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Protein

C-type lectin domain family 2 member D

Gene

Clec2d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis (PubMed:14990792, PubMed:16751398). Inhibits osteoclast formation (PubMed:11278931, PubMed:12374791). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).5 Publications

GO - Molecular functioni

  • carbohydrate binding Source: MGI
  • natural killer cell lectin-like receptor binding Source: MGI
  • transmembrane signaling receptor activity Source: MGI

GO - Biological processi

  • cellular defense response Source: MGI
  • negative regulation of osteoclast differentiation Source: MGI
  • protection from natural killer cell mediated cytotoxicity Source: MGI

Keywordsi

Molecular functionReceptor
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 2 member D
Alternative name(s):
C-type lectin-related protein B
Short name:
Clr-b
Lectin-like transmembrane protein
Osteoclast inhibitory lectin
Gene namesi
Name:Clec2d
Synonyms:Clrb, Ocil
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2135589. Clec2d.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini63 – 207ExtracellularSequence analysisAdd BLAST145

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003152861 – 207C-type lectin domain family 2 member DAdd BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineCombined sources1
Modified residuei12PhosphoserineCombined sources1
Disulfide bondi80 ↔ 91PROSITE-ProRule annotation
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ91V08.
MaxQBiQ91V08.
PaxDbiQ91V08.
PRIDEiQ91V08.

PTM databases

iPTMnetiQ91V08.
PhosphoSitePlusiQ91V08.
SwissPalmiQ91V08.

Expressioni

Tissue specificityi

Detected in fetal heart, brain, lung, chondrocytes, perichondrium and osteoblasts, and in adult splenocytes, thymocytes, lymph-node cells, osteoblasts, growth plate chondrocytes and skeltal muscle overlying the bone (at protein level). Ubiquitous. Detected in thymus, bone marrow, lung, gut, heart, skeletal muscle, ovary, spleen, ileum, liver and kidney.5 Publications

Inductioni

Constitutively expressed in bone marrow cells. Down-regulated by treatment with 1,25-dihydroxyvitamin D3. Up-regulated in calvarial osteoblast cells by IL-1alpha, IL11, and 1,25-dihydroxyvitamin D3.1 Publication

Gene expression databases

BgeeiENSMUSG00000030157.
CleanExiMM_CLEC2D.
ExpressionAtlasiQ91V08. baseline and differential.
GenevisibleiQ91V08. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

  • natural killer cell lectin-like receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032260.

Structurei

3D structure databases

ProteinModelPortaliQ91V08.
SMRiQ91V08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 202C-type lectinPROSITE-ProRule annotationAdd BLAST116

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00710000106527.
HOGENOMiHOG000060206.
HOVERGENiHBG107716.
InParanoidiQ91V08.
OMAiRENTEAW.
OrthoDBiEOG091G0NP8.
PhylomeDBiQ91V08.
TreeFamiTF351467.

Family and domain databases

CDDicd03593. CLECT_NK_receptors_like. 1 hit.
Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR033992. NKR-like_CTLD.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS50041. C_TYPE_LECTIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91V08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCVTKASLPM LSPTGSPQEV EVGKILQGKR HGTISPESCA KLYCYYGVIM
60 70 80 90 100
VLTVAVIALS VALSATKTEQ IPVNKTYAAC PQNWIGVENK CFYFSEYPSN
110 120 130 140 150
WTFAQAFCMA QEAQLARFDN QDELNFLMRY KANFDSWIGL HRESSEHPWK
160 170 180 190 200
WTDNTEYNNT IPIRGEERFA YLNNNGISST RIYSLRMWIC SKLNSYSLHC

QTPFFPS
Length:207
Mass (Da):23,647
Last modified:December 1, 2001 - v1
Checksum:iE4340FCB1E0BD718
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF350409 mRNA. Translation: AAK70357.1.
AF320598 Genomic DNA. Translation: AAL37198.1.
AF320599 Genomic DNA. Translation: AAL37199.1.
AF321553 mRNA. Translation: AAK50881.1.
AY137338 Genomic DNA. Translation: AAN15947.1.
AY320031 mRNA. Translation: AAQ16529.1.
BC106776 mRNA. Translation: AAI06777.1.
DQ143111 Genomic DNA. Translation: ABA43361.1.
CCDSiCCDS20581.1.
RefSeqiNP_444339.1. NM_053109.3.
UniGeneiMm.197536.

Genome annotation databases

EnsembliENSMUST00000032260; ENSMUSP00000032260; ENSMUSG00000030157.
GeneIDi93694.
KEGGimmu:93694.
UCSCiuc009efe.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiCLC2D_MOUSE
AccessioniPrimary (citable) accession number: Q91V08
Secondary accession number(s): Q1AFZ3, Q8VI19, Q8VI20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot