

    Phagocytosis, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_197984. ABCA transporters in lipid homeostasis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family A member 7
    Gene namesi
    Name:Abca7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1351646. Abca7.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein
    Note: Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney.

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. cell surface Source: Alzheimers_University_of_Toronto
    3. endosome membrane Source: UniProtKB-SubCell
    4. Golgi membrane Source: UniProtKB-SubCell
    5. integral component of membrane Source: UniProtKB-KW
    6. intracellular Source: MGI
    7. phagocytic cup Source: Alzheimers_University_of_Toronto
    8. plasma membrane Source: Alzheimers_University_of_Toronto
    9. ruffle membrane Source: Alzheimers_University_of_Toronto

    Keywords - Cellular componenti

    Cell membrane, Endosome, Golgi apparatus, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    According to PubMed:16908670, mice are not viable and heterozygous knockout mice display impaired phagocytosis of apoptotic cells. Depletion of Abca7 in macrophages by RNAi reduces phagocytosis of apoptotic cells. According to PubMed:15550377, mice are viable and females have less visceral fat and lower total serum and high density lipoprotein cholesterol level.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21592159ATP-binding cassette sub-family A member 7PRO_0000250675Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi75 ↔ 222By similarity
    Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1359 ↔ 1373By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ91V24.
    PRIDEiQ91V24.

    PTM databases

    PhosphoSiteiQ91V24.

    Expressioni

    Tissue specificityi

    Widely expressed with higher expression in brain, lung, adrenal gland and spleen (at protein level). Highly expressed in spleen and hematopoietic tissues.3 Publications

