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Q91V24

- ABCA7_MOUSE

UniProt

Q91V24 - ABCA7_MOUSE

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Protein

ATP-binding cassette sub-family A member 7

Gene
Abca7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi838 – 8458ATP 1 Reviewed prediction
Nucleotide bindingi1841 – 18488ATP 2 Reviewed prediction

GO - Molecular functioni

  1. apolipoprotein A-I receptor activity Source: Alzheimers_University_of_Toronto
  2. ATPase activity Source: InterPro
  3. ATP binding Source: UniProtKB-KW
  4. phospholipid transporter activity Source: MGI
  5. protein binding Source: Alzheimers_University_of_Toronto

GO - Biological processi

  1. apolipoprotein A-I-mediated signaling pathway Source: Alzheimers_University_of_Toronto
  2. cholesterol efflux Source: Alzheimers_University_of_Toronto
  3. high-density lipoprotein particle assembly Source: Alzheimers_University_of_Toronto
  4. memory Source: Alzheimers_University_of_Toronto
  5. negative regulation of amyloid precursor protein biosynthetic process Source: Alzheimers_University_of_Toronto
  6. negative regulation of ATPase activity Source: Alzheimers_University_of_Toronto
  7. negative regulation of beta-amyloid formation Source: Alzheimers_University_of_Toronto
  8. peptide cross-linking Source: Alzheimers_University_of_Toronto
  9. phagocytosis Source: UniProtKB-KW
  10. phospholipid efflux Source: MGI
  11. phospholipid scrambling Source: Alzheimers_University_of_Toronto
  12. positive regulation of ATPase activity Source: Alzheimers_University_of_Toronto
  13. positive regulation of beta-amyloid clearance Source: Alzheimers_University_of_Toronto
  14. positive regulation of cholesterol efflux Source: Alzheimers_University_of_Toronto
  15. positive regulation of engulfment of apoptotic cell Source: Alzheimers_University_of_Toronto
  16. positive regulation of ERK1 and ERK2 cascade Source: Alzheimers_University_of_Toronto
  17. positive regulation of phagocytosis Source: Alzheimers_University_of_Toronto
  18. positive regulation of phospholipid efflux Source: Alzheimers_University_of_Toronto
  19. protein localization to nucleus Source: Alzheimers_University_of_Toronto
Complete GO annotation...

Keywords - Biological processi

Phagocytosis, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_197984. ABCA transporters in lipid homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 7
Gene namesi
Name:Abca7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1351646. Abca7.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein
Note: Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney.2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221Helical; Reviewed predictionAdd
BLAST
Topological domaini43 – 546504Extracellular By similarityAdd
BLAST
Transmembranei547 – 56721Helical; Reviewed predictionAdd
BLAST
Transmembranei590 – 61021Helical; Reviewed predictionAdd
BLAST
Transmembranei623 – 64321Helical; Reviewed predictionAdd
BLAST
Transmembranei652 – 67221Helical; Reviewed predictionAdd
BLAST
Transmembranei678 – 69821Helical; Reviewed predictionAdd
BLAST
Transmembranei732 – 75221Helical; Reviewed predictionAdd
BLAST
Transmembranei846 – 86621Helical; Reviewed predictionAdd
BLAST
Transmembranei1246 – 126621Helical; Reviewed predictionAdd
BLAST
Topological domaini1267 – 1551285Extracellular By similarityAdd
BLAST
Transmembranei1552 – 157221Helical; Reviewed predictionAdd
BLAST
Transmembranei1598 – 161821Helical; Reviewed predictionAdd
BLAST
Transmembranei1635 – 165521Helical; Reviewed predictionAdd
BLAST
Transmembranei1663 – 168321Helical; Reviewed predictionAdd
BLAST
Transmembranei1743 – 176321Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. cell surface Source: Alzheimers_University_of_Toronto
  3. endosome membrane Source: UniProtKB-SubCell
  4. Golgi membrane Source: UniProtKB-SubCell
  5. integral component of membrane Source: UniProtKB-KW
  6. intracellular Source: MGI
  7. phagocytic cup Source: Alzheimers_University_of_Toronto
  8. plasma membrane Source: Alzheimers_University_of_Toronto
  9. ruffle membrane Source: Alzheimers_University_of_Toronto
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

