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Protein

Liver-expressed antimicrobial peptide 2

Gene

Leap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has an antimicrobial activity.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Liver-expressed antimicrobial peptide 2
Short name:
LEAP-2
Gene namesi
Name:Leap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2672795. Leap2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 3614Sequence analysisPRO_0000017359Add
BLAST
Chaini37 – 7640Liver-expressed antimicrobial peptide 2PRO_0000017360Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 64By similarity
Disulfide bondi59 ↔ 69By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ91V13.
PRIDEiQ91V13.

Expressioni

Gene expression databases

BgeeiQ91V13.
CleanExiMM_LEAP2.
GenevisibleiQ91V13. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044166.

Structurei

3D structure databases

ProteinModelPortaliQ91V13.
SMRiQ91V13. Positions 37-76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LEAP2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7PZ. Eukaryota.
ENOG410Y6EA. LUCA.
GeneTreeiENSGT00390000013467.
HOGENOMiHOG000037938.
HOVERGENiHBG052319.
InParanoidiQ91V13.
OMAiMWHLKLL.
OrthoDBiEOG7673F2.
PhylomeDBiQ91V13.
TreeFamiTF336274.

Family and domain databases

InterProiIPR009955. LEAP-2.
[Graphical view]
PANTHERiPTHR21007. PTHR21007. 1 hit.
PfamiPF07359. LEAP-2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91V13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQLKLFAVL LTCLLLLGQV NSSPVPEVSS AKRSRRMTPF WRGVSLRPIG
60 70
ASCRDDSECI TRLCRKRRCS LSVAQE
Length:76
Mass (Da):8,536
Last modified:December 1, 2001 - v1
Checksum:iE0E1BE1595FE1ACC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ409055 mRNA. Translation: CAC51472.1.
AJ409063 Genomic DNA. Translation: CAC51519.1.
BC089593 mRNA. Translation: AAH89593.1.
CCDSiCCDS36150.1.
RefSeqiNP_694709.1. NM_153069.3.
UniGeneiMm.24283.

Genome annotation databases

EnsembliENSMUST00000036045; ENSMUSP00000044166; ENSMUSG00000036216.
GeneIDi259301.
KEGGimmu:259301.
UCSCiuc007ivx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ409055 mRNA. Translation: CAC51472.1.
AJ409063 Genomic DNA. Translation: CAC51519.1.
BC089593 mRNA. Translation: AAH89593.1.
CCDSiCCDS36150.1.
RefSeqiNP_694709.1. NM_153069.3.
UniGeneiMm.24283.

3D structure databases

ProteinModelPortaliQ91V13.
SMRiQ91V13. Positions 37-76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044166.

Proteomic databases

PaxDbiQ91V13.
PRIDEiQ91V13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036045; ENSMUSP00000044166; ENSMUSG00000036216.
GeneIDi259301.
KEGGimmu:259301.
UCSCiuc007ivx.1. mouse.

Organism-specific databases

CTDi116842.
MGIiMGI:2672795. Leap2.

Phylogenomic databases

eggNOGiENOG410J7PZ. Eukaryota.
ENOG410Y6EA. LUCA.
GeneTreeiENSGT00390000013467.
HOGENOMiHOG000037938.
HOVERGENiHBG052319.
InParanoidiQ91V13.
OMAiMWHLKLL.
OrthoDBiEOG7673F2.
PhylomeDBiQ91V13.
TreeFamiTF336274.

Miscellaneous databases

PROiQ91V13.
SOURCEiSearch...

Gene expression databases

BgeeiQ91V13.
CleanExiMM_LEAP2.
GenevisibleiQ91V13. MM.

Family and domain databases

InterProiIPR009955. LEAP-2.
[Graphical view]
PANTHERiPTHR21007. PTHR21007. 1 hit.
PfamiPF07359. LEAP-2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver."
    Krause A., Sillard R., Kleemeier B., Kluever E., Maronde E., Conejo-Garcia J.-R., Forssmann W.-G., Schulz-Knappe P., Nehls M.C., Wattler F., Wattler S., Adermann K.
    Protein Sci. 12:143-152(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv.
    Tissue: Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiLEAP2_MOUSE
AccessioniPrimary (citable) accession number: Q91V13
Secondary accession number(s): Q5EBH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.