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Protein

C-type lectin domain family 2 member D

Gene

Clec2d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Binds high molecular weight sulfated glycosaminoglycans.4 Publications

GO - Molecular functioni

  • carbohydrate binding Source: MGI
  • natural killer cell lectin-like receptor binding Source: MGI
  • transmembrane signaling receptor activity Source: MGI

GO - Biological processi

  • cellular defense response Source: MGI
  • negative regulation of osteoclast differentiation Source: MGI
  • protection from natural killer cell mediated cytotoxicity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 2 member D
Alternative name(s):
C-type lectin-related protein B
Short name:
Clr-b
Lectin-like transmembrane protein
Osteoclast inhibitory lectin
Gene namesi
Name:Clec2d
Synonyms:Clrb, Ocil
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2135589. Clec2d.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141CytoplasmicSequence analysisAdd
BLAST
Transmembranei42 – 6221Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini63 – 207145ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207C-type lectin domain family 2 member DPRO_0000315286Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphoserineCombined sources
Modified residuei12 – 121PhosphoserineCombined sources
Disulfide bondi80 ↔ 91PROSITE-ProRule annotation
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ91V08.
MaxQBiQ91V08.
PaxDbiQ91V08.
PRIDEiQ91V08.

PTM databases

iPTMnetiQ91V08.
PhosphoSiteiQ91V08.
SwissPalmiQ91V08.

Expressioni

Tissue specificityi

Detected in fetal heart, brain, lung, chondrocytes, perichondrium and osteoblasts, and in adult splenocytes, thymocytes, lymph-node cells, osteoblasts, growth plate chondrocytes and skeltal muscle overlying the bone (at protein level). Ubiquitous. Detected in thymus, bone marrow, lung, gut, heart, skeletal muscle, ovary, spleen, ileum, liver and kidney.5 Publications

Inductioni

Constitutively expressed in bone marrow cells. Down-regulated by treatment with 1,25-dihydroxyvitamin D3. Up-regulated in calvarial osteoblast cells by IL-1alpha, IL11, and 1,25-dihydroxyvitamin D3.1 Publication

Gene expression databases

BgeeiENSMUSG00000030157.
CleanExiMM_CLEC2D.
ExpressionAtlasiQ91V08. baseline and differential.
GenevisibleiQ91V08. MM.

Interactioni

Subunit structurei

Homodimer or heterodimer; disulfide-linked.By similarity

GO - Molecular functioni

  • natural killer cell lectin-like receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032260.

Structurei

3D structure databases

ProteinModelPortaliQ91V08.
SMRiQ91V08. Positions 73-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini87 – 202116C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00710000106527.
HOGENOMiHOG000060206.
HOVERGENiHBG107716.
InParanoidiQ91V08.
OMAiNTEYNNT.
OrthoDBiEOG091G0NP8.
PhylomeDBiQ91V08.
TreeFamiTF351467.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91V08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCVTKASLPM LSPTGSPQEV EVGKILQGKR HGTISPESCA KLYCYYGVIM
60 70 80 90 100
VLTVAVIALS VALSATKTEQ IPVNKTYAAC PQNWIGVENK CFYFSEYPSN
110 120 130 140 150
WTFAQAFCMA QEAQLARFDN QDELNFLMRY KANFDSWIGL HRESSEHPWK
160 170 180 190 200
WTDNTEYNNT IPIRGEERFA YLNNNGISST RIYSLRMWIC SKLNSYSLHC

QTPFFPS
Length:207
Mass (Da):23,647
Last modified:December 1, 2001 - v1
Checksum:iE4340FCB1E0BD718
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF350409 mRNA. Translation: AAK70357.1.
AF320598 Genomic DNA. Translation: AAL37198.1.
AF320599 Genomic DNA. Translation: AAL37199.1.
AF321553 mRNA. Translation: AAK50881.1.
AY137338 Genomic DNA. Translation: AAN15947.1.
AY320031 mRNA. Translation: AAQ16529.1.
BC106776 mRNA. Translation: AAI06777.1.
DQ143111 Genomic DNA. Translation: ABA43361.1.
CCDSiCCDS20581.1.
RefSeqiNP_444339.1. NM_053109.3.
UniGeneiMm.197536.

Genome annotation databases

EnsembliENSMUST00000032260; ENSMUSP00000032260; ENSMUSG00000030157.
GeneIDi93694.
KEGGimmu:93694.
UCSCiuc009efe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF350409 mRNA. Translation: AAK70357.1.
AF320598 Genomic DNA. Translation: AAL37198.1.
AF320599 Genomic DNA. Translation: AAL37199.1.
AF321553 mRNA. Translation: AAK50881.1.
AY137338 Genomic DNA. Translation: AAN15947.1.
AY320031 mRNA. Translation: AAQ16529.1.
BC106776 mRNA. Translation: AAI06777.1.
DQ143111 Genomic DNA. Translation: ABA43361.1.
CCDSiCCDS20581.1.
RefSeqiNP_444339.1. NM_053109.3.
UniGeneiMm.197536.

3D structure databases

ProteinModelPortaliQ91V08.
SMRiQ91V08. Positions 73-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032260.

PTM databases

iPTMnetiQ91V08.
PhosphoSiteiQ91V08.
SwissPalmiQ91V08.

Proteomic databases

EPDiQ91V08.
MaxQBiQ91V08.
PaxDbiQ91V08.
PRIDEiQ91V08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032260; ENSMUSP00000032260; ENSMUSG00000030157.
GeneIDi93694.
KEGGimmu:93694.
UCSCiuc009efe.2. mouse.

Organism-specific databases

CTDi29121.
MGIiMGI:2135589. Clec2d.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00710000106527.
HOGENOMiHOG000060206.
HOVERGENiHBG107716.
InParanoidiQ91V08.
OMAiNTEYNNT.
OrthoDBiEOG091G0NP8.
PhylomeDBiQ91V08.
TreeFamiTF351467.

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSiClec2d. mouse.
PROiQ91V08.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030157.
CleanExiMM_CLEC2D.
ExpressionAtlasiQ91V08. baseline and differential.
GenevisibleiQ91V08. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLC2D_MOUSE
AccessioniPrimary (citable) accession number: Q91V08
Secondary accession number(s): Q1AFZ3, Q8VI19, Q8VI20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.