Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q91V10

- VSX1_MOUSE

UniProt

Q91V10 - VSX1_MOUSE

Protein

Visual system homeobox 1

Gene

Vsx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at earlier stages of development By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi171 – 23060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. neuron development Source: MGI
    2. neuron maturation Source: MGI
    3. response to stimulus Source: UniProtKB-KW
    4. retinal bipolar neuron differentiation Source: MGI
    5. transcription, DNA-templated Source: UniProtKB-KW
    6. visual perception Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Sensory transduction, Transcription, Transcription regulation, Vision

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Visual system homeobox 1
    Alternative name(s):
    Homeodomain protein RINX
    Retinal inner nuclear layer homeobox protein
    Transcription factor VSX1
    Gene namesi
    Name:Vsx1
    Synonyms:Rinx
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1890816. Vsx1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Visual system homeobox 1PRO_0000049356Add
    BLAST

    Proteomic databases

    PRIDEiQ91V10.

    PTM databases

    PhosphoSiteiQ91V10.

    Expressioni

    Tissue specificityi

    In the adult, expressed exclusively in the cells of the neural retina with expression restricted to postnatal cone bipolar interneurons.

    Developmental stagei

    Expressed at P5, solely within the inner nuclear layer (INL) of the central neuroretina. By days P6 and P7, expression expands peripherally during neurogenesis. By P12, expression is restricted to the outer margin of the INL and reaches the outer periphery of the neuroretina.

    Gene expression databases

    ArrayExpressiQ91V10.
    BgeeiQ91V10.
    CleanExiMM_VSX1.
    GenevestigatoriQ91V10.

    Interactioni

    Protein-protein interaction databases

    BioGridi227900. 1 interaction.
    STRINGi10090.ENSMUSP00000039088.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91V10.
    SMRiQ91V10. Positions 178-227.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini231 – 28353CVCPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi31 – 388Octapeptide motif
    Motifi168 – 1736Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi44 – 12784Pro-richAdd
    BLAST
    Compositional biasi80 – 9314Gly/Leu-richAdd
    BLAST
    Compositional biasi142 – 15211Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the paired homeobox family.Curated
    Contains 1 CVC domain.PROSITE-ProRule annotation
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG237888.
    GeneTreeiENSGT00750000117223.
    HOGENOMiHOG000115909.
    HOVERGENiHBG036251.
    InParanoidiQ91V10.
    KOiK09335.
    OMAiWGSDHLK.
    OrthoDBiEOG76474B.
    PhylomeDBiQ91V10.
    TreeFamiTF350743.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR023339. CVC.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS51496. CVC. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91V10-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGRDGLSDA RSRSRALAPG CPPTGSRLRS FAINDLLGLE ADLPTPAEPG    50
    LRSNSGDPAE AIGSGPGPGP GLCGSCPARG ALPLGLGLLC GFGAQPPSAA 100
    AAARARCLLL ADLRLLPSAG PEPAVAQGPV HPPPALGSQQ RSESVSTSDG 150
    DSPSEEKNDP KMSLILGKRK KRRHRTVFTA HQLEELEKAF GEAHYPDVYA 200
    REMLAAKTEL PEDRIQVWFQ NRRAKWRKRE KRWGGSSVMA EYGLYGAMVR 250
    HCIPLPDSVL NSADSLQGSC APWLLGMHKK STGMRKPESE DKLAGLWEFD 300
    HLKKGANKDE DGPERGPDET TQNPENSLED VAIDLSSSSR QETKKMPPGS 350
    STQLPQPPQV GAS 363
    Length:363
    Mass (Da):38,755
    Last modified:December 1, 2001 - v1
    Checksum:iE250D452C77228C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY056825 mRNA. Translation: AAL11431.1.
    AF395732 mRNA. Translation: AAL08947.1.
    AF391757 Genomic DNA. Translation: AAL09584.1.
    AF391758 mRNA. Translation: AAL09585.1.
    BC057647 mRNA. Translation: AAH57647.1.
    CCDSiCCDS16860.1.
    PIRiJC7750.
    RefSeqiNP_473409.1. NM_054068.2.
    UniGeneiMm.207061.

    Genome annotation databases

    EnsembliENSMUST00000046095; ENSMUSP00000039088; ENSMUSG00000033080.
    GeneIDi114889.
    KEGGimmu:114889.
    UCSCiuc008muh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY056825 mRNA. Translation: AAL11431.1 .
    AF395732 mRNA. Translation: AAL08947.1 .
    AF391757 Genomic DNA. Translation: AAL09584.1 .
    AF391758 mRNA. Translation: AAL09585.1 .
    BC057647 mRNA. Translation: AAH57647.1 .
    CCDSi CCDS16860.1.
    PIRi JC7750.
    RefSeqi NP_473409.1. NM_054068.2.
    UniGenei Mm.207061.

    3D structure databases

    ProteinModelPortali Q91V10.
    SMRi Q91V10. Positions 178-227.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 227900. 1 interaction.
    STRINGi 10090.ENSMUSP00000039088.

    PTM databases

    PhosphoSitei Q91V10.

    Proteomic databases

    PRIDEi Q91V10.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046095 ; ENSMUSP00000039088 ; ENSMUSG00000033080 .
    GeneIDi 114889.
    KEGGi mmu:114889.
    UCSCi uc008muh.2. mouse.

    Organism-specific databases

    CTDi 30813.
    MGIi MGI:1890816. Vsx1.

    Phylogenomic databases

    eggNOGi NOG237888.
    GeneTreei ENSGT00750000117223.
    HOGENOMi HOG000115909.
    HOVERGENi HBG036251.
    InParanoidi Q91V10.
    KOi K09335.
    OMAi WGSDHLK.
    OrthoDBi EOG76474B.
    PhylomeDBi Q91V10.
    TreeFami TF350743.

    Miscellaneous databases

    NextBioi 368909.
    PROi Q91V10.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91V10.
    Bgeei Q91V10.
    CleanExi MM_VSX1.
    Genevestigatori Q91V10.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR023339. CVC.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS51496. CVC. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Vsx1, a rapidly evolving paired-like homeobox gene expressed in cone bipolar cells."
      Chow R.L., Snow B., Novak J., Looser J., Freund C., Vidgen D., Ploder L., McInnes R.R.
      Mech. Dev. 109:315-322(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Retina.
    2. "Isolation and characterization of Vsx1, a novel mouse CVC paired-like homeobox gene expressed during embryogenesis and in the retina."
      Ohtoshi A., Justice M.J., Behringer R.R.
      Biochem. Biophys. Res. Commun. 286:133-140(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss.
    3. "Expression of rinx/vsx1 during postnatal eye development in cone-bipolar, differentiating ganglion, and lens fiber cells."
      Hayashi T., Huang J., Deeb S.S.
      Jpn. J. Ophthalmol. 49:93-105(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvJ.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiVSX1_MOUSE
    AccessioniPrimary (citable) accession number: Q91V10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3