    Developmental stagei

    Widely expressed during embryogenesis.1 Publication

    Inductioni

    Down-regulated by digoxin.1 Publication

    Gene expression databases

    ArrayExpressiQ91V24.
    BgeeiQ91V24.
    GenevestigatoriQ91V24.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91V24.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini43 – 546504ExtracellularBy similarityAdd
    BLAST
    Topological domaini1267 – 1551285ExtracellularBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei547 – 56721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei590 – 61021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei623 – 64321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei652 – 67221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei678 – 69821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei732 – 75221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei846 – 86621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1246 – 126621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1552 – 157221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1598 – 161821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1635 – 165521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1663 – 168321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1743 – 176321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini804 – 1035232ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1807 – 2039233ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1131.
    GeneTreeiENSGT00720000108414.
    HOVERGENiHBG050436.
    InParanoidiQ91V24.
    KOiK05645.
    OrthoDBiEOG78D7J6.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR026082. ABC_A.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR19229. PTHR19229. 1 hit.
    PfamiPF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91V24-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALGTQLMLL LWKNYTYRRR QPIQLLVELL WPLFLFFILV AVRHSHPPLE     50
    HHECHFPNKP LPSAGTVPWL QGLVCNVNNS CFQHPTPGEK PGVLSNFKDS 100
    LISRLLADTR TVLGGHSIQD MLDALGKLIP VLRAVGGGAR PQESDQPTSQ 150
    GSVTKLLEKI LQRASLDPVL GQAQDSMRKF SDAIRDLAQE LLTLPSLMEL 200
    RALLRRPRGS AGSLELVSEA LCSTKGPSSP GGLSLNWYEA NQLNEFMGPE 250
    VAPALPDNSL SPACSEFVGT LDDHPVSRLL WRRLKPLILG KILFAPDTNF 300
    TRKLMAQVNQ TFEELALLRD LHELWGVLGP QIFNFMNDST NVAMLQRLLD 350
    VGGTGQRQQT PRAQKKLEAI KDFLDPSRGG YSWREAHADM GRLAGILGQM 400
    MECVSLDKLE AVPSEEALVS RALELLGERR LWAGIVFLSP EHPLDPSELS 450
    SPALSPGHLR FKIRMDIDDV TRTNKIRDKF WDPGPSADPF MDLRYVWGGF 500
    VYLQDLLEQA AVRVLGGGNS RTGLYLQQMP HPCYVDDVFL RVLSRSLPLF 550
    LTLAWIYSVA LTVKAVVREK ETRLRETMRA MGLSRAVLWL GWFLSCLGPF 600
    LVSAALLVLV LKLGNILPYS HPVVIFLFLA AFAVATVAQS FLLSAFFSRA 650
    NLAAACGGLA YFALYLPYVL CVAWRERLHL GGLLAASLLS PVAFGFGCES 700
    LALLEEQGDG AQWHNLGTGP AEDVFSLAQV SAFLLLDAVI YGLALWYLEA 750
    VCPGQYGIPE PWNFPFRRSY WCGPGPPKSS VLAPAPQDPK VLVEEPPLGL 800
    VPGVSIRGLK KHFRGCPQPA LQGLNLDFYE GHITAFLGHN GAGKTTTLSI 850
    LSGLFPPSSG SASILGHDVQ TNMAAIRPHL GICPQYNVLF DMLTVEEHVW 900
    FYGRLKGVSA AAMGPERERL IRDVGLTLKR DTQTRHLSGG MQRKLSVAIA 950
    FVGGSRVVIM DEPTAGVDPA SRRGIWELLL KYREGRTLIL STHHLDEAEL 1000
    LGDRVAMVAG GSLCCCGSPL FLRRHLGCGY YLTLVKSSQS LVTHDAKGDS 1050
    EDPRREKKSD GNGRTSDTAF TRGTSDKSNQ APAPGAVPIT PSTARILELV 1100
    QQHVPGAQLV EDLPHELLLV LPYAGALDGS FAMVFQELDQ QLELLGLTGY 1150
    GISDTNLEEI FLKVVEDAHR EGGDSRPQLH LRTCTPQPPT GPEASVLENG 1200
    ELAPQGLAPN AAQVQGWTLT CQQLRALLHK RFLLARRSRR GLFAQVVLPA 1250
    LFVGLALFFS LIVPPFGQYP PLQLSPAMYG PQVSFFSEDA PGDPNRMKLL 1300
    EALLGEAGLQ EPSMQDKDAR GSECTHSLAC YFTVPEVPPD VASILASGNW 1350
    TPESPSPACQ CSQPGARRLL PDCPAGAGGP PPPQAVAGLG EVVQNLTGRN 1400
    VSDFLVKTYP SLVRRGLKTK KWVDEVRYGG FSLGGRDPDL PTGHEVVRTL 1450
    AEIRALLSPQ PGNALDRILN NLTQWALGLD ARNSLKIWFN NKGWHAMVAF 1500
    VNRANNGLLH ALLPSGPVRH AHSITTLNHP LNLTKEQLSE ATLIASSVDV 1550
    LVSICVVFAM SFVPASFTLV LIEERITRAK HLQLVSGLPQ TLYWLGNFLW 1600
    DMCNYLVAVC IVVFIFLAFQ QRAYVAPENL PALLLLLLLY GWSITPLMYP 1650
    ASFFFSVPST AYVVLTCINL FIGINSSMAT FVLELLSDQN LQEVSRILKQ 1700
    VFLIFPHFCL GRGLIDMVRN QAMADAFERL GDKQFQSPLR WDIIGKNLLA 1750
    MMAQGPLFLL ITLLLQHRNR LLPQSKPRLL PPLGEEDEDV AQERERVTKG 1800
    ATQGDVLVLR DLTKVYRGQR NPAVDRLCLG IPPGECFGLL GVNGAGKTST 1850
    FRMVTGDTLP SSGEAVLAGH NVAQERSAAH RSMGYCPQSD AIFDLLTGRE 1900
    HLELFARLRG VPEAQVAQTA LSGLVRLGLP SYADRPAGTY SGGNKRKLAT 1950
    ALALVGDPAV VFLDEPTTGM DPSARRFLWN SLLSVVREGR SVVLTSHSME 2000
    ECEALCTRLA IMVNGRFRCL GSSQHLKGRF GAGHTLTLRV PPDQPEPAIA 2050
    FIRITFPGAE LREVHGSRLR FQLPPGGRCT LTRVFRELAA QGRAHGVEDF 2100
    SVSQTTLEEV FLYFSKDQGE EEESSRQEAE EEEVSKPGRQ HPKRVSRFLE 2150
    DPSSVETMI 2159
    Length:2,159
    Mass (Da):236,884
    Last modified:December 1, 2001 - v1
    Checksum:iCD2BE3FE0D8B822B
    GO

    Sequence cautioni

    The sequence AAF31434.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1944 – 19441N → D in AAF31434. (PubMed:10708515)Curated
    Sequence conflicti2004 – 20041A → R in AAF31434. (PubMed:10708515)Curated
    Sequence conflicti2069 – 20691L → M in AAF31434. (PubMed:10708515)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF287141 mRNA. Translation: AAK56862.1.
    AF287142 Genomic DNA. Translation: AAK56863.1.
    AF213395 mRNA. Translation: AAF31434.1. Frameshift.
    CCDSiCCDS24004.1.
    RefSeqiNP_038878.1. NM_013850.1.
    UniGeneiMm.103351.

    Genome annotation databases

    EnsembliENSMUST00000043866; ENSMUSP00000043090; ENSMUSG00000035722.
    ENSMUST00000132517; ENSMUSP00000115111; ENSMUSG00000035722.
    GeneIDi27403.
    KEGGimmu:27403.
    UCSCiuc007gba.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF287141 mRNA. Translation: AAK56862.1 .
    AF287142 Genomic DNA. Translation: AAK56863.1 .
    AF213395 mRNA. Translation: AAF31434.1 . Frameshift.
    CCDSi CCDS24004.1.
    RefSeqi NP_038878.1. NM_013850.1.
    UniGenei Mm.103351.

    3D structure databases

    ProteinModelPortali Q91V24.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91V24.

    Proteomic databases

    PaxDbi Q91V24.
    PRIDEi Q91V24.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043866 ; ENSMUSP00000043090 ; ENSMUSG00000035722 .
    ENSMUST00000132517 ; ENSMUSP00000115111 ; ENSMUSG00000035722 .
    GeneIDi 27403.
    KEGGi mmu:27403.
    UCSCi uc007gba.1. mouse.

    Organism-specific databases

    CTDi 10347.
    MGIi MGI:1351646. Abca7.

    Phylogenomic databases

    eggNOGi COG1131.
    GeneTreei ENSGT00720000108414.
    HOVERGENi HBG050436.
    InParanoidi Q91V24.
    KOi K05645.
    OrthoDBi EOG78D7J6.

    Enzyme and pathway databases

    Reactomei REACT_197984. ABCA transporters in lipid homeostasis.

    Miscellaneous databases

    NextBioi 305402.
    PROi Q91V24.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91V24.
    Bgeei Q91V24.
    Genevestigatori Q91V24.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR026082. ABC_A.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR19229. PTHR19229. 1 hit.
    Pfami PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter."
      Broccardo C., Osorio J., Luciani M.-F., Schriml L.M., Prades C., Shulenin S., Arnould I., Naudin L., Lafargue C., Rosier M., Jordan B., Mattei M.-G., Dean M., Denefle P., Chimini G.
      Cytogenet. Cell Genet. 92:264-270(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: DBA/2.
      Tissue: Lymphoma.
    2. "Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus."
      Schriml L.M., Dean M.
      Genomics 64:24-31(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1920-2159.
      Strain: C57BL/6J.
    3. "ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux."
      Wang N., Lan D., Gerbod-Giannone M., Linsel-Nitschke P., Jehle A.W., Chen W., Martinez L.O., Tall A.R.
      J. Biol. Chem. 278:42906-42912(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    4. "Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver."
      Wakaumi M., Ishibashi K., Ando H., Kasanuki H., Tsuruoka S.
      Clin. Exp. Pharmacol. Physiol. 32:1034-1041(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    5. "Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels."
      Kim W.S., Fitzgerald M.L., Kang K., Okuhira K., Bell S.A., Manning J.J., Koehn S.L., Lu N., Moore K.J., Freeman M.W.
      J. Biol. Chem. 280:3989-3995(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    6. "ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages."
      Jehle A.W., Gardai S.J., Li S., Linsel-Nitschke P., Morimoto K., Janssen W.J., Vandivier R.W., Wang N., Greenberg S., Dale B.M., Qin C., Henson P.M., Tall A.R.
      J. Cell Biol. 174:547-556(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
    7. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiABCA7_MOUSE
    AccessioniPrimary (citable) accession number: Q91V24
    Secondary accession number(s): Q9JL36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3