According to 1 Publication, mice are not viable and heterozygous knockout mice display impaired phagocytosis of apoptotic cells. Depletion of Abca7 in macrophages by RNAi reduces phagocytosis of apoptotic cells. According to 1 Publication, mice are viable and females have less visceral fat and lower total serum and high density lipoprotein cholesterol level.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21592159ATP-binding cassette sub-family A member 7PRO_0000250675Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi75 ↔ 222 By similarity
Glycosylationi309 – 3091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1359 ↔ 1373 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91V24.
PRIDEiQ91V24.

PTM databases

PhosphoSiteiQ91V24.

Expressioni

Tissue specificityi

Widely expressed with higher expression in brain, lung, adrenal gland and spleen (at protein level). Highly expressed in spleen and hematopoietic tissues.3 Publications

Developmental stagei

Widely expressed during embryogenesis.1 Publication

Inductioni

Down-regulated by digoxin.1 Publication

Gene expression databases

ArrayExpressiQ91V24.
BgeeiQ91V24.
GenevestigatoriQ91V24.

Structurei

3D structure databases

ProteinModelPortaliQ91V24.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini804 – 1035232ABC transporter 1Add
BLAST
Domaini1807 – 2039233ABC transporter 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1131.
GeneTreeiENSGT00720000108414.
HOVERGENiHBG050436.
InParanoidiQ91V24.
KOiK05645.
OrthoDBiEOG78D7J6.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91V24-1 [UniParc]FASTAAdd to Basket

« Hide

MALGTQLMLL LWKNYTYRRR QPIQLLVELL WPLFLFFILV AVRHSHPPLE     50
HHECHFPNKP LPSAGTVPWL QGLVCNVNNS CFQHPTPGEK PGVLSNFKDS 100
LISRLLADTR TVLGGHSIQD MLDALGKLIP VLRAVGGGAR PQESDQPTSQ 150
GSVTKLLEKI LQRASLDPVL GQAQDSMRKF SDAIRDLAQE LLTLPSLMEL 200
RALLRRPRGS AGSLELVSEA LCSTKGPSSP GGLSLNWYEA NQLNEFMGPE 250
VAPALPDNSL SPACSEFVGT LDDHPVSRLL WRRLKPLILG KILFAPDTNF 300
TRKLMAQVNQ TFEELALLRD LHELWGVLGP QIFNFMNDST NVAMLQRLLD 350
VGGTGQRQQT PRAQKKLEAI KDFLDPSRGG YSWREAHADM GRLAGILGQM 400
MECVSLDKLE AVPSEEALVS RALELLGERR LWAGIVFLSP EHPLDPSELS 450
SPALSPGHLR FKIRMDIDDV TRTNKIRDKF WDPGPSADPF MDLRYVWGGF 500
VYLQDLLEQA AVRVLGGGNS RTGLYLQQMP HPCYVDDVFL RVLSRSLPLF 550
LTLAWIYSVA LTVKAVVREK ETRLRETMRA MGLSRAVLWL GWFLSCLGPF 600
LVSAALLVLV LKLGNILPYS HPVVIFLFLA AFAVATVAQS FLLSAFFSRA 650
NLAAACGGLA YFALYLPYVL CVAWRERLHL GGLLAASLLS PVAFGFGCES 700
LALLEEQGDG AQWHNLGTGP AEDVFSLAQV SAFLLLDAVI YGLALWYLEA 750
VCPGQYGIPE PWNFPFRRSY WCGPGPPKSS VLAPAPQDPK VLVEEPPLGL 800
VPGVSIRGLK KHFRGCPQPA LQGLNLDFYE GHITAFLGHN GAGKTTTLSI 850
LSGLFPPSSG SASILGHDVQ TNMAAIRPHL GICPQYNVLF DMLTVEEHVW 900
FYGRLKGVSA AAMGPERERL IRDVGLTLKR DTQTRHLSGG MQRKLSVAIA 950
FVGGSRVVIM DEPTAGVDPA SRRGIWELLL KYREGRTLIL STHHLDEAEL 1000
LGDRVAMVAG GSLCCCGSPL FLRRHLGCGY YLTLVKSSQS LVTHDAKGDS 1050
EDPRREKKSD GNGRTSDTAF TRGTSDKSNQ APAPGAVPIT PSTARILELV 1100
QQHVPGAQLV EDLPHELLLV LPYAGALDGS FAMVFQELDQ QLELLGLTGY 1150
GISDTNLEEI FLKVVEDAHR EGGDSRPQLH LRTCTPQPPT GPEASVLENG 1200
ELAPQGLAPN AAQVQGWTLT CQQLRALLHK RFLLARRSRR GLFAQVVLPA 1250
LFVGLALFFS LIVPPFGQYP PLQLSPAMYG PQVSFFSEDA PGDPNRMKLL 1300
EALLGEAGLQ EPSMQDKDAR GSECTHSLAC YFTVPEVPPD VASILASGNW 1350
TPESPSPACQ CSQPGARRLL PDCPAGAGGP PPPQAVAGLG EVVQNLTGRN 1400
VSDFLVKTYP SLVRRGLKTK KWVDEVRYGG FSLGGRDPDL PTGHEVVRTL 1450
AEIRALLSPQ PGNALDRILN NLTQWALGLD ARNSLKIWFN NKGWHAMVAF 1500
VNRANNGLLH ALLPSGPVRH AHSITTLNHP LNLTKEQLSE ATLIASSVDV 1550
LVSICVVFAM SFVPASFTLV LIEERITRAK HLQLVSGLPQ TLYWLGNFLW 1600
DMCNYLVAVC IVVFIFLAFQ QRAYVAPENL PALLLLLLLY GWSITPLMYP 1650
ASFFFSVPST AYVVLTCINL FIGINSSMAT FVLELLSDQN LQEVSRILKQ 1700
VFLIFPHFCL GRGLIDMVRN QAMADAFERL GDKQFQSPLR WDIIGKNLLA 1750
MMAQGPLFLL ITLLLQHRNR LLPQSKPRLL PPLGEEDEDV AQERERVTKG 1800
ATQGDVLVLR DLTKVYRGQR NPAVDRLCLG IPPGECFGLL GVNGAGKTST 1850
FRMVTGDTLP SSGEAVLAGH NVAQERSAAH RSMGYCPQSD AIFDLLTGRE 1900
HLELFARLRG VPEAQVAQTA LSGLVRLGLP SYADRPAGTY SGGNKRKLAT 1950
ALALVGDPAV VFLDEPTTGM DPSARRFLWN SLLSVVREGR SVVLTSHSME 2000
ECEALCTRLA IMVNGRFRCL GSSQHLKGRF GAGHTLTLRV PPDQPEPAIA 2050
FIRITFPGAE LREVHGSRLR FQLPPGGRCT LTRVFRELAA QGRAHGVEDF 2100
SVSQTTLEEV FLYFSKDQGE EEESSRQEAE EEEVSKPGRQ HPKRVSRFLE 2150
DPSSVETMI 2159
Length:2,159
Mass (Da):236,884
Last modified:December 1, 2001 - v1
Checksum:iCD2BE3FE0D8B822B
GO

Sequence cautioni

The sequence AAF31434.1 differs from that shown. Reason: Frameshift at several positions.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1944 – 19441N → D in AAF31434. 1 Publication
Sequence conflicti2004 – 20041A → R in AAF31434. 1 Publication
Sequence conflicti2069 – 20691L → M in AAF31434. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF287141 mRNA. Translation: AAK56862.1.
AF287142 Genomic DNA. Translation: AAK56863.1.
AF213395 mRNA. Translation: AAF31434.1. Frameshift.
CCDSiCCDS24004.1.
RefSeqiNP_038878.1. NM_013850.1.
UniGeneiMm.103351.

Genome annotation databases

EnsembliENSMUST00000043866; ENSMUSP00000043090; ENSMUSG00000035722.
ENSMUST00000132517; ENSMUSP00000115111; ENSMUSG00000035722.
GeneIDi27403.
KEGGimmu:27403.
UCSCiuc007gba.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF287141 mRNA. Translation: AAK56862.1 .
AF287142 Genomic DNA. Translation: AAK56863.1 .
AF213395 mRNA. Translation: AAF31434.1 . Frameshift.
CCDSi CCDS24004.1.
RefSeqi NP_038878.1. NM_013850.1.
UniGenei Mm.103351.

3D structure databases

ProteinModelPortali Q91V24.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91V24.

Proteomic databases

PaxDbi Q91V24.
PRIDEi Q91V24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043866 ; ENSMUSP00000043090 ; ENSMUSG00000035722 .
ENSMUST00000132517 ; ENSMUSP00000115111 ; ENSMUSG00000035722 .
GeneIDi 27403.
KEGGi mmu:27403.
UCSCi uc007gba.1. mouse.

Organism-specific databases

CTDi 10347.
MGIi MGI:1351646. Abca7.

Phylogenomic databases

eggNOGi COG1131.
GeneTreei ENSGT00720000108414.
HOVERGENi HBG050436.
InParanoidi Q91V24.
KOi K05645.
OrthoDBi EOG78D7J6.

Enzyme and pathway databases

Reactomei REACT_197984. ABCA transporters in lipid homeostasis.

Miscellaneous databases

NextBioi 305402.
PROi Q91V24.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91V24.
Bgeei Q91V24.
Genevestigatori Q91V24.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR19229. PTHR19229. 1 hit.
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter."
    Broccardo C., Osorio J., Luciani M.-F., Schriml L.M., Prades C., Shulenin S., Arnould I., Naudin L., Lafargue C., Rosier M., Jordan B., Mattei M.-G., Dean M., Denefle P., Chimini G.
    Cytogenet. Cell Genet. 92:264-270(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: DBA/2.
    Tissue: Lymphoma.
  2. "Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus."
    Schriml L.M., Dean M.
    Genomics 64:24-31(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1920-2159.
    Strain: C57BL/6J.
  3. "ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux."
    Wang N., Lan D., Gerbod-Giannone M., Linsel-Nitschke P., Jehle A.W., Chen W., Martinez L.O., Tall A.R.
    J. Biol. Chem. 278:42906-42912(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  4. "Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver."
    Wakaumi M., Ishibashi K., Ando H., Kasanuki H., Tsuruoka S.
    Clin. Exp. Pharmacol. Physiol. 32:1034-1041(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. "Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels."
    Kim W.S., Fitzgerald M.L., Kang K., Okuhira K., Bell S.A., Manning J.J., Koehn S.L., Lu N., Moore K.J., Freeman M.W.
    J. Biol. Chem. 280:3989-3995(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  6. "ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages."
    Jehle A.W., Gardai S.J., Li S., Linsel-Nitschke P., Morimoto K., Janssen W.J., Vandivier R.W., Wang N., Greenberg S., Dale B.M., Qin C., Henson P.M., Tall A.R.
    J. Cell Biol. 174:547-556(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  7. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiABCA7_MOUSE
AccessioniPrimary (citable) accession number: Q91V24
Secondary accession number(s): Q9JL36